CN104069477A - Traditional Chinese medicine oral liquid for preventing and treating chicken avian influenza and preparation method thereof - Google Patents
Traditional Chinese medicine oral liquid for preventing and treating chicken avian influenza and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine oral liquid for preventing and treating chicken avian influenza and a preparation method thereof, the oral liquid comprises the following raw materials in parts by weight: 10 to 20 parts of ephedra, 5 to 10 parts of ginger, 5 to 10 parts of Chinese dates, 3 to 5 parts of glycyrrhiza, 8 to 10 parts of cassia twig, 5 to 10 parts of white peony root, 5 to 10 parts of almonds, 10 to 15 parts of gypsum, 5 to 10 parts of rhizoma fagopyri dibotryis, 5 to 10 parts of platycodon grandiflorum and 300 to 500 parts of water. The preparation method comprises the following steps: (1), grinding the materials to 40 to 60 meshes; (2), mixing the material powder; (3), adding water and the mixed material powder into a traditional Chinese medicine extracting tank and heating the mixture to 40 to 90 DEG C and boiling for 8 to 12 hours; (4), filtering the heated and boiled mixture to remove the herb residue; (5), bottle filling the filtered mixture with 150 to 250 ml of medicine liquid in each bottle. The traditional Chinese medicine composition provided by the invention can effectively prevent and treat chicken avian influenza, and the cure rate reaches 90% above; besides, the composition has the functions of relieving exterior syndrome, relieving a cough and bringing down a fever as well as eliminating phlegm and discharging pus.
Description
Technical field
The invention belongs to herbal medicine formulation art, especially a kind of Chinese medicine oral liquid of preventing and treating avian influenza and preparation method thereof.
Background technology
The feature that avian influenza is fast with its spread speed, infection rate is high, mortality rate is high has become one of main killer of domestic poultry husbandry.Symptom and pathological change difference that its main diseases type obtains bird flu according to chicken can be divided into acute septic, acute respiratory type and atypia three classes.The main Symptoms of the sick fowl of acute septic bird flu (typical bird flu) is highly depressed, lethargy, dehisces to breathe, and the watery nasal discharge of shedding tears, hat whisker cyanosis, hemorrhage, incidence enlargement, acute death.There is ataxia, tremble in some cases, partially head, turn round the nervous symptoms such as neck.Pathological change feature is that cornea is muddy, conjunctival hemorrhage, ulcer; Wing, crop portion skin surface have reddish black speckle shape hemorrhage etc.; The hemorrhage edema of common foot shin also; Subcutaneous dropsy or be and freeze gelatinous infiltration; Pulmonary hemorrhage edema, spleen has canescence speckle sample downright bad, and pancreas has that brown macules point sample is hemorrhage, degeneration, necrosis; Fabricius bursa is hemorrhage; , ulcer hemorrhage to the whole alimentary canal mucous membrane of cloaca from oral cavity or have canescence speckle, bar grain pattern membranoid substance, other histoorgans also may have hemorrhage, and Chang Kejian has obvious fiber disposition peritonitis, airsacculitis etc.The sick Cor Gigeriae Galli flesh having has canescence gangrenosum acne striped.The sick fowl main manifestations of acute respiratory type bird flu (typical bird flu) is the watery nasal discharge of shedding tears, rapid breathing, cough, sneeze, nasal sinuses swelling, and dysentery, part occurs dead.Main pathology is changed to larynx tracheorrhagia, and nasal sinuses gathers secretions, and eye chemosis is hemorrhage, sometimes also sees the pathological change of similar acute septic bird flu.Atypia avian influenza fowl generally shows as and sheds tears, coughs, breathes, dysentery, and laying rate significantly declines, and occurs fragmentary dead.General pathology is changed to nasal sinuses, trachea, air bag, intestinal some exudative inflammations, sometimes sees that air bag has fiber disposition to ooze out, and cyst wall thickens, and egg fowl generation yolk peritonitis, has inflammation exudate during fallopian tube.
The current progressively standard along with country's medicine related management for animals, has prohibited end user when treatment fowl poultry kind zoosis toxicity disease and has used antiviral chemicals.Chemical medicine does not have antivirus veterinary medicine simultaneously, causes the clinical situation that can use without medicine while facing bird flu.Therefore, the tcm product of exploitation treatment bird flu has become extremely urgent requirement.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, a kind of good effect, no drug residue, safe and reliable control avian influenza oral liquid are provided.
