CN103272226A - Pharmaceutical composition for controlling poultry mould infection - Google Patents
Pharmaceutical composition for controlling poultry mould infection Download PDFInfo
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- CN103272226A CN103272226A CN 201210371301 CN201210371301A CN103272226A CN 103272226 A CN103272226 A CN 103272226A CN 201210371301 CN201210371301 CN 201210371301 CN 201210371301 A CN201210371301 A CN 201210371301A CN 103272226 A CN103272226 A CN 103272226A
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Abstract
The invention relates to a pharmaceutical composition for controlling poultry mould infection, which comprises natamycin, Radix Astragali polysaccharide, cellulose, xylanase, protease, anhydrous glucose, etc. The invention has good control effects for immunity decrease, gastrointestinal tract inflammation, forage dyspepsia and other symptoms of poultry caused by forage and environment mould infection. The invention has the advantages of definite therapeutic effect and cheap price and the materials are easily available, and the composition is an ideal medicament for treating poultry mould infection.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the fungal infection of control poultry, be particularly related to the natamycin that contains the mould fungus inhibition growth, improving the astragalus polysaccharides of immunity of organisms and having promotes feedstuff to digest and assimilate the cellulase of effect, xylanase, protease etc., according to conventional pressed powder mixing method mix homogeneously, symptom such as the poultry immunity power decline that fungal infection poultry in feedstuff and the environment is caused, gastrointestinal tract inflammation, feedstuff dyspepsia has good preventive and therapeutic effect.
Background technology
In recent years, because increasing the weight of of Global Greenhouse Effect makes grain or feedstuff be become clear day by day by the degree of mycete and endotoxin contamination thereof and scope.According to statistics, the whole world has 25% corn be polluted by mycotoxin every year approximately.Mycotoxin is except directly making poultry poison to cause death, immune function and the fertility performance of poultry are descended, be in sub-health state for a long time, the disease that has caused many immuning failures and seriously taken place and be difficult to prevent and treat again and again produces harm by food chains such as meat, eggs to human health simultaneously.
Because mycotoxin produces under field conditions (factors), can have multiple mycotoxin simultaneously in grain or the feedstuff.Under the combined effect of multiple mycotoxin, the kind chicken house that can give produce 5000000 meat sold on the market chickens every year per year cause damage and surpass 5,000,000 yuan, because feed quality, the harm of causing for chicken for commodity is equally also very serious.
In recent years, more and more serious to the influence of poultry in view of mycete, also more and more to the research of mycete and toxin thereof, the main harm of concluding summary mycete and toxin thereof shows as:
1, suppresses immune function, cause immunosuppressive disease.
2, the sick obstinate of intestinal, feedstuff just frequently takes place, the outbreak repeatedly in several days of dispensing back.
3, the one of the main reasons of poultry ventriculitis and proventriculitis: the laboratory moldy feed of feeding causes that artificial onset's model of chicken ventriculitis and proventriculitis sees accompanying drawing 1.
4, cause fertility performance to descend:
A, to the influence of laying hen: the variation of liver causes the synthetic minimizing of liver yolk precursor, and then causes degradation under the laying rate of laying hen;
B, to the influence of kind of chicken: laying rate descends, husky preserved egg, soft-shelled egg increases, fallopian tube attenuates, edema, ovarian atrophy even total crop failure, causes kind of chicken rate of fertilization to descend, incubation rate reduces, the embryonic death in the hatching is seen more;
C, to the influence of broiler: immunity degradation, disease be occurred frequently, take place frequently, feed conversion rate is low, the rate of animals delivered to the slaughter-house reduces.
5, the organic lesion of internal organs: the laboratory moldy feed of feeding causes that artificial onset's model of liver enlargement sees accompanying drawing 2.
In view of above reason, develop a kind of product that is used for the fungal infection of control poultry safe and efficient, cheap and easy to get and have very important significance.
The present invention with mould fungus inhibition growth, removing poultry immunity that mycete and toxin thereof cause, to suppress, help poultry to digest and assimilate be principle, select for use safe and efficient, orally not absorb, mycete is had efficient inhibiting natamycin mould fungus inhibition growth; Select for use the astragalus polysaccharides with immunological enhancement to remove the poultry immunity inhibition that mycotoxin causes; In view of after mycete causes poultry digestive tract damage, digestive enzyme hyposecretion in the digestive tract, simultaneously because poultry does not secrete cellulase, cellulose in the feedstuff causes secondary damage to the digestive tract that sustains damage, therefore add cellulase, xylanase, protease among the present invention, help digesting and assimilating of feedstuff, alleviate the gastrointestinal burden, improve food conversion ratio.Several composition use in conjunction have good preventive and therapeutic effect to the poultry fungal infection.The present invention adopts stable in properties, anhydrous glucose cheap and easy to get as adjuvant.
