CN104147568A - Traditional Chinese medicinal oral liquid for treating poultry infectious proventriculitis, and preparation method thereof - Google Patents
Traditional Chinese medicinal oral liquid for treating poultry infectious proventriculitis, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal oral liquid for treating poultry infectious proventriculitis, and a preparation method thereof. The oral liquid is prepared by using licorice root, white peony root, Radix Scutellariae, dry ginger, Chinese date, ginseng, Rhizoma Coptidis, Radix Astragali, Chinese angelica, Flos Inulae, reddle and Pinellia Tuber. The above traditional Chinese medicinal composition can be an oral liquid. The preparation method comprises the following steps: 1, crushing traditional Chinese medicines to 80-100 meshes, weighing according to formula amounts, and carrying out three dimensional mixing to obtain traditional Chinese medicinal powder; 2, adding the mixed traditional Chinese medicinal powder and 100-200 parts of water to an extraction tank, and immersing for 5-20h; 3, heating to 40-100DEG C, and extracting for 6-10h; 5, filtering the above collected medicinal liquid; 5, continuously adding 100-200 parts of water to medicinal residues, and extracting at 40-100DEG C for 6-10h; 6, filtering to remove medicinal residues, mixing two time extraction liquids, and carrying out reduced pressure concentration at 30-70DEG C until the final volume is 20-40% of an original volume; and 7, bottling according to a specification of 500ml/bottle in order to obtain a finished product. The traditional Chinese medicinal oral liquid provided by the invention can effectively treat the poultry infectious proventriculitis, and the cure rate is above 85%. The oral liquid has middle energizer regulating, vacuity supplementing, stomach harmonizing, glomus dispersing, qi tonifying and spleen invigorating effects.
Description
Technical field
The invention belongs to herbal medicine formulation art, especially a kind of Chinese medicine oral liquid for the treatment of poultry infectious proventriculitis and preparation method thereof.
Background technology
Poultry infectious proventriculitis be a kind of with poultry undergrowth, become thin, regularity is poor, the outward appearance symptoms such as punishment in advance, glandular stomach enlargement, or glandular stomach applanation nipple even disappears, glandular stomach mucosa hemorrhage ulcer, come off, epidemic diseases that muscular stomach Endothelium corneum and muscular stomach mucosal surface crateriform ulcer, gizzard erosion are principal character.
Poultry infectious proventriculitis all has generation in the whole world, can betide the poultry (birds such as chicken, duck, goose, Columba livia, Carnis Coturnicis japonicae) of different cultivars, age in days at the avian infectious gland ventriculitis of man of China.Primary disease, without obvious seasonality, all can occur throughout the year.Present explosive growth nearly one or two years in China, all there is morbidity all parts of the country, and morbidity age in days is more and more less, disease is more and more serious, and after morbidity, swelling, the ulcer of glandular stomach become so obvious not as falling ill in the past, and the pathological changes such as the ulcer of muscular stomach are more and more serious, the death that disease concurrent or secondary is brought is more and more higher.Infectious proventriculitis main infection chicken in the past, and closely aquatic bird one or two years (duck, goose), rare bird (Columba livia, Carnis Coturnicis japonicae, pheasant, Gallus jabouillei, Ostriches) also all start morbidity, and the order of severity of morbidity is not second to laying hen and broiler; At present primary disease in the morbidity ratio of poultry farming chicken house up to more than 90%.The fowl all living creatures length of morbidity is seriously obstructed, and uneven, colony and standard age in days value differ greatly.The simultaneously disease such as the easy secondary escherichia coli of primary disease, mycoplasma, newcastle, influenza, coccidiosis, if secondary other diseases, M & M has increasing to a certain degree.
At present, poultry infectious proventriculitis has become affects the main disease that aquaculture develops in a healthy way, the conventional western medicine effect of antibiotic, gastric acid secretion inhibiting is very undesirable, and the Chinese medicine that therefore infectious proventriculitis can be effectively treated in exploitation has become an urgent demand in market.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, a kind of good effect, no drug residue, safe and reliable treatment poultry infectious proventriculitis Chinese medicine oral liquid are provided.
Another technical problem that the present invention will solve is: a kind of Chinese medicine formula for the treatment of poultry infectious proventriculitis is provided.
