CN116196355B - Traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN116196355B CN116196355B CN202310271669.3A CN202310271669A CN116196355B CN 116196355 B CN116196355 B CN 116196355B CN 202310271669 A CN202310271669 A CN 202310271669A CN 116196355 B CN116196355 B CN 116196355B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- gout
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 70
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 52
- 201000005569 Gout Diseases 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 108050004290 Cecropin Proteins 0.000 claims abstract description 20
- 244000144977 poultry Species 0.000 claims abstract description 20
- 241001673966 Magnolia officinalis Species 0.000 claims abstract description 16
- 241000903946 Clematidis Species 0.000 claims abstract description 13
- 241000628997 Flos Species 0.000 claims abstract description 4
- 210000000582 semen Anatomy 0.000 claims abstract description 4
- 241000205585 Aquilegia canadensis Species 0.000 claims description 24
- 244000037364 Cinnamomum aromaticum Species 0.000 claims description 14
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims description 14
- 244000144725 Amygdalus communis Species 0.000 claims description 12
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 12
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 12
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 12
- 235000020224 almond Nutrition 0.000 claims description 12
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 12
- 235000011477 liquorice Nutrition 0.000 claims description 12
- 244000153955 Reynoutria sachalinensis Species 0.000 claims description 11
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 claims description 11
- 235000003805 Musa ABB Group Nutrition 0.000 claims description 10
- 240000008790 Musa x paradisiaca Species 0.000 claims description 10
- 241000972673 Phellodendron amurense Species 0.000 claims description 10
- 235000015266 Plantago major Nutrition 0.000 claims description 10
- 241001571764 Lysimachia christinae Species 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 241000108463 Hygrophila <snail> Species 0.000 claims description 7
- 244000183685 Citrus aurantium Species 0.000 claims description 6
- 235000007716 Citrus aurantium Nutrition 0.000 claims description 6
- 244000170916 Paeonia officinalis Species 0.000 claims description 6
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 206010017533 Fungal infection Diseases 0.000 claims description 3
- 208000024386 fungal infectious disease Diseases 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 17
- 229940079593 drug Drugs 0.000 abstract description 17
- 201000010099 disease Diseases 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 15
- 241000721047 Danaus plexippus Species 0.000 abstract description 10
- 208000035473 Communicable disease Diseases 0.000 abstract description 4
- 241000204031 Mycoplasma Species 0.000 abstract description 4
- 244000144972 livestock Species 0.000 abstract description 3
- 230000004060 metabolic process Effects 0.000 abstract description 3
- 230000001681 protective effect Effects 0.000 abstract description 2
- 235000013330 chicken meat Nutrition 0.000 description 37
- 235000013594 poultry meat Nutrition 0.000 description 17
- 208000006820 Arthralgia Diseases 0.000 description 6
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 230000002195 synergetic effect Effects 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 4
- 230000015271 coagulation Effects 0.000 description 4
- 238000005345 coagulation Methods 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- 241000612166 Lysimachia Species 0.000 description 3
- 241000204003 Mycoplasmatales Species 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 210000003746 feather Anatomy 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 244000268002 Andropogon fragilis Species 0.000 description 2
- 241000218158 Clematis Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 241000286209 Phasianidae Species 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000027954 Poultry disease Diseases 0.000 description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 208000030175 lameness Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 230000007102 metabolic function Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 229940116269 uric acid Drugs 0.000 description 2
- 239000000273 veterinary drug Substances 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 description 1
- 206010000117 Abnormal behaviour Diseases 0.000 description 1
- 241000272517 Anseriformes Species 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 241001260012 Bursa Species 0.000 description 1
- 208000027312 Bursal disease Diseases 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- 241000601164 Clematis orientalis Species 0.000 description 1
- 108010078777 Colistin Proteins 0.000 description 1
- 241000272201 Columbiformes Species 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 241000522190 Desmodium Species 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010019842 Hepatomegaly Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010023232 Joint swelling Diseases 0.000 description 1
