CN106236879A - A kind of poultry compound medicine containing Fructus Rosae Laevigatae and ceftiofur sodium - Google Patents
A kind of poultry compound medicine containing Fructus Rosae Laevigatae and ceftiofur sodium Download PDFInfo
- Publication number
- CN106236879A CN106236879A CN201610704745.5A CN201610704745A CN106236879A CN 106236879 A CN106236879 A CN 106236879A CN 201610704745 A CN201610704745 A CN 201610704745A CN 106236879 A CN106236879 A CN 106236879A
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- China
- Prior art keywords
- fructus rosae
- rosae laevigatae
- ceftiofur sodium
- compound medicine
- poultry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Fructus Rosae Laevigatae and ceftiofur sodium, be made up of ceftiofur sodium and Fructus Rosae Laevigatae, the weight ratio of ceftiofur sodium and Fructus Rosae Laevigatae is 1:10 1:30.Described ceftiofur sodium and the weight ratio of Fructus Rosae Laevigatae are preferably 1:10.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, ceftiofur sodium is used in combination with specific part by weight with Fructus Rosae Laevigatae, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of containing Fructus Rosae Laevigatae with the poultry of ceftiofur sodium
Fowl compound medicine, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Ceftiofur sodium, norfloxacin, florfenicol etc. are to prevent and treat this
The conventional Western medicine of class disease, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but
It is therapeutic effect and drug resistance situation is not taken a turn for the better, go from bad to worse on the contrary.
Through retrieval, do not inquire and Fructus Rosae Laevigatae and ceftiofur sodium are combined for treating poultry by colon bacillus sense
The relevant report of the disease that dye causes.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Fructus Rosae Laevigatae and ceftiofur sodium,
Its synergism is obvious, it is possible to eliminate the colon bacillus drug resistance to ceftiofur sodium, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Fructus Rosae Laevigatae and ceftiofur sodium
Poultry compound medicine, is made up of ceftiofur sodium and Fructus Rosae Laevigatae, and the weight ratio of ceftiofur sodium and Fructus Rosae Laevigatae is 1:10-1:
30。
Described ceftiofur sodium and the weight ratio of Fructus Rosae Laevigatae are preferably 1:10.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and ceftiofur sodium and Fructus Rosae Laevigatae are with specific weight
Ratio is used in combination, and has synergism obvious, and curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Fructus Rosae Laevigatae weight of the present invention is the dry weight of Fructus Rosae Laevigatae.
One, the Fructus Rosae Laevigatae mensuration to the drug resistance elimination effect of ceftiofur sodium
1. assay method
It is the mixing that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Fructus Rosae Laevigatae and various Western medicine respectively according to weight ratio
Medicinal liquid；Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicine
The liquid MIC situation of change to Resistant strain；Set the Western medicine being not added with Fructus Rosae Laevigatae to compare as sun, if being not added with Fructus Rosae Laevigatae and Western medicine work simultaneously
Compare for the moon.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of ceftiofur sodium Yu Fructus Rosae Laevigatae is 1:10,1:30, ceftiofur sodium is to drug resistance
The minimal inhibitory concentration of colon bacillus reduces 128 times, more than 32 times respectively, it is seen then that drug resistance colon bacillus is to cephalo
The drug resistance of ceftiofur sodium substantially reduces.
And when ceftiofur sodium and Fructus Rosae Laevigatae are other weight ratios, ceftiofur sodium is to drug resistance colon bacillus
Little Mlc, compared with the sun comparison being not added with Fructus Rosae Laevigatae, does not has significant change.
Two, the experiment in vitro that ceftiofur sodium and Fructus Rosae Laevigatae are used in combination
It is 1:10 mixing by ceftiofur sodium and Fructus Rosae Laevigatae (powder) according to weight ratio, makes powder, as test group；Separately set
Ceftiofur sodium single dose and Fructus Rosae Laevigatae single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 6g/kg feedstuff, matched group 1 cephalo thiophene
Furan sodium single dose is administered according to the addition of 0.5g/kg feedstuff, and matched group 2 uses Fructus Rosae Laevigatae single dose according to the addition of 6g/kg feedstuff
It is administered；The equal SM of each group 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover；Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 5%；Chicken group's great majority of matched group 2 are also still wans, have
The sick chicken death of 12%.
Claims (3)
1. one kind contains Fructus Rosae Laevigatae and the poultry compound medicine of ceftiofur sodium, it is characterised in that by ceftiofur sodium and Fructus Rosae Laevigatae
Son composition, the weight ratio of ceftiofur sodium and Fructus Rosae Laevigatae is 1:10-1:30.
Poultry compound medicine containing Fructus Rosae Laevigatae and ceftiofur sodium the most according to claim 1, it is characterised in that described
Ceftiofur sodium and the weight ratio of Fructus Rosae Laevigatae be 1:10.
3. by the compound preparation become prepared by the poultry compound medicine described in claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610704745.5A CN106236879A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and ceftiofur sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610704745.5A CN106236879A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and ceftiofur sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106236879A true CN106236879A (en) | 2016-12-21 |
Family
ID=57595813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610704745.5A Withdrawn CN106236879A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and ceftiofur sodium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106236879A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989728A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and beta-lactam antibacterial medicine containing compound medicine for livestock and poultry |
-
2016
- 2016-08-22 CN CN201610704745.5A patent/CN106236879A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989728A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and beta-lactam antibacterial medicine containing compound medicine for livestock and poultry |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161221 |