CN1085801A - Spirit increasing white blood cell compound Chinese medicinal preparation and manufacture method thereof - Google Patents
Spirit increasing white blood cell compound Chinese medicinal preparation and manufacture method thereof Download PDFInfo
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- CN1085801A CN1085801A CN 92111469 CN92111469A CN1085801A CN 1085801 A CN1085801 A CN 1085801A CN 92111469 CN92111469 CN 92111469 CN 92111469 A CN92111469 A CN 92111469A CN 1085801 A CN1085801 A CN 1085801A
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Abstract
What the present invention relates to is a kind of compound Chinese medicinal preparation and manufacture method thereof.Be characterized in that making the Ganoderma fermentation liquid with the submerged fermentation technology is equipped with the Radix Astragali, Radix Codonopsis, Fructus Ligustri Lucidi, Fructus Lycii, Caulis Spatholobi plurality of Chinese composition prescription, manufacture nontoxic effective compound Chinese medicinal preparation with industrialized method, in order to effective leukocyte increasing, the enhancing human body immunity ability, the ameliorate tumor patient put, bone marrow depression stomach function regulating, intestinal toxicity in the chemotherapy process, and protection radiation and poisonous substance cause immunity of organisms to hang down inferior infringement.
Description
The present invention is a kind of compound Chinese medicinal preparation, mainly is with fungus submerged fermentation liquid, is equipped with the compound Chinese medicinal preparation and the manufacture method thereof of the plurality of Chinese of strengthening the body resistance.
The medicine of existing leukocyte increasing is mainly Western medicine and some Chinese medicine preparation, as: batilol, Rubidate, Caulis Spatholobi syrup, sharp blood liter, Colla Corii Asini rise medicines such as white liquid, inosine, the Chinese herbal medicine mix preparation has: nineteen eighty-three, electuary was made with the Radix Astragali, Radix Salviae Miltiorrhizae, Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, Radix Glycyrrhizae Preparata by Hangzhou tumour hospital, and the expensive human Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, the Radix Linderae, Caulis Spatholobi, the Radix Rehmanniae, Radix Scutellariae, the Radix Glycyrrhizae Preparata of waiting of Zhao Li made prescription in 1984.Along with the development of medical science, can not satisfy clinical needs far away.Particularly in recent years along with the raising to the oncotherapy technology, radiotherapy and chemotherapy constantly develop, and prolongation has in various degree been arranged the catabasis of malignant tumor and life cycle.Yet, bone marrow depression phenomenons such as caused leukocyte of chemotherapy radiotherapy and hematoblastic minimizing, and stomach, intestinal toxic reactions such as patient feels sick, vomiting remain a difficult problem that needs to be resolved hurrily in the present treatment.Particularly because leukocytic decline, the low inferior reason of toxicity and Abwehrkraft des Koepers often makes treatment plan not implement when causing suffering to patient again, and is forced to later treatment or stopped treatment and causes treatment and fail.Though adding batilol, Rubidate, sharp blood liter, Colla Corii Asini simultaneously in treatment rises medicines such as white liquid, inosine and still can not very ideally alleviate the variation of blood picture and patient's misery.The exposed individual increases gradually socially simultaneously, owing to professional reason is accepted radiation, the personnel that cause body to come to harm near poisonous substance and working environment pollution etc. also have suitable quantity, many personnel's body's immunities among them are low, leukopenia, what have begins canceration, and health is bad.So far, there almost do not have protective agent administration after people's raying of low toxicity can recover the especially orally active radioprotectant of hemopoietic tissue of major injury to be rare especially.Therefore, the new drug of the effective again less leukocyte increasing of development and exploitation toxic and side effects, enhancing human body immunity ability, most important to low leukocyte counts personnel and tumour patient.For personnel's development of professional raying and poisonous substance injury has leukogenic effect, the radiation protection preparation that improves immunity is also very urgent.Existing products mostly is the manufacturing of single submerged fermentation extract in similar technology: artificial fermentation extracts tremella polysaccharide, ganoderan, Ganoderma polysaccharide, lentinan, pachyman, polyporusum bellatus.In existing these shengbai drugs, though Western medicine has certain effect, often toxic and side effects is big or effect is undesirable.Chinese herbal medicine and edible fungus medicine can promote the body hematopoietic reconstitution, and the human body immunity improving function rises white effect and is better than Western medicine, but because prescription is good inadequately, and effect is still not ideal enough, the making that has is also relatively more difficult, does not more reach industrial scale.The medicine that the employing deep layer is sent out alcohol cultivation fungal cell making can reach suitability for industrialized production, guarantees medicine source abundance, and is cheap, has advantage, but more limited owing to being mainly its effect of single fermented product extract.
The objective of the invention is with the large edible fungus that the medicine source can fully be provided is raw material, adopt the submerged fermentation technology in the biological engineering, make the fermentation liquid that is rich in fungus polysaccharide, be equipped with multiple natural Chinese medicine, manufacture nontoxic effective compound Chinese medicinal preparation with industrialized method, in order to effective leukocyte increasing, the enhancing human body immunity ability, the ameliorate tumor patient put, bone marrow depression stomach function regulating, intestinal toxicity in the chemotherapy process, and protection radiation and poisonous substance cause immunity of organisms to hang down inferior infringement.
Prescription composition of the present invention and preparation technology are as follows: (prescription) Ganoderma fermentation liquid (500ml-1000ml), the Radix Astragali (50g-100g), Radix Codonopsis (50g-100g), Fructus Ligustri Lucidi (5g-50g), Fructus Lycii (5g-50g), Caulis Spatholobi (100g-200g).(preparation technology) above Six-element, except that Ganoderma fermentation liquid, the five tastes such as all the other Radixs Astragali decoct with water secondary, each two hours, collecting decoction filtered, it is 1.15-1.20(26 ℃-30 ℃ that filtrate is concentrated into relative density), Ganoderma fermentation liquid presses recipe quantity and above-mentioned medicinal liquid merges, and boils, and adds gelatin 1-5 gram, grind, adjust total amount to 800ml-1000ml, fill, sterilization.The Ganoderma fermentation liquid that the present invention relates to is fabricated to: (prescription) analysis for soybean powder 1-5Kg, glucose 1-5Kg, peptone 100-300g, sodium chloride 10-50g, calcium carbonate 10-100g, ammonium sulfate 10-50g, potassium dihydrogen phosphate 10-100g; (method for making) drops into above-mentioned raw materials in the fermentation tank, stirs, and boils, and when being cooled to 26 ℃-30 ℃, inserting 5-30 and rise Ganderma lucidum strain, 50-90 hour, promptly.Essence of the present invention is made Ganoderma fermentation liquid for using the submerged fermentation technology, is equipped with the above-mentioned all flavor natural drugs that decoct and forms prescription, makes clever increasing white blood cell compound Chinese medicinal preparation.
The present invention has tangible advantage and effect.Theory of Chinese medical science thinks that the disease of leukopenia, hypoimmunity shows as QI and blood deficiency, and minority has heat in blood concurrently, is the disease of " pyretic toxicity ", must start with from boosting qi and nourishing yin in line with the principle of " the body resistance strengthening and constitution consolidating ".In close relations between the QI and blood, " tangible blood can not be spontaneous, is born in invisible gas ", " qi promoting blood production must QI invigorating so enrich blood.Advantage of the present invention just is to follow theory of Chinese medical science, the reasonable compatibility prescription, and advanced technology, technology is simple, is convenient to large-scale industrial production.The traditional Chinese medical science pharmacology of its prescription is: be monarch drug with the Ganoderma, its property is done flat, classifies as top gradely in the Shennong's Herbal, claims that it can " beneficial vital essence, hard muscles and bones ".Compendium of Material Medica claims its energy " tonifying five ZANG-organs is treated empty virtue ".Be strengthening by means of tonics, the product of strengthening the body resistance.The Radix Astragali, Radix Codonopsis are ministerial drug, the Radix Astragali wherein, and sweet tepor is gone into spleen, lung meridian, function tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration.Radix Codonopsis, sweet flat, go into spleen, lung meridian, invigorating the spleen and replenishing QI.Both share principal drug assistance with invigorating the spleen and benefiting QI, the lucid yang sending up nourishing the stomach, qi-supplementing, blood-engendering.Fructus Ligustri Lucidi, Fructus Lycii are adjuvant drug, Fructus Ligustri Lucidi wherein, and the Liver and kidney warp is gone in the sweetness and bitterness cold, function nourishing kidney the liver benefiting.Fructus Lycii, sweet flat, go into the Liver and kidney warp, function tonification Liver and kidney, replenishing vital essence to improve eyesight.Fructus Ligustri Lucidi, Fructus Lycii are share assistant monarch drug, nourishing liver yin, enriching kidney essence.Caulis Spatholobi is an adjuvant, and its bitter little sweet temperature is gone into Liver and kidney, the promoting the circulation of blood of enriching blood, relaxing muscles and tendons and activating QI and blood in the collateral.Full side plays vigorate qi and replenish the blood, nourishing the liver and kidney, active replenishing essence altogether.We's negative and positive of qi and blood giving young employees remedial-courses in general knowledge and vocational skills, Yin grows while yang is generating, negative and positive are two transfers, and active meaning is arranged again among enriching blood, and tonify without causing stagnation is grown and oiliness, is applicable to QI and blood deficiency, deficiency of the liver and kindey, complexion HUANGBAI(sic), shortness of breath and fatigue, inappetence, soreness of the waist and knees, diseases such as palpitation and insomnia.Technical characterstic is the biological engineering submerged fermentation technology with the advanced person, make the Ganoderma fermentation liquid (oral result is better than the fungus polysaccharide that sporophore extracts) that is rich in fungus polysaccharide, (Chinese medicine of respectively distinguishing the flavor of is to decoct and makes the Chinese medicine of compatibility multi-flavor vigorate qi and replenish the blood, nourishing the liver and kidney, active replenishing essence, the characteristics that kept traditional medicine synthetic therapy), to malignant tumor patient accept to put, after the chemotherapy, because of suppressing the peripheral blood picture, reduces hemopoietic system, particularly leukocyte, platelet are more very, good therapeutical effect is arranged, and rising BAIYAO than the routine of present use, to improve the effect of blood picture more remarkable.Owing to can significantly improve the E-rosette and the immunoglobulin index of human body, strengthen patient's humoral immunization and cellular immune function greatly.Can obviously improve subjective symptoms such as feeling sick of causing of chemotherapy, inappetence simultaneously.This compound formulation also can become the injury of professional raying and poisonous substance and the used radiation protection preparation that leukogenic effect is arranged, improve immunity of the personnel of immunity reduction.
Embodiment 1:
The preparation of Ganoderma fermentation liquid:
(prescription) analysis for soybean powder 1Kg
Glucose 2Kg
Peptone 100g
Sodium chloride 22.5g
Calcium carbonate 25g
Ammonium sulfate 10g
Potassium dihydrogen phosphate 22.5g
(method for making) drops into above-mentioned raw materials in 100 liters of fermentation tanks, stirs, and boils, and when being cooled to 26 ℃, inserts 5 liters of Ganderma lucidum strains, through 26 ℃ of cultivations 60 hours, promptly gets Ganoderma fermentation liquid.