At present, being used for control poultry mycete and toxi-infectious product thereof clinically has a lot, all is to be grown to the master with silicates absorbing mycotoxin and some insoluble fungus growth inhibitor mould fungus inhibitions basically.But these products substantially all are the mode that adopts spice to feed on administering mode, and are inapplicable to the broiler with the intensive culture of water way administration.In this case, develop a kind of control poultry mycotoxin infection product that is used for safe, efficient, easy to use and have very significantly society and economic benefit.
Summary of the invention
The invention provides a kind of pharmaceutical composition for the fungal infection of control poultry, this compositions is added to the water in the ratio of 1:500-1000, freely drinks for poultry, and use safely, conveniently, effectively.
Described compositions comprises natamycin, astragalus polysaccharides, cellulase, xylanase, protease, anhydrous glucose, and its prescription consists of:
Various component contents are in every 1000g this product:
Described compositions is its preparation technology realize by following technical step: after natamycin, astragalus polysaccharides, cellulase, xylanase, protease are fully mixed, the anhydrous glucose that adds equivalent, after fully mixing, go over 60 mesh sieves, anhydrous glucose with remainder adds fully mixing of back again, after three times 60 mesh sieves, range estimation is even, namely.
The invention has the beneficial effects as follows:
The present invention is directed to poultry and adopt moldy feed and toxin thereof to cause characteristics such as immunosuppressant, digestive tract are impaired, digestive function declines, feed conversion rate reduction, select for use safe and efficient, orally not absorb, mycete is had efficient inhibiting natamycin mould fungus inhibition grow; Select for use the astragalus polysaccharides with immunological enhancement to remove the poultry immunity inhibition that mycotoxin causes; Select for use cellulase, xylanase, protease to help digesting and assimilating of feedstuff, alleviate the gastrointestinal burden, improve food conversion ratio.Several composition use in conjunction have good preventive and therapeutic effect to the poultry fungal infection.
The specific embodiment
The present invention can be illustrated with prescription and the preparation method of following feature embodiment.
Embodiment 1: a kind of pharmaceutical composition prescription for the fungal infection of control poultry:
Preparation method: after natamycin, astragalus polysaccharides, cellulase, xylanase, protease fully mixed, add the anhydrous glucose of equivalent, after fully mixing, go over 60 mesh sieves, the anhydrous glucose with remainder adds fully mixing of back again, after three times 60 mesh sieves, range estimation is even, namely.
Embodiment 2: a kind of pharmaceutical composition prescription for the fungal infection of control poultry:
Preparation method: after natamycin, astragalus polysaccharides, cellulase, xylanase, protease fully mixed, add the anhydrous glucose of equivalent, after fully mixing, go over 60 mesh sieves, the anhydrous glucose with remainder adds fully mixing of back again, after three times 60 mesh sieves, range estimation is even, namely.
Embodiment 3: a kind of pharmaceutical composition prescription for the fungal infection of control poultry:
Preparation method: after natamycin, astragalus polysaccharides, cellulase, xylanase, protease fully mixed, the anhydrous glucose that adds equivalent, after fully mixing, go over 60 mesh sieves, anhydrous glucose with remainder adds fully mixing of back again, after three times 60 mesh sieves, range estimation is even, namely.
Embodiment 4: a kind of pharmaceutical composition prescription for the fungal infection of control poultry:
Preparation method: after natamycin, astragalus polysaccharides, cellulase, xylanase, protease fully mixed, add the anhydrous glucose of equivalent, after fully mixing, go over 60 mesh sieves, the anhydrous glucose with remainder adds fully mixing of back again, after three times 60 mesh sieves, range estimation is even, namely.
Embodiment 5: prophylactic tria
1. test material
The sample of the embodiment of the invention 4 preparations
2. method
The place of feedstuff being placed dark humidity is as seen obviously mouldy to naked eyes, then mouldy feedstuff is carried out abundant mixing.
120 7 age in days broiler chicks are divided into 4 groups at random, one group of negative matched group, the high-quality feed of feeding; One group of positive matched group, the above-mentioned moldy feed of feeding; One group is high dose group of the present invention, the above-mentioned moldy feed of feeding, and the ratio in 1:500 adds product of the present invention in drinking-water simultaneously; One group is low dose group of the present invention, the above-mentioned moldy feed of feeding, and the ratio in 1:1000 adds product of the present invention in drinking-water simultaneously.After feeding continuously 10 days, the pathological change of survival rate, growing state and internal organs by chicken comes the comparative test result.
4. experimental result
The prevention result of use of 4 pairs of chicken fungal infections of embodiment
As can be seen from the test results, the sample of the embodiment of the invention 4 preparation by the mould fungus inhibition growth, improve effects such as immunity of organisms, facilitating digestion absorption, stoped in the feedstuff mycete to the influence of chicken.
Embodiment 6: therapeutic test
1. material
The sample of the embodiment of the invention 3 preparations
2. test
The AA broiler plant of 6000 chickens finds chicken group lassitude when 15 ages in days, the decline of searching for food, and about 40% chicken draws feedstuff just, turns up after cuing open and examine back visible sick chicken glandular stomach swelling, cutting off, muscular stomach blackout, erosion, Endothelium Corneum Gigeriae Galli is easily peeled off.Freely drink for chicken in the ratio adding drinking-water of the sample of employing embodiment 3 in 1:500, be used in conjunction 5 days, in the 6th day therapeutic outcome is paid a return visit.
3. result of the test
Used behind the sample of embodiment 3 second day, the chicken appetite of mining massively begins to rise, and feedstuff just begins to reduce, and the mental status also begins to take a turn for the better; Use the sample of embodiment 3 after the 5th day, chicken is mined massively food, drinking-water and mental status recovery normally.
Although the present invention describes with reference to specific embodiment, this description and not meaning that is construed as limiting the present invention.With reference to description of the invention, other distortion of the disclosed embodiments all can be expected for those skilled in the art.Therefore, such distortion can not break away from affiliated claim restricted portion and spirit.
Description of drawings:
Fig. 1: the laboratory moldy feed of feeding causes artificial onset's model of chicken ventriculitis and proventriculitis
Fig. 2: the laboratory moldy feed of feeding causes artificial onset's model of liver enlargement
Left side figure is matched group
Right figure is the moldy feed group of feeding
Claims (4)
1. a pharmaceutical composition that is used for the fungal infection of control poultry is characterized in that described compositions comprises natamycin, astragalus polysaccharides, cellulase, mould, the protease of xylan.
2. according to claim 1 a kind of for the pharmaceutical composition of preventing and treating the poultry fungal infection, it is characterized in that each amounts of components of described compositions is:
3. according to claim 1 and 2 a kind of for the pharmaceutical composition of preventing and treating the poultry fungal infection, it is characterized in that its preparation realizes by following technical step: after natamycin, astragalus polysaccharides, cellulase, xylanase, protease are fully mixed, the anhydrous glucose that adds equivalent, after fully mixing, go over 60 mesh sieves, the anhydrous glucose with remainder adds fully mixing of back again, after three times 60 mesh sieves, range estimation is even, namely.
4. according to claim 1 or 2 or 3 described a kind of pharmaceutical compositions for the fungal infection of control poultry, it is characterized in that described compositions is added to the water in the ratio of 1:500-1000, freely drink for fowl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210371301 CN103272226A (en) | 2012-09-28 | 2012-09-28 | Pharmaceutical composition for controlling poultry mould infection |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210371301 CN103272226A (en) | 2012-09-28 | 2012-09-28 | Pharmaceutical composition for controlling poultry mould infection |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109984250A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of composition for preventing and treating chicken proventriculitis |
| CN112616777A (en) * | 2021-01-20 | 2021-04-09 | 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） | Method for quickly constructing chicken glandular myositis model |
-
2012
- 2012-09-28 CN CN 201210371301 patent/CN103272226A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109984250A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of composition for preventing and treating chicken proventriculitis |
| CN112616777A (en) * | 2021-01-20 | 2021-04-09 | 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） | Method for quickly constructing chicken glandular myositis model |
| CN112616777B (en) * | 2021-01-20 | 2022-04-19 | 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） | Method for quickly constructing chicken glandular myositis model |
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Application publication date: 20130904 |