Another technical problem that the present invention will solve is: a kind of Chinese medicine formula of preventing and treating avian influenza is provided.
Another technical problem that the present invention will solve is: the preparation method that above-mentioned avian influenza Chinese medicine oral liquid is provided.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine oral liquid of preventing and treating avian influenza, is characterized in that: the raw material by following mass fraction is prepared from: Herba Ephedrae 10-20 part, Rhizoma Zingiberis Recens 5-10 part, Fructus Jujubae 5-10 part, Radix Glycyrrhizae 3-5 part, Ramulus Cinnamomi 8-10 part, Radix Paeoniae Alba 5-10 part, Semen Armeniacae Amarum 5-10 part, Gypsum Fibrosum 10-15 part, Rhizoma Fagopyri Dibotryis 5-10 part, Radix Platycodonis 5-10 part, water 300-500 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine oral liquid or concentration are as follows:
20 parts, Herba Ephedrae, 5 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae, 5 parts, Radix Glycyrrhizae, 10 parts of Ramulus Cinnamomi, 10 parts of the Radix Paeoniae Albas, 8 parts, Semen Armeniacae Amarum, 15 parts, Gypsum Fibrosum, 10 parts of Rhizoma Fagopyri Dibotryiss, 10 parts of Radix Platycodoniss, 400 parts, water.
Further, described preparation can be oral liquid.
Further, the preparation method of the powder of said composition is: (1) is broken to 40-60 order by Chinese medicine powder; (2) mix Chinese medicine powder; (3) water and mixed Chinese medicine powder are fed in Chinese medicine extracting tank, are heated to 40-90 degree, boil 8-12 hour; (4) remove by filter medicinal residues; (5) fill, every bottle of 150-250ml
Advantage and good effect that the present invention has are:
(1) the present invention is according to tcm theory, and science compatibility has retained the combined effect of Chinese medicinal formulae determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, through clinical verification determined curative effect, is a kind of green veterinary drug of nuisanceless no drug residue.
(2) Chinese medicine ingredients that the present invention contains can effectively be prevented and treated avian influenza, and cure rate can reach more than 90%, sees Chinese medicine oral liquid and antibiotic therapy Contrast on effect table.
This prescription have send out that flesh induces sweat, the effect of suppressing cough and abating fever, the evacuation of pus of eliminating the phlegm.Drug resistance and the drug residue problem of chemicals have been avoided simultaneously.
(3) pharmacology of each raw material of Chinese medicine of the present invention is:
Herba Ephedrae: relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema.
Rhizoma Zingiberis Recens: cold expelling diaphoresis, preventing phlegm from forming and stopping coughing.
Radix Paeoniae: the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.
Radix Glycyrrhizae: heat-clearing and toxic substances removing, expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription.
Ramulus Cinnamomi: send out flesh and induce sweat, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI.
Fructus Jujubae: invigorating the spleen and replenishing QI.
Semen Armeniacae Amarum: sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.
Gypsum Fibrosum: expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst, heat-clearing and toxic substances removing.
Rhizoma Fagopyri Dibotryis: heat-clearing and toxic substances removing, invigorating spleen to remove dampness, blood circulation promoting and blood stasis dispelling.
Radix Platycodonis: lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus.
Among formula, Herba Ephedrae is our principal agent, and the merit of have diaphoresis, diuretic, relievining asthma, is three of things.Associate with Ramulus Cinnamomi again, strengthen the effect in the Xuanhua of activating yang.Ramulus Cinnamomi and Radix Paeoniae match, harmonizing yingfen and weifen.Rhizoma Zingiberis Recens warming middle-JIAO is dispeled cold, and preventing phlegm from forming and stopping coughing kills two birds with one stone.Semen Armeniacae Amarum, Radix Platycodonis depressed lung-energy dispersing relieving cough and resolving phlegm, match with Rhizoma Fagopyri Dibotryis, has strengthen to get rid of expectorant and become silted up, and prevents the stifled trunnion of expectorant and the effect of suffocating.Fructus Jujubae invigorating the spleen and replenishing QI in side, can increase the strong gas of body, prevents from rising sending out excessively and gas in damage.Gypsum Fibrosum is removed dysphoria with smothery sensation, can play the refrigerant effect of bringing down a fever.Radix Glycyrrhizae can expelling phlegm for arresting cough again can coordinating the actions of various ingredients in a prescription.
