CN106267152A - A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and colistin - Google Patents
A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and colistin Download PDFInfo
- Publication number
- CN106267152A CN106267152A CN201610705492.3A CN201610705492A CN106267152A CN 106267152 A CN106267152 A CN 106267152A CN 201610705492 A CN201610705492 A CN 201610705492A CN 106267152 A CN106267152 A CN 106267152A
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- CN
- China
- Prior art keywords
- colistin
- herba euphorbiae
- euphorbiae humifusae
- compound medicine
- poultry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Herba Euphorbiae Humifusae and colistin, be made up of colistin and Herba Euphorbiae Humifusae, the weight ratio of colistin and Herba Euphorbiae Humifusae is 1:3 1:10.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, colistin is used in combination with specific part by weight with Herba Euphorbiae Humifusae, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of containing Herba Euphorbiae Humifusae with the poultry of colistin
By compound medicine, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Amoxicillin, norfloxacin, colistin etc. are to prevent and treat this type of
The conventional Western medicine of disease, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but
Therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire to combine Herba Euphorbiae Humifusae and colistin and infected by colon bacillus for treating poultry
The relevant report of the disease caused.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Herba Euphorbiae Humifusae and colistin, its
Synergism is obvious, it is possible to eliminate the colon bacillus drug resistance to colistin, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Herba Euphorbiae Humifusae with the poultry of colistin
Fowl compound medicine, is made up of colistin and Herba Euphorbiae Humifusae, and the weight ratio of colistin and Herba Euphorbiae Humifusae is 1:3-1:10.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and colistin and Herba Euphorbiae Humifusae are with specific weight ratio
Example is used in combination, and has synergism obvious, and curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Herba Euphorbiae Humifusae weight of the present invention is the dry weight of Herba Euphorbiae Humifusae.
One, the Herba Euphorbiae Humifusae mensuration to the drug resistance elimination effect of colistin
1. assay method
It is the mixing that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Herba Euphorbiae Humifusae and various Western medicine respectively according to weight ratio
Medicinal liquid；Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicine
The liquid MIC situation of change to Resistant strain；Set the Western medicine being not added with Herba Euphorbiae Humifusae to compare as sun, if being not added with Herba Euphorbiae Humifusae and Western medicine work simultaneously
Compare for the moon.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC (μ g/mL) of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of colistin Yu Herba Euphorbiae Humifusae is 1:3,1:5 and 1:10, colistin is to drug resistance
The minimal inhibitory concentration of colon bacillus all reduces more than 256 times, it is seen then that resistance to colistin of drug resistance colon bacillus
The property of medicine substantially reduces.
And when colistin and Herba Euphorbiae Humifusae are other weight ratios, the minimum of drug resistance colon bacillus is pressed down by colistin
Bacteria concentration, compared with the sun comparison being not added with Herba Euphorbiae Humifusae, does not has significant change.
Two, the experiment in vitro that colistin and Herba Euphorbiae Humifusae are used in combination
It is 1:5 mixing by colistin and Herba Euphorbiae Humifusae (powder) according to weight ratio, makes powder, as test group；Separately set viscous
Bacillin single dose and Herba Euphorbiae Humifusae single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 2g/kg feedstuff, and matched group 1 uses Bacillus adhaerens
Element single dose is administered according to the addition of 0.4g/kg feedstuff, and matched group 2 Herba Euphorbiae Humifusae single dose is given according to the addition of 2g/kg feedstuff
Medicine；The equal SM of each group 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover；Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 5%；Chicken group's great majority of matched group 2 are also still wans, have
The sick chicken death of 12%.
Claims (2)
1. one kind contains Herba Euphorbiae Humifusae and the poultry compound medicine of colistin, it is characterised in that by colistin and Herba Euphorbiae Humifusae group
Becoming, the weight ratio of colistin and Herba Euphorbiae Humifusae is 1:3-1:10.
2. by the compound preparation become prepared by the poultry compound medicine described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610705492.3A CN106267152A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and colistin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610705492.3A CN106267152A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and colistin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106267152A true CN106267152A (en) | 2017-01-04 |
Family
ID=57615344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610705492.3A Withdrawn CN106267152A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and colistin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106267152A (en) |
-
2016
- 2016-08-22 CN CN201610705492.3A patent/CN106267152A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170104 |