CN101669959A - Medical composite for treating livestock and poultry intestinal canal diseases and preparation method and application thereof - Google Patents
Medical composite for treating livestock and poultry intestinal canal diseases and preparation method and application thereof Download PDFInfo
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- CN101669959A CN101669959A CN200910305346A CN200910305346A CN101669959A CN 101669959 A CN101669959 A CN 101669959A CN 200910305346 A CN200910305346 A CN 200910305346A CN 200910305346 A CN200910305346 A CN 200910305346A CN 101669959 A CN101669959 A CN 101669959A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention discloses a medical composite for treating livestock and poultry intestinal canal diseases and a preparation method and an application thereof, aiming at providing a medical composite and the preparation method and the application thereof, which can fast and effectively prevent and cure intestinal canal diseases. The composite comprises the following components in weight percent, 2%to 5% of pirquinozol antibiotics, 3% to 10% of beta-lactam antibiotics, 0.6% to 2% of beta-lactam inhibitor, 3% to 10% of aminoglycoside antibiotics and the balance auxiliary material acceptable in pharmacy. The pirquinozol antibiotics, such as norfloxacin lactate, is broad-spectrum antibiotics; the beta-lactam inhibitor has the functions of inhibiting enzyme and strengthening the effect; and thebeta-lactam antibiotics can destroy bacterial cell walls, which is favorable for aminoglycoside antibiotics to enter cells to take effect, increases the antibacterial effect and simultaneously enlarges the antibacterial spectrum. The composite of the invention can effectively cure canal diseases caused by Gram negative bacteria or anaerobe and the mixed infection of the Gram negative bacteria andthe anaerobe.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases and its production and application.
Background technology
In recent years, pilositys such as livestock and poultry intestinal canal diseases such as poultry colibacillosis, Pullorum Disease, enteritis, piglet pujos blancos or yellow scour of piglet, generally be by gram negative bacteria or the microbial enteritis of anaerobism, age in 2-5 week raise on the chicken in the broiler on the bedding and padding and 7-12 age in week, take place commonplace.The clinical manifestation of sick chicken be in various degree spiritual depressed, and appetite descends, and is reluctant to walk about, and arranges black or is with bloody stool just, and feather is fluffy and disorderly.The course of disease is short, usually is detected in disease fowl acute death.Pathological change often is confined to small intestinal, sees with jejunum and ileum more, can see caecum lesion once in a while.The small intestinal attenuation that becomes fragile is frangible, gassy.Often with the concurrent or secondary of little intestinal coccidiosis, and general medicine and routine dose are difficult to produce curative effect.Caused bigger economic loss for vast chicken farm (family).
At present should the disease general Therapeutic Method that adopts single chemicals is as adopting antibiotics colistin sulfate, metronidazole, LIJUNJING etc.But, country has issued that some food allow the medicine catalogue of using at present, limited the use of medicines such as metronidazole, LIJUNJING has certain effect to intestinal tract disease, during therapeutic dose chicken, pig there is not harmful effect, but because poultry is comparatively responsive to it, when using dosage is higher than 3-5 times of clinical treatment amount, or long-time application can cause toxic reaction, even dead.So greatly limited the use of this product.For colibacillosis etc., because the overlong time of medication, antibacterial is easy to produce drug resistance in addition, and general single antibacterials are difficult to onset, cause treatment to be failed.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, a kind of pharmaceutical composition that can rapidly, effectively prevent and treat livestock and poultry intestinal canal diseases to be provided.
Second purpose of the present invention provide a kind of treat livestock and poultry intestinal canal diseases the preparation of drug combination method.
The 3rd purpose of the present invention provides a kind of application for the treatment of the pharmaceutical composition of livestock and poultry intestinal canal diseases.
The present invention is achieved through the following technical solutions:
A kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases, it is characterized in that consisting of of percent by weight: the similar antibiotic 2-5% of quinoline promise, beta-lactam antibiotic 3%-10%, beta-lactamase inhibitor 0.6-2%, aminoglycoside antibiotics 3-10%, surplus is receivable adjuvant pharmaceutically; The similar antibiotic of described quinoline promise is any in Norfloxacin Lactate, ciprofloxacin, Enrofloxacin HCL, the ofloxacin; Described beta-lactam antibiotic is any in potassium v calcium, ampicillin, amoxicillin, cefotaxime sodium, the ceftriaxone sodium; Described beta-lactamase inhibitor is any in sulbactam sodium, clavulanate potassium, sodium benemid, the sodium-tazobactam; Described aminoglycoside antibiotics is any in streptomycin sulfate, gentamycin sulfate, polygynax, the AI3-29795.
Consisting of of percent by weight: Norfloxacin Lactate 2%, potassium v calcium 5%, sulbactam sodium 1%, streptomycin sulfate 5%, surplus are acceptable accessories.
Described pharmaceutically receivable adjuvant is at least a in sucrose, lactose, glucose, the water soluble starch.Multiple adjuvant can mix by arbitrary proportion.
A kind of preparation of drug combination method for the treatment of livestock and poultry intestinal canal diseases, it is characterized in that comprising the steps: with the similar antibiotic of quinoline promise, beta-lactam antibiotic, beta-lactamase inhibitor, aminoglycoside antibiotics, sieve behind the acceptable accessories pulverize separately, percent is got the similar antibiotic 2-5% of quinoline promise by weight, beta-lactam antibiotic 3%-10%, beta-lactamase inhibitor 0.6-2%, aminoglycoside antibiotics 3-10%, the pharmaceutically receivable adjuvant mix homogeneously of surplus is promptly made a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases; The similar antibiotic of described quinoline promise is any in Norfloxacin Lactate, ciprofloxacin, Enrofloxacin HCL, the ofloxacin; Described beta-lactam antibiotic is any in potassium v calcium, ampicillin, amoxicillin, cefotaxime sodium, the ceftriaxone sodium; Described beta-lactamase inhibitor is any in sulbactam sodium, clavulanate potassium, sodium benemid, the sodium-tazobactam; Described aminoglycoside antibiotics is any in streptomycin sulfate, gentamycin sulfate, polygynax, the AI3-29795.
A kind of application of pharmaceutical composition in the medicine of preparation livestock and poultry intestinal canal diseases for the treatment of livestock and poultry intestinal canal diseases.
The present invention has following technique effect:
The pharmaceutical composition of treatment livestock and poultry intestinal canal diseases of the present invention is a compound Western medicine preparation, Norfloxacin Lactate wherein, ciprofloxacin, Enrofloxacin HCL, ofloxacin etc. are extensive pedigree antibiotics, mechanism of action is different from other antimicrobial drugs, thereby there is not the crossing drug resistant phenomenon with most of antibacterials, toxicity is less, therapeutic dose does not have teratogenesis or mutagenic action, and is clinical safe in utilization, and escherichia coli, Salmonella are had antibacterial action preferably.Beta-lactam antibiotic belongs to bactericidal antibiotic, antibacterial activity is strong.But the destruction that is subjected to beta-lactamase owing to beta-lactam antibiotic was easily lost efficacy.And beta-lactamase inhibitor has the enzyme and the synergistic function of pressing down, and can protective effect be arranged to beta-lactam antibiotic class medicine, makes the bigger drug effect of beta-lactam antibiotic class medicine performance.The aminoglycoside antibiotics medicine all has effect to most of gram negative bacilli as escherichia coli, Salmonella etc.Beta-lactam antibiotic class medicine and aminoglycoside antibiotics class drug regimen, beta-lactam antibiotic class medicine destroys bacteria cell wall, helping aminoglycoside antibiotics medicine class medicine enters in the cell and plays a role, synergism is arranged, strengthen antibacterial effect, also enlarged antimicrobial spectrum simultaneously.Prescription of the present invention can effectively be treated the intestinal tract disease that is caused by gram negative bacteria or anaerobe and the two mixed infection.
The pharmaceutical composition of treatment livestock and poultry intestinal canal diseases of the present invention adds in the animal and fowl fodder or in the drinking-water, can alleviate domestic animal and fowl's enteritis, diarrhoea rapidly, the stool colour remarkable improvement, and sick chicken sx, feed intake increases, transference cure, it is normal that the chicken group recovers.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Standby with crossing 80 mesh sieves behind Norfloxacin Lactate, ciprofloxacin, Enrofloxacin HCL, the ofloxacin pulverize separately.
Standby with crossing 80 mesh sieves behind potassium v calcium, ampicillin, amoxicillin, cefotaxime class, the ceftriaxone class pulverize separately.
Standby with crossing 80 mesh sieves behind sulbactam sodium, clavulanate potassium, sodium benemid, the sodium-tazobactam pulverize separately.
Standby with crossing 80 mesh sieves behind streptomycin sulfate, gentamycin sulfate, polygynax, the AI3-29795 pulverize separately.
It is standby to cross 80 mesh sieves behind sucrose, lactose, glucose, the water soluble starch pulverize separately.
