CN109984250A - A kind of composition for preventing and treating chicken proventriculitis - Google Patents
A kind of composition for preventing and treating chicken proventriculitis Download PDFInfo
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- CN109984250A CN109984250A CN201711485298.XA CN201711485298A CN109984250A CN 109984250 A CN109984250 A CN 109984250A CN 201711485298 A CN201711485298 A CN 201711485298A CN 109984250 A CN109984250 A CN 109984250A
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- composition
- preventing
- chicken proventriculitis
- proventriculitis
- treating
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
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- A23K20/189—Enzymes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
Abstract
The present invention relates to a kind of compositions for preventing and treating chicken proventriculitis, prescription includes the complex enzyme that the composite reactive peptide that is made of soya-bean polypeptides, Semen Maydis polypeptide and protease, amylase, cellulase form, and B family vitamin and is combined by the probiotics that saccharomycete, bacillus subtilis, Bifidobacterium form.With colony balance is maintained, promotes to digest and assimilate, improve the curative effect of immunity of organisms.The invention definite effect has no toxic side effect and drug resistance, can effectively prevent chicken proventriculitis.
Description
Technical field
The invention belongs to veterinary drug field, in particular to a kind of addition composite reactive peptide can prevent and treat chicken proventriculitis
Novel compositions formula.
Technical background
Chicken proventriculitis be it is a kind of using chicken undergrowth, feed conversion rate is low, glandular stomach swelling is the infectious disease of main feature,
By Dutch certain chicken house discovery, it is then named as Transmissible Viral Proventriculitis of Chickens within 1978.China is in the similar disease of discovery in 1994
Example is simultaneously gradually gradually popular in broiler breeding compact district.Age of onset is 7-8 age in days to the disease earliest, and -50 age in days of 15 age in days is more
The hair phase, peak mortality is generally at 5-8 days after the onset；And can it occur throughout the year, but the most serious with autumn, winter；After the onset
The diseases such as secondary Escherichia coli, mycoplasma, coccidia, enteritis, cause the death rate to rise, to bring great warp to poultry farming
Ji loss.
Since a variety of viruses separated in diseased chicken glandular stomach at this stage can not replicate in laboratory, it is considered that this disease
It is since infectious agent and non-pathogenic factors are jointly caused.Infectious agent includes the infection of bacterium, virus,
Non-pathogenic factors include malnutrition, feed mold caused by mismanagement etc..Current therapeutic modality be mainly Western medicine and
Chinese medicine, but easily the remaining of antibiotic, be also easy to produce drug resistance and keep clinical application limited, and traditional Chinese medicinal components are complicated, with Western medicine medical raw
Reason difference leads to that its due curative effect cannot be played.
Summary of the invention
The present invention be in order to overcome the shortcomings in the prior art place, provide it is a kind of add composite reactive peptide composition,
Effectively prevent chicken proventriculitis.
The present invention relates to a kind of prescription of compound anti-chicken gastroadenitis is provided, the composition includes each of following parts by weight
Component: 10-40 parts of composite reactive peptide, 5-10 parts of complex enzyme, 10-20 parts of microorganism formulation, 1-2 parts of B family vitamin, auxiliary material 28-
74 parts.
The composite reactive peptide includes Semen Maydis polypeptide, soya-bean polypeptides.
The composition of the Semen Maydis polypeptide and soya-bean polypeptides is 1:1 to 4:1.
The complex enzyme includes cellulase, protease, amylase.
The cellulase, protease, amylase composition are 1:(1-3): (1-2).
The microorganism formulation includes saccharomycete: bacillus subtilis: bacillus licheniformis: Bifidobacterium.
The saccharomycete: bacillus subtilis: bacillus licheniformis: Bifidobacterium composition is 1:(1-4): (1-2):
(1-4), wherein total viable count is 1 × 1010CFU/g-5×1010CFU/g。
The B family vitamin includes vitamin B1、B2、B6、B12One or more of.
The auxiliary material is one or more of DEXTROSE ANHYDROUS, starch.
The mechanism of each raw material in the pharmaceutical preparation for the treatment of chicken proventriculitis of the invention is as follows:
Soya-bean polypeptides: soya-bean polypeptides can promote the breeding and metabolism of profitable strain, can especially reinforce lactic acid in enteron aisle
The metabolism of bacterium, Bifidobacterium, while inhibiting the growth and breeding of Escherichia coli and some other aerobic bacteria；It is turned into antioxygen
With；The effects of improving absorptivity of the body to mineral element such as calcium, zinc, iron etc..
Semen Maydis polypeptide: corn is the main component in chicken feed, various nutrient elements needed for possessing chicken growth.But by
The stomach lining caused by proventriculitis is impaired, digestive function declines, and reduces the absorption to nutriment in feed.Semen Maydis polypeptide is
Using corn protein powder as raw material, the micromolecule polypeptide obtained using orientation enzyme incision technology is had and easily absorbs, is anti-oxidant and immune
Activity is particular enable to improve the function of suffering from gastrointestinal disease birds nutrition.
Complex enzyme:
Cellulase, protease, amylase: making up the hyposecretion of digestive ferment during injury to alimentary tract, and digestion is promoted to inhale
It receives, accelerates the speed of body recovery health, reduce feedstuff-meat ratio；
B family vitamin: appropriate supplement is to alleviate since vitamin lacks caused by food-intake is low, abilities of digestive and absorption is poor
It is weary.
Probiotics: it is appropriate to adjust to maintain colony balance, inhibit the growth of harmful bacteria, reinforces the function of its digestion and absorption
Can, to prevent and treat chicken proventriculitis.
The beneficial effects of the present invention are:
1. antibiotic-free addition of the present invention, will not develop drug resistance；Prescription safety, does not influence meat feed ratio.
2. the addition of composite reactive peptide improves the enzyme activity of added complex enzyme, reinforce the numerous of added probiotics
Metabolism is grown, acting on the independent addition compared to complex enzyme and probiotics has better effect.
3. different dosage forms can be made as needed since ingredient has very high solubization in composition.
The beneficial effects of the present invention are: the present invention increases on the basis of complex enzyme, B family vitamin and probiotics
The composite reactive peptide that is made of Semen Maydis polypeptide, soya-bean polypeptides, considerably increase birds body is anti-oxidant and immunity, from root
Body resistance infection is improved in sheet, prevents and treats the generation of chicken proventriculitis.
Specific embodiment:
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1:
Prescription:
Preparation method:
(1) vitamin B is taken1、B2、B6、B12With DEXTROSE ANHYDROUS equivalent progressively increase dilution method dilute 4 times, cross 80 meshes, obtain
Mixture；
(2) cellulase, protease, amylase, saccharomycete, bacillus subtilis, bacillus licheniformis and bifid are taken
Bacillus is uniformly mixed, and crosses 80 meshes, obtains mixture；
(3) mixture obtained by (1) (2) and Semen Maydis polypeptide, soya-bean polypeptides, DEXTROSE ANHYDROUS are mixed in ratio described in prescription
30min, packing to get.
Embodiment 2:
Preparation method:
(1) vitamin B is taken1、B2、B6、B12With DEXTROSE ANHYDROUS equivalent progressively increase dilution method dilute 5 times, cross 80 meshes, obtain
Mixture；
(2) cellulase, protease, amylase, saccharomycete, bacillus subtilis, bacillus licheniformis and bifid are taken
Bacillus is uniformly mixed, and crosses 80 meshes, obtains mixture；
(3) mixture obtained by (1) (2) and Semen Maydis polypeptide, soya-bean polypeptides, DEXTROSE ANHYDROUS are mixed in ratio described in prescription
30min, packing to get.
Embodiment 3:
Preparation method:
(1) vitamin B is taken1、B2、B6、B12With DEXTROSE ANHYDROUS equivalent progressively increase dilution method dilute 2 times, cross 80 meshes, obtain
Mixture；
(2) cellulase, protease, amylase, saccharomycete, bacillus subtilis, bacillus licheniformis and bifid are taken
Bacillus is uniformly mixed, and crosses 80 meshes, obtains mixture；
(3) mixture obtained by (1) (2) and Semen Maydis polypeptide, soya-bean polypeptides, DEXTROSE ANHYDROUS are mixed in ratio described in prescription
30min, packing to get.