Another technical problem that the present invention will solve is: the preparation method that the oral liquid formulations of above-mentioned fowl Chinese medicine composition is provided.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of poultry infectious proventriculitis inflammation, is prepared from by the raw material of following mass fraction: Radix Glycyrrhizae 10-20 part, Radix Paeoniae Alba 10-20 part, Radix Scutellariae 10-20 part, Rhizoma Zingiberis 10-20 part, Fructus Jujubae 10-20 part, Radix Ginseng 5-10 part, Rhizoma Coptidis 10-20 part, Radix Astragali 10-20 part, Radix Angelicae Sinensis 10-20 part, Flos Inulae 10-20 part, Haematitum 10-20 part, Rhizoma Pinelliae 10-20 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows:
20 parts, Radix Glycyrrhizae, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Scutellariaes, 20 parts of Rhizoma Zingiberiss, 20 parts, Fructus Jujubae, 10 parts of Radix Ginsengs, 10 parts of Rhizoma Coptidis, 20 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Flos Inulaes, 10 parts of Haematitums, 10 parts of the Rhizoma Pinelliaes.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form that contains or do not contain pharmaceutic adjuvant.
Further, the preparation method of the oral liquid formulations of said composition is: Chinese medicine powder is broken to 80-100 order by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, 100-200 part water are put in extraction pot, soaked 5-20 hour; (3) be heated to 40-100 DEG C and extract 6-10 hour; (4) filter and collect medicinal liquid; (5) last medicinal residues continue to add 100-200 part water, and 40-100 DEG C is extracted 6-10 hour; (6) remove by filter medicinal residues, merge extracted twice liquid, 30-70 DEG C is evaporated to original volume 20%-40%; (7) fill becomes bottle, and every bottle of 500ml, gets product.
Advantage and good effect that the present invention has are:
(1) the present invention is according to tcm theory, and science compatibility has retained the combined effect of Chinese medicinal formulae determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, through clinical verification determined curative effect, is a kind of green veterinary drug of nuisanceless, no drug residue.
(2) Chinese medicine ingredients that the present invention contains can effectively be treated poultry infectious proventriculitis, and cure rate can reach more than 85%.This prescription has the effect of tonify deficiency and diabetes involving middle-JIAO painful abdominal mass in tune, replenishing QI to invigorate the spleen.
(3) pharmacology of the each raw material of Chinese medicine of the present invention is:
Radix Glycyrrhizae: invigorating the spleen and regulating the stomach, coordinating the actions of various ingredients in a prescription.
The Radix Paeoniae Alba: the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain.
Radix Scutellariae: heat clearing and damp drying, removing toxic substances.
Rhizoma Zingiberis: warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation.
Fructus Jujubae: warming middle-JIAO nourishes blood, strengthening QI of middle-JIAO.
Radix Ginseng: strongly invigorating primordial QI, invigorating the spleen to benefit the lung.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.
The Radix Astragali: invigorating the spleen and replenishing QI, consolidating superficial resistance.
Radix Angelicae Sinensis: blood circulation promoting and enriching.
Flos Inulae: stopping nausea and vomiting by lowering the adverse flow of QI
Haematitum: stopping nausea and vomiting by lowering the adverse flow of QI
The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass
Assertive evidence is coldheat complex, due to middle burnt disorder in ascending and descending.In the sweet temperature compensation of Radix Glycyrrhizae, invigorating the spleen and regulating the stomach, contrary to delay on courteous.Assistant, with Radix Ginseng, Fructus Jujubae, more increases the power of its invigorating middle warmer; Radix Astragali invigorating the spleen and replenishing QI, Chinese angelica blood supplementing is invigorated blood circulation, and reaches effect of qi and blood tonifying; Rhizoma Zingiberis, Rhizoma Pinelliae warming spleen and stomach for dispelling cold, the pungent stomach function regulating that falls, is aided with Flos Inulae, Haematitum and can strengthens effect of its sending down the abnormal ascending QI stomach function regulating.A kind of reed mentioned in ancient books connects the clearing up internal heat by using drugs of bitter in taste and cold in nature painful abdominal mass that disappears and closes and make that taste are strong and Central Region must be answered, and negative and positive are adjusted and lifting consonance.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
A Chinese medicine oral liquid for poultry infectious proventriculitis, the parts by weight of each raw material are as follows: 20 parts, Radix Glycyrrhizae, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Scutellariaes, 20 parts of Rhizoma Zingiberiss, 20 parts, Fructus Jujubae, 10 parts of Radix Ginsengs, 10 parts of Rhizoma Coptidis, 20 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Flos Inulaes, 10 parts of Haematitums, 10 parts of the Rhizoma Pinelliaes.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 200 parts of water are put in extraction pot, soaked 8 hours; (3) being heated to 100 DEG C extracts 8 hours; (4) filter and collect medicinal liquid; (5) last medicinal residues continue to add 200 parts of water, and 100 DEG C are extracted 8 hours; (6) remove by filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 20%; (7) fill becomes bottle, and every bottle of 500ml, gets product.
