WO2012031526A1

WO2012031526A1 - Chinese medicine composition for prevention and treatment of nephropathogenic infectious bronchitis and avian nephrosis

Info

Publication number: WO2012031526A1
Application number: PCT/CN2011/078963
Authority: WO
Inventors: 陈鹏举; 赵全成; 王慧杰; 谢二伟
Original assignee: 漯河市宇信生物科技有限公司
Priority date: 2010-09-07
Filing date: 2011-08-26
Publication date: 2012-03-15
Also published as: CN101940646B; LU91982B1; CN101940646A

Abstract

Disclosed is a Chinese medicine composition for preventing and treating nephropathogenic infectious bronchitis and avian nephrosis, composed mainly of 10～15 parts by weight of Semen Armeniacae Amarum,15～25 parts by weight of Ramulus Cinnamomi,15～22 parts by weight of Herba Artemisiae Scopariae,8～15 parts by weight of Radix Glycyrrhizae,15～25 parts by weight of Pericarpium Citri Reticulatae,10～15 parts by weight of Semen Plantaginis,16～25 parts by weight of Radix Astragali,18～30 parts by weight of Radix Platycodi,20～30 parts by weight of Herba Lysimachiae, 20～30 parts by weight of Herba Dianthi, based on the total weight of the composition.

Description

Traditional Chinese medicine composition for preventing and treating renal infectious bronchitis and avian kidney disease

Technical field

The invention belongs to the field of veterinary medicine and relates to a traditional Chinese medicine composition for preventing and treating renal infectious bronchitis and avian kidney disease caused by various factors.

Background technique

With the development of the national economy, people's ability to consume meat and meat has been increasing, and the demand for poultry meat products has also shown a clear upward trend. In order to meet the strong market demand, this requires vigorous development of the aquaculture industry and the promotion of large-scale production of the aquaculture industry.

Infectious bronchitis is a highly contagious viral infection caused by renal infectious bronchitis virus (kidney type IBV). Kidney IBV not only invades the respiratory organs of poultry, but also invades the urinary and reproductive organs. Kidney disease. Renal infectious bronchitis has been sporadic in many provinces and regions for many years, and chickens are the most susceptible, which has brought great economic losses to China's poultry industry. In the past, anti-viral drugs such as ribavirin and ribavirin have been used in the treatment of renal infectious bronchitis, but the effect is not significant. At the same time, these drugs are also prone to residue. Because there are few Western medicine antiviral drugs that can be used, and these drugs are now banned by the Ministry of Agriculture, there is a gap in the therapeutic drugs for avian viral diseases. It can be seen that renal infectious bronchitis is one of the common viral diseases in poultry, and there is currently no good therapeutic drug in clinical practice. Therefore, it is urgent to develop a safe and reliable antiviral drug to meet actual production. Demand.

Avian nephropathy is a general term for renal dysfunction caused by various causes. Renal infectious bronchitis is one of the causes of avian nephropathy. In addition to renal infectious bronchitis, chicken infectious bursal disease, chicken white diarrhea, chicken viral nephritis, Newcastle disease, poultry typhoid, poultry paratyphoid and other diseases as well as drug abuse, improper feeding, etc. may cause different The degree of renal lesions, mainly manifested as kidney swelling, pallor, hemorrhage, urate deposition, gout, etc., lighter hinders the growth of young birds, reduces the growth performance of adult birds, and causes a large number of deaths, causing serious problems in the poultry industry. Economic losses.

Summary of the invention

The object of the present invention is to provide a traditional Chinese medicine composition for renal infectious bronchitis and avian kidney swelling, plaque kidney, kidney urate deposition, gout, etc. caused by various other causes.

Based on this purpose, the technical scheme adopted by the present invention is: a traditional Chinese medicine composition for preventing and treating kidney-type infectious bronchitis and avian nephropathy, which is mainly composed of the following Chinese herbal medicines: 10-15 parts of almonds, cassia 15 ~25 parts, Yinchen 15~22 parts, licorice 8~15 parts, tangerine peel 15~25 parts, Psyllium chinensis 10~15 parts, Astragalus 16~25 parts, Campanulaceae 18~30 parts, Lysimachia 20~30 parts, Buckwheat 20~30 servings.

In terms of parts by weight, the traditional Chinese medicine composition further comprises: 16 to 28 parts of Polygonum cuspidatum, 25 to 36 parts of Atractylodes, 20 to 30 parts of medlar, 10 to 15 parts of gentian, 10 to 18 parts of malt, and 10 to 15 parts of porcine. 12~18 servings, 25~36 parts of Radix, 20~30 of Astragalus, 8~12 of Codonopsis, 25~36 of Epimedium, 4~8 of Clove, 12~20 of Divine Comedy, 8~20 15 parts, 8-15 parts of Haijinsha, 8~15 parts of ephedra, and 12~20 parts of Houttuynia cordata.

Chinese medicine believes that: the kidney is the northern king of the water, the lungs are the western Geng Xinjin, according to the rule of the five elements of restraint, the two are the relationship between gold and water. Therefore, the lungs and kidneys interact with each other physiologically and pathologically, which is inseparable. The main air of the lungs can breathe, and the kidneys are the main gas. Only the lungs are sufficient, and the kidneys are fixed in the lower part. The two echoes up and down, and cooperate with each other. The inhaled gas is placed in the lungs, and the breathing can be adjusted evenly. If the kidney function is insufficient, the patient does not have the right to take it. If the kidney is not suffocated, there may be more respiratory absorption, less asthma, and difficulty breathing. Therefore, there is a saying that "the lung is the master of Qi, and the kidney is the root of Qi". In addition, the lung is at a high level above the water source, the main water of the kidney can be opened and closed, and the gasification wastewater of the main water is discharged. Under normal physiological conditions, the lungs declare the hair, regulate the waterway, participate in the metabolism of water in the body, and help the kidney water to benefit from the down; in the pathological situation, the lungs feel the external cold, the wind and the heat, and the evil spirits are closed in the lungs. The lungs are not falling, the dysfunction of Xuan Tong, causing the lungs to not fall, then cough. The lungs are not declared, but the cough, the chest is full, the breathing is unfavorable, but also the gas is not good, the water is unfavorable, and the function of the water channel is dereliction of duty, causing the water of metabolism to stay in the lungs, thereby affecting the gasification function of the kidney. The clearer does not rise, and the turbidity does not fall, resulting in clinical renal necrosis and massive deposition of urate. The etiology, clinical symptoms and pathological changes of renal infectious bronchitis are basically consistent with the theory of traditional Chinese medicine. In the treatment of traditional Chinese medicine, it is necessary to adopt the method of treating the lungs and kidneys in order to achieve the expected therapeutic effect.

Above the cassia twig, ephedra for the monarch medicine, cassia twig, sweet, warm, into the heart, lung, bladder, sweating muscles, warming the meridians, helping the yang, can not only divergence of the cold of the lungs, but also Warming bladder gas diuretic. Mahuang Xin, slightly bitter, warm, into the lungs, bladder meridians, good sweating and dispelling cold, Xuanfei Pingchuan, diuresis and swelling, the focus is on Xuanfei. Almond, platycodon for the drug, almond, bitter, warm, into the lungs, large intestine, cough and asthma, can stop cough and asthma, bitter venting, laxative; platycodon, bitter, cold, into the lung, longer than Xuanfei sputum, evacuation of wind evil, discharge of pus and swelling, is a commonly used medicine for treating cough, sore throat and so on caused by cold or wind. Almonds and platycodon not only have the effect of relieving cough and relieving asthma, but also help the kidney to gasify, and benefit the water channel and diuretic drainage (uric acid and other wastes), which is the "declaration of the law" of Chinese medicine. Pork chop, Yinchen, psyllium, money grass, and buckwheat. Pigs are sweet, light, flat, into the kidney, bladder, can be drenched with water, dehumidification and swelling. Yin Chen bitter, slightly cold, into the spleen, stomach, liver, gallbladder, the product of the bitter discharge decreased, the purpose of clearing the heat and damp heat. The car is sweet, light, cold, into the liver, kidney, small intestine, the character is cold and smooth, so it can be drenched with water, clearing the liver and eyesight. Money grass is sweet, salty, slightly cold, returning to the liver, gallbladder, kidney, bladder, with the effect of dampness and yellowing, diuretic Tonglin, detoxification and swelling. Buckwheat bitter, cold, into the heart, small intestine, bitter cold settling, through the heart and blood, diuretic and clear heat. Gancao Gan, Ping, into the twelve classics, with Buzhong Yiqi, Qingrejiedu, Runfei and Cough, etc., can alleviate the medicinal properties and make the medicine for the party. Various medicines are used for each other, so that the symptoms of tonifying lungs and Tongli kidneys are naturally eliminated, and symptoms such as cough, kidney swelling, and spotted kidney are naturally eliminated.