The manufacturing of spirit increasing white blood cell liquid:
(prescription) Ganoderma fermentation liquid 400ml
Radix Astragali 40g
Radix Codonopsis 40g
Fructus Ligustri Lucidi 10g
Fructus Lycii 20g
Caulis Spatholobi 60g
(method for making) above Six-element, except that Ganoderma fermentation liquid, the five tastes such as all the other Radixs Astragali decoct with water secondary, each one and a half hours, collecting decoction filtered, it is 1.15-1.20(26 ℃ that filtrate is concentrated into relative density), Ganoderma fermentation liquid and above-mentioned medicinal liquid merge, and boil, and add gelatin 2 grams, grind, adjust total amount to 500ml, fill, sterilization is promptly.
Embodiment 2:
The preparation of Ganoderma fermentation liquid:
(prescription) analysis for soybean powder 2Kg
Glucose 4Kg
Peptone 200g
Sodium chloride 25g
Calcium carbonate 50g
Ammonium sulfate 20g
Potassium dihydrogen phosphate 50g
(method for making) drops into above-mentioned raw materials in 100 liters of fermentation tanks, stirs, and boils, and when being cooled to 28 ℃, inserts 10 liters of Ganderma lucidum strains, through 28 ℃ of cultivations 72 hours, promptly gets Ganoderma fermentation liquid.
The manufacturing of spirit increasing white blood cell liquid:
(prescription) Ganoderma fermentation liquid 800ml
Radix Astragali 80g
Radix Codonopsis 80g
Fructus Ligustri Lucidi 20g
Fructus Lycii 40g
Caulis Spatholobi 120g
(method for making) above Six-element, except that Ganoderma fermentation liquid, the five tastes such as all the other Radixs Astragali decoct with water secondary, each two hours, collecting decoction filtered, it is 1.15-1.20(28 ℃ that filtrate is concentrated into relative density), Ganoderma fermentation liquid and above-mentioned medicinal liquid merge, and boil, and add gelatin 3 grams, grind, adjust total amount to 1000ml, fill, sterilization is promptly.
Embodiment 3:
The preparation of Ganoderma fermentation liquid:
(prescription) analysis for soybean powder 3Kg
Glucose 5Kg
Peptone 300g
Sodium chloride 30g
Calcium carbonate 80g
Ammonium sulfate 40g
Potassium dihydrogen phosphate 80g
(method for making) drops into above-mentioned raw materials in 200 liters of fermentation tanks, stirs, and boils, and when being cooled to 30 ℃, inserts 15 liters of Ganderma lucidum strains, through 30 ℃ of cultivations 80 hours, promptly gets the Ganoderma fermentation liquid.
The manufacturing of spirit increasing white blood cell liquid:
(prescription) Ganoderma fermentation liquid 1000ml
Radix Astragali 90g
Radix Codonopsis 90g
Fructus Ligustri Lucidi 10g
Fructus Lycii 50g
Caulis Spatholobi 150g
(method for making) above Six-element, except that Ganoderma fermentation liquid, the five tastes such as all the other Radixs Astragali decoct with water secondary, each two hours, collecting decoction filtered, it is 1.15-1.20(30 ℃ that filtrate is concentrated into relative density), Ganoderma fermentation liquid and above-mentioned medicinal liquid merge, and boil, and add gelatin 4 grams, grind, adjust total amount to 1500ml, fill, sterilization is promptly.
Claims (2)
1, clever increasing white blood cell compound Chinese medicinal preparation.It is characterized in that:
(1). prescription: Ganoderma fermentation liquid (500ml-1000ml), the Radix Astragali (50g-100g), Radix Codonopsis (50g-100g), Fructus Ligustri Lucidi (5g-50g), Fructus Lycii (5g-50g), Caulis Spatholobi (100g-200g).
(2). the prescription of making Ganoderma fermentation liquid is: Ganderma lucidum strain 5-30 liter, analysis for soybean powder 1-5Kg, glucose 1-5Kg, peptone 100-300g, sodium chloride 10-50g, calcium carbonate 10-100g, ammonium sulfate 10-50g, potassium dihydrogen phosphate 10-100g.