Embodiment 2
A Chinese medicine oral liquid for poultry infectious proventriculitis, the parts by weight of each raw material are as follows: 15 parts, Radix Glycyrrhizae, 10 parts of the Radix Paeoniae Albas, 15 parts of Radix Scutellariaes, 10 parts of Rhizoma Zingiberiss, 10 parts, Fructus Jujubae, 10 parts of Radix Ginsengs, 10 parts of Rhizoma Coptidis, 10 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Flos Inulaes, 10 parts of Haematitums, 20 parts of the Rhizoma Pinelliaes.。Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) 200 parts, mixed Chinese medicine powder and water is put in extraction pot, soaked 8 hours; (3) being heated to 100 DEG C extracts 8 hours; (4) filter and collect medicinal liquid; (5) last medicinal residues continue to add 200 parts of water, and 100 DEG C are extracted 8 hours; (6) remove by filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 20%; (7) fill becomes bottle, and every bottle of 500ml, gets product.
Embodiment 3
A Chinese medicine oral liquid for poultry infectious proventriculitis, the parts by weight of each raw material are as follows: 15 parts, Radix Glycyrrhizae, 20 parts of the Radix Paeoniae Albas, 15 parts of Radix Scutellariaes, 10 parts of Rhizoma Zingiberiss, 10 parts, Fructus Jujubae, 5 parts of Radix Ginsengs, 10 parts of Rhizoma Coptidis, 10 parts of the Radixs Astragali, 20 parts of Radix Angelicae Sinensis, 10 parts of Flos Inulaes, 10 parts of Haematitums, 20 parts of the Rhizoma Pinelliaes.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) 200 parts of mixed Chinese medicine powders, water are put in extraction pot, soaked 8 hours; (3) being heated to 100 DEG C extracts 8 hours; (4) filter and collect medicinal liquid; (5) last medicinal residues continue to add 200 parts of water, and 100 DEG C are extracted 8 hours; (6) remove by filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 20%; (7) fill becomes bottle, and every bottle of 500ml, gets product
Clinical trial
Experiment 1:
Jiangsu Mou Ya plant, gold is determined 60000 of duck breeding stocks, 10000 of morbidity ducks.Clinical manifestation is depressed, the poor growth of spirit, inappetence, watery stools.Dissection shows as glandular stomach enlargement as table tennis, gizzard erosion.Be infectious proventriculitis through clinical diagnosis.To wherein 5000 use embodiment 1 obtained products.Every bottle is watered 100 kilograms, and every twice-daily is treated three days.Second day symptom of medication obviously alleviates, and within the 3rd day, removing indivedual serious symptoms still needs to continue medication one beyond the highest heavens, and jumpbogroup is cured.Cure rate reaches 88%.Another 3000 use ofloxacin to coordinate cimetidine, treat five days.Within the 3rd day, start onset, within the 5th day, jumpbogroup is cured, cure rate 65%.Also have 2000 to use cefquinome to share ranitidine, treat five days.The 3rd day starts to take effect, and within the 7th day, jumpbogroup is cured, and cure rate reaches 55%.
Experimental results show that the obtained product curative effect of embodiment 1 is obviously better than the medicine of the treatment infectious proventriculitis of commonly using on the market.
Experiment 2:
Shandong chicken house, 20000 of white plumage broiler breeding stocks, 15000 of morbidity ducks.Clinical manifestation is poor growth, inappetence, after dissecting, finds that glandular stomach is great, and slightly rotten to the corn with muscular stomach.Clinical diagnosis is infectious proventriculitis.Wherein 10000 use the obtained product of embodiment 1.Every bottle is watered 100 kilograms, and every twice-daily is treated three days.Second day symptom of medication obviously alleviates, and within the 3rd day, jumpbogroup is cured.Cure rate reaches 84%.Another 3000 use ampicillin to share ranitidine, treat seven days.Within the 4th day, start onset, within the 7th day, jumpbogroup is cured, cure rate 62%.Also have 2000 to use ofloxacin to share ranitidine, treat six days.The 3rd day starts to take effect, and within the 6th day, jumpbogroup is cured, and cure rate reaches 62%.
