CN106176896A - A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amikacin - Google Patents
A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amikacin Download PDFInfo
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- CN106176896A CN106176896A CN201610705285.8A CN201610705285A CN106176896A CN 106176896 A CN106176896 A CN 106176896A CN 201610705285 A CN201610705285 A CN 201610705285A CN 106176896 A CN106176896 A CN 106176896A
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- Prior art keywords
- amikacin
- herba euphorbiae
- euphorbiae humifusae
- compound medicine
- poultry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
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- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amikacin, be made up of amikacin and Herba Euphorbiae Humifusae, the weight ratio of amikacin and Herba Euphorbiae Humifusae is 1:3 1:10.Described amikacin and the weight ratio of Herba Euphorbiae Humifusae are preferably 1:10.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, amikacin is used in combination with specific part by weight with Herba Euphorbiae Humifusae, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of containing Herba Euphorbiae Humifusae with the poultry of amikacin
By compound medicine, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Amoxicillin, norfloxacin, amikacin etc. are to prevent and treat this type of
The conventional Western medicine of disease, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but
Therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire to combine Herba Euphorbiae Humifusae and amikacin and infected by colon bacillus for treating poultry
The relevant report of the disease caused.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amikacin, its
Synergism is obvious, it is possible to eliminate the colon bacillus drug resistance to amikacin, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Herba Euphorbiae Humifusae with the poultry of amikacin
Fowl compound medicine, is made up of amikacin and Herba Euphorbiae Humifusae, and the weight ratio of amikacin and Herba Euphorbiae Humifusae is 1:3-1:10.
Described amikacin and the weight ratio of Herba Euphorbiae Humifusae are preferably 1:10.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and amikacin and Herba Euphorbiae Humifusae are with specific weight ratio
Example is used in combination, and has synergism obvious, and curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Herba Euphorbiae Humifusae weight of the present invention is the dry weight of Herba Euphorbiae Humifusae.
One, the Herba Euphorbiae Humifusae mensuration to the drug resistance elimination effect of amikacin
1. assay method
It is the mixing that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Herba Euphorbiae Humifusae and various Western medicine respectively according to weight ratio
Medicinal liquid;Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicine
The liquid MIC situation of change to Resistant strain;Set the Western medicine being not added with Herba Euphorbiae Humifusae to compare as sun, if being not added with Herba Euphorbiae Humifusae and Western medicine work simultaneously
Compare for the moon.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of amikacin Yu Herba Euphorbiae Humifusae is 1:3, amikacin is to drug resistance E
The minimal inhibitory concentration of bacterium all reduces more than 64 times, when weight ratio is 1:5, and the amikacin minimum to drug resistance colon bacillus
Mlc all reduces more than 128 times, and when weight ratio is 1:10, amikacin is antibacterial to the minimum of drug resistance colon bacillus
Concentration all reduces more than 256 times, it is seen then that the drug resistance of amikacin is substantially reduced by drug resistance colon bacillus.
And when the weight ratio of amikacin Yu Herba Euphorbiae Humifusae is 1:1,1:30 and 1:50, drug resistance large intestine angstrom is wished by amikacin
The minimal inhibitory concentration of Salmonella, compared with the sun comparison being not added with Herba Euphorbiae Humifusae, does not has significant change.
Two, the experiment in vitro that amikacin and Herba Euphorbiae Humifusae are used in combination
It is 1:5 mixing by amikacin and Herba Euphorbiae Humifusae (powder) according to weight ratio, makes powder, as test group;Separately set Ah
Meter Ka Xing single dose and Herba Euphorbiae Humifusae single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 1.5g/kg feedstuff, and matched group 1 uses Ah rice
Card star single dose is administered according to the addition of 0.3g/kg feedstuff, and matched group 2 uses Herba Euphorbiae Humifusae single dose according to the interpolation of 1.5g/kg feedstuff
Amount is administered;The equal SM of each group 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover;Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 4%;Chicken group's great majority of matched group 2 are also still wans, have
The sick chicken death of 10%.
Claims (3)
1. one kind contains Herba Euphorbiae Humifusae and the poultry compound medicine of amikacin, it is characterised in that by amikacin and Herba Euphorbiae Humifusae group
Becoming, the weight ratio of amikacin and Herba Euphorbiae Humifusae is 1:3-1:10.
Poultry compound medicine containing Herba Euphorbiae Humifusae and amikacin the most according to claim 1, it is characterised in that described
The weight ratio of amikacin and Herba Euphorbiae Humifusae is 1:10.
3. by the compound preparation become prepared by the poultry compound medicine described in claim 1 or 2.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610705285.8A CN106176896A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amikacin |
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CN201610705285.8A CN106176896A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amikacin |
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CN106176896A true CN106176896A (en) | 2016-12-07 |
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CN201610705285.8A Withdrawn CN106176896A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amikacin |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103948692A (en) * | 2014-05-14 | 2014-07-30 | 广西南宁市桃源兽药厂 | Red paeonia/amikacin-containing compound medicine for livestock and fowl |
CN103989725A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and amikacin containing compound medicine for livestock and poultry |
CN104435013A (en) * | 2014-11-12 | 2015-03-25 | 华南农业大学 | Pteris multifida and amikacin-containing compound drug for livestock and poultry |
-
2016
- 2016-08-22 CN CN201610705285.8A patent/CN106176896A/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103948692A (en) * | 2014-05-14 | 2014-07-30 | 广西南宁市桃源兽药厂 | Red paeonia/amikacin-containing compound medicine for livestock and fowl |
CN103989725A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and amikacin containing compound medicine for livestock and poultry |
CN104435013A (en) * | 2014-11-12 | 2015-03-25 | 华南农业大学 | Pteris multifida and amikacin-containing compound drug for livestock and poultry |
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Application publication date: 20161207 |
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