CN106176910A - A kind of poultry compound medicine containing Radix Glycyrrhizae and fosfomycin - Google Patents
A kind of poultry compound medicine containing Radix Glycyrrhizae and fosfomycin Download PDFInfo
- Publication number
- CN106176910A CN106176910A CN201610704795.3A CN201610704795A CN106176910A CN 106176910 A CN106176910 A CN 106176910A CN 201610704795 A CN201610704795 A CN 201610704795A CN 106176910 A CN106176910 A CN 106176910A
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- Prior art keywords
- radix glycyrrhizae
- fosfomycin
- poultry
- compound medicine
- poultry compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Radix Glycyrrhizae and fosfomycin, be made up of fosfomycin and Radix Glycyrrhizae, the weight ratio of fosfomycin and Radix Glycyrrhizae is 1:5.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, fosfomycin is used in combination with specific part by weight with Radix Glycyrrhizae, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of poultry containing Radix Glycyrrhizae and fosfomycin with multiple
Side's medicine, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
Radix Glycyrrhizae is pulse family Glycyrrhiza perennial herb, and the root and rhizome of Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, eliminates the phlegm
Many effects such as cough-relieving, relieving spasm to stop pain, the mediation property of medicine, raising animal body immunity.At present, the root and rhizome of Radix Glycyrrhizae frequently as in
Medical herbs feed additive, medicine source is enriched, is had no side effect in animal body, almost without residual, does not the most produce drug resistance, collects nutrition
Keep healthy, prevent disease, seasoning flavouring, promote Production of Livestock and Poultry and improve animal meat quality in one.Radix Glycyrrhizae root and rhizome is raised poultry
Feed additives not only has stimulating appetite, strengthening digestion, improve local flavor, function that growth promotion is fattened, and there is prevention and control
Treating the function of multiple livestock and poultry, research shows, adds Radix Glycyrrhizae and can promote growth of animals or poultry, eat for a long time in additive for farm animal feed
With making poultry fur light, domestic animal gets fat soon, and poultry egg laying is many.Radix Glycyrrhizae adds in the Chinese medicine fodder of prevention and treatment common diseases of chickens
When adding in agent application, have that prophylactic treatment is effective, without any side effects, raw material is easy to get, cheap advantage.Additionally,
Radix Glycyrrhizae root and rhizome can be additionally used in the poisoning of piglet furazolidone, domestic animal eats the poisoning of the animal such as toxic plant poisoning, pig mouldy cron poisoning by mistake
Rescue, rescued effect is preferable.Radix Glycyrrhizae root and rhizome can be used for the treatment and prevention of multiple livestock and poultry as veterinary medicine, and obtains
Extraordinary treatment and prevention effect.
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Fosfomycin, norfloxacin, florfenicol etc. are to prevent and treat this type of disease
Sick conventional Western medicine, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but controls
Therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire Radix Glycyrrhizae and fosfomycin are combined for treat poultry by colon bacillus infect cause
The relevant report of disease.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Radix Glycyrrhizae and fosfomycin, and it is worked in coordination with
Effect is substantially, it is possible to eliminate the colon bacillus drug resistance to fosfomycin, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of poultry containing Radix Glycyrrhizae and fosfomycin are used
Compound medicine, is made up of fosfomycin and Radix Glycyrrhizae, and the weight ratio of fosfomycin and Radix Glycyrrhizae is 1:5.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: proving through experimental study, fosfomycin joins with specific part by weight with Radix Glycyrrhizae
Closing and use, have synergism obvious, curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Radix Glycyrrhizae weight of the present invention is the dry weight of Radix Glycyrrhizae.
One, the Radix Glycyrrhizae mensuration to the drug resistance elimination effect of fosfomycin
1. assay method
It is the mixing medicine that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Radix Glycyrrhizae and various Western medicine respectively according to weight ratio
Liquid；Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicinal liquid
MIC situation of change to Resistant strain；Set the Western medicine being not added with Radix Glycyrrhizae to compare as sun, if it is right as the moon to be not added with Radix Glycyrrhizae and Western medicine simultaneously
According to.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of fosfomycin Yu Radix Glycyrrhizae is 1:5, fosfomycin is to drug resistance colon bacillus
Little Mlc reduces more than 32 times, it is seen then that the drug resistance of fosfomycin is substantially reduced by drug resistance colon bacillus.
And when fosfomycin and Radix Glycyrrhizae are other weight ratios, the fosfomycin minimal inhibitory concentration to drug resistance colon bacillus
Compared with the sun comparison being not added with Radix Glycyrrhizae, there is no significant change.
Two, the experiment in vitro that fosfomycin and Radix Glycyrrhizae are used in combination
It is 1:5 mixing by fosfomycin and Radix Glycyrrhizae (powder) according to weight ratio, makes powder, as test group；Separately set fosfomycin
Single dose and Radix Glycyrrhizae single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 5g/kg feedstuff, and matched group 1 uses fosfomycin
Single dose is administered according to the addition of 1g/kg feedstuff, and matched group 2 Radix Glycyrrhizae single dose is administered according to the addition of 5g/kg feedstuff；Each group
All SMs 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover；Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 5%；Chicken group's great majority of matched group 2 are also still wans, have
The sick chicken death of 13%.
Claims (2)
1. one kind contains Radix Glycyrrhizae and the poultry compound medicine of fosfomycin, it is characterised in that be made up of fosfomycin and Radix Glycyrrhizae, fosfomycin
It is 1:5 with the weight ratio of Radix Glycyrrhizae.
2. by the compound preparation become prepared by the poultry compound medicine described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610704795.3A CN106176910A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Radix Glycyrrhizae and fosfomycin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610704795.3A CN106176910A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Radix Glycyrrhizae and fosfomycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106176910A true CN106176910A (en) | 2016-12-07 |
Family
ID=57523806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610704795.3A Withdrawn CN106176910A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Radix Glycyrrhizae and fosfomycin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106176910A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948656A (en) * | 2014-04-25 | 2014-07-30 | 广西大学 | Creat/fosfomycin-containing compound medicine for livestock and fowl |
| CN103977089A (en) * | 2014-05-14 | 2014-08-13 | 广西大学 | Compound medicine containing radix paeoniae rubrathe and phosphonomycin used for livestock and poultry |
| CN104337847A (en) * | 2014-11-12 | 2015-02-11 | 中国农业科学院哈尔滨兽医研究所 | Compound medicine containing bracken and fosfomycin for livestock |
-
2016
- 2016-08-22 CN CN201610704795.3A patent/CN106176910A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948656A (en) * | 2014-04-25 | 2014-07-30 | 广西大学 | Creat/fosfomycin-containing compound medicine for livestock and fowl |
| CN103977089A (en) * | 2014-05-14 | 2014-08-13 | 广西大学 | Compound medicine containing radix paeoniae rubrathe and phosphonomycin used for livestock and poultry |
| CN104337847A (en) * | 2014-11-12 | 2015-02-11 | 中国农业科学院哈尔滨兽医研究所 | Compound medicine containing bracken and fosfomycin for livestock |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161207 |