CN102631658A - Antiviral influenza drug and preparation method thereof - Google Patents
Antiviral influenza drug and preparation method thereof Download PDFInfo
- Publication number
- CN102631658A CN102631658A CN2012101350304A CN201210135030A CN102631658A CN 102631658 A CN102631658 A CN 102631658A CN 2012101350304 A CN2012101350304 A CN 2012101350304A CN 201210135030 A CN201210135030 A CN 201210135030A CN 102631658 A CN102631658 A CN 102631658A
- Authority
- CN
- China
- Prior art keywords
- parts
- medicine
- extract
- antiviral
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to an antiviral influenza drug and a preparation method of the antiviral influenza drug. The drug comprises the following ingredient by weight: 8-12 parts of ephedra, 8-12 parts of cassia twig, 5-7 parts of processed licorice root, 8-12 parts of semen armeniacae amarae, 8-12 parts of ginger, 18-22 parts of Chinese-date and 18-22 parts of gypsum. The preparation method comprises the steps of soaking the cassia twig and the ginger, extracting to obtain volatile oil and liquid medicine for standby application; then mixing the drug dregs and other crude drugs, extracting to obtain liquid medicine, mixing the liquid medicines obtained from the above two steps, then concentrating, spraying and drying to obtain a drug extract; and finally, mixing the extract with a pharmaceutically acceptable carrier or a drug excipient according to proportion, pelletizing and drying, and adding the standby volatile oil to prepare the antiviral influenza drug. The antiviral influenza drug has obvious curative effect, can be used in large range, and is convenient to take, accurate in curative effect, controllable in quality, simple in manufacturing process flow, controllable in quality standard, energy-saving in energy resources, free from environment pollution, small in potential safety hazard, and suitable for industrial production.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of antiviral influenza medicine and preparation method thereof.
Background technology
Cure holy Zhang Zhongjing and create in the treatise on Febrile Diseases classical side's Daqinglong Tang and form by Herba Ephedrae, Ramulus Cinnamomi, Radix Glycyrrhizae, Rhizoma Zingiberis Recens, Fructus Jujubae, Semen Armeniacae Amarum, Gypsum Fibrosum 7 flavors, original text " wind syndrome of TAI YANG, floating and tense pulse, fever with chills, body pain, the restlessness without perspiration person, the Daqinglong Tang master it ".The clinical exterior cold that is used for of this prescription is heavily demonstrate,proved, because of cold-evil's external beam, pathogenic factor in the exterior are heavily held back, evil quadrature is striven, just must not stretch, so be seen in disease; " cold excessive, as to control " " cold excessive victory, flat " with hot with sweet heat in interior; The cold five elements belong to water, sweet dependent territory, and Tu Shengshui is so Gan Yizhi is cold; The cold class mutually of water, the Xin Ganwu of Gypsum Fibrosum is with the suffering temperature in numb osmanthus, and one with sweet light victory water, and one with the lung qi dispersing temperatureization, plays the merit of controlling drink altogether; Causing resembling of rain because of there being cloud to rise, is with Daqinglong Tang by name.
According to bibliographical information, Daqinglong Tang has the real effect of hot and suffocating card of holding concurrently of treatment cold table; More very, the modern clinical treatment table that whenever is used for closes lossless obvious and double interior-heat person than Ephedrae Decoction for Daqinglong Tang expelling pathogen from the exterior and clearing up internal heat, its diaphoresis strength; Its drug effect is high violent, is difficult to appropriateness and grasps, so also be in the form that the doctor takes according to the concrete evolution of patient's situation for the application of Daqinglong Tang, uses report rarely seen for observing at clinical large sample.
In addition; The Chinese medicine traditional decoction adopts traditional decoct mostly; Its amount of water, the factors such as number of times, decocting time that decoct influence big to clinical efficacy; Also exist to extract many, the drawbacks such as loss of effective components is big, effective substance is unstable, contaminated environment of impurity, simultaneously Chinese medicine decoction also have taking dose greatly, carry shortcoming such as inconvenience.Therefore, in order to satisfy the modernization of industry of Chinese materia medica requirement, we need develop the Chinese medicine novel form that is fit to industrialization.
Summary of the invention
One of the object of the invention is to improve to the defective of above-mentioned traditional classical prescription, obtains a kind of evident in efficacy, antiviral cold medicine that can use, have modern novel form on a large scale.
Another object of the present invention is the defective to above-mentioned Chinese medicine traditional decoction, provides that a kind of technology is simple, quality controllable, production cost is low, the method for preparing the antiviral cold medicine of energy savings, non-environmental-pollution.
Technical scheme of the present invention:
The invention discloses a kind of antiviral influenza medicine, comprise following material by weight: 8～12 parts in Herba Ephedrae, 8～12 parts of Ramulus Cinnamomi, 5～7 parts of Radix Glycyrrhizae Preparatas, 8～12 parts of Semen Armeniacae Amarums, 8～12 parts in Rhizoma Zingiberis Recens, 18～22 parts in Fructus Jujubae, 18～22 parts in Gypsum Fibrosum.
A kind of antiviral influenza medicine comprises following material by weight: 10 parts in Herba Ephedrae, 10 parts of Ramulus Cinnamomi, 6 parts of Radix Glycyrrhizae Preparatas, 10 parts of Semen Armeniacae Amarums, 10 parts in Rhizoma Zingiberis Recens, 20 parts in Fructus Jujubae, 20 parts in Gypsum Fibrosum.
A kind of antiviral influenza medicine comprises following material by weight: 8 parts in Herba Ephedrae, 8 parts of Ramulus Cinnamomi, 7 parts of Radix Glycyrrhizae Preparatas, 8 parts of Semen Armeniacae Amarums, 8 parts in Rhizoma Zingiberis Recens, 22 parts in Fructus Jujubae, 22 parts in Gypsum Fibrosum.
A kind of antiviral influenza medicine comprises following material by weight: 12 parts in Herba Ephedrae, 12 parts of Ramulus Cinnamomi, 5 parts of Radix Glycyrrhizae Preparatas, 12 parts of Semen Armeniacae Amarums, 12 parts in Rhizoma Zingiberis Recens, 18 parts in Fructus Jujubae, 18 parts in Gypsum Fibrosum.
A kind of antