CN106214742A - A kind of poultry compound medicine containing Cortex Cinnamomi and ceftiofur sodium - Google Patents
A kind of poultry compound medicine containing Cortex Cinnamomi and ceftiofur sodium Download PDFInfo
- Publication number
- CN106214742A CN106214742A CN201610705510.8A CN201610705510A CN106214742A CN 106214742 A CN106214742 A CN 106214742A CN 201610705510 A CN201610705510 A CN 201610705510A CN 106214742 A CN106214742 A CN 106214742A
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- Prior art keywords
- cortex cinnamomi
- ceftiofur sodium
- compound medicine
- poultry
- weight ratio
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Cortex Cinnamomi and ceftiofur sodium, be made up of ceftiofur sodium and Cortex Cinnamomi, the weight ratio of ceftiofur sodium and Cortex Cinnamomi is 1:5 1:50.Described ceftiofur sodium and the weight ratio of Cortex Cinnamomi are preferably 1:10.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, ceftiofur sodium is used in combination with specific part by weight with Cortex Cinnamomi, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of containing Cortex Cinnamomi with the poultry of ceftiofur sodium
By compound medicine, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Ceftiofur sodium, norfloxacin, florfenicol etc. are to prevent and treat this
The conventional Western medicine of class disease, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but
It is therapeutic effect and drug resistance situation is not taken a turn for the better, go from bad to worse on the contrary.
Through retrieval, do not inquire to combine Cortex Cinnamomi and ceftiofur sodium and infected by colon bacillus for treating poultry
The relevant report of the disease caused.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Cortex Cinnamomi and ceftiofur sodium, its
Synergism is obvious, it is possible to eliminate the colon bacillus drug resistance to ceftiofur sodium, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Cortex Cinnamomi with the poultry of ceftiofur sodium
Fowl compound medicine, is made up of ceftiofur sodium and Cortex Cinnamomi, and the weight ratio of ceftiofur sodium and Cortex Cinnamomi is 1:5-1:50.
Described ceftiofur sodium and the weight ratio of Cortex Cinnamomi are preferably 1:10.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and ceftiofur sodium and Cortex Cinnamomi are with specific weight ratio
Example is used in combination, and has synergism obvious, and curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Cortex Cinnamomi weight of the present invention is the dry weight of Cortex Cinnamomi.
One, the Cortex Cinnamomi mensuration to the drug resistance elimination effect of ceftiofur sodium
1. assay method
It is the mixing medicine that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Cortex Cinnamomi and various Western medicine respectively according to weight ratio
Liquid；Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicinal liquid
MIC situation of change to Resistant strain；Set the Western medicine being not added with Cortex Cinnamomi to compare as sun, if it is right as the moon to be not added with Cortex Cinnamomi and Western medicine simultaneously
According to.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of ceftiofur sodium Yu Cortex Cinnamomi is 1:5,1:10,1:30,1:50, ceftiofur
Sodium reduces 64 times, 128 times, 32 times, more than 16 times respectively to the minimal inhibitory concentration of drug resistance colon bacillus, it is seen then that drug resistance
The drug resistance of ceftiofur sodium is substantially reduced by colon bacillus.
And when the weight ratio of ceftiofur sodium Yu Cortex Cinnamomi is 1:1 and 1:3, ceftiofur sodium is to drug resistance colon bacillus
Minimal inhibitory concentration be not added with Cortex Cinnamomi sun comparison compared with, there is no significant change.
Two, the experiment in vitro that ceftiofur sodium and Cortex Cinnamomi are used in combination
It is 1:5 mixing by ceftiofur sodium and Cortex Cinnamomi (powder) according to weight ratio, makes powder, as test group；Separately set head
Spore ceftiofur sodium single dose and Cortex Cinnamomi single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 2.5g/kg feedstuff, and matched group 1 uses cephalo
Ceftiofur sodium single dose is administered according to the addition of 0.5g/kg feedstuff, and matched group 2 uses Cortex Cinnamomi single dose according to the interpolation of 2.5g/kg feedstuff
Amount is administered；The equal SM of each group 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover；Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 5%；Chicken group's great majority of matched group 2 are also still wans, have 9%
Sick chicken death.
Claims (3)
1. one kind contains Cortex Cinnamomi and the poultry compound medicine of ceftiofur sodium, it is characterised in that by ceftiofur sodium and Cortex Cinnamomi group
Becoming, the weight ratio of ceftiofur sodium and Cortex Cinnamomi is 1:5-1:50.
Poultry compound medicine containing Cortex Cinnamomi and ceftiofur sodium the most according to claim 1, it is characterised in that described
The weight ratio of ceftiofur sodium and Cortex Cinnamomi is 1:10.
3. by the compound preparation become prepared by the poultry compound medicine described in claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610705510.8A CN106214742A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and ceftiofur sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610705510.8A CN106214742A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and ceftiofur sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106214742A true CN106214742A (en) | 2016-12-14 |
Family
ID=57552830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610705510.8A Withdrawn CN106214742A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and ceftiofur sodium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106214742A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948930A (en) * | 2014-05-14 | 2014-07-30 | 广西大学 | Red paeonia/beta-lactam-antibacterial-agent-containing compound medicine for livestock and fowl |
| CN103989728A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and beta-lactam antibacterial medicine containing compound medicine for livestock and poultry |
-
2016
- 2016-08-22 CN CN201610705510.8A patent/CN106214742A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948930A (en) * | 2014-05-14 | 2014-07-30 | 广西大学 | Red paeonia/beta-lactam-antibacterial-agent-containing compound medicine for livestock and fowl |
| CN103989728A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and beta-lactam antibacterial medicine containing compound medicine for livestock and poultry |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161214 |