CN102078371A - Pharmaceutical composition for preventing and treating chicken proventriculitis - Google Patents
Pharmaceutical composition for preventing and treating chicken proventriculitis Download PDFInfo
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- CN102078371A CN102078371A CN 200910228815 CN200910228815A CN102078371A CN 102078371 A CN102078371 A CN 102078371A CN 200910228815 CN200910228815 CN 200910228815 CN 200910228815 A CN200910228815 A CN 200910228815A CN 102078371 A CN102078371 A CN 102078371A
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Abstract
The invention relates to a pharmaceutical composition for preventing and treating chicken proventriculitis, which can be used for effectively preventing and treating chicken proventriculitis caused by non-infectious factors. The pharmaceutical composition provided by the invention is mainly prepared from the following components: B-complex vitamins, amino acids, toxin adsorbents, traditional Chinese medicine extracts and pharmaceutical auxiliary materials. The pharmaceutical composition has the functions of stimulating the appetite, moisturizing the intestine, protecting the gastric mucosa, promoting the mucosa repair and preventing the mucosa from being damaged by harmful substances, and provides a feasible path for industrialized production.
Description
Technical field
The invention belongs to the veterinary drug technical field, relate in particular to a kind of pharmaceutical composition of preventing and treating the chicken proventriculitis and preparation method thereof.
Background technology
Proventriculitis is a kind of disease that the glandular stomach function that caused by multiple factor (inducement+cause of disease) combined effect and structure change.
The glandular stomach of chicken is made of many lobules, and each lobule comprises some compound tubular glands with secretory function.The hydrochloric acid of glandular secretion and pepsinogen are discharged into the glandular stomach chamber by conduit, mix the back with food and participate in its digestion.Therefore, the glandular stomach of chicken is equivalent to mammiferous abomasum.Numerous disease can destroy glandular stomach secretory cell and Musclar layer, causes food digestion and transmission obstacle.
One, risk factor
(1) non-infectious factor
1, is more common in the chicken group of the low fiber daily ration of feeding.Contained biogenic amine (histamine, cadaverine, histidine etc.) in the chicken group daily ration.Day grain raw material fish flour, bean cake, vitamin premix, fat, Fowl meat powder and meat meal tankage etc. are subject to bacterial decomposition, thereby contain higher biogenic amine, and these biogenic amine are to the toxic effect of body.
2, feedstuff condition.The feed nutrition imbalance, albumen is low, vitamin deficiency, feed and contain the feedstuff that goes mouldy etc. and all can bring out this disease for a long time.Wherein mycotoxin is the major reason that causes full group's high incidence.
(2) infectiousness factor
1, fowlpox: especially the ocular form fowlpox is the major reason of bringing out proventriculitis.
But 2, multiple infectious disease secondary proventriculitis.Have a liking for the visceroatonia type newcastle and often cause that the glandular stomach epithelium destroys, and causes typical glandular stomach thelorrhagia.Infectious bursal disease can cause glandular stomach and the muscular stomach joint portion is hemorrhage.Spirillum sufferer chicken glandular stomach and muscular stomach junction present streak-like hemorrhage.In the chicken infectious anemia example, the glandular stomach mucosa is coarse, and there is red exudate on the surface, and the serous coat that often occurs together is hemorrhage.The sick chicken glandular stomach of avian encephalomyelitis serous coat forms lymph follicle, presents less, greyish white focus.Reovirus infects and Marek all can cause glandular stomach wall hypertrophy in various degree.
3, the ophthalmia of unknown cause: prop up as passing, pass the ophthalmia that larynx, various antibacterial, vitamin A deficiency or improper ventilation cause, all can cause the generation of proventriculitis.In addition, the cause of disease of some vertical transmissions may also be this sick inducement, as RE hypertrophy disease, chicken anemia factor, horse Garrick etc.
Two, clinical symptoms
The chicken group before morbidity, general well-grown all, in case morbidity, sick chicken shows as lassitude, drop-head, the wing that hangs down, arrange white loose stool, material just, feed intake descends, undergrowth, sick chicken weight ratio normal type descends 40%～75%; Last sick chicken dies because of seriously dying of exhaustion.Anti-ly cross the chicken size, body weight is uneven.Some chicken group also shows serious anemia.Some chicken group shows respiratory symptoms such as cough, ataxia.This disease course of disease is long, is generally 10～15 days, and the elder can surpass 30 days, and when serious secondary infection, death rate is higher, and it is long bad to recover back chicken all living creatures, the laying hen no peak of laying eggs.
