CN106109547A - A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and fosfomycin - Google Patents
A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and fosfomycin Download PDFInfo
- Publication number
- CN106109547A CN106109547A CN201610705373.8A CN201610705373A CN106109547A CN 106109547 A CN106109547 A CN 106109547A CN 201610705373 A CN201610705373 A CN 201610705373A CN 106109547 A CN106109547 A CN 106109547A
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- Prior art keywords
- fosfomycin
- herba euphorbiae
- euphorbiae humifusae
- compound medicine
- poultry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Herba Euphorbiae Humifusae and fosfomycin, be made up of fosfomycin and Herba Euphorbiae Humifusae, the weight ratio of fosfomycin and Herba Euphorbiae Humifusae is 1:10 1:30.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, fosfomycin is used in combination with specific part by weight with Herba Euphorbiae Humifusae, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of poultry containing Herba Euphorbiae Humifusae and fosfomycin and use
Compound medicine, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Fosfomycin, norfloxacin, florfenicol etc. are to prevent and treat this type of disease
Sick conventional Western medicine, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but controls
Therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire Herba Euphorbiae Humifusae and fosfomycin are combined for treat poultry by colon bacillus infect draw
The relevant report of the disease risen.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Herba Euphorbiae Humifusae and fosfomycin, its association
Same-action is obvious, it is possible to eliminate the colon bacillus drug resistance to fosfomycin, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Herba Euphorbiae Humifusae with the poultry of fosfomycin
With compound medicine, being made up of fosfomycin and Herba Euphorbiae Humifusae, the weight ratio of fosfomycin and Herba Euphorbiae Humifusae is 1:10-1:30.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and fosfomycin and Herba Euphorbiae Humifusae are with specific part by weight
Being used in combination, have synergism obvious, curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Herba Euphorbiae Humifusae weight of the present invention is the dry weight of Herba Euphorbiae Humifusae.
One, the Herba Euphorbiae Humifusae mensuration to the drug resistance elimination effect of fosfomycin
1. assay method
It is the mixing that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Herba Euphorbiae Humifusae and various Western medicine respectively according to weight ratio
Medicinal liquid；Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicine
The liquid MIC situation of change to Resistant strain；Set the Western medicine being not added with Herba Euphorbiae Humifusae to compare as sun, if being not added with Herba Euphorbiae Humifusae and Western medicine work simultaneously
Compare for the moon.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC (μ g/mL) of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of fosfomycin Yu Herba Euphorbiae Humifusae is 1:10 and 1:30, fosfomycin is to drug resistance large intestine angstrom
The minimal inhibitory concentration of uncommon Salmonella reduces 16 times and more than 32 times respectively, it is seen then that resistance to fosfomycin of drug resistance colon bacillus
The property of medicine substantially reduces.
And when fosfomycin and Herba Euphorbiae Humifusae are other weight ratios, fosfomycin is antibacterial dense to the minimum of drug resistance colon bacillus
Compared with the sun comparison spent and be not added with Herba Euphorbiae Humifusae, there is no significant change.
Two, the experiment in vitro that fosfomycin and Herba Euphorbiae Humifusae are used in combination
It is 1:10 mixing by fosfomycin and Herba Euphorbiae Humifusae (powder) according to weight ratio, makes powder, as test group；Separately set phosphorus mould
Element single dose and Herba Euphorbiae Humifusae single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 12g/kg feedstuff, and matched group 1 is mould with phosphorus
Element single dose is administered according to the addition of 1g/kg feedstuff, and matched group 2 Herba Euphorbiae Humifusae single dose is given according to the addition of 12g/kg feedstuff
Medicine；The equal SM of each group 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover；Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 5%；Chicken group's great majority of matched group 2 are also still wans, have 6%
Sick chicken death.
Claims (2)
1. one kind contains Herba Euphorbiae Humifusae and the poultry compound medicine of fosfomycin, it is characterised in that be made up of fosfomycin and Herba Euphorbiae Humifusae, phosphorus
The weight ratio of mycin and Herba Euphorbiae Humifusae is 1:10-1:30.
2. by the compound preparation become prepared by the poultry compound medicine described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610705373.8A CN106109547A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and fosfomycin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610705373.8A CN106109547A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and fosfomycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106109547A true CN106109547A (en) | 2016-11-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610705373.8A Withdrawn CN106109547A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and fosfomycin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106109547A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948656A (en) * | 2014-04-25 | 2014-07-30 | 广西大学 | Creat/fosfomycin-containing compound medicine for livestock and fowl |
| CN103977089A (en) * | 2014-05-14 | 2014-08-13 | 广西大学 | Compound medicine containing radix paeoniae rubrathe and phosphonomycin used for livestock and poultry |
| CN104337847A (en) * | 2014-11-12 | 2015-02-11 | 中国农业科学院哈尔滨兽医研究所 | Compound medicine containing bracken and fosfomycin for livestock |
-
2016
- 2016-08-22 CN CN201610705373.8A patent/CN106109547A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948656A (en) * | 2014-04-25 | 2014-07-30 | 广西大学 | Creat/fosfomycin-containing compound medicine for livestock and fowl |
| CN103977089A (en) * | 2014-05-14 | 2014-08-13 | 广西大学 | Compound medicine containing radix paeoniae rubrathe and phosphonomycin used for livestock and poultry |
| CN104337847A (en) * | 2014-11-12 | 2015-02-11 | 中国农业科学院哈尔滨兽医研究所 | Compound medicine containing bracken and fosfomycin for livestock |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161116 |