CN106166176A - A kind of poultry compound medicine containing Cortex Cinnamomi and fosfomycin - Google Patents
A kind of poultry compound medicine containing Cortex Cinnamomi and fosfomycin Download PDFInfo
- Publication number
- CN106166176A CN106166176A CN201610704060.0A CN201610704060A CN106166176A CN 106166176 A CN106166176 A CN 106166176A CN 201610704060 A CN201610704060 A CN 201610704060A CN 106166176 A CN106166176 A CN 106166176A
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- CN
- China
- Prior art keywords
- fosfomycin
- cortex cinnamomi
- compound medicine
- poultry
- poultry compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Cortex Cinnamomi and fosfomycin, be made up of fosfomycin and Cortex Cinnamomi, the weight ratio of fosfomycin and Cortex Cinnamomi is 1:10 1:30.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, fosfomycin is used in combination with specific part by weight with Cortex Cinnamomi, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of poultry containing Cortex Cinnamomi and fosfomycin with multiple
Side's medicine, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Fosfomycin, norfloxacin, florfenicol etc. are to prevent and treat this type of disease
Sick conventional Western medicine, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but controls
Therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire Cortex Cinnamomi and fosfomycin are combined for treat poultry by colon bacillus infect cause
The relevant report of disease.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Cortex Cinnamomi and fosfomycin, and it is worked in coordination with
Effect is substantially, it is possible to eliminate the colon bacillus drug resistance to fosfomycin, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of poultry containing Cortex Cinnamomi and fosfomycin are used
Compound medicine, is made up of fosfomycin and Cortex Cinnamomi, and the weight ratio of fosfomycin and Cortex Cinnamomi is 1:10-1:30.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: proving through experimental study, fosfomycin joins with specific part by weight with Cortex Cinnamomi
Closing and use, have synergism obvious, curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Cortex Cinnamomi weight of the present invention is the dry weight of Cortex Cinnamomi.
One, the Cortex Cinnamomi mensuration to the drug resistance elimination effect of fosfomycin
1. assay method
It is the mixing medicine that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Cortex Cinnamomi and various Western medicine respectively according to weight ratio
Liquid；Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicinal liquid
MIC situation of change to Resistant strain；Set the Western medicine being not added with Cortex Cinnamomi to compare as sun, if it is right as the moon to be not added with Cortex Cinnamomi and Western medicine simultaneously
According to.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC (μ g/mL) of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of fosfomycin Yu Cortex Cinnamomi is 1:10 and 1:30, drug resistance large intestine angstrom is wished by fosfomycin
The minimal inhibitory concentration of Salmonella reduces 16 times and more than 32 times respectively, it is seen then that the drug resistance colon bacillus drug resistance to fosfomycin
Property substantially reduces.
And when fosfomycin and Cortex Cinnamomi are other weight ratios, the fosfomycin minimal inhibitory concentration to drug resistance colon bacillus
Compared with the sun comparison being not added with Cortex Cinnamomi, there is no significant change.
Two, the experiment in vitro that fosfomycin and Cortex Cinnamomi are used in combination
It is 1:10 mixing by fosfomycin and Cortex Cinnamomi (powder) according to weight ratio, makes powder, as test group；Separately set fosfomycin
Single dose and Cortex Cinnamomi single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 12g/kg feedstuff, and matched group 1 is mould with phosphorus
Element single dose is administered according to the addition of 1g/kg feedstuff, and matched group 2 Cortex Cinnamomi single dose is administered according to the addition of 12g/kg feedstuff；
The equal SM of each group 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover；Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 4%；Chicken group's great majority of matched group 2 are also still wans, have 7%
Sick chicken death.
Claims (2)
1. one kind contains Cortex Cinnamomi and the poultry compound medicine of fosfomycin, it is characterised in that be made up of fosfomycin and Cortex Cinnamomi, fosfomycin
It is 1:10-1:30 with the weight ratio of Cortex Cinnamomi.
2. by the compound preparation become prepared by the poultry compound medicine described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610704060.0A CN106166176A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and fosfomycin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610704060.0A CN106166176A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and fosfomycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106166176A true CN106166176A (en) | 2016-11-30 |
Family
ID=57376620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610704060.0A Withdrawn CN106166176A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and fosfomycin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106166176A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977089A (en) * | 2014-05-14 | 2014-08-13 | 广西大学 | Compound medicine containing radix paeoniae rubrathe and phosphonomycin used for livestock and poultry |
| CN104337847A (en) * | 2014-11-12 | 2015-02-11 | 中国农业科学院哈尔滨兽医研究所 | Compound medicine containing bracken and fosfomycin for livestock |
| CN104435040A (en) * | 2014-11-07 | 2015-03-25 | 广西大学 | Balsamiferou blumea herb and fosfomycin containing compound medicine for livestock and poultry |
-
2016
- 2016-08-22 CN CN201610704060.0A patent/CN106166176A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977089A (en) * | 2014-05-14 | 2014-08-13 | 广西大学 | Compound medicine containing radix paeoniae rubrathe and phosphonomycin used for livestock and poultry |
| CN104435040A (en) * | 2014-11-07 | 2015-03-25 | 广西大学 | Balsamiferou blumea herb and fosfomycin containing compound medicine for livestock and poultry |
| CN104337847A (en) * | 2014-11-12 | 2015-02-11 | 中国农业科学院哈尔滨兽医研究所 | Compound medicine containing bracken and fosfomycin for livestock |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161130 |
|
| WW01 | Invention patent application withdrawn after publication |