Embodiment 4: measure of merit
1, Tianjin airport economic zone laying hen field has 20 age in days chickens to show lassitude, feed intake decline；Through dissect
It is diagnosed as proventriculitis.These laying hens to fall ill are randomly divided into 5 groups.Wherein blank group not medication；Control group uses in antiviral
Medicine eliminating pestilence and relieving toxicity oral liquid treatment, uses to specifications；Group 1-3 uses treatment according to the formula of embodiment 1-3 respectively, according to
The mixture 1kg of feed mixing embodiment 1-3 per ton, is discontinued after three days.Effect such as following table.
| Group | Sample size (only) | Extremely naughty quantity (only) | Death and culling rate (%) |
| Blank group | 203 | 23 | 11.33 |
| Control group | 197 | 13 | 6.60 |
| Embodiment group 1 | 198 | 2 | 1.01 |
| Embodiment group 2 | 205 | 3 | 1.46 |
| Embodiment group 3 | 200 | 2 | 1.00 |
As the data of upper table it is found that the composition of embodiment group 1-3 can be reduced significantly as proventriculitis and caused by
The death rate of chicken；Find that the glandular stomach of the chicken of embodiment 1-3 group is gradually recovered normally, and feed intake gradually rises by dissection.It says
Bright composition of the invention has good therapeutic effect to laying hen proventriculitis.
2, the prophylactic tria that chicken proventriculitis is carried out in Tianjin airport economic zone chicken house is randomly divided into 1000 young chickens
5 groups, every group 200.Wherein blank group feeding conventional feed, control group feeding routine Chinese medicine fodder organize 1-3 respectively according to implementation
The formula of example 1-3 is using treatment, according to the mixture 500g of feed mixing embodiment 1-3 per ton.Fall ill chicken in record 10 days
Number of elements, preventive effect such as following table.
| Group | Sample size (only) | It falls ill quantity (only) | Disease incidence (%) |
| Blank group | 200 | 76 | 38.0 |
| Control group | 200 | 31 | 15.5 |
| Embodiment group 1 | 200 | 3 | 1.5 |
| Embodiment group 2 | 200 | 5 | 2.5 |
| Embodiment group 3 | 200 | 2 | 1.0 |
By upper table data it is found that the composition of embodiment group 1-3 can significantly reduce the disease incidence of chicken proventriculitis, this is said
Bright composition of the invention has good preventive effect to chicken proventriculitis.
Claims (9)
1. a kind of for preventing and treating the composition of chicken proventriculitis, it is characterised in that: the composition includes each group of following parts by weight
Point: 10-40 parts of composite reactive peptide, 5-10 parts of complex enzyme, 10-20 parts of microorganism formulation, 1-2 parts of B family vitamin, auxiliary material 28-74
Part.
2. a kind of composition for preventing and treating chicken proventriculitis according to claim 1, which is characterized in that the composite reactive peptide packet
Include Semen Maydis polypeptide, soya-bean polypeptides.
3. a kind of composition for preventing and treating chicken proventriculitis according to claims 1 and 2, which is characterized in that the Semen Maydis polypeptide
Composition with soya-bean polypeptides is 1:1 to 4:1.
4. a kind of composition for preventing and treating chicken proventriculitis according to claim 1, which is characterized in that the complex enzyme includes fibre
Tie up plain enzyme, protease, amylase.
5. according to claim 1 with a kind of composition of prevention and treatment chicken proventriculitis described in 4, which is characterized in that the cellulase,
Protease, amylase composition are 1:(1-3): (1-2).
6. a kind of composition for preventing and treating chicken proventriculitis according to claim 1, which is characterized in that the microorganism formulation packet
Include saccharomycete: bacillus subtilis: bacillus licheniformis: Bifidobacterium.
7. according to claim 1 with a kind of composition of prevention and treatment chicken proventriculitis described in 6, which is characterized in that the saccharomycete: withered
Careless bacillus: bacillus licheniformis: Bifidobacterium composition is 1:(1-4): (1-2): (1-4), wherein total viable count
It is 1 × 1010CFU/g-5×1010CFU/g。
8. a kind of composition for preventing and treating chicken proventriculitis according to claim 1, which is characterized in that the B family vitamin packet
Include vitamin B1、B2、B6、B12One or more of.
9. a kind of composition for preventing and treating chicken proventriculitis according to claim 1, which is characterized in that the auxiliary material is anhydrous Portugal
One or more of grape sugar, starch.
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Inventor after: Yang Jihan Inventor after: Nie Lina Inventor after: Liu Guilan Inventor after: Xia Xuelin Inventor after: Liu Ailing Inventor after: Li Xudong Inventor before: Yang Jihan Inventor before: Nie Lina Inventor before: Liu Guilan Inventor before: Xia Xuelin Inventor before: Liu Ailing Inventor before: Li Xudong |
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Application publication date: 20190709 |