Three, cut open inspection variation and diagnosis
Cut open the visible glandular stomach swelling of inspection, congested hemorrhage; Papilledema, base portion pinkiness, periphery is hemorrhage; Finger pressure has lead liquid to flow out; Later stage ulcer of nipple, depression, disappearance, even glandular stomach perforation.Intestinal mucosa comes off and is full of indigested feedstuff, later stage intestinal inanition.Thymus, pancreas, the serious atrophy of fabricius bursa, the sick Testis et penis Gallus domesticus enlargement of part has urate.When the bacterial disease secondary infection, the liver enlargement, downright bad point is arranged.According to the clinical symptoms of primary disease, cut open inspection and change etc. and can make tentative diagnosis.
Four, prophylactico-therapeutic measures
Carry out corresponding immunity inoculation at the infectious proventriculitis main pathogen, help to be controlled at this disease sickness rate minimum.To control the various harm that various mycetes, fungus and toxin thereof cause the chicken group in the daily ration simultaneously, the biogenic acidic amino acid in the daily ration in addition, the control that comprises histamine, histidine etc. also is to reduce the effective measures that the chicken proventriculitis takes place.
Summary of the invention
For these reasons, the present invention is primarily aimed at the control pharmaceutical composition owing to the chicken proventriculitis that caused by non-infectious factors such as antibacterial, fungal infection.
1, an object of the present invention is to provide a kind of pharmaceutical composition for the treatment of the chicken proventriculitis, this pharmaceutical composition is made up of following component: composite B vitamin, aminoacid, endotoxin adsorbent, Chinese medicine extract, pharmaceutic adjuvant.
2, the parts by weight of above-mentioned described each component are: composite B vitamin 0.5-2 part, aminoacid 5-20 part, endotoxin adsorbent 5-20 part, Chinese medicine extract 5-20 part, pharmaceutic adjuvant 38-84.5 part.
3, above-mentioned described composite B vitamin comprises vitamin B
1, vitamin B
2, vitamin B
6, pantothenic acid, nicotiamide, biotin, folic acid, vitamin B
12Deng more than three kinds the combination.
4, above-mentioned aminoacid be birds commonly used various amino acid whose one or more, comprise lysine, methionine, threonine, aspartic acid etc.
5, above-mentioned endotoxin adsorbent comprises Montmorillonitum, bentonite.
6, antibacterial is selected from one or more combinations of dimethyl fumarate, ethoxy quinoline, potassium sorbate, sodium diacetate.
7, above-mentioned Chinese medicine extract is selected from one or more combinations of Caulis et Folium Lactucae sativae, Herba Xanthii, Radix Sophorae Flavescentis, Herba Sophorae alopecuroidis, Chinese walnut stem, root of Broussonetiapapyrifera(I)vent root, Radix Glycyrrhizae, Pericarpium Granati, preferred Radix Sophorae Flavescentis extract.
8, above-mentioned pharmaceutic adjuvant is selected from all acceptable pharmacy adjuvants.
Another object of the present invention provides a kind of method of preventing and treating chicken proventriculitis disease.And use the sickness rate that can effectively reduce the chicken proventriculitis behind the above-mentioned composition, the chicken of their early stage is had therapeutical effect preferably.
The invention has the beneficial effects as follows:
1, can suppress the growth of antibacterial, mycete in the feedstuff;
2, can active adsorption be subjected to toxin in the feedstuff of antibacterial, mycotoxin contamination and the toxin in the intestinal, form layer protecting film simultaneously in gastrointestinal tract, it is gastrointestinal tract mucous that toxin can not damaged.
3, spice uses, and is easy to use;
4, raw material is easy to obtain, and is suitable for extension and produces.
The specific embodiment
Can observe beneficial effect of the present invention with the following Examples, these embodiment are illustrative, can not be construed as limiting the present invention.
Embodiment 1,
Prescription:
Preparation method:
1, gets anhydrous glucose and pulverize, cross 80 mesh sieves;
2, get vitamin B
1, vitamin B
2, vitamin B
6, the dilution method dilution four times of progressively increasing of nicotiamide, biotin, sodium diacetate, dimethyl fumarate and anhydrous glucose equivalent, cross 60 order fine screens, obtain the uniform mixture of several elementary mixing.