The specific embodiment
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
Prevent and treat a Chinese medicine oral liquid for avian influenza, the parts by weight of each raw material are as follows: 20 parts, Herba Ephedrae, 5 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae, 5 parts, Radix Glycyrrhizae, 10 parts of Ramulus Cinnamomi, 10 parts of the Radix Paeoniae Albas, 8 parts, Semen Armeniacae Amarum, 15 parts, Gypsum Fibrosum, 10 parts of Rhizoma Fagopyri Dibotryiss, 10 parts of Radix Platycodoniss, 400 parts, water.Its preparation method is: (1) is broken to 60 orders by Chinese medicine powder; (2) mix Chinese medicine powder; (3) water and mixed Chinese medicine powder are fed in Chinese medicine extracting tank, are heated to 90 degree, boil 10 hours; (4) remove by filter medicinal residues; (5) fill, every bottle of 250ml gets product.
Embodiment 2
Prevent and treat a Chinese medicine oral liquid for avian influenza, the parts by weight of each raw material are as follows: 15 parts, Herba Ephedrae, 5 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae, 5 parts, Radix Glycyrrhizae, 8 parts of Ramulus Cinnamomi, 10 parts of the Radix Paeoniae Albas, 10 parts, Semen Armeniacae Amarum, 10 parts, Gypsum Fibrosum, 10 parts of Rhizoma Fagopyri Dibotryiss, 5 parts of Radix Platycodoniss, 300 parts, water.Its preparation method is: (1) is broken to 60 orders by Chinese medicine powder; (2) mix Chinese medicine powder; (3) water and mixed Chinese medicine powder are fed in Chinese medicine extracting tank, are heated to 80 degree, boil 12 hours; (4) remove by filter medicinal residues; (5) fill, every bottle of 250ml, gets product.
Embodiment 3
Prevent and treat a Chinese medicine oral liquid for avian influenza, the parts by weight of each raw material are as follows: 20 parts, Herba Ephedrae, 10 parts, Rhizoma Zingiberis Recens, 5 parts, Fructus Jujubae, 3 parts, Radix Glycyrrhizae, 10 parts of Ramulus Cinnamomi, 5 parts of the Radix Paeoniae Albas, 5 parts, Semen Armeniacae Amarum, 15 parts, Gypsum Fibrosum, 10 parts of Rhizoma Fagopyri Dibotryiss, 10 parts of Radix Platycodoniss, 400 parts, water.Its preparation method is: (1) is broken to 60 orders by Chinese medicine powder; (2) mix Chinese medicine powder; (3) water and mixed Chinese medicine powder are fed in Chinese medicine extracting tank, are heated to 80 degree, boil 10 hours; (4) remove by filter medicinal residues; (5) fill, every bottle of 250ml, gets product.
Clinical trial
Experiment 1:
5000 of the AA of Hebei province plant white feather chickens, jumpbogroup infects bird flu, and fervescence cuts open inspection heart hat fat hemorrhage, glandular stomach thelorrhagia, respiratory tract has a small amount of cheese thing.Dead 80 of medication proxima luce (prox. luc).Be diagnosed as after diagnosing bird flu.Use the prepared product of embodiment 1, every 250ml is watered 150 kilograms, concentrates and drinks, twice of every day.The heating of second day jumpbogroup is obviously alleviated, and cough reduces, and spirit takes a turn for the better, and death drops to 40.Within the 3rd day, large group temperature recovers normal, and spirit is normal, still has on a small quantity cough, dead 15.To the 4th day jumpbogroup, cure, without cough, spirit is normal, and feed intake is normal, without dead.
Experiment 2:
10000 of the sea blue laying hens of Shandong Province plant, jumpbogroup infects bird flu, and fervescence, draws HUANGBAI(sic) loose stool, occurs soft shell, abnormal-shape egg, and egg drop reduction 50% is cutd open detector tube hyperemia, follicle distortion blackout, intestinal lymph protuberance, glandular stomach thelorrhagia.Dead 120 of medication proxima luce (prox. luc).Use the prepared product of embodiment 1, every 250ml is watered 150 kilograms, concentrates and drinks, twice of every day.Second day jumpbogroup spirit takes a turn for the better, temperature decline, and it is normal 80% that feed intake returns to, and lays eggs that it is normal 80% to return to, and death drops to 85.Within the 3rd day, large group temperature recovers normal, and spirit is normal, and feed intake is normal, and lay eggs and return to normally, without soft shell, abnormal-shape egg, dead near 30.To the 4th day jumpbogroup, cure, nothing is dead.