- 241000202942 Mycoplasma synoviae Species 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 240000001341 Reynoutria japonica Species 0.000 description 1
- 235000018167 Reynoutria japonica Nutrition 0.000 description 1
- 206010041660 Splenomegaly Diseases 0.000 description 1
- 208000005400 Synovial Cyst Diseases 0.000 description 1
- 229930194936 Tylosin Natural products 0.000 description 1
- 239000004182 Tylosin Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229960001127 colistin sulfate Drugs 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 208000026500 emaciation Diseases 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004399 eye closure Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 229960003760 florfenicol Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 210000000281 joint capsule Anatomy 0.000 description 1
- ZESIAEVDVPWEKB-ORCFLVBFSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O ZESIAEVDVPWEKB-ORCFLVBFSA-N 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- UURAUHCOJAIIRQ-QGLSALSOSA-N tiamulin Chemical compound CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@@H]2C(=O)CC3 UURAUHCOJAIIRQ-QGLSALSOSA-N 0.000 description 1
- 229960004885 tiamulin Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The application discloses a traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout, and a preparation method and application thereof, wherein the traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout comprises the following components: rhizoma Atractylodis, cortex Phellodendri, ramulus Cinnamomi, flos Lonicerae, caulis Lonicerae, rhizoma Polygoni Cuspidati, radix Clematidis, herba Lysimachiae Christinae, cortex Magnolia officinalis, semen Armeniacae amarum, fructus Aurantii, herba Potentillae Discoloris, radix Paeoniae Rubra, glycyrrhrizae radix, herba plantaginis and cecropin. The traditional Chinese medicine composition provided by the application has a definite treatment effect on chicken bursal mycoplasma disease and poultry gout through scientific cooperation of monarch, minister, assistant and guide and synergism between medicines, is green and safe, can be used for preventing feeding, improves the immune metabolism level of poultry and livestock, and plays a good protective role in preventing various epidemic infectious diseases.
Description
Technical Field
The application relates to a traditional Chinese medicine composition for treating chicken synovial cyst mycoplasma disease and poultry gout, and a preparation method and application thereof, and belongs to the technical field of traditional Chinese veterinary medicines.
Background
The mycoplasma synoviae disease of chickens, also known as infectious bursal disease or bursal mycosis of chickens, is an acute or chronic infectious disease of chickens and turkeys caused by mycoplasma synoviae of chickens. The disease is characterized in that the disease mainly invades a joint synovial membrane and a cavity sheath membrane to cause joint enlargement, synovial sac, gliangiitis and subclinical respiratory tract infection, the disease course is long, and the disease chicken is characterized by poor spirit, head shrinkage and eye closure, rough and disordered feathers, emaciation, lameness and decubitus, the joint enlargement has obvious inflammation symptoms of the synovial sac and the tendon sheath, and the production capacity of the chicken is seriously influenced.
Gout is a disease in which uric acid content in blood is remarkably increased due to excessive production or excretion disorder of uric acid in birds, and further urate is deposited on joint capsules, joint cartilages, around joints, pleuroperitoneal cavity and various viscera surfaces and other interstitial tissues. Bird gout is one of the common and frequently occurring diseases of poultry throughout the world. Chicken, turkey, waterfowl, pigeon, quail, etc. all occur, and have high morbidity and mortality. In recent years, the occurrence of the disease has been increasing, and particularly, the intensive raising of chicken flocks is caused by a plurality of factors which can induce gout in the feed production and raising management level. Therefore, the gout is one of important problems facing the poultry industry in China and is one of the more common poultry diseases in China so far. The two poultry diseases have high incidence rate in China and overlap disease symptoms, and are difficult to distinguish and confirm for inexperienced breeders.
At present, aiming at chicken bursal mycoplasmosis, antibiotics such as tylosin, tiamulin and the like are mostly adopted for treatment in the prior art, the defects of drug resistance, limited production safety of drug residues, incomplete treatment after healing, long treatment course and the like exist, the gout of the poultry also faces the limit of antiviral drugs, the water-liquid metabolic disorder is treated with the auxiliary treatment of glucose and baking soda liquid for symptomatic treatment, and the effect and the treatment after healing have great uncertainty.