3, get vitamin B
12With the dilution method dilution 9 times of progressively increasing of anhydrous glucose equivalent, cross 60 order fine screens, obtain the uniform mixture of a kind of elementary mixing.
4, other compositions of said mixture and residue, anhydrous glucose add in the mixer, mix 30 minutes, promptly.
Embodiment 2,
Prescription:
Preparation method:
1, gets vitamin B
1, vitamin B
2, vitamin B
6, the dilution method dilution four times of progressively increasing of folic acid, threonine, potassium sorbate, ethoxy quinoline and starch equivalent, cross 60 order fine screens, obtain the uniform mixture of several elementary mixing.
2, get vitamin B
12With the dilution method dilution 9 times of progressively increasing of starch equivalent, cross 60 order fine screens, obtain the uniform mixture of a kind of elementary mixing.
3, other compositions of said mixture and residue, starch add in the mixer, mix 30 minutes, promptly.
The effect test of embodiment 3, present composition control chicken proventriculitis
(1) experimental animal
The Tianjin chicken house has a collection of 10 aa broiler chicken, and 10 ages in days are found the feces punishment in advance, and the chicken appetite of mining massively is low, and standing, it is listless to beat.Cut open visible glandular stomach swelling of inspection such as ball, turn white.Be diagnosed as proventriculitis.
(2) EXPERIMENTAL DESIGN and method
Select 300 of the sick chickens of this chicken house at random, test group is low dose group (mixed feeding, every 1kg feedstuff, this product 1g), free choice feeding, logotype three days; Testing two groups is middle dosage group (mixed feeding, every 1kg feedstuff, this product 2g), free choice feeding, logotype three days; Testing three groups is high dose group (mixed feeding, every 1kg feedstuff, this product 4g) free choice feeding, logotype three days; Testing four groups is the routine administration group, selects commercially available ampicillin soluble powder (specification 10%) for use, mixes drink, every 1L water, 0.4g, logotype three days.
(3) curative effect determinate standard
Cure rate: spirit, appetite, clinical symptoms are recovered normal sick chicken fully and are accounted for the ratio that this organizes total chicken number after the off-test.
Effective percentage: the sick chicken that spirit, appetite, clinical symptoms are clearly better after the off-test accounts for the ratio that this organizes total chicken number.
Inefficiency: duration of test occurs dead, and the sick chicken of not feeling any better after the medication accounts for the ratio that this organizes total chicken number.
Table 1 medicine of the present invention is to chicken proventriculitis control test grouping
(4) result of the test
Medicine of the present invention is to the therapeutic effect of chicken proventriculitis.
Table 2 clinical test results
Pharmaceutical composition of the present invention as can be seen from the above table can effectively be prevented and treated the chicken proventriculitis.Dosage group effect is better in selecting for use.Composite B vitamin has the appetizing intestine moistening in the pharmaceutical composition of the present invention, the effect of protection gastric mucosa, and antibacterial, the mycotoxin of endotoxin adsorbent in can not only adsorption feed, and the toxin in the gastrointestinal tract also had adsorption, form layer protecting film on the gastrointestinal tract surface simultaneously, promote the mucosa reparation, stop the infringement of harmful substance it, antibacterial can effectively suppress to be harmful to growing of bacterium in the feedstuff, prevents its infringement to body; Chinese medicine extract can not only suppress and kill the harmful bacterium in the feedstuff and antibacterial in the body also had more powerful killing action.Therefore the present invention is remarkable as the chicken proventriculitis effect that non-infection factor causes.
Claims (8)
1. a pharmaceutical composition that is used to prevent and treat the chicken proventriculitis is characterized in that, this pharmaceutical composition is made up of following component: composite B vitamin, aminoacid, endotoxin adsorbent, Chinese medicine extract, pharmaceutic adjuvant.
2. a kind of pharmaceutical composition that is used to prevent and treat the chicken proventriculitis according to claim 1, it is characterized in that the parts by weight of said components are: composite B vitamin 0.5-2 part, aminoacid 5-20 part, endotoxin adsorbent 5-20 part, Chinese medicine extract 5-20 part, pharmaceutic adjuvant 38-84.5 part.
