CN106176944A - A kind of poultry compound medicine containing Cortex Cinnamomi and amikacin - Google Patents
A kind of poultry compound medicine containing Cortex Cinnamomi and amikacin Download PDFInfo
- Publication number
- CN106176944A CN106176944A CN201610705324.4A CN201610705324A CN106176944A CN 106176944 A CN106176944 A CN 106176944A CN 201610705324 A CN201610705324 A CN 201610705324A CN 106176944 A CN106176944 A CN 106176944A
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- Prior art keywords
- amikacin
- cortex cinnamomi
- compound medicine
- poultry
- weight ratio
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Cortex Cinnamomi and amikacin, be made up of amikacin and Cortex Cinnamomi, the weight ratio of amikacin and Cortex Cinnamomi is 1:3 1:10.Described amikacin and the weight ratio of Cortex Cinnamomi are preferably 1:10.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, amikacin is used in combination with specific part by weight with Cortex Cinnamomi, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of poultry containing Cortex Cinnamomi and amikacin and use
Compound medicine, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Amoxicillin, norfloxacin, amikacin etc. are to prevent and treat this type of
The conventional Western medicine of disease, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but
Therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire Cortex Cinnamomi and amikacin are combined for treat poultry by colon bacillus infect draw
The relevant report of the disease risen.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Cortex Cinnamomi and amikacin, its association
Same-action is obvious, it is possible to eliminate the colon bacillus drug resistance to amikacin, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Cortex Cinnamomi with the poultry of amikacin
With compound medicine, being made up of amikacin and Cortex Cinnamomi, the weight ratio of amikacin and Cortex Cinnamomi is 1:3-1:10.
Described amikacin and the weight ratio of Cortex Cinnamomi are preferably 1:10.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and amikacin and Cortex Cinnamomi are with specific part by weight
Being used in combination, have synergism obvious, curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Cortex Cinnamomi weight of the present invention is the dry weight of Cortex Cinnamomi.
One, the Cortex Cinnamomi mensuration to the drug resistance elimination effect of amikacin
1. assay method
It is the mixing medicine that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Cortex Cinnamomi and various Western medicine respectively according to weight ratio
Liquid;Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicinal liquid
MIC situation of change to Resistant strain;Set the Western medicine being not added with Cortex Cinnamomi to compare as sun, if it is right as the moon to be not added with Cortex Cinnamomi and Western medicine simultaneously
According to.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of amikacin Yu Cortex Cinnamomi is 1:3, amikacin is to drug resistance colon bacillus
Minimal inhibitory concentration all reduce more than 64 times, when weight ratio is 1:5, the minimum of drug resistance colon bacillus is pressed down by amikacin
Bacteria concentration all reduces more than 128 times, and when weight ratio is 1:10, amikacin is antibacterial dense to the minimum of drug resistance colon bacillus
Degree all reduces more than 256 times, it is seen then that the drug resistance of amikacin is substantially reduced by drug resistance colon bacillus.
And when the weight ratio of amikacin Yu Cortex Cinnamomi is 1:1,1:30 and 1:50, amikacin is to drug resistance E
The minimal inhibitory concentration of bacterium, compared with the sun comparison being not added with Cortex Cinnamomi, does not has significant change.
Two, the experiment in vitro that amikacin and Cortex Cinnamomi are used in combination
It is 1:5 mixing by amikacin and Cortex Cinnamomi (powder) according to weight ratio, makes powder, as test group;Separately set Ah rice
Card star single dose and Cortex Cinnamomi single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 1.5g/kg feedstuff, and matched group 1 uses Ah rice
Card star single dose is administered according to the addition of 0.3g/kg feedstuff, and matched group 2 uses Cortex Cinnamomi single dose according to the addition of 1.5g/kg feedstuff
It is administered;The equal SM of each group 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover;Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 4%;Chicken group's great majority of matched group 2 are also still wans, have
The sick chicken death of 11%.
Claims (3)
1. one kind contains Cortex Cinnamomi and the poultry compound medicine of amikacin, it is characterised in that be made up of amikacin and Cortex Cinnamomi, Ah
The weight ratio of meter Ka Xing and Cortex Cinnamomi is 1:3-1:10.
Poultry compound medicine containing Cortex Cinnamomi and amikacin the most according to claim 1, it is characterised in that described Ah
The weight ratio of meter Ka Xing and Cortex Cinnamomi is 1:10.
3. by the compound preparation become prepared by the poultry compound medicine described in claim 1 or 2.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610705324.4A CN106176944A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and amikacin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610705324.4A CN106176944A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and amikacin |
Publications (1)
Publication Number | Publication Date |
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CN106176944A true CN106176944A (en) | 2016-12-07 |
Family
ID=57523399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201610705324.4A Withdrawn CN106176944A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and amikacin |
Country Status (1)
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CN (1) | CN106176944A (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103933087A (en) * | 2014-04-25 | 2014-07-23 | 广西大学 | Method for treating Escherichia coli infection diseases by using creat and amikacin |
CN103948692A (en) * | 2014-05-14 | 2014-07-30 | 广西南宁市桃源兽药厂 | Red paeonia/amikacin-containing compound medicine for livestock and fowl |
-
2016
- 2016-08-22 CN CN201610705324.4A patent/CN106176944A/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103933087A (en) * | 2014-04-25 | 2014-07-23 | 广西大学 | Method for treating Escherichia coli infection diseases by using creat and amikacin |
CN103948692A (en) * | 2014-05-14 | 2014-07-30 | 广西南宁市桃源兽药厂 | Red paeonia/amikacin-containing compound medicine for livestock and fowl |
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WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161207 |
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WW01 | Invention patent application withdrawn after publication |