Experimental results show that the obtained product curative effect of embodiment 1 is obviously better than the medicine of the treatment infectious proventriculitis of commonly using on the market.
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiment according to limited range, therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (9)
1. treat Chinese medicine oral liquid of poultry infectious proventriculitis and preparation method thereof for one kind, it is characterized in that: the raw material by following mass fraction is prepared from: Radix Glycyrrhizae 10-20 part, Radix Paeoniae Alba 10-20 part, Radix Scutellariae 10-20 part, Rhizoma Zingiberis 10-20 part, Fructus Jujubae 10-20 part, Radix Ginseng 5-10 part, Rhizoma Coptidis 10-20 part, Radix Astragali 10-20 part, Radix Angelicae Sinensis 10-20 part, Flos Inulae 10-20 part, Haematitum 10-20 part, Rhizoma Pinelliae 10-20 part.
2. the Chinese medicine oral liquid for the treatment of poultry infectious proventriculitis according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
20 parts, Radix Glycyrrhizae, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Scutellariaes, 20 parts of Rhizoma Zingiberiss, 20 parts, Fructus Jujubae, 10 parts of Radix Ginsengs, 10 parts of Rhizoma Coptidis, 20 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Flos Inulaes, 10 parts of Haematitums, 10 parts of the Rhizoma Pinelliaes.
3. the Chinese medicine oral liquid for the treatment of poultry infectious proventriculitis according to claim 1 and 2, is characterized in that: this Chinese medicine composition is the various conventional extract oral medicine dosage form that contains or do not contain pharmaceutic adjuvant.
4. the Chinese medicine oral liquid for the treatment of poultry infectious proventriculitis according to claim 3, is characterized in that: described preparation can be oral liquid.
5. a method of preparing the Chinese medicine oral liquid for the treatment of poultry infectious proventriculitis as claimed in claim 4, is characterized in that: preparation method is that Chinese medicine powder is broken to certain order number by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, aqueous solution are put in extraction pot, soaked the regular hour; (3) be heated to uniform temperature, extract certain hour; (4) filter and collect extracting solution; (5) secondary adds a certain amount of water in medicinal residues, continues to extract at a certain temperature certain hour; (6) merge extracted twice liquid, be evaporated at a certain temperature certain volume; (7) fill becomes bottle, gets product.
6. the preparation method of the Chinese medicine oral liquid for the treatment of poultry infectious proventriculitis according to claim 5, is characterized in that: described pulverizing order number is 80-100 order.
7. the preparation method of the Chinese medicine oral liquid for the treatment of poultry infectious proventriculitis according to claim 5, is characterized in that: the extracted twice time is 6-10 hour.
8. the preparation method of the extract oral for the treatment of poultry infectious proventriculitis according to claim 5, is characterized in that: described concentrating under reduced pressure temperature is 30-70 DEG C.
9. the preparation method of the Chinese medicine oral liquid for the treatment of poultry infectious proventriculitis according to claim 5, is characterized in that: described concentrating under reduced pressure volume is original volume 20%-40%.
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Cited By (2)
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| CN104771686A (en) * | 2015-03-20 | 2015-07-15 | 河南大德广动物药业有限公司 | Traditional Chinese medicine formula for treating poultry muscular stomach and glandular stomach inflammation and preparation method thereof |
| CN107890531A (en) * | 2017-11-17 | 2018-04-10 | 锦州景良动物药业有限公司 | A kind of traditional Chinese medicine oral liquid for treating avian infectious proventriculitis and preparation method thereof |
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| CN101647883A (en) * | 2009-09-17 | 2010-02-17 | 天津市慧瑞动物药业有限公司 | Chinese-Western compound preparation for treating infective proventriculitis of chicken and preparation method thereof |
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Cited By (3)
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| CN104771686A (en) * | 2015-03-20 | 2015-07-15 | 河南大德广动物药业有限公司 | Traditional Chinese medicine formula for treating poultry muscular stomach and glandular stomach inflammation and preparation method thereof |
| CN104771686B (en) * | 2015-03-20 | 2018-03-27 | 河南大德广动物药业有限公司 | A kind of Chinese medicine preparation for treating poultry ventriculitis proventriculitis and preparation method thereof |
| CN107890531A (en) * | 2017-11-17 | 2018-04-10 | 锦州景良动物药业有限公司 | A kind of traditional Chinese medicine oral liquid for treating avian infectious proventriculitis and preparation method thereof |
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