3. a kind of pharmaceutical composition that is used to prevent and treat the chicken proventriculitis according to claim 1 is characterized in that composite B vitamin comprises vitamin B
1, vitamin B
2, vitamin B
6, pantothenic acid, nicotiamide, biotin, folic acid, vitamin B
12Deng three or more combination.
4. a kind of pharmaceutical composition that is used to prevent and treat the chicken proventriculitis according to claim 1 is characterized in that, aminoacid be birds commonly used various amino acid whose one or more, comprise lysine, methionine, threonine, aspartic acid etc.
5. a kind of pharmaceutical composition that is used to prevent and treat the chicken proventriculitis according to claim 1 is characterized in that endotoxin adsorbent is Montmorillonitum, bentonite.
6. a kind of pharmaceutical composition that is used to prevent and treat the chicken proventriculitis according to claim 1 is characterized in that antibacterial is selected from one or more combinations in dimethyl fumarate, ethoxy quinoline, potassium sorbate, the sodium diacetate.
7. a kind of pharmaceutical composition that is used to prevent and treat the chicken proventriculitis according to claim 1, it is characterized in that, Chinese medicine extract is selected from one or more combinations of Caulis et Folium Lactucae sativae, Herba Xanthii, Radix Sophorae Flavescentis, Herba Sophorae alopecuroidis, Chinese walnut stem, root of Broussonetiapapyrifera(I)vent root, Radix Glycyrrhizae, Pericarpium Granati, preferred Radix Sophorae Flavescentis extract.
8. a kind of pharmaceutical composition that is used to prevent and treat the chicken proventriculitis according to claim 1 is characterized in that, pharmaceutic adjuvant is selected from all acceptable pharmacy adjuvants.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910228815 CN102078371A (en) | 2009-11-27 | 2009-11-27 | Pharmaceutical composition for preventing and treating chicken proventriculitis |
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|---|---|---|---|
| CN 200910228815 CN102078371A (en) | 2009-11-27 | 2009-11-27 | Pharmaceutical composition for preventing and treating chicken proventriculitis |
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| CN102078371A true CN102078371A (en) | 2011-06-01 |
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389033A (en) * | 2011-09-30 | 2012-03-28 | 广东紫金正天药业有限公司 | Composition containing montmorillonite, and application of composition |
| CN103394021A (en) * | 2013-08-05 | 2013-11-20 | 山东新希望六和集团有限公司 | Compound medicament for treating proventriculitis and gizzard erosion of poultry and preparation method thereof |
| CN104147568A (en) * | 2014-08-18 | 2014-11-19 | 格特生物制药（天津）有限公司 | Traditional Chinese medicinal oral liquid for treating poultry infectious proventriculitis, and preparation method thereof |
| CN104222650A (en) * | 2014-09-25 | 2014-12-24 | 青岛蓝盈禽业科技有限公司 | Chicken raising method |
| CN104288181A (en) * | 2014-10-27 | 2015-01-21 | 武汉中博绿亚生物科技有限公司 | Ointment for treating discomfort caused by expelling parasites on pet and preparation method of ointment |
| CN104323004A (en) * | 2014-10-30 | 2015-02-04 | 马辉 | Feed additive capable of preventing and treating gastric diseases of livestock and poultry |
| CN104491770A (en) * | 2014-08-13 | 2015-04-08 | 济南瑞谷生物科技有限公司 | Traditional Chinese medicine composition for preventing and treating poultry mycotic gland and muscular gastritis |
| CN104686581A (en) * | 2013-12-05 | 2015-06-10 | 无锡钻石地毯制造有限公司 | Ecological carpet antioxidation mildew inhibitor |
| CN104686519A (en) * | 2013-12-05 | 2015-06-10 | 无锡市锡源锅炉有限公司 | Antioxidation mildew inhibitor for drying furnace |
| CN105381456A (en) * | 2015-11-11 | 2016-03-09 | 镇江荣邦生物科技有限公司 | Pharmaceutical preparation for treating chicken proventriculitis |
| CN105663546A (en) * | 2016-03-10 | 2016-06-15 | 中国农业科学院兰州畜牧与兽药研究所 | Chinese traditional medicine composition for treating proventriculitis of chicken |
| CN106177459A (en) * | 2016-08-11 | 2016-12-07 | 大连民族大学 | For treating pharmaceutical composition of broiler proventriculitis and preparation method thereof |
| CN107789362A (en) * | 2016-08-31 | 2018-03-13 | 瑞普（天津）生物药业有限公司 | A kind of gravel for treating birds ventriculitis and preparation method thereof |
| CN107927343A (en) * | 2017-11-30 | 2018-04-20 | 南宁学院 | A kind of additive for preventing chicken infectious anemia |
| CN109984250A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of composition for preventing and treating chicken proventriculitis |
| CN110720630A (en) * | 2018-12-29 | 2020-01-24 | 瑞普（天津）生物药业有限公司 | Nutritional composition for relieving adenofibromyositis and gastritis symptoms |
| CN114246940A (en) * | 2020-09-23 | 2022-03-29 | 洛阳惠中兽药有限公司 | Application of pharmaceutical composition containing kuh-seng mahonia granules |
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2009
- 2009-11-27 CN CN 200910228815 patent/CN102078371A/en active Pending
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389033A (en) * | 2011-09-30 | 2012-03-28 | 广东紫金正天药业有限公司 | Composition containing montmorillonite, and application of composition |
| CN103394021A (en) * | 2013-08-05 | 2013-11-20 | 山东新希望六和集团有限公司 | Compound medicament for treating proventriculitis and gizzard erosion of poultry and preparation method thereof |
| CN103394021B (en) * | 2013-08-05 | 2015-03-25 | 山东新希望六和集团有限公司 | Compound medicament for treating proventriculitis and gizzard erosion of poultry and preparation method thereof |
| CN104686581A (en) * | 2013-12-05 | 2015-06-10 | 无锡钻石地毯制造有限公司 | Ecological carpet antioxidation mildew inhibitor |
| CN104686519A (en) * | 2013-12-05 | 2015-06-10 | 无锡市锡源锅炉有限公司 | Antioxidation mildew inhibitor for drying furnace |
| CN104491770A (en) * | 2014-08-13 | 2015-04-08 | 济南瑞谷生物科技有限公司 | Traditional Chinese medicine composition for preventing and treating poultry mycotic gland and muscular gastritis |
| CN104147568A (en) * | 2014-08-18 | 2014-11-19 | 格特生物制药（天津）有限公司 | Traditional Chinese medicinal oral liquid for treating poultry infectious proventriculitis, and preparation method thereof |
| CN104222650A (en) * | 2014-09-25 | 2014-12-24 | 青岛蓝盈禽业科技有限公司 | Chicken raising method |
| CN104288181A (en) * | 2014-10-27 | 2015-01-21 | 武汉中博绿亚生物科技有限公司 | Ointment for treating discomfort caused by expelling parasites on pet and preparation method of ointment |
| CN104288181B (en) * | 2014-10-27 | 2018-05-04 | 武汉中博绿亚生物科技有限公司 | It is a kind of to treat pet because expelling parasite causes paste for not relaxing and preparation method thereof |
| CN104323004A (en) * | 2014-10-30 | 2015-02-04 | 马辉 | Feed additive capable of preventing and treating gastric diseases of livestock and poultry |
| CN105381456A (en) * | 2015-11-11 | 2016-03-09 | 镇江荣邦生物科技有限公司 | Pharmaceutical preparation for treating chicken proventriculitis |
| CN105663546A (en) * | 2016-03-10 | 2016-06-15 | 中国农业科学院兰州畜牧与兽药研究所 | Chinese traditional medicine composition for treating proventriculitis of chicken |
| CN106177459A (en) * | 2016-08-11 | 2016-12-07 | 大连民族大学 | For treating pharmaceutical composition of broiler proventriculitis and preparation method thereof |
| CN107789362A (en) * | 2016-08-31 | 2018-03-13 | 瑞普（天津）生物药业有限公司 | A kind of gravel for treating birds ventriculitis and preparation method thereof |
| CN107927343A (en) * | 2017-11-30 | 2018-04-20 | 南宁学院 | A kind of additive for preventing chicken infectious anemia |
| CN109984250A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of composition for preventing and treating chicken proventriculitis |
| CN110720630A (en) * | 2018-12-29 | 2020-01-24 | 瑞普（天津）生物药业有限公司 | Nutritional composition for relieving adenofibromyositis and gastritis symptoms |
| CN114246940A (en) * | 2020-09-23 | 2022-03-29 | 洛阳惠中兽药有限公司 | Application of pharmaceutical composition containing kuh-seng mahonia granules |
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Application publication date: 20110601 |