Disclosure of Invention
In order to solve the problems, according to one aspect of the application, a traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout is provided, which comprises the following components: rhizoma Atractylodis, cortex Phellodendri, ramulus Cinnamomi, flos Lonicerae, caulis Lonicerae, rhizoma Polygoni Cuspidati, radix Clematidis, herba Lysimachiae Christinae, cortex Magnolia officinalis, semen Armeniacae amarum, fructus Aurantii, herba Potentillae Discoloris, radix Paeoniae Rubra, glycyrrhrizae radix, herba plantaginis and cecropin.
According to the application, the rhizoma atractylodis, the phellodendron bark and the cassia twig are used as monarch drugs, the rhizoma atractylodis and the phellodendron bark are used for clearing heat and drying dampness, eliminating swelling, and the wind-cold-dampness arthralgia is wonderful, and the cassia twig is matched for warming yang and activating pulse, so that the synergistic effect is better; honeysuckle, honeysuckle stem, giant knotweed, clematis root and lysimachia are used as ministerial drugs, the effects of promoting diuresis and treating stranguria, eliminating turbid pathogen and dredging collaterals are good, and the ministerial drugs and the monarch drugs are matched, so that the effects of eliminating dampness and removing arthralgia are facilitated, and the normal body water and body metabolism function is recovered; the magnolia officinalis, the almond, the bitter orange and the phlegm fire grass are used as adjuvants, have the effects of relieving asthma and cough and moistening the lung by moisture, effectively play roles in dispersing and descending qi and activating the qi-flowing, and assist monarch and minister medicines to better exert the efficacy; the radix paeoniae rubra and the liquorice can activate blood and expel toxin, can harmonize the effects and actions of the medicines, and have good guiding effect on eliminating cold coagulation and stasis. The traditional Chinese medicine composition provided by the application has a definite treatment effect on chicken bursal mycoplasma diseases and poultry gout through scientific cooperation of monarch, minister, assistant and guide and synergism between medicines, is green and safe, can be used for preventing feeding, improves the immune metabolism level of poultry and livestock, and plays a good protective role in preventing various epidemic infectious diseases.
Optionally, the composition comprises the following components in parts by weight: 30-60 parts of rhizoma atractylodis, 30-60 parts of cortex phellodendri, 30-60 parts of cassia twig, 15-40 parts of honeysuckle, 30-60 parts of honeysuckle stem, 30-60 parts of giant knotweed, 30-50 parts of radix clematidis, 30-60 parts of lysimachia christinae, 30-50 parts of magnolia officinalis, 30-50 parts of almond, 15-30 parts of fructus aurantii, 30-60 parts of phlegmatic hygrophila, 30-60 parts of radix paeoniae rubra, 30-60 parts of liquorice, 30-60 parts of plantain herb and 20-60 parts of cecropin.
Optionally, the composition comprises the following components in parts by weight: 20-40 parts of rhizoma atractylodis, 20-40 parts of amur corktree bark, 20-35 parts of cassia twig, 20-30 parts of honeysuckle, 20-45 parts of honeysuckle stem, 20-40 parts of giant knotweed, 35-45 parts of radix clematidis, 20-40 parts of lysimachia christinae hance, 35-45 parts of magnolia officinalis, 20-40 parts of almond, 15-25 parts of fructus aurantii, 35-50 parts of phlegmatic hygrophila, 35-55 parts of red paeony root, 30-50 parts of liquorice, 35-55 parts of plantain herb and 25-55 parts of cecropin.
Optionally, the composition comprises the following components in parts by weight: 30 parts of rhizoma atractylodis, 35 parts of amur corktree bark, 30 parts of cassia twig, 25 parts of honeysuckle, 30 parts of honeysuckle stem, 25 parts of giant knotweed, 35 parts of radix clematidis, 30 parts of lysimachia christinae, 37 parts of magnolia officinalis, 35 parts of almond, 20 parts of bitter orange, 35 parts of phlegmatic hygrophila, 35 parts of red paeony root, 30 parts of liquorice, 35 parts of plantain herb and 40 parts of cecropin.
In another aspect of the present application, a method for preparing a traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout according to any one of claims 1 to 4 is provided, comprising the following steps:
(1) Weighing rhizoma Atractylodis, cortex Phellodendri, ramulus Cinnamomi, flos Lonicerae, caulis Lonicerae, rhizoma Polygoni Cuspidati, radix Clematidis, herba Lysimachiae Christinae, cortex Magnolia officinalis, semen Armeniacae amarum, fructus Aurantii, herba Potentillae Discoloris, radix Paeoniae Rubra, glycyrrhrizae radix, and herba plantaginis at a certain ratio, mixing, and pulverizing;
(2) The cecropin is added according to the proportion and stirred uniformly, thus obtaining the traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout.
Optionally, the number of the crushing meshes in the step (1) is 60-300 meshes.
In still another aspect, the application also provides an application of the traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and poultry gout in preparing feed according to any one of claims 1-4.
Optionally, the method comprises uniformly stirring the traditional Chinese medicine composition and the feed.
Optionally, the mass ratio of the traditional Chinese medicine composition to the feed is 1: 190-210.
The beneficial effects of the application include, but are not limited to:
1. according to the application, the rhizoma atractylodis, the phellodendron bark and the cassia twig are used as monarch drugs, the rhizoma atractylodis and the phellodendron bark are used for clearing heat and drying dampness, eliminating swelling, and the wind-cold-dampness arthralgia is wonderful, and the cassia twig is matched for warming yang and activating pulse, so that the synergistic effect is better; honeysuckle, honeysuckle stem, giant knotweed, clematis root and lysimachia are used as ministerial drugs, the effects of promoting diuresis and treating stranguria, eliminating turbid pathogen and dredging collaterals are good, and the ministerial drugs and the monarch drugs are matched, so that dampness and arthralgia are eliminated, and the normal water extract and the body metabolism function are recovered; the magnolia officinalis, the almond, the bitter orange and the phlegm fire grass are used as adjuvants, have the effects of relieving asthma and cough and moistening the lung by moisture, effectively play roles in dispersing and descending qi and activating the qi-flowing, and assist monarch and minister medicines to better exert the efficacy; the radix paeoniae rubra and the liquorice can activate blood and expel toxin, can harmonize the effects and actions of the medicines, and have good guiding effect on eliminating cold coagulation and stasis. The medicines are matched through scientific monarch, minister, assistant and guide, and the medicines have synergistic effect, so that the medicine has a definite treatment effect on chicken bursal mycoplasma disease and poultry gout, is green and safe, can be used for preventing feeding, improves the immune metabolism level of poultry and livestock, and plays a good protection role in preventing various epidemic infectious diseases.
2. According to the traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and poultry gout, the green clinical effective components such as Chinese herbal medicines and cecropin are compounded in a specific proportion, so that the immunity and disease resistance of organisms are synergistically improved, and the traditional Chinese medicine composition has the double characteristics of treating two diseases by one formula and treating and preventing the two diseases by aiming at the common wet arthralgia and stasis and cold coagulation caused by chicken bursal mycoplasmosis and poultry gout, belongs to veterinary Chinese herbal medicines, reduces the risk of medicine residues, and is efficient, green and safe.
3. The preparation method of the traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and poultry gout has the advantages of simple step operation and suitability for industrial continuous production.
4. The application ensures that the traditional Chinese medicine composition under a specific proportion can exert the maximum efficacy to the greatest extent by limiting the crushing mesh number of the traditional Chinese medicine and the mass ratio of the traditional Chinese medicine composition to the feed in the application of the traditional Chinese medicine composition in preparing the feed, thereby being beneficial to improving the water metabolism disorder symptoms of damp arthralgia, stasis and cold coagulation diseases.
Detailed Description
The present application is described in detail below with reference to examples, but the present application is not limited to these examples.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. The reagents or materials used in the present application may be purchased in conventional manners, and unless otherwise indicated, they may be used in conventional manners in the art or according to the product specifications. In addition, any methods and materials similar or equivalent to those described herein can be used in the methods of the present application. The preferred methods and materials described in this patent are illustrative only.
Example 1
The preparation method of the traditional Chinese medicine composition 1# for treating chicken bursal mycoplasmosis and bird gout (each part is calculated by 10 g) comprises the following steps:
(1) Weighing 30 parts of rhizoma atractylodis, 30 parts of amur corktree bark, 30 parts of cassia twig, 15 parts of honeysuckle, 30 parts of honeysuckle stem, 30 parts of giant knotweed rhizome, 30 parts of Chinese clematis, 30 parts of desmodium, 30 parts of officinal magnolia bark, 30 parts of almond, 15 parts of bitter orange, 30 parts of phlegmatic hygrosis herb, 30 parts of red paeony root, 30 parts of liquorice and 30 parts of plantain herb, mixing and crushing to 60 meshes;
(2) Adding 20 parts of cecropin, and uniformly stirring to obtain the traditional Chinese medicine composition No. 1 for treating chicken bursal mycoplasmosis and poultry gout.
Example 2
The preparation method of the traditional Chinese medicine composition 2# for treating chicken bursal mycoplasmosis and bird gout (each part is calculated by 10 g) comprises the following steps:
(1) Weighing 60 parts of rhizoma atractylodis, 60 parts of cortex phellodendri, 60 parts of cassia twig, 40 parts of honeysuckle, 60 parts of honeysuckle stem, 60 parts of giant knotweed, 50 parts of radix clematidis, 60 parts of lysimachia christinae, 50 parts of magnolia officinalis, 50 parts of almond, 30 parts of fructus aurantii, 60 parts of phlegmatic hygrosis, 60 parts of radix paeoniae rubra, 60 parts of liquorice and 60 parts of plantain herb, mixing and crushing to 300 meshes;
(2) 60 parts of cecropin is added and stirred uniformly to obtain the traditional Chinese medicine composition No. 2 for treating chicken bursal mycoplasmosis and bird gout.
Example 3
The preparation method of the traditional Chinese medicine composition 3# for treating chicken bursal mycoplasmosis and bird gout (each part is calculated by 10 g) comprises the following steps:
(1) Weighing 30 parts of rhizoma atractylodis, 35 parts of amur corktree bark, 30 parts of cassia twig, 25 parts of honeysuckle, 30 parts of honeysuckle stem, 25 parts of giant knotweed, 35 parts of radix clematidis, 30 parts of lysimachia christinae, 37 parts of magnolia officinalis, 35 parts of almond, 20 parts of bitter orange, 35 parts of phlegmatic hygrosis, 35 parts of red paeony root, 30 parts of liquorice and 35 parts of plantain herb, mixing and crushing to 80 meshes;
(2) Adding 40 parts of cecropin, and uniformly stirring to obtain the traditional Chinese medicine composition No. 3 for treating chicken bursal mycoplasmosis and poultry gout.
Comparative example 1
The preparation of the traditional Chinese medicine composition D1# for treating chicken bursal mycoplasmosis and bird gout is different from that of the embodiment 3 in that the traditional Chinese medicine composition mixture with equal weight and same proportion obtained in the step (1) is adopted to replace cecropin, and the rest is the same.
Comparative example 2
The preparation of the traditional Chinese medicine composition D2# for treating chicken bursal mycoplasmosis and bird gout is different from that in example 3 in that 80 parts of cecropin are added, and the rest are the same.
Comparative example 3
The preparation of the traditional Chinese medicine composition D3# for treating chicken bursa mycoplasmosis and bird gout is different from that in the embodiment 3 in that 15 parts of rhizoma atractylodis, 20 parts of cortex phellodendri, 20 parts of cassia twig, 25 parts of honeysuckle, 30 parts of honeysuckle stem, 25 parts of polygonum cuspidatum, 35 parts of radix clematidis, 30 parts of lysimachia, 37 parts of magnolia officinalis, 35 parts of almond, 20 parts of fructus aurantii, 20 parts of phlegmatis hygrophila, 35 parts of radix paeoniae rubra, 70 parts of liquorice and 35 parts of plantain herb, and the balance is the same.
Experimental example 1
Safety test:
80 healthy broilers of 30 days old are selected, the traditional Chinese medicine composition prepared in the embodiment 3 of the application is mixed with materials at 10 times of recommended dosage, and during the administration period, the healthy chickens have no bad or abnormal behavior, and the difference between the healthy chickens with normal drinking water and weight gain is not obvious compared with healthy broilers without administration.
Clinical trial:
a batch of sick chickens are randomly selected from a certain farm in Ningjin county, leg limp, joint swelling and purple and lameness appear at 30 days of the feathers, tenosynovial membranes and joint synovial fluid bags are provided with cheese-like substances and are accompanied with hepatomegaly, splenomegaly and renal megaly, and white urate deposits are arranged at the periphery of pericardium, and cough, head throwing and eye excrement appear.
The diagnosis is as follows: the serum plate experiment of the mycoplasma synoviae is positive in 'agglutination', a large amount of sharp urate crystals can be observed under a microscope after urate sediment is scraped, and the conclusion is that the mycoplasma synoviae and gout mixed complications are obtained.
The above-mentioned sick chickens were randomly divided into 7 groups of 100 feathers each. Groups I to III are traditional Chinese medicine compositions prepared in the embodiment 1 to 3 of the application, groups IV to VI are traditional Chinese medicine compositions prepared in the comparative embodiment 1 to 3 of the application, and the traditional Chinese medicine compositions are mixed with 200 jin of feed according to 1 jin, evenly mixed with the feed and intensively and freely ingested; the VII group is the conventional administration group, namely, 10% florfenicol 100g (commercial veterinary drug word product) is administered in the morning, 10% colistin sulfate 100g (commercial veterinary drug word product) is administered in the afternoon, 10% baking soda and 1% glucose are given to drink water freely, and the feed is commercial conventional feed. The medicine is continuously taken for 6 days, and the daily feed intake of each group is 240 jin.
Curative effect judgment standard:
and (3) curing: after the test is finished, the spirit, appetite and clinical symptoms of the sick chicken are restored to normal levels;
the method is effective: after the test is finished, the pathogenesis spirit, appetite and clinical symptoms are all improved;
invalidation: death occurred during the test period and no improvement was seen after administration.
The test results are shown in the following table:
as shown in the table above, the traditional Chinese medicine composition has good treatment effect on chicken bursal mycoplasmosis and poultry gout, the cure rate is obviously improved, and the cure is thorough. The effective rate of the IV group is reduced, the cure rate is obviously reduced, the analysis reasons may be that the traditional Chinese medicine composition D1# for treating chicken bursal mycoplasmosis and poultry gout is prepared, the mixture of the traditional Chinese medicine composition with equal weight and equal proportion obtained in the step (1) is adopted to replace cecropin, the synergistic effect between traditional Chinese medicine components and the cecropin is reduced, and the cure rate is reduced; the effective rate of group V is reduced, the cure rate is obviously reduced, the analysis reasons may be the preparation of a traditional Chinese medicine composition D2# for treating chicken bursal mycoplasmosis and poultry gout, 80 parts of cecropin are added, the synergistic effect of traditional Chinese medicine components and the cecropin is reduced, and the cure rate is obviously reduced; the effective rate of the group VI is reduced, the cure rate is obviously reduced, the analysis reasons are that the proportion of each traditional Chinese medicine component is not in the protection range of the application, the compatibility of monarch, minister, assistant and guide is changed, the synergistic effect of each traditional Chinese medicine component is affected, and the cure rate and the effective rate are reduced; the cure rate and the effective rate of the VII group are reduced compared with the examples, and the existing conventional administration treatment mode can improve clinical symptoms, but the cure rate is low because the cure rate is incomplete after the cure.
The above description is only an example of the present application, and the scope of the present application is not limited to the specific examples, but is defined by the claims of the present application. Various modifications and variations of the present application will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the technical idea and principle of the present application should be included in the protection scope of the present application.
Claims (8)
1. The traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout is characterized by being prepared from the following components in parts by weight: 30-60 parts of rhizoma atractylodis, 30-60 parts of cortex phellodendri, 30-60 parts of cassia twig, 15-40 parts of honeysuckle, 30-60 parts of honeysuckle stem, 30-60 parts of giant knotweed, 30-50 parts of radix clematidis, 30-60 parts of lysimachia christinae, 30-50 parts of magnolia officinalis, 30-50 parts of almond, 15-30 parts of fructus aurantii, 30-60 parts of phlegmatic hygrophila, 30-60 parts of radix paeoniae rubra, 30-60 parts of liquorice, 30-60 parts of plantain herb and 20-60 parts of cecropin.
2. The traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout is characterized by being prepared from the following components in parts by weight: 20-40 parts of rhizoma atractylodis, 20-40 parts of amur corktree bark, 20-35 parts of cassia twig, 20-30 parts of honeysuckle, 20-45 parts of honeysuckle stem, 20-40 parts of giant knotweed, 35-45 parts of radix clematidis, 20-40 parts of lysimachia christinae hance, 35-45 parts of magnolia officinalis, 20-40 parts of almond, 15-25 parts of fructus aurantii, 35-50 parts of phlegmatic hygrophila, 35-55 parts of red paeony root, 30-50 parts of liquorice, 35-55 parts of plantain herb and 25-55 parts of cecropin.
3. The traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout according to claim 2, which is characterized by comprising the following components in parts by weight: 30 parts of rhizoma atractylodis, 35 parts of amur corktree bark, 30 parts of cassia twig, 25 parts of honeysuckle, 30 parts of honeysuckle stem, 25 parts of giant knotweed, 35 parts of radix clematidis, 30 parts of lysimachia christinae, 37 parts of magnolia officinalis, 35 parts of almond, 20 parts of bitter orange, 35 parts of phlegmatic hygrophila, 35 parts of red paeony root, 30 parts of liquorice, 35 parts of plantain herb and 40 parts of cecropin.
4. A method for preparing a traditional Chinese medicine composition for treating chicken bursal mycosis and bird gout according to any one of claims 1-3, which is characterized by comprising the following steps:
(1) Weighing rhizoma Atractylodis, cortex Phellodendri, ramulus Cinnamomi, flos Lonicerae, caulis Lonicerae, rhizoma Polygoni Cuspidati, radix Clematidis, herba Lysimachiae Christinae, cortex Magnolia officinalis, semen Armeniacae amarum, fructus Aurantii, herba Potentillae Discoloris, radix Paeoniae Rubra, glycyrrhrizae radix, and herba plantaginis at a certain ratio, mixing, and pulverizing;
(2) The cecropin is added according to the proportion and stirred uniformly, thus obtaining the traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout.
5. The method for preparing a Chinese medicinal composition for treating chicken bursal mycoplasmosis and gout according to claim 4, wherein the crushing mesh number in the step (1) is 60-300 mesh.
6. Use of a traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout according to any of claims 1-3 in preparing feed.
7. The use of a Chinese medicinal composition for treating chicken bursal mycosis and bird gout in preparing feed as claimed in claim 6, wherein the Chinese medicinal composition and feed are uniformly stirred.
8. The application of the traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and poultry gout in preparing feeds, which is characterized in that the mass ratio of the traditional Chinese medicine composition to the feeds is 1: 190-210.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310271669.3A CN116196355B (en) | 2023-03-20 | 2023-03-20 | Traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310271669.3A CN116196355B (en) | 2023-03-20 | 2023-03-20 | Traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout as well as preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116196355A CN116196355A (en) | 2023-06-02 |
| CN116196355B true CN116196355B (en) | 2023-12-01 |
Family
ID=86519229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310271669.3A Active CN116196355B (en) | 2023-03-20 | 2023-03-20 | Traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116196355B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038719A (en) * | 2016-05-06 | 2016-10-26 | 佛山科学技术学院 | A traditional Chinese medicine for treating and preventing poultry gout and a preparing method thereof |
| CN108671158A (en) * | 2018-06-26 | 2018-10-19 | 祝殿业 | A kind of livestock and poultry cultivation dual-purpose herbal medicine of green medicine feeding |
-
2023
- 2023-03-20 CN CN202310271669.3A patent/CN116196355B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038719A (en) * | 2016-05-06 | 2016-10-26 | 佛山科学技术学院 | A traditional Chinese medicine for treating and preventing poultry gout and a preparing method thereof |
| CN108671158A (en) * | 2018-06-26 | 2018-10-19 | 祝殿业 | A kind of livestock and poultry cultivation dual-purpose herbal medicine of green medicine feeding |
Non-Patent Citations (3)
| Title |
|---|
| 加味白头翁散在防治沙门氏杆菌病中的应用;祝殿业;;今日畜牧兽医(08);全文 * |
| 抗菌肽在畜禽养殖上的应用研究;赵红梅;;饲料广角(23);全文 * |
| 按中草药对畜禽机体的作用归纳介绍;张国红;云南畜牧兽医(02);全文 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116196355A (en) | 2023-06-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1176684C (en) | 'Jiwenning' for treating chicken pest and its preparing process | |
| CN105641149B (en) | Jingfang toxicity-removing oral liquid and preparation method thereof | |
| CN104800819B (en) | A kind of Chinese medicine preparation for treating checken pest | |
| CN104887890A (en) | Medicine composition for treating white scour of chicken and preparation method thereof | |
| CN103920069A (en) | Scourge-clearing toxin-vanquishing oral solution and method for preventing and treating livestock virus and respiratory tract infection | |
| WO2020155318A1 (en) | Traditional chinese medicine preparation for treatment of bacterial respiratory tract disease in livestock and production technique thereof | |
| CN101703601B (en) | Chinese medicinal composition for preventing and treating Mycoplasma gallisepticum and preparation method thereof | |
| CN103494927B (en) | Traditional Chinese medicine composition for treating chicken respiratory disease and preparation method thereof | |
| CN116196355B (en) | Traditional Chinese medicine composition for treating chicken bursal mycoplasmosis and bird gout as well as preparation method and application thereof | |
| CN108524746B (en) | Traditional Chinese medicine composition for preventing and treating poultry cold | |
| CN114886961A (en) | Traditional Chinese medicine composition for treating/preventing avian gout and preparation method and application thereof | |
| CN104840591B (en) | A kind of Chinese medicine composition for having effects that to prevent ewcastle disease | |
| CN101279028B (en) | Method of preparing Oral liquid vaccine for preventing and controlling avian influenza of domestic animals and domestic birds | |
| CN112089799A (en) | Compound preparation for treating chicken bronchial embolism and preparation method thereof | |
| CN109432287B (en) | Traditional Chinese medicine oral liquid for preventing and treating excessive heat syndrome of poultry qi system and preparation method thereof | |
| CN111603514A (en) | Veterinary anti-mycoplasma infection traditional Chinese medicine compound preparation and preparation method and application thereof | |
| CN105381044A (en) | Traditional Chinese medicine composition for preventing and controlling muscular stomach erosion symptoms of poultry | |
| CN101376006A (en) | Chinese medicine oral liquid with heat-clearing and detoxicating, cough-suppressing and asthma-relieving functions as well as application thereof for livestock and poultry | |
| CN104644742A (en) | Traditional Chinese medicine composition for treating infectious rhinitis of chicken and preparation method thereof | |
| CN104524291A (en) | Method for preparing medicine preparation for treating swine fever | |
| CN118370787B (en) | A Chinese medicinal oral liquid for removing toxic substances of livestock and fowl, and its preparation method | |
| CN108904691A (en) | A kind of removing summer-heat mixture and preparation method thereof for preventing and treating newcastle disease | |
| CN102698040A (en) | Medicament for treating porcine respiratory disease and preparation method of medicament | |
| CN114246940B (en) | Application of medicinal composition containing kuh-seng and mahonia powder | |
| CN108420861B (en) | Traditional Chinese medicine composition for preventing and treating poultry group I adenovirus and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |