CN106109577A - A kind of poultry compound medicine containing Cortex Cinnamomi and sulfamonomethoxine sodium - Google Patents
A kind of poultry compound medicine containing Cortex Cinnamomi and sulfamonomethoxine sodium Download PDFInfo
- Publication number
- CN106109577A CN106109577A CN201610704857.0A CN201610704857A CN106109577A CN 106109577 A CN106109577 A CN 106109577A CN 201610704857 A CN201610704857 A CN 201610704857A CN 106109577 A CN106109577 A CN 106109577A
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- China
- Prior art keywords
- cortex cinnamomi
- sulfamonomethoxine sodium
- sodium
- sulfamonomethoxine
- compound medicine
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Cortex Cinnamomi and sulfamonomethoxine sodium, be made up of sulfamonomethoxine sodium and Cortex Cinnamomi, the weight ratio of sulfamonomethoxine sodium and Cortex Cinnamomi is 1:5 1:30.Described sulfamonomethoxine sodium and the weight ratio of Cortex Cinnamomi are preferably 1:30.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, sulfamonomethoxine sodium is used in combination with specific part by weight with Cortex Cinnamomi, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of containing Cortex Cinnamomi and sulfamonomethoxine sodium
Poultry compound medicine, infected, by colon bacillus, the disease that causes for treating poultry.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Sulfamonomethoxine sodium, norfloxacin, florfenicol etc. are
Preventing and treating the conventional Western medicine of this type of disease, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasingly
Greatly, but therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire and Cortex Cinnamomi and sulfamonomethoxine sodium are combined for treating poultry by E
Bacterium infects the relevant report of the disease caused.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound recipe containing Cortex Cinnamomi and sulfamonomethoxine sodium
Medicine, its synergism is obvious, it is possible to eliminate the colon bacillus drug resistance to sulfamonomethoxine sodium, improves treatment effect
Really.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Cortex Cinnamomi and sulfamonomethoxine
The poultry compound medicine of sodium, is made up of sulfamonomethoxine sodium and Cortex Cinnamomi, sulfamonomethoxine sodium and the weight of Cortex Cinnamomi
Ratio is 1:5-1:30.
Described sulfamonomethoxine sodium and the weight ratio of Cortex Cinnamomi are preferably 1:30.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and sulfamonomethoxine sodium and Cortex Cinnamomi are with specifically
Part by weight is used in combination, and has synergism obvious, and curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Cortex Cinnamomi weight of the present invention is the dry weight of Cortex Cinnamomi.
One, the Cortex Cinnamomi mensuration to the drug resistance elimination effect of sulfamonomethoxine sodium
1. assay method
It is the mixing medicine that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Cortex Cinnamomi and various Western medicine respectively according to weight ratio
Liquid；Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicinal liquid
MIC situation of change to Resistant strain；Set the Western medicine being not added with Cortex Cinnamomi to compare as sun, if it is right as the moon to be not added with Cortex Cinnamomi and Western medicine simultaneously
According to.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of sulfamonomethoxine sodium Yu Cortex Cinnamomi is 1:5, sulfamonomethoxine sodium pair
The minimal inhibitory concentration of drug resistance colon bacillus reduces more than 32 times, when weight ratio is 1:10, and sulfamonomethoxine sodium pair
The minimal inhibitory concentration of drug resistance colon bacillus all reduces more than 256 times, when weight ratio is 1:30, and sulfamonomethoxine sodium
The minimal inhibitory concentration of drug resistance colon bacillus is all reduced more than 512 times, it is seen then that between drug resistance colon bacillus is to sulfanilamide
The drug resistance of Sulfamonomethoxine sodium substantially reduces.
And when the weight ratio of sulfamonomethoxine sodium Yu Cortex Cinnamomi is 1:1,1:3 and 1:50, sulfamonomethoxine sodium
To the minimal inhibitory concentration of drug resistance colon bacillus compared with the sun comparison being not added with Cortex Cinnamomi, there is no significant change.
Two, the experiment in vitro that sulfamonomethoxine sodium and Cortex Cinnamomi are used in combination
It is 1:5 mixing by sulfamonomethoxine sodium and Cortex Cinnamomi (powder) according to weight ratio, makes powder, as test group；
Separately set sulfamonomethoxine sodium single dose and Cortex Cinnamomi single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 1g/kg feedstuff, and matched group 1 is used between sulfanilamide
Sulfamonomethoxine sodium single dose is administered according to the addition of 0.2g/kg feedstuff, and matched group 2 is with Cortex Cinnamomi single dose adding according to 1g/kg feedstuff
Dosage is administered；The equal SM of each group 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover；Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 5%；Chicken group's great majority of matched group 2 are also still wans, have
The sick chicken death of 14%.
Claims (3)
1. one kind contains Cortex Cinnamomi and the poultry compound medicine of sulfamonomethoxine sodium, it is characterised in that phonetic by methoxy between sulfanilamide
Pyridine sodium and Cortex Cinnamomi composition, the weight ratio of sulfamonomethoxine sodium and Cortex Cinnamomi is 1:5-1:30.
Poultry compound medicine containing Cortex Cinnamomi and sulfamonomethoxine sodium the most according to claim 1, it is characterised in that
Described sulfamonomethoxine sodium and the weight ratio of Cortex Cinnamomi are 1:30.
3. by the compound preparation become prepared by the poultry compound medicine described in claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610704857.0A CN106109577A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and sulfamonomethoxine sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610704857.0A CN106109577A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and sulfamonomethoxine sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106109577A true CN106109577A (en) | 2016-11-16 |
Family
ID=57274032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610704857.0A Withdrawn CN106109577A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Cortex Cinnamomi and sulfamonomethoxine sodium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106109577A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948691A (en) * | 2014-05-14 | 2014-07-30 | 广西大学 | Red paeonia/sulfamonomethoxine sodium-containing compound medicine for livestock and fowl |
| CN103961401A (en) * | 2013-03-18 | 2014-08-06 | 广西大学 | Compound medicine comprising herba lycopi and sulfamonomethoxine sodium and used for livestock and poultry |
| CN103989729A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and sulfamonomethoxine sodium containing compound medicine for livestock and poultry |
-
2016
- 2016-08-22 CN CN201610704857.0A patent/CN106109577A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961401A (en) * | 2013-03-18 | 2014-08-06 | 广西大学 | Compound medicine comprising herba lycopi and sulfamonomethoxine sodium and used for livestock and poultry |
| CN103948691A (en) * | 2014-05-14 | 2014-07-30 | 广西大学 | Red paeonia/sulfamonomethoxine sodium-containing compound medicine for livestock and fowl |
| CN103989729A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and sulfamonomethoxine sodium containing compound medicine for livestock and poultry |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161116 |