CN106177904A - A kind of poultry compound medicine containing Cortex Cinnamomi and colistin - Google Patents
A kind of poultry compound medicine containing Cortex Cinnamomi and colistin Download PDFInfo
- Publication number
- CN106177904A CN106177904A CN201610703968.XA CN201610703968A CN106177904A CN 106177904 A CN106177904 A CN 106177904A CN 201610703968 A CN201610703968 A CN 201610703968A CN 106177904 A CN106177904 A CN 106177904A
- Authority
- CN
- China
- Prior art keywords
- colistin
- cortex cinnamomi
- compound medicine
- poultry
- poultry compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
Abstract
The present invention relates to a kind of poultry compound medicine containing Cortex Cinnamomi and colistin, be made up of colistin and Cortex Cinnamomi, the weight ratio of colistin and Cortex Cinnamomi is 1:5 1:10.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, colistin is used in combination with specific part by weight with Cortex Cinnamomi, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of poultry containing Cortex Cinnamomi and colistin and use
Compound medicine, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Amoxicillin, norfloxacin, colistin etc. are to prevent and treat this type of
The conventional Western medicine of disease, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but
Therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire Cortex Cinnamomi and colistin are combined for treat poultry by colon bacillus infect draw
The relevant report of the disease risen.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Cortex Cinnamomi and colistin, its association
Same-action is obvious, it is possible to eliminate the colon bacillus drug resistance to colistin, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Cortex Cinnamomi with the poultry of colistin
With compound medicine, being made up of colistin and Cortex Cinnamomi, the weight ratio of colistin and Cortex Cinnamomi is 1:5-1:10.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and colistin and Cortex Cinnamomi are with specific part by weight
Being used in combination, have synergism obvious, curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Cortex Cinnamomi weight of the present invention is the dry weight of Cortex Cinnamomi.
One, the Cortex Cinnamomi mensuration to the drug resistance elimination effect of colistin
1. assay method
It is the mixing medicine that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Cortex Cinnamomi and various Western medicine respectively according to weight ratio
Liquid；Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicinal liquid
MIC situation of change to Resistant strain；Set the Western medicine being not added with Cortex Cinnamomi to compare as sun, if it is right as the moon to be not added with Cortex Cinnamomi and Western medicine simultaneously
According to.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of colistin Yu Cortex Cinnamomi is 1:5 and 1:10, colistin is to drug resistance large intestine angstrom
The minimal inhibitory concentration of uncommon Salmonella all reduces more than 256 times, it is seen then that drug resistance colon bacillus is bright to the drug resistance of colistin
Aobvious reduction.
And when colistin and Cortex Cinnamomi are other weight ratios, colistin is antibacterial to the minimum of drug resistance colon bacillus
Concentration, compared with the sun comparison being not added with Cortex Cinnamomi, does not has significant change.
Two, the experiment in vitro that colistin and Cortex Cinnamomi are used in combination
It is 1:5 mixing by colistin and Cortex Cinnamomi (powder) according to weight ratio, makes powder, as test group；Separately set viscous bar
Rhzomorph single dose and Cortex Cinnamomi single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 2g/kg feedstuff, and matched group 1 uses Bacillus adhaerens
Element single dose is administered according to the addition of 0.4g/kg feedstuff, and matched group 2 Cortex Cinnamomi single dose is administered according to the addition of 2g/kg feedstuff；
The equal SM of each group 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover；Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 6%；Chicken group's great majority of matched group 2 are also still wans, have 9%
Sick chicken death.
Claims (2)
1. one kind contains Cortex Cinnamomi and the poultry compound medicine of colistin, it is characterised in that be made up of colistin and Cortex Cinnamomi, viscous
The weight ratio of bacillin and Cortex Cinnamomi is 1:5-1:10.
2. by the compound preparation become prepared by the poultry compound medicine described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610703968.XA CN106177904A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and colistin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610703968.XA CN106177904A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and colistin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106177904A true CN106177904A (en) | 2016-12-07 |
Family
ID=57524348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610703968.XA Withdrawn CN106177904A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and colistin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106177904A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436160A (en) * | 2014-11-07 | 2015-03-25 | 广西大学 | Balsamiferou blumea herb and colistin containing compound medicine for livestock and poultry |
| CN105341474A (en) * | 2015-11-06 | 2016-02-24 | 陈琳 | Broiler healthcare feed additive and preparation method thereof |
-
2016
- 2016-08-22 CN CN201610703968.XA patent/CN106177904A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436160A (en) * | 2014-11-07 | 2015-03-25 | 广西大学 | Balsamiferou blumea herb and colistin containing compound medicine for livestock and poultry |
| CN105341474A (en) * | 2015-11-06 | 2016-02-24 | 陈琳 | Broiler healthcare feed additive and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| ITSARAPORN UTCHARIYAKIAT ET AL.: "Efficacy of cinnamon bark oil and cinnamaldehyde on anti-multidrug resistant Pseudomonas aeruginosa and the synergistic effects in combination with other antimicrobial agents.", 《BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE》 * |
| 中成药: "美国学者发现肉桂可以杀灭大肠杆菌", 《中成药》 * |
| 张桂枝等: "左氧氟沙星与多黏菌素联合抗菌活性研究", 《安徽农业科学》 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161207 |
|
| WW01 | Invention patent application withdrawn after publication |