Embodiment 1
Take by weighing Norfloxacin Lactate 2.5 grams, potassium v calcium 10 grams, sulbactam sodium 2 grams, streptomycin sulfate 10 grams, glucose 75.5 gram mix homogeneously, promptly make a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 2
Take by weighing ciprofloxacin 5 grams, ceftriaxone sodium 5 grams, sulbactam sodium 1 gram, gentamycin sulfate 5 grams, water soluble starch 84 gram mix homogeneously, promptly make a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 3
Take by weighing Enrofloxacin HCL 2.5 grams, cefotaxime sodium 5 grams, sodium benemid 1 gram, AI3-29795 5 grams, sucrose 86.5 gram mix homogeneously are promptly made a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 4
Take by weighing ofloxacin 2 grams, ampicillin 5.5 grams, sodium-tazobactam 1.1 grams, polygynax 5 grams, glucose 86.4 gram mix homogeneously are promptly made a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 5
Take by weighing Norfloxacin Lactate 2.5 grams, amoxicillin 10 grams, clavulanate potassium 2 grams, polygynax 10 grams, lactose 75.5 gram mix homogeneously, promptly make a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 6
Take by weighing ciprofloxacin 5 grams, cefotaxime sodium 5 grams, sodium benemid 1 gram, gentamycin sulfate 5 grams, sucrose 84 gram mix homogeneously, promptly make a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 7
Take by weighing Norfloxacin Lactate 2.5 grams, potassium v calcium 10 grams, sulbactam sodium 2 grams, streptomycin sulfate 10 grams, glucose 75.5 gram mix homogeneously, promptly make a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 8
Take by weighing ciprofloxacin 5 grams, ceftriaxone sodium 5 grams, sulbactam sodium 1 gram, gentamycin sulfate 5 grams, water soluble starch 84 gram mix homogeneously, promptly make a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 9
Taking by weighing Enrofloxacin HCL is 2.5 grams, and cefotaxime sodium 5 grams, sodium benemid 1 gram, AI3-29795 5 grams, sucrose 71 grams, water soluble starch 15.5 gram mix homogeneously are promptly made a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 10
Take by weighing Norfloxacin Lactate 2.5 grams, potassium v calcium 3 grams, sulbactam sodium 0.6 gram, streptomycin sulfate 3 grams, glucose 75.5 grams, sucrose 15.4 gram mix homogeneously, promptly make a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases.
Laboratory report:
Laboratory animal:
150 of the ill one-tenth of picked at random chickens are divided into five groups at random by body weight, 30 every group.
A organizes positive matched group, does not give Drug therapy.
The B group is healthy group.
The C group is 5% ciprofloxacin matched group, and mix drink: every 100g is used for 100kg water, every day 2 times, logotype 3 days.
The medicine composite for curing group of the treatment livestock and poultry intestinal canal diseases that the D group is made for the embodiment of the invention 8, mix drink: every 100g is used for 100kg water, every day 2 times, logotype 3 days.
The E group is 5% ceftriaxone sodium matched group, and mix drink: every 100g is used for 100kg water, every day 2 times, logotype 3 days.
The clinical efficacy result of the test is as shown in table 1.
Table 1
| Numbering | Group | Sickness rate % | Mortality rate % | The course of disease |
| ??A | Positive controls | ??70(21/30) | ??16.67(5/30) | ??7 |
| ??B | Healthy group | ??0(0/30) | ??0(0/30) | ??0 |
| ??C | 5% ciprofloxacin matched group | ??60(18/30) | ??3.33(1/30) | ??6 |
| ??D | The medicine composite for curing group of the treatment livestock and poultry intestinal canal diseases that the embodiment of the invention 8 is made | ??0(0/30) | ??0(0/30) | ??3 |
| ??E | 5% ceftriaxone sodium matched group | ??6.67(2/30) | ??3.33(1/30) | ??5 |
Through table 1 statistical analysis, the medicine composite for curing group of the treatment livestock and poultry intestinal canal diseases that embodiments of the invention 8 are made and 5% ciprofloxacin matched group difference is (P＜0.01) extremely significantly, the medicine composite for curing group of the treatment livestock and poultry intestinal canal diseases that embodiments of the invention 8 are made and 5% ceftriaxone sodium matched group significant difference (P＜0.05).
Claims (5)
1. pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases, it is characterized in that consisting of of percent by weight: the similar antibiotic 2-5% of quinoline promise, beta-lactam antibiotic 3%-10%, beta-lactamase inhibitor 0.6-2%, aminoglycoside antibiotics 3-10%, surplus is receivable adjuvant pharmaceutically; The similar antibiotic of described quinoline promise is any in Norfloxacin Lactate, ciprofloxacin, Enrofloxacin HCL, the ofloxacin; Described beta-lactam antibiotic is any in potassium v calcium, ampicillin, amoxicillin, cefotaxime sodium, the ceftriaxone sodium; Described beta-lactamase inhibitor is any in sulbactam sodium, clavulanate potassium, sodium benemid, the sodium-tazobactam; Described aminoglycoside antibiotics is any in streptomycin sulfate, gentamycin sulfate, polygynax, the AI3-29795.