2, the described compound Chinese medicinal preparation manufacture method of claim 1 is:
(1). clever increasing white blood cell compound Chinese medicinal preparation manufacture method is: except that Ganoderma fermentation liquid, the five tastes such as all the other Radixs Astragali decoct with water secondary, each 1-3 hour, collecting decoction, filter, it is 1.0-2.0(26 ℃-30 ℃ that filtrate is concentrated into relative density), Ganoderma fermentation liquid presses recipe quantity and above-mentioned medicinal liquid merges, boil, add gelatin 1-5 gram, grind, adjust total amount to 800ml-1500ml, fill, sterilization.
(2). the manufacture method of Ganoderma fermentation liquid is: raw material described in will writing out a prescription drops in the fermentation tank, stirs, and boils, and when being cooled to 26 ℃-30 ℃, pressing recipe quantity and inserts Ganderma lucidum strain 50-90 hour, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92111469 CN1085801A (en) | 1992-10-17 | 1992-10-17 | Spirit increasing white blood cell compound Chinese medicinal preparation and manufacture method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92111469 CN1085801A (en) | 1992-10-17 | 1992-10-17 | Spirit increasing white blood cell compound Chinese medicinal preparation and manufacture method thereof |
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| CN1085801A true CN1085801A (en) | 1994-04-27 |
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| CN 92111469 Pending CN1085801A (en) | 1992-10-17 | 1992-10-17 | Spirit increasing white blood cell compound Chinese medicinal preparation and manufacture method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049837C (en) * | 1996-12-06 | 2000-03-01 | 李浪辉 | Liver invigorating health tea |
| CN1086296C (en) * | 1999-03-25 | 2002-06-19 | 王淳 | Compound donkey-hide gelatin preparation for preventing arrest of bone marrow in chemotherapy and radiotherapy and preparing process thereof |
| CN1092055C (en) * | 2000-06-09 | 2002-10-09 | 中国人民解放军军事医学科学院放射医学研究所 | Chinese medicine preparation |
| CN101791379B (en) * | 2009-12-22 | 2012-07-04 | 沈阳亿灵医药科技有限公司 | Traditional Chinese medicine compound oral preparation for preventing and treating tumor diseases |
| CN104095993A (en) * | 2014-07-08 | 2014-10-15 | 朱正来 | Ganoderma granular for enhancing immunity and preparation method for ganoderma granular |
| CN104324153A (en) * | 2014-10-22 | 2015-02-04 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for improving immunity of animals and preparation method thereof |
-
1992
- 1992-10-17 CN CN 92111469 patent/CN1085801A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049837C (en) * | 1996-12-06 | 2000-03-01 | 李浪辉 | Liver invigorating health tea |
| CN1086296C (en) * | 1999-03-25 | 2002-06-19 | 王淳 | Compound donkey-hide gelatin preparation for preventing arrest of bone marrow in chemotherapy and radiotherapy and preparing process thereof |
| CN1092055C (en) * | 2000-06-09 | 2002-10-09 | 中国人民解放军军事医学科学院放射医学研究所 | Chinese medicine preparation |
| CN101791379B (en) * | 2009-12-22 | 2012-07-04 | 沈阳亿灵医药科技有限公司 | Traditional Chinese medicine compound oral preparation for preventing and treating tumor diseases |
| CN104095993A (en) * | 2014-07-08 | 2014-10-15 | 朱正来 | Ganoderma granular for enhancing immunity and preparation method for ganoderma granular |
| CN104095993B (en) * | 2014-07-08 | 2017-07-28 | 南京千佛手医药科技发展有限责任公司 | A kind of ganoderma particles of strengthen immunity and preparation method thereof |
| CN104324153A (en) * | 2014-10-22 | 2015-02-04 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for improving immunity of animals and preparation method thereof |
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