After the above medicinal scent is crushed, the bag is mixed with a 300 mesh sieve to form a powder. For the treatment of renal infectious bronchitis, you can take 2~3wt% of the amount of food to boil water, drink water, and dregs. A large number of clinical trials have shown that 10 to 15 servings of almonds, 15 to 25 parts of Guizhi, 15 to 22 parts of Yinchen, 8 to 15 parts of licorice, 15 to 25 parts of dried tangerine peel, 10 to 15 parts of psyllium, and 16 to 25 parts of psyllium. 18, 30 parts of platycodon, 20~30 parts of Lysimachia, 20~30 parts of buckwheat for 5 days, the cure rate is about 85%; if 10~15 parts of almonds, 15~25 parts of cassia twigs, Yinchen 15 ~22 parts, licorice 8~15 parts, tangerine peel 15~25 parts, psyllium 10~15 parts, astragalus 16~25 parts, platycodon 18~30 parts, Lysimachia 20~30 parts, buckwheat 20~30 parts, Polygonum cuspidatum 16~28 parts, Atractylodes 25~36, 茯苓20~30, gentian 10~15, malt 10~18, piglet 10~15, continuation 12~18, Banlangen 25~36, Astragalus 20~30, Codonopsis 8~12, Epimedium 25~36, Clove 4~8, Divine 12~20, Alisma 8~15, Haijinsha 8~15, Ephedra 8~15 12 to 20 parts of Houttuynia cordata were treated continuously for 5 days, and about 97% of the sick birds disappeared and basically healed.

In addition to renal infectious bronchitis, the pharmaceutical composition of the present invention has various other factors such as chicken infectious bursal disease, chick white diarrhea, chicken viral nephritis, Newcastle disease, poultry typhoid, poultry paratyphoid and the like. Kidney enlargement, plaque kidney, kidney urate deposition, gout, etc. caused by drug abuse, mildew of feed, and unreasonable nutritional configuration have good curative effects. When treating the above-mentioned diseases, the powder can be boiled according to the amount of 0.5~1.5wt% of the amount of food to be eaten, the medicine water is used for drinking, and the medicine residue is mixed. A large number of clinical trials have confirmed that for 4 days of continuous use, kidney enlargement and plaque kidney embolism can basically disappear.

The medicine of the invention is pure Chinese medicine product, can effectively avoid the problem of drug residue and food safety, and is suitable for promotion in livestock production.

detailed description

Example 1

The traditional Chinese medicine composition for preventing and treating kidney-type infectious bronchitis and avian nephropathy is composed of the following Chinese herbal medicines: 10 parts of almond, 15 parts of Guizhi, 15 parts of Yinchen, 10 parts of licorice, 15 parts of dried tangerine peel, and car 10 parts of anterior, 16 parts of astragalus, 18 parts of platycodon, 20 parts of Lysimachia, 20 parts of buckwheat.

Example 2

The traditional Chinese medicine composition for preventing and treating kidney-type infectious bronchitis and avian nephropathy is composed of the following Chinese herbal medicines: 12 parts of almond, 20 parts of cassia twig, 18 parts of Yinchen, 12 parts of licorice, 20 parts of dried tangerine peel, and car 15 parts of anterior, 20 parts of Astragalus, 25 parts of Campanulaceae, 25 parts of Lysimachia, 25 parts of buckwheat.

Example 3

The traditional Chinese medicine composition for preventing and treating renal infectious bronchitis and avian nephropathy is composed of the following Chinese herbal medicines: 16 pieces of Polygonum cuspidatum, 10 parts of almond, 25 parts of Atractylodes, 15 parts of Guizhi, 20 parts of medlar, gentian 10 parts, 15 parts of capillaris, 10 parts of malt, 8 parts of licorice, 15 parts of dried tangerine peel, 10 parts of psyllium, 10 parts of piglet, 12 parts of scutellaria, 16 parts of astragalus, 25 parts of Radix, 25 parts of Astragalus, Campanulaceae 18 8 parts of Codonopsis, 8 parts of Epimedium, 25 parts of Epimedium, 4 parts of clove, 20 parts of Lysimachia, 20 parts of buckwheat, 12 parts of Divine Comedy, 8 parts of Alisma, 8 parts of Haijinsha, 8 parts of Ephedra, 12 parts of Houttuynia.

Example 4

The traditional Chinese medicine composition for preventing and treating renal infectious bronchitis and avian nephropathy is composed of the following Chinese herbal medicines: 20 pieces of Polygonum cuspidatum, 12 parts of almond, 30 parts of Atractylodes, 20 parts of cassia twig, 25 parts of medlar, gentian 12 parts, 18 parts of Yinchen, 15 parts of malt, 10 parts of licorice, 20 parts of dried tangerine peel, 12 parts of psyllium, 12 parts of piglet, 15 parts of scutellaria, 20 parts of Astragalus, 30 parts of Radix, 30 parts of Astragalus, Campanulaceae 22 10 parts of Codonopsis, 10 parts of Epimedium, 30 parts of Epimedium, 5 parts of clove, 25 parts of Lysimachia, 25 parts of buckwheat, 15 parts of Divine Comedy, 10 parts of Alisma, 10 parts of Haijinsha, 10 parts of Ephedra, 15 parts of Houttuynia.

Example 5

The traditional Chinese medicine composition for preventing and treating kidney-type infectious bronchitis and avian nephropathy is composed of the following Chinese herbal medicines: 28 pieces of Polygonum cuspidatum, 15 parts of almond, 36 parts of Atractylodes, 25 parts of Guizhi, 30 parts of medlar, gentian 15 parts, 22 parts of capillaris, 18 parts of malt, 15 parts of licorice, 25 parts of dried tangerine peel, 15 parts of psyllium, 15 parts of piglets, 18 parts of squid, 25 parts of astragalus, 36 parts of Radix, 30 parts of Astragalus, Campanulaceae 30 12 parts of Codonopsis, 12 parts of Epimedium, 36 parts of Epimedium, 8 parts of Lilac, 30 parts of Lysimachia, 30 parts of buckwheat, 20 parts of Divine Comedy, 15 parts of Alisma, 15 parts of Haijinsha, 15 parts of Ephedra, 20 parts of Houttuynia.

Case 1

In December 2008, 1000 fast chickens from Wangmou, the owner of Zhongmu County, Zhengzhou City, Henan Province, breathed and pulled white cockroaches. The mortality rate was not too high, about 5%. The pathological changes were nephrotic kidney, mucus and cheese-like substances at the mouth of the bronchi, and the diagnosis of renal infectious bronchitis was diagnosed by combining the vaccine immunization program and the laboratory test results. The traditional Chinese medicine composition of Example 1 was pulverized, passed through a 300 mesh sieve and mixed; the powder was boiled according to the amount of the feed amount, the syrup was boiled, the slag was mixed, and the symptoms disappeared after 5 days, and the disease was cured. There was no death during the medication.

Case 2

In March 2009, about 80% of the 5,000 three-yellow chickens fed by Li, a livestock owner in Xinzheng City, Henan Province, had respiratory symptoms such as voice and cough, pulling gray and white feces, lack of energy, loss of appetite, and increased desire for thirst. The mortality rate is about 8%. Pathological changes were observed in air sulcus, mucus and cheese-like substances in the plaque kidney and bronchial sputum, combined with vaccination immunization procedures and laboratory tests to diagnose renal infectious bronchitis and mycoplasma infection. The traditional Chinese medicine composition of Example 4 was pulverized, passed through a 300 mesh sieve and mixed; the boiled water was taken at a dose of 2 wt% of the feed amount, the syrup was boiled, the dregs were mixed, and the doxycycline (oral drinking water, 50 mg/ L), after 5 days of continuous use, 97% of the sick chickens completely disappeared and the disease became healed.

Case 3

In April 2009, a large group of sick chickens appeared in 3,200 21-day-old Kebao 50 broilers raised by Wang in Heze City, Shandong Province. Their spirits were sluggish, their feathers were fluffy, their wings were drooping, their eyes closed, their appetite decreased or they were abolished, drinking water. The amount has increased dramatically, and the mortality rate is around 3.7%. The pathological changes were kidney swelling of the diseased chicken with paleened plaque kidney, urate deposition, brushy or filamentous hemorrhage in the lateral thigh muscle and chest muscles, large bursal cyst, creamy or cheese-like exudate in the sac. Individual chicken bursal mucosal folds have bleeding points. Infectious bursal disease was diagnosed in combination with vaccine immunization procedures and laboratory tests. The traditional Chinese medicine composition of Example 2 was pulverized, sieved through a 300 mesh sieve, and mixed; 1 wt% of the feed amount was taken to boil water, the syrup was boiled, and the dregs were mixed for 4 days, while the intramuscular injection of bursal sac was high. Egg yolk 1 time, the dose is 1.5ml / only. After 4 days, 97% of the sick chickens recovered.

Case 4

In October 2009, a large number of 5,000 42-day-old laying hens raised by Xie Mou in Henan Province showed signs of depression, general weakness, sharp loss of appetite, shortness of breath, cyanosis, visible mucosal jaundice and anemia. 372 died during the onset; pathological changes were skin, muscle and liver hemorrhage, liver enlargement was yellow-brown; kidney enlargement was yellowish, bleeding spots, ureter became thick, urate deposits inside; glandular gastric mucosa, And small intestinal mucosal bleeding; splenomegaly has bleeding points. Combined with clinical symptoms, pathological changes and the use of sulfamonomethoxine sodium drinking water to treat diarrhea before the onset of the disease, the diagnosis of sulfa drug poisoning. The traditional Chinese medicine composition of Example 5 was pulverized, passed through a 300 mesh sieve and mixed; 1.5 wt% of the feed amount was taken to boil water, the syrup was boiled, the dregs were mixed, and 0.25 w% of VC was mixed into the feed. , used for 4 days. After 4 days, 98% of the sick chickens recovered.

Case 5

In 2010, there were a large number of sick chickens in 4200 28-day-old large-scale white-feather broilers raised in Shen's County, Henan Province. They were depressed, with loose feathers, loss of appetite, white water or paste-like dung, containing a large amount of urine. Acid salt, 8% of chickens died. The pathological changes are various white organs such as liver capsule, mesentery and peritoneum, spleen, air bag and so on. The kidneys are swollen and pale, the surface is filled with urate and forms white spots. The ureter of the diseased chicken enlarges and becomes thick, and the ureter Filled with lime-like sediment. According to the above symptoms and pathological changes combined with feed nutrients, it is diagnosed as gout caused by improper feeding. The traditional Chinese medicine composition of Example 3 was pulverized and passed through a 300 mesh sieve, and the boiled water was taken according to 0.75 wt% of the feed amount, the syrup was boiled, and the dregs were mixed for 4 days, and the feed was replaced with corn. In addition to 332 chickens died within 24 hours of treatment, a total of 16 died within 3 days. After 5 days, dead chickens no longer appeared, and the sick chickens recovered completely.

Claims

The traditional Chinese medicine composition for preventing and treating kidney-type infectious bronchitis and avian nephropathy is mainly composed of the following Chinese herbal medicines: 10~15 parts of almond, 15~25 parts of cassia twig, 15~22 parts of Yinchen, licorice 8 ~15 parts, 15~25 parts of dried tangerine peel, 10~15 parts of Psyllium chinensis, 16~25 parts of Astragalus, 18~30 parts of Campanulaceae, 20~30 parts of Lysimachia, 20~30 parts of buckwheat.
The traditional Chinese medicine composition for preventing and treating kidney-type infectious bronchitis and avian nephropathy according to claim 1, wherein the composition further comprises, in parts by weight, 16 to 28 parts of Polygonum cuspidatum, 25 to 36 parts of Atractylodes macrocephala, and 20 ~30 parts, 10~15 parts of gentian, 10~18 parts of malt, 10~15 parts of pork scorpion, 12~18 parts of squid, 25~36 parts of Radix striata, 20~30 parts of Astragalus, 8~12 parts of Codonopsis, kinky 25~36 parts of alpaca, 4~8 parts of cloves, 12~20 parts of Divine Comedy, 8~15 copies of Alisma, 8~15 parts of Haijinsha, 8~15 parts of ephedra, 12~20 parts of Houttuynia cordata.