CN104548042A - Traditional Chinese medicine oral liquid for treating gosling plague and preparation method of traditional Chinese medicine oral liquid - Google Patents
Traditional Chinese medicine oral liquid for treating gosling plague and preparation method of traditional Chinese medicine oral liquid Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine oral liquid for treating gosling plague and a preparation method of the traditional Chinese medicine oral liquid. The traditional Chinese medicine oral liquid is prepared from red halloysite, dried ginger, polished round-grained rice, kudzu vine roots, ephedra, asarum, fructus evodiae, dates, liquorice and monkshood. The traditional Chinese medicine oral liquid can be an oral liquid. The preparation method comprises the following steps: (1) crushing the traditional Chinese medicines to be 60-80 meshes, weighing according to the formula portions, and mixing in a three-dimensional manner, thereby obtaining traditional Chinese medicine powder; (2) respectively feeding the mixed traditional Chinese medicine powder and 300-600 parts of water into an extraction tank to soak for 5-20 hours; (3) heating to 40-100 DEG C, and extracting for 10-15 hours; (4) filtering and collecting decoction; (5) continuously adding 300-600 parts of water into the residual decoction dregs, and extracting for 10-15 hours at 40-100 DEG C; (6) filtering to remove the decoction dregs, combining the extraction liquids, and performing vacuum concentration at 30-70 DEG C until the volume is 10-20% of the original volume; and (7) filling 250ml of the liquid into one bottles respectively, thereby obtaining a finished product. The traditional Chinese medicine oral liquid provided by the invention can be used for effectively treating gosling plague, and the recovery rate can be greater than 90%. The traditional Chinese medicine oral liquid has the effects of warming the middle warmer and relieving exterior syndromes, astringing intestine to stop diarrhea and astringing to stop bleeding.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially a kind of Chinese medicine oral liquid for the treatment of gosling plague and preparation method thereof.
Background technology
Gosling plague is the acute or subacute septic infectious disease of one of the young goose caused by Goose Parvovirus.Clinical tired with spirit, peel off solely even, serosity nose liquid is flowed out in nostril, suffers from goose and again and again shakes the head, draw lark or yellow green loose stool, neurological disorders, and the mucosa necrosis of small intestinal posterior segment comes off and solidifies formation embolus with fibrinous exudate, and shape such as sausage shape is feature.Normal in deteriorated blood process, M & M is very high, very big to foster goose industry disserve to produce.Primary disease all has generation the whole year, but is multiplely born at the beginning of last month of spring in winter, the young goose of main infringement 3-20 age in days.Gaggle morbidity is in outbreak of epidemic, and morbidity suddenly, is propagated rapidly, has infectiousness and the mortality rate of height.Ill gaggle, if having mixed infection or secondary infection, its M & M is apparently higher than the Simple infection of primary disease.Clinical symptom primary disease incubation period is 3-5 days, upsets as main manifestations with digestive system and central nervous system.Different according to the length of the course of disease, can be faced and examine type and be divided into most three kinds, acute, acute and subacute type.
The most multiple young goose being born in 3-10 age in days of acute of most acute, normally loseing has any prodrome, and septicemia and sudden death occur, or after generation dull mind a few hours namely present weak, fall down to the ground and draw a lower limb, struggle several lower just dead, patient's condition is propagated rapidly, and can propagate in a few days can group.
Acute acute is multiple is born in young goose about 15 ages in days, and ill young goose performance spirit is depressed, loss of appetite or absolutely useless, and disorderly, head and neck shrinks feather pine, closes one's eyes slow-witted vertical, peels off and stay alone, be reluctant to walk about, slow in action; Search for food though can do as everybody else does, the grass adopted do not swallow, with adopting with losing; Serosity nose liquid is flowed out in sick young goose nostril, and stain nares, sick goose shakes the head again and again; And then amount of drinking water increases, and engenders and has loose bowels, ash discharge white or the water sample loose stool of lark, normal for Rice & peanut milk sample is muddy and with bubble or there is fibrous fragment, perianal tomentum stains; Beak end and web subduing (cyanosis); Indivedual ill young goose is had before to occur the nervous symptoms such as cervical region torsion or tic, paralysis on one's deathbed.According to clinical findings, most of young goose betides acute, and the course of disease is generally 2-3 days, and increase with ill young goose age in days, the course of disease gradually transfers subacute type to.
Subacute type betides the young goose of more than popular latter stage or 20 ages in days usually, and its symptom is slight, mainly to be slow in action, walks about and waves, have loose bowels, and feed intake reduces, and the mental status is slightly poor is feature.The general 4-7 days of the course of disease, or have longer, have the sick goose of only a few can spontaneous recovery, but young goose material feeding is abnormal, growth promoter be subject to serious obstruction, becomes " stiff goose ".The most acute case of the most acute of pathological change, when cuing open inspection, rarely seen Duodenal Mucosa swelling is congested, sometimes hemorrhage as seen, is coated with a large amount of faint yellow mucus in the above; Liver enlargement hyperemia is hemorrhage, and matter is crisp frangible; Gallbladder swells, be full of bile, and the pathological changes of other organs is not obvious.
Clinically at present specific medicament be there is no for gosling plague, mainly by putting prevention first.Therefore develop a kind of Chinese medicine oral liquid can treating gosling plague, greatly can improve the actual effect of clinical treatment.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, provides a kind of good effect, no drug residue, safe and reliable treatment gosling plague Chinese medicine oral liquid.
Another technical problem that the present invention will solve is: provide a kind of Chinese medicine formula for the treatment of gosling plague.
Another technical problem that the present invention will solve is: the preparation method providing the oral liquid formulations of above-mentioned goose Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of gosling plague, is prepared from by the raw material of following mass fraction: Halloysitum Rubrum 20-40 part, Rhizoma Zingiberis 20-40 part, Semen oryzae sativae 20-40 part, Radix Puerariae 20-40 part, Herba Ephedrae 20-40 part, Herba Asari 20-40 part, Fructus Evodiae 20-40 part, Fructus Jujubae 20-40 part, Radix Glycyrrhizae 20-40 part, Radix Aconiti Lateralis Preparata 20-40 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows:
Halloysitum Rubrum 40 parts, Rhizoma Zingiberis 30 parts, Semen oryzae sativae 40 parts, Radix Puerariae 20 parts, 30 parts, Herba Ephedrae, Herba Asari 30 parts, Fructus Evodiae 40 parts, 30 parts, Fructus Jujubae, 20 parts, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata 20 parts.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
Further, the preparation method of the oral liquid formulations of said composition is: Chinese medicine powder is broken to 60-80 order by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 300-600 part water are put in extraction pot respectively, soak 5-20 hour; (3) be heated to 40-100 DEG C and extract 10-15 hour; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 300-600 part water, and 40-100 DEG C is extracted 10-15 hour; (6) excessively filter medicinal residues, merge extracted twice liquid, 30-70 DEG C is evaporated to original volume 10%-20%; (7) fill becomes bottle, and every bottle of 250ml, gets product.
The advantage that the present invention has and good effect are:
(1) the present invention is according to tcm theory, and scientific compatibility, remains the combined effect of Chinese medicinal formulae determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, through clinical verification determined curative effect, is a kind of green veterinary drug of nuisanceless, no drug residue.
(2) Chinese medicine ingredients that the present invention contains effectively can treat gosling plague, and cure rate can reach more than 90%.This prescription has warming middle-JIAO and relieving exterior syndrome, relieving dysentery with astringents, anastaltic effect.
(3) pharmacology of each raw material of Chinese medicine of the present invention is:
Halloysitum Rubrum: astringing intestine to stop diarrhea hemostasis, removing dampness granulation promoting;
Rhizoma Zingiberis: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation;
Semen oryzae sativae: gas in strengthening the spleen and stomach, training;
Radix Puerariae: induce sweat bring down a fever, yang invigorating antidiarrheal;
Herba Ephedrae: relieving the exterior syndrome by diaphoresis;
Herba Asari: expelling wind and cold, Hang Shui have one's ideas straightened out;
Fructus Evodiae: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal;
Radix Aconiti Lateralis Preparata: mend supporing yang, the dispersing cold for relieving pain of fire;
Fructus Jujubae: warming middle-JIAO spleen reinforcing;
Radix Glycyrrhizae: coordinating the actions of various ingredients in a prescription;
We's Halloysitum Rubrum, Rhizoma Zingiberis, Semen oryzae sativae, Radix Puerariae, Fructus Evodiae share and can play yang invigorating, stopping diarrhea with astringents, anastaltic object.Good therapeutic effect is had for the diarrhoea caused by gosling plague, hemafecia.Herba Ephedrae, Radix Aconiti Lateralis Preparata, Herba Asari relieving exterior-interior syndrome, warming middle-JIAO and relieving exterior syndrome, the spleen invigorating of Fructus Jujubae warming middle-JIAO for easing the stomach, the property of medicine of Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
A treatment gosling plague's Chinese medicine oral liquid, the parts by weight of each raw material are as follows: Halloysitum Rubrum 40 parts, Rhizoma Zingiberis 30 parts, Semen oryzae sativae 40 parts, Radix Puerariae 20 parts, 30 parts, Herba Ephedrae, Herba Asari 30 parts, Fructus Evodiae 40 parts, 30 parts, Fructus Jujubae, 20 parts, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata 20 parts.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product.
Embodiment 2
A treatment gosling plague's Chinese medicine oral liquid, the parts by weight of each raw material are as follows: Halloysitum Rubrum 40 parts, Rhizoma Zingiberis 30 parts, Semen oryzae sativae 30 parts, Radix Puerariae 30 parts, 30 parts, Herba Ephedrae, Herba Asari 30 parts, Fructus Evodiae 40 parts, 30 parts, Fructus Jujubae, 20 parts, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata 20 parts.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product
Embodiment 3
A treatment gosling plague's Chinese medicine oral liquid, the parts by weight of each raw material are as follows: Halloysitum Rubrum 40 parts, Rhizoma Zingiberis 40 parts, Semen oryzae sativae 40 parts, Radix Puerariae 20 parts, 30 parts, Herba Ephedrae, Herba Asari 30 parts, Fructus Evodiae 40 parts, 30 parts, Fructus Jujubae, 30 parts, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata 30 parts.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product
Clinical trial
Experimental example:
Goose field, Shandong, gosling 3000, falls ill 500.Clinical identification is gosling plague.To wherein 300 use product obtained by embodiments 1.Every bottle of spice 100 kilograms, once a day, treats three days.Medication the second symptom is obviously alleviated, and spirit takes a turn for the better, and feed intake increases, and diarrhoea stops substantially.Recovery from illness in 3rd day.After drug withdrawal, do not occur repeatedly.Cure rate reaches 95%, does not occur death.Another 200 use astragalus polysaccharides to coordinate norfloxacin, treatment three days continuously, cure rate 82%, dead 2.
Experiment proves that product obtained by embodiment 1 subtracts effect fast, determined curative effect, not easily repeatedly.
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiments according to limited range, therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (7)
1. Chinese medicine oral liquid for the treatment of gosling plague and preparation method thereof, is characterized in that: be prepared from by the raw material of following mass fraction: Halloysitum Rubrum 20-40 part, Rhizoma Zingiberis 20-40 part, Semen oryzae sativae 20-40 part, Radix Puerariae 20-40 part, Herba Ephedrae 20-40 part, Herba Asari 20-40 part, Fructus Evodiae 20-40 part, Fructus Jujubae 20-40 part, Radix Glycyrrhizae 20-40 part, Radix Aconiti Lateralis Preparata 20-40 part.
2. the Chinese medicine oral liquid for the treatment of gosling plague according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
Halloysitum Rubrum 40 parts, Rhizoma Zingiberis 30 parts, Semen oryzae sativae 40 parts, Radix Puerariae 20 parts, 30 parts, Herba Ephedrae, Herba Asari 30 parts, Fructus Evodiae 40 parts, 30 parts, Fructus Jujubae, 20 parts, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata 20 parts.
3. the Chinese medicine oral liquid for the treatment of gosling plague according to claim 1 and 2, is characterized in that: this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
4. the Chinese medicine oral liquid for the treatment of gosling plague according to claim 3, is characterized in that: described preparation can be oral liquid.
5. prepare a method for the Chinese medicine oral liquid for the treatment of gosling plague as claimed in claim 4, it is characterized in that: preparation method is that Chinese medicine powder is broken to certain order number by (1), and take by formula ratio, three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, aqueous solution are put in extraction pot respectively, soak the regular hour; (3) be heated to uniform temperature, extract certain hour; (4) collecting by filtration extracting solution; (5) secondary adds a certain amount of water in medicinal residues, continues to extract certain hour at a certain temperature; (6) merge extracted twice liquid, be evaporated to certain volume at a certain temperature; (7) fill becomes bottle, gets product.
6. the preparation method of the Chinese medicine oral liquid for the treatment of gosling plague according to claim 5, is characterized in that: described pulverizing order number is 60-80 order.
7. the preparation method of the Chinese medicine oral liquid for the treatment of gosling plague according to claim 5, is characterized in that: the extracted twice time is 10-15 hour.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106798149A (en) * | 2016-12-14 | 2017-06-06 | 新昌县拜瑞珂生物技术有限公司 | Mixed feed and preparation method thereof for controlling treating gosling plague |
| CN111840475A (en) * | 2020-08-25 | 2020-10-30 | 陈丙乾 | Traditional Chinese medicine preparation for treating gosling plague and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106798149A (en) * | 2016-12-14 | 2017-06-06 | 新昌县拜瑞珂生物技术有限公司 | Mixed feed and preparation method thereof for controlling treating gosling plague |
| CN111840475A (en) * | 2020-08-25 | 2020-10-30 | 陈丙乾 | Traditional Chinese medicine preparation for treating gosling plague and preparation method thereof |
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