2. the pharmaceutical composition of treatment livestock and poultry intestinal canal diseases according to claim 1, it is characterized in that consisting of of percent by weight: Norfloxacin Lactate 2%, potassium v calcium 5%, sulbactam sodium 1%, streptomycin sulfate 5%, surplus are acceptable accessories.
3. the pharmaceutical composition of treatment livestock and poultry intestinal canal diseases according to claim 1 and 2 is characterized in that described pharmaceutically receivable adjuvant is at least a in sucrose, lactose, glucose, the water soluble starch.
4. the preparation of drug combination method of the described treatment livestock and poultry intestinal canal diseases of claim 1, it is characterized in that comprising the steps: with the similar antibiotic of quinoline promise, beta-lactam antibiotic, beta-lactamase inhibitor, aminoglycoside antibiotics, sieve behind the acceptable accessories pulverize separately, percent is got the similar antibiotic 2-5% of quinoline promise by weight, beta-lactam antibiotic 3%-10%, beta-lactamase inhibitor 0.6-2%, aminoglycoside antibiotics 3-10%, the pharmaceutically receivable adjuvant of surplus, mix homogeneously is promptly made a kind of pharmaceutical composition for the treatment of livestock and poultry intestinal canal diseases; The similar antibiotic of described quinoline promise is any in Norfloxacin Lactate, ciprofloxacin, Enrofloxacin HCL, the ofloxacin; Described beta-lactam antibiotic is any in potassium v calcium, ampicillin, amoxicillin, cefotaxime sodium, the ceftriaxone sodium; Described beta-lactamase inhibitor is any in sulbactam sodium, clavulanate potassium, sodium benemid, the sodium-tazobactam; Described aminoglycoside antibiotics is any in streptomycin sulfate, gentamycin sulfate, polygynax, the AI3-29795.
5. the application of the pharmaceutical composition of each described treatment livestock and poultry intestinal canal diseases in the medicine of preparation livestock and poultry intestinal canal diseases among the claim 1-3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910305346A CN101669959A (en) | 2009-08-07 | 2009-08-07 | Medical composite for treating livestock and poultry intestinal canal diseases and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910305346A CN101669959A (en) | 2009-08-07 | 2009-08-07 | Medical composite for treating livestock and poultry intestinal canal diseases and preparation method and application thereof |
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| CN101669959A true CN101669959A (en) | 2010-03-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200910305346A Pending CN101669959A (en) | 2009-08-07 | 2009-08-07 | Medical composite for treating livestock and poultry intestinal canal diseases and preparation method and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247387A (en) * | 2011-03-21 | 2011-11-23 | 陕西宏府怡悦制药有限公司 | Norfloxacin phenazopyridine tablets and preparation process method and use thereof |
| CN102698274A (en) * | 2012-06-13 | 2012-10-03 | 郑州爱诺生物科技有限公司 | Medicine composition for treating intractable escherichia coli of fowls |
| RU2477894C1 (en) * | 2011-12-05 | 2013-03-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "ВЯТСКИЙ ГОСУДАРСТВЕННЫЙ УНИВЕРСИТЕТ" (ФГБОУ ВПО "ВятГУ" | Method for simulating intestinal dysbacteriosis in laboratory animals |
| CN109200277A (en) * | 2017-07-05 | 2019-01-15 | 江西邦诚动物药业有限公司 | A kind of domestic animal pig stomach enteropathy treatment veterinary drug and preparation method thereof |
| RU217803U1 (en) * | 2023-01-29 | 2023-04-19 | Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) | Model of the gastrointestinal tract |
-
2009
- 2009-08-07 CN CN200910305346A patent/CN101669959A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247387A (en) * | 2011-03-21 | 2011-11-23 | 陕西宏府怡悦制药有限公司 | Norfloxacin phenazopyridine tablets and preparation process method and use thereof |
| RU2477894C1 (en) * | 2011-12-05 | 2013-03-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "ВЯТСКИЙ ГОСУДАРСТВЕННЫЙ УНИВЕРСИТЕТ" (ФГБОУ ВПО "ВятГУ" | Method for simulating intestinal dysbacteriosis in laboratory animals |
| CN102698274A (en) * | 2012-06-13 | 2012-10-03 | 郑州爱诺生物科技有限公司 | Medicine composition for treating intractable escherichia coli of fowls |
| CN109200277A (en) * | 2017-07-05 | 2019-01-15 | 江西邦诚动物药业有限公司 | A kind of domestic animal pig stomach enteropathy treatment veterinary drug and preparation method thereof |
| RU217803U1 (en) * | 2023-01-29 | 2023-04-19 | Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) | Model of the gastrointestinal tract |
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Application publication date: 20100317 |