CN104524291A

CN104524291A - Method for preparing medicine preparation for treating swine fever

Info

Publication number: CN104524291A
Application number: CN201410825484.3A
Authority: CN
Inventors: 万雪
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-12-28
Filing date: 2014-12-28
Publication date: 2015-04-22

Abstract

The invention relates to a method for preparing a medicine preparation for treating swine fever. The preparation is prepared from the following raw materials in parts by weight: 30 parts of largehead atractylodes rhizome, 30 parts of indigowoad root, 30 parts of fineleaf schizonepeta herb, 25 parts of bamboo leaf, 25 parts of ash bark, 25 parts of lightyellow sophora root, 25 parts of amur corktree bark, 20 parts of mongolian dandelion herb, 20 parts of common andrographis herb, 20 parts of white ramping fumitory, 15 parts of cape jasmine flower, 15 parts of white mulberry root-bark, 15 parts of loquat leaf, 15 parts of weeping forsythia capsule, 10 parts of officinal magnolia bark, 10 parts of plantain seed, 7 parts of immature bitter orange, 7 parts of coptis chinensis, 5 parts of kudzuvine root, 5 parts of Chinese thorowax root, 5 parts of common anemarrhena rhizome and 5 parts of tree peony bark. The medicine preparation prepared by using the method disclosed by the invention can be used for treating both symptoms and root causes, is significant in effective rate, and has wide application prospects.

Description

Method for preparing pharmaceutical preparation for swine fever

Technical Field

The invention belongs to the technical field of veterinary medicines, and particularly relates to a method for preparing a medicinal preparation for swine fever.

Background

Hog cholera is a highly contagious and lethal epidemic caused by hog cholera virus, characterized by extensive bleeding, infarction and necrosis due to high heat retention and small vessel degeneration. The disease resistance of pigs infected with the swine fever virus is reduced, and the pigs are extremely easy to have complication or secondary swine plague. Especially, under the adverse conditions of cold, humidity, cold and hot alternation, drastic change of weather, crowding, poor ventilation and the like, the resistance of the pig body is reduced, pasteurella can be propagated in a large quantity, virulence is enhanced to cause diseases, and if the diseases are not controlled in time, the pigs can be killed in large quantities. The swine fever is commonly called as 'bad gut plague', is one of the main infectious diseases threatening the pig industry, clinically ill pigs have depressed spirit, and the body temperature is raised to 40-41.5 ℃. It is manifested as heat retention, anorexia, even abolition, and eye-fluid-rich secretion. The mucous membrane was cyanotic. Constipation at the beginning of the disease, diarrhea, foul odor with blood and white mucous membrane mixed. Redness of the whole body, purple spots on the skin of the ear tip, abdomen, neck and limbs, and no discoloration due to finger pressure. The prepuce of the boar has turbid urine, the neck is swollen and hard, and the boar is sensitive to touch. Cough, dyspnea, hoarseness, serous or sticky secretion from the nose, bloody foam from the nostril of an individual pig, severe canine sitting mouth-opening respiration, and death due to asphyxia. Pathological changes are basically similar, and lymph nodes of the whole body are swollen, bleed and are dark red; bleeding from mucous membrane at the bottom of stomach and mucous membrane of bladder; the spleen surface has papular punctum hemorrhage and mung bean dark purple hemorrhage infarction, and the surface has needle point large hemorrhage; the ileocecal valve, the caecum and the colon mucosa have button-shaped ulcer; bleeding spots and bleeding spots on the larynx; fat in the coronary heart and bleeding spots in the endocardium.

The disease only infects pigs under natural conditions, and the pigs of different ages, sexes and breeds and wild pigs are susceptible and can occur all the year round; the sick pig is the main source of infection, the excretion and secretion of the sick pig, the feed polluted by blood, meat, viscera, waste water and waste materials of the sick and dead pig, viscera and corpses of the sick and dead pig, drinking water can spread virus, and the spreading of the swine fever is mainly through contact and infection of the digestive tract; in addition, sows with diseased and low virulent strain infections may also be placenta-vertically infected with fetuses, resulting in weak piglets, dead fetuses, mummy fetuses, and the like.

In the prior art, chemical reagents commonly used for treating swine fever, such as bismuth subnitrate, magnesium sulfate, sodium sulfate, methylene blue and the like, have poor curative effects. Traditional Chinese herbal medicines or decoction and western medicines cannot rapidly and effectively treat the swine fever. Due to long-term abuse of antibiotics and chemicals and use of conventional medicines, the dosage is greatly increased, the curative effect is reduced, the harm of the medicine residue in the piglet body and the toxic and side effects thereof to the human body is increased, the breeding cost is increased, and the competitiveness of pork exports in China is reduced.

