CN106511644A - Compound medicine containing Radix Glycyrrhizae, Cissus pteroclada Hayata and amoxicillin and used for livestock and poultry - Google Patents
Compound medicine containing Radix Glycyrrhizae, Cissus pteroclada Hayata and amoxicillin and used for livestock and poultry Download PDFInfo
- Publication number
- CN106511644A CN106511644A CN201611173514.2A CN201611173514A CN106511644A CN 106511644 A CN106511644 A CN 106511644A CN 201611173514 A CN201611173514 A CN 201611173514A CN 106511644 A CN106511644 A CN 106511644A
- Authority
- CN
- China
- Prior art keywords
- amoxicillin
- radix glycyrrhizae
- livestock
- compound medicine
- poultry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a compound medicine containing Radix Glycyrrhizae, Cissus pteroclada Hayata and amoxicillin and used for livestock and poultry. The compound medicine consists of the amoxicillin, the Radix Glycyrrhizae and the Cissus pteroclada Hayata, and the weight ratio of the amoxicillin, the Radix Glycyrrhizae and the Cissus pteroclada Hayata is 1: 10-20: 1-5. The invention further claims a compound preparation prepared from the compound medicine for livestock and poultry. The compound medicine has the beneficial effects that test research proves that if the amoxicillin, the Radix Glycyrrhizae and the Cissus pteroclada Hayata are combined and used in a specific weight ratio, the compound medicine has the advantages of obvious synergistic effect, rapid curative effect, low cost and the like.
Description
Technical field
The invention belongs to livestock and poultry compound medicine technical field, more particularly to it is a kind of containing Radix Glycyrrhizae, treebine stem and Amoxicillin
Livestock and poultry compound medicine, for treating livestock and poultry by the ETEC disease that causes of infection.
Background technology
After livestock and poultry are by ETEC infection, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, cause huge economic loss to livestock and poultry cultivation.Amoxicillin, Florfenicol etc. are the conventional of the such disease of preventing and treating
Western medicine, as medication is more and more spread unchecked, its antibody-resistant bacterium is more and more more, and drug cost is also increasing, but therapeutic effect and
Resistance situation is not taken a turn for the better, and is gone from bad to worse on the contrary.
Jing is retrieved, and is not inquired and is combined Radix Glycyrrhizae, treebine stem and Western medicine for treating livestock and poultry by ETEC sense
The relevant report of the disease that dye causes.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of livestock and poultry compound medicine containing Radix Glycyrrhizae, treebine stem and Amoxicillin
Thing, its synergy are obvious, can eliminate drug resistance of the ETEC to Amoxicillin, improve therapeutic effect.
To solve above technical problem, the present invention is employed the following technical solutions：It is a kind of to contain Radix Glycyrrhizae, treebine stem and Amoxicillin
Livestock and poultry compound medicine, be made up of Amoxicillin and Radix Glycyrrhizae, treebine stem, Amoxicillin and Radix Glycyrrhizae, the weight ratio of treebine stem are
1:10-20:1-5。
The present invention be also claimed by prepared by above-mentioned livestock and poultry compound medicine into compound preparation.
The beneficial effect that the present invention possesses is：Jing experimental studies prove, Amoxicillin and Radix Glycyrrhizae, treebine stem are specifically weighing
Amount ratio is used in combination, obvious with synergy, and curative effect is fast, low cost and other advantages.
Specific embodiment
Technical scheme and beneficial effect are described further with reference to specific embodiment, except Special Statement
Outward, Radix Glycyrrhizae of the present invention, treebine stem weight are dry weight.
First, the measure that the resistance elimination of Radix Glycyrrhizae, treebine stem to Western medicine is acted on
1. assay method
It is 1 according to Western medicine and Radix Glycyrrhizae, the weight ratio of treebine stem:10:1、1:20:2、1:20:5、1:30:5、1:25:4、1:
40:5 prepare Western medicine and Radix Glycyrrhizae, the admixing medical solutions of treebine stem respectively；The bacterial strain to Western medicine resistance is chosen as subjects, is utilized
Plate dilution method carries out Secondary Culture, determines each process MIC situation of change of the liquid to antibody-resistant bacterium；Set Radix Glycyrrhizae, four directions simultaneously
Rattan, each Western medicine single dose are sun control, if being not added with any medicine as cloudy control.
Above-mentioned process is continuous respectively to cultivate for 3 generations.
2. result of the test
After 3 generations of continuous culture, the process flat board of cloudy control is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC (μ g/mL) of uncommon Salmonella is as shown in table 1：
Can be drawn to draw a conclusion by upper table：
1. it is 1 to work as Amoxicillin and Radix Glycyrrhizae, the weight ratio of treebine stem:10:1、1:20:2、1:20:When 5, Amoxicillin pair
The minimal inhibitory concentration of resistance ETEC reduces more than 16 times, it is seen then that resistance ETEC is to Amoxicillin
Drug resistance substantially reduce.And it is 1 to work as Amoxicillin and Radix Glycyrrhizae, the weight ratio of treebine stem:25:4、1:30:5 and 1:40:When 5,
Amoxicillin compares (pure Western medicine) phase with Radix Glycyrrhizae, the positive of treebine stem is not added with to the minimal inhibitory concentration of resistance ETEC
Than no significant change.
2. it is 1 to work as phosphonomycin and Radix Glycyrrhizae, the combination weight ratio of treebine stem:10:1、1:20:2、1:20:5、1:25:4、1:
30:5、1:40:When 5, (pure west is compareed with Radix Glycyrrhizae, the positive of treebine stem is not added with to the minimal inhibitory concentration of resistance ETEC
Medicine) compare, no significant change.
2nd, the experiment in vitro that Western medicine and Radix Glycyrrhizae, treebine stem are used in combination
It is 1 according to weight ratio by Amoxicillin and Radix Glycyrrhizae (powder) and treebine stem (powder):20:5 mixing, make powder, respectively
As test group 1#；Amoxicillin, Radix Glycyrrhizae single dose, treebine stem single dose, Radix Glycyrrhizae+treebine stem (20 are set separately:5) respectively as control group
1#-4#。
Subjects are to make a definite diagnosis the chicken group for having infected E.coli from chickens disease.
Morbidity chicken group is divided into into 5 groups of administrations.The equal SM of each group 5 days.
Dosage and result of the test are as shown in the table：
Claims (2)
1. a kind of livestock and poultry compound medicine containing Radix Glycyrrhizae, treebine stem and Amoxicillin, it is characterised in that by Amoxicillin and sweet
Grass, treebine stem composition, Amoxicillin and Radix Glycyrrhizae, the weight ratio of treebine stem are 1:10-20:1-5.
2. by prepared by the livestock and poultry compound medicine described in claim 1 into compound preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611173514.2A CN106511644A (en) | 2016-12-16 | 2016-12-16 | Compound medicine containing Radix Glycyrrhizae, Cissus pteroclada Hayata and amoxicillin and used for livestock and poultry |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611173514.2A CN106511644A (en) | 2016-12-16 | 2016-12-16 | Compound medicine containing Radix Glycyrrhizae, Cissus pteroclada Hayata and amoxicillin and used for livestock and poultry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106511644A true CN106511644A (en) | 2017-03-22 |
Family
ID=58341100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611173514.2A Pending CN106511644A (en) | 2016-12-16 | 2016-12-16 | Compound medicine containing Radix Glycyrrhizae, Cissus pteroclada Hayata and amoxicillin and used for livestock and poultry |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106511644A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109579A (en) * | 2016-09-21 | 2016-11-16 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae, Cortex Cinnamomi and amoxicillin |
| CN106138184A (en) * | 2016-08-22 | 2016-11-23 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae and amoxicillin |
-
2016
- 2016-12-16 CN CN201611173514.2A patent/CN106511644A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138184A (en) * | 2016-08-22 | 2016-11-23 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae and amoxicillin |
| CN106109579A (en) * | 2016-09-21 | 2016-11-16 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae, Cortex Cinnamomi and amoxicillin |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106511644A (en) | Compound medicine containing Radix Glycyrrhizae, Cissus pteroclada Hayata and amoxicillin and used for livestock and poultry | |
| CN106138320A (en) | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and norfloxacin | |
| CN106138318A (en) | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and amoxicillin | |
| CN106109549A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and norfloxacin | |
| CN106109638A (en) | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and LIJUNJING | |
| CN106176897A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and LIJUNJING | |
| CN106139121A (en) | A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and colistin | |
| CN106729612A (en) | A kind of livestock and poultry compound medicine containing treebine stem, the fruit of Cherokee rose and colistin | |
| CN106620058A (en) | Livestock and poultry compound medicine containing euphorbia humifusa, cissus pteroclada hayata and norfloxacin | |
| CN106728479A (en) | A kind of livestock and poultry compound medicine containing treebine stem and LIJUNJING | |
| CN106166184A (en) | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and amikacin | |
| CN106334011A (en) | Liquorice, fructus rosae laevigatae and florfenicol-containing compound medicine for livestock | |
| CN106176896A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amikacin | |
| CN106421007A (en) | Compound medicine containing humifuse euphorbia herb, cherokeeRose and sulfamonomethoxine sodium used for poultry and livestock | |
| CN106309632A (en) | Livestock and poultry compound drug with Cortex Cinnamomi, Fructus Rosae Laevigatae and norfloxacin | |
| CN106309633A (en) | Livestock and poultry compound drug with Cortex Cinnamomi, Fructus Rosae Laevigatae and florfenicol | |
| CN106109577A (en) | A kind of poultry compound medicine containing Cortex Cinnamomi and sulfamonomethoxine sodium | |
| CN106176942A (en) | A kind of poultry compound medicine containing Cortex Cinnamomi and norfloxacin | |
| CN106236879A (en) | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and ceftiofur sodium | |
| CN106309634A (en) | Composite medicine containing cinnamon, cherokee rose fruit and ceftiofur sodium for beasts and birds | |
| CN106309631A (en) | Livestock and poultry compound drug with Radix Glycyrrhizae, Fructus Rosae Laevigatae and norfloxacin | |
| CN106176895A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amoxicillin | |
| CN106266049A (en) | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and sulfamonomethoxine sodium | |
| CN106266056A (en) | A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amoxicillin | |
| CN106176944A (en) | A kind of poultry compound medicine containing Cortex Cinnamomi and amikacin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170322 |
|
| WD01 | Invention patent application deemed withdrawn after publication |