Experiment 3:
Chinese medicine oral liquid and antibiotic contrast therapy bird flu.1, white plumage broiler morbidity is 5000, and wherein 2000 are used embodiment 1 gained Chinese medicine oral liquid (every 250ml is watered 150 kilograms).1500 are used enrofloxacin to coordinate dipyrone (according to pharmacopeia specified volume).1500 are used tilmicosin to coordinate dipyrone (according to pharmacopeia specified volume).2, Sanhuang chicken morbidity is 1000, and wherein 500 are used embodiment 1 gained Chinese medicine oral liquid (every 250ml is watered 150 kilograms).200 are used enrofloxacin to coordinate dipyrone (according to pharmacopeia specified volume).300 are used tilmicosin to coordinate dipyrone (according to pharmacopeia specified volume).3, the morbidity of Jinmen common chicken is 3000, and wherein 1000 are used embodiment 1 gained Chinese medicine oral liquid (every 250ml is watered 150 kilograms).1000 are used enrofloxacin to coordinate dipyrone, (according to pharmacopeia specified volume).1000 are used tilmicosin to coordinate dipyrone (according to pharmacopeia specified volume).Concrete outcome is shown in Chinese medicine oral liquid and antibiotic therapy Contrast on effect table
Oral liquid and antibiotic therapy Contrast on effect table
The above, be only preferred embodiments of the present invention, is illustrative rather than determinate, can list several embodiment according to limited range, therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. a Chinese medicine oral liquid of preventing and treating avian influenza, is characterized in that: the raw material by following mass fraction is prepared from: Herba Ephedrae 10-20 part, Rhizoma Zingiberis Recens 5-10 part, Fructus Jujubae 5-10 part, Radix Glycyrrhizae 3-5 part, Ramulus Cinnamomi 8-10 part, Radix Paeoniae Alba 5-10 part, Semen Armeniacae Amarum 5-10 part, Gypsum Fibrosum 10-15 part, Rhizoma Fagopyri Dibotryis 5-10 part, Radix Platycodonis 5-10 part, water 300-500 part.
2. the Chinese medicine oral liquid of control avian influenza according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
20 parts, Herba Ephedrae, 5 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae, 5 parts, Radix Glycyrrhizae, 10 parts of Ramulus Cinnamomi, 10 parts of the Radix Paeoniae Albas, 8 parts, Semen Armeniacae Amarum, 15 parts, Gypsum Fibrosum, 10 parts of Rhizoma Fagopyri Dibotryiss, 10 parts of Radix Platycodoniss, 400 parts, water.
3. a method of preparing the Chinese medicine oral liquid of control avian influenza as claimed in claim 1, is characterized in that: preparation method is: (1) is broken to 40-60 order by Chinese medicine powder; (2) mix Chinese medicine powder; (3) water and mixed Chinese medicine powder are fed in Chinese medicine extracting tank, are heated to 40-90 degree, boil 8-12 hour; (4) remove by filter medicinal residues; (5) fill, every bottle of 150-250ml gets product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111068039A (en) * | 2020-02-18 | 2020-04-28 | 江苏周春祥生物科技有限公司 | Poultry drinking water additive composition for preventing and treating viral diseases of livestock and poultry |
| CN111544561A (en) * | 2020-06-08 | 2020-08-18 | 石家庄恒泰和动物药业有限公司 | Pharmaceutical composition for treating poultry influenza and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631658A (en) * | 2012-05-03 | 2012-08-15 | 东莞市沙田医院 | Antiviral influenza drug and preparation method thereof |
| CN102823809A (en) * | 2012-08-23 | 2012-12-19 | 青岛森源畜禽养殖有限公司 | Traditional Chinese medicine feed additive of broiler chicken |
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- 2014-07-26 CN CN201410361060.6A patent/CN104069477A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631658A (en) * | 2012-05-03 | 2012-08-15 | 东莞市沙田医院 | Antiviral influenza drug and preparation method thereof |
| CN102823809A (en) * | 2012-08-23 | 2012-12-19 | 青岛森源畜禽养殖有限公司 | Traditional Chinese medicine feed additive of broiler chicken |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111068039A (en) * | 2020-02-18 | 2020-04-28 | 江苏周春祥生物科技有限公司 | Poultry drinking water additive composition for preventing and treating viral diseases of livestock and poultry |
| CN111544561A (en) * | 2020-06-08 | 2020-08-18 | 石家庄恒泰和动物药业有限公司 | Pharmaceutical composition for treating poultry influenza and preparation method thereof |
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