Pestilence was well documented in the history of China. As recorded in Zhouyi, Tianguan, Tukamur: "Ji Yi Zhang Yan Min's diseases, all four seasons have pestilential diseases. The record of the 'Lushi spring and autumn, spring and spring era': "summer season in spring, people are infected with diseases. "it shows that the understanding of pestilence at that time has reached a certain level, and it is considered that epidemic can occur all the year round, one of the reasons is caused by abnormal seasonal qi, which is caused by" untimely qi ". The earliest ancient book of traditional Chinese medicine, Huangdi's classic, is also documented. As pointed out in Su Wen & Ci Fang Lun: the five epidemic diseases are all easy to infect and have similar symptoms as … …, the healthy qi exists in the interior, the pathogenic qi cannot be dried, and the toxic qi is avoided. "Su Wen & Ben Nei Bing" (plain questions, instinct diseases): "Jueyin does not return, i.e. wind rises early, rain does not fall down, dampness does not change, and disease, epidemic disease and defect are wasted. Wind-borne disease, civil disease all have pain in the joints and joints, headache and eyes, restlessness due to wind-heat, dry throat and drank-fluid. "indicate that epidemic febrile disease has similar infectivity, epidemic, clinical manifestation, disease and climate related characteristics, and think that as long as" the healthy atmosphere stores in the interior ", can" avoid its toxic gas ".

The traditional Chinese medicine has knowledge on pestilence two thousand years ago, and reasonable prevention and treatment are proposed, for example, the infectious and epidemic characteristics of pestilence are clearly proposed in the records of ' Mengchunxing autumn Community ' of Oidan ' in the past, the conditions of five epidemics are similar to those of questions in the yellow emperor's internal classic ', and in addition, the method for treating malaria by using southernwood is internationally recognized as a special antimalarial medicine in the world, and in combination with the ' first class ' prevention and treatment, the national ministry of health clearly proposes the participation of traditional Chinese medicine in prevention and treatment schemes, and further proves the status and the effect of the traditional Chinese medicine in prevention and treatment of pestilence in China, so that the development of the low-toxicity effective traditional Chinese medicine formula for preventing and treating swine pestilence is the main research direction in the prior art.

Disclosure of Invention

The invention refers to the understanding of the traditional Chinese medicine on the mechanism of the swine fever and the precious experience of the treatment, refers to the existing reasonable formula, treats the syndrome by differentiation, and promotes the new development of the disease by advancing the aging according to the Chinese pharmacopoeia and pharmacological compatibility, the treatment by differentiation of the syndrome is always the core theory of the traditional Chinese medicine for treating the disease, how to take the main pathogenesis into consideration and the secondary pathogenesis into account, and take the common and individual treatment into account, thereby reflecting the connotation and the extension of the traditional Chinese medicine for treating the disease to the maximum extent, and being a practical problem of the compatibility of the traditional Chinese medicine.

The traditional Chinese medicine has abundant medical contents, some traditional Chinese medicines have antibacterial and antiviral functions, and some traditional Chinese medicines have the functions of improving the immunity and improving the cold resistance. The reasonable configuration of the Chinese herbal compound can simultaneously give consideration to a plurality of functions: antibacterial and antiviral effects, and can improve immunity and cold resistance, thereby achieving good clinical effects of preventing and treating swine fever.

In order to realize the purpose of the invention, the technical scheme adopted by the invention is as follows:

the method for preparing the pharmaceutical preparation for the swine fever comprises the following raw materials in parts by weight:

30 parts of largehead atractylodes rhizome, 30 parts of indigowoad root, 30 parts of fineleaf schizonepeta herb, 25 parts of bamboo leaf, 25 parts of ash bark,

25 parts of lightyellow sophora root, 25 parts of amur corktree bark, 20 parts of dandelion, 20 parts of common andrographis herb, 20 parts of corydalis tuber,

15 parts of gardenia, 15 parts of white mulberry root-bark, 15 parts of loquat leaf, 15 parts of weeping forsythia, 10 parts of magnolia bark,

10 parts of plantain seed, 7 parts of immature bitter orange, 7 parts of coptis root, 5 parts of kudzuvine root, 5 parts of bupleurum, 5 parts of common anemarrhena rhizome and 5 parts of tree peony bark.

The preparation method comprises the following steps:

1 weighing raw materials according to a weight ratio, mixing the bighead atractylodes rhizome, the ash bark, the radix sophorae flavescentis, the golden cypress, the common andrographis herb, the officinal magnolia bark, the golden thread, the radix bupleuri and the tree peony bark according to the ratio, grinding and crushing the mixture, and sieving the ground mixture by a sieve of 80-100 meshes to prepare medicine powder;

2) soaking the rest raw materials in 70% ethanol for 2 hr, reflux extracting for 2 times, each for 1 hr, mixing extractive solutions, concentrating to obtain fluid extract with density of 1.2g/ml, oven drying at 80 deg.C, and pulverizing to obtain compound;

the pharmaceutical formulations of the present application are prepared by homogenizing the powders and complexes prepared by the above steps.

The traditional Chinese medicine composition for treating swine fever is simple and convenient to prepare, wide in medicine source and low in cost, adopts different extraction methods to obtain the active ingredients of the traditional Chinese medicine to the maximum extent, follows the prescription medication principle of the traditional Chinese medicine, combines the medicines, brings out the best in each other, and has the effects of clearing away heat and toxic materials, cooling blood and purging intense heat, promoting diuresis and removing vexation, cleaning intestines and clearing bowels, regulating qi and strengthening body resistance, regulating liver and spleen and the like.

Detailed Description

Example 1

The preparation method comprises the following steps:

1 weighing raw materials according to a weight ratio, mixing the bighead atractylodes rhizome, the ash bark, the radix sophorae flavescentis, the golden cypress, the common andrographis herb, the officinal magnolia bark, the golden thread, the radix bupleuri and the tree peony bark according to the ratio, grinding and crushing the mixture, and sieving the ground mixture with a 80-mesh sieve to prepare medicine powder;

2) soaking the rest raw materials in 70% (v/v) ethanol for 2 hr, reflux extracting for 2 times (each time for 1 hr), mixing extractive solutions, concentrating to obtain fluid extract with density of 1.2g/ml, oven drying at 80 deg.C, and pulverizing to obtain compound;

homogenizing the powder prepared in step 1) and the complex prepared in step 2) to prepare the pharmaceutical formulation of the present application.

The using method comprises the following steps: adding pig feed according to the amount of 2g/Kg, and feeding in the morning, at noon and at night for three times.

When feeding, the medicine composition is added into a certain amount of concentrated feed, stirred evenly, kept at a proper temperature and then drenched. Generally, the patients can be cured after being fed for three to four days, and can be cured after being fed for five to six days in individual cases. During the treatment, it should also be noted that: firstly, pigs are quickly isolated, healthy pigs without infection need to be isolated from infected sick pigs, and strict disinfection and sterilization are required in a new pigsty; secondly, attention is paid to wind and moisture prevention and good ventilation.

Example 2

Selecting 250 pigs infected with swine fever, wherein the symptoms are as follows: hyperpyrexia, anorexia or disappearance, conjunctivitis with purulent secretion, pus mucus in nasal cavity, emesis, and hematochezia; the skin on the ear root, abdomen, and medial side of the thigh often has many punctate bleeding or large red spots. Mesenteric lymph nodes swell, often presenting with hemorrhagic enteritis, as button ulcers in the mucosa of the large intestine. The same were equally divided into two groups, group 1 was administered with the pharmaceutical preparation prepared in example 1 of the present invention, and pig feed was added in an amount of 2 g/Kg; group 2 is the conventional medicine scourge-clearing toxin-vanquishing powder, the dosage is according to the instruction,

the evaluation standard of curative effect is as follows:

and (3) curing: the symptoms completely disappear, and the main physical and chemical inspection indexes are normal;

improvement: all aspects of symptoms are improved compared with before treatment;

no obvious effect: compared with the prior treatment, all symptoms are not obviously improved.

The case statistics are given in the table below:

TABLE 1 case statistics

Numbering	Group of	Number of examples	Cure of disease	Improvement of life	Has no obvious effect	Display efficiency
							1	Experimental group (drug prepared in example 1)	120	98	16	6	95％
2	Powder for clearing away pestilence and relieving toxicity	130	39	10	81	37.6%

After the administration of the drug combination, the feed intake of the sick pigs is obviously increased, the feces are recovered to be normal, and all diseases are gradually disappeared, so that the drug combination has good effect on treating the swine fever, and the significant efficiency reaches 95%.

A typical example is as follows:

in a certain farm, 137 pigs and 43 pigs suffering from swine fever are cured by the pharmaceutical preparation prepared in the embodiment 1 of the invention for 4 days, and the rest pigs are prevented and fed with the pharmaceutical preparation according to the dosage without suffering from diseases.

The foregoing list is only illustrative of the preferred embodiments of the present invention. It is obvious that the invention is not limited to the above embodiments, but that many variations are possible. All modifications which can be derived or suggested by a person skilled in the art from the disclosure of the present invention are to be considered within the scope of the invention.

Claims

1. A process for the preparation of a pharmaceutical formulation for swine fever, comprising the steps of:

1) weighing the following raw materials in parts by weight for later use; wherein,

10 parts of plantain seed, 7 parts of immature bitter orange, 7 parts of coptis root, 5 parts of kudzu root, 5 parts of bupleurum root,

5 parts of rhizoma anemarrhenae and 5 parts of cortex moutan;

2) mixing Atractylodis rhizoma, cortex Fraxini, radix Sophorae Flavescentis, cortex Phellodendri, herba Andrographitis, cortex Magnolia officinalis, Coptidis rhizoma, bupleuri radix, and cortex moutan, grinding, sieving with 80-100 mesh sieve to obtain powder;

3) soaking the rest raw materials in 70% ethanol for 2 hr, reflux-extracting for 2 times (each for 1 hr), mixing extractive solutions, concentrating to obtain fluid extract with density of 1.2g/ml, oven drying at 80 deg.C, and pulverizing to obtain compound;

4) uniformly mixing the powder prepared in the step 2) and the compound prepared in the step 3).

2. The use of the method of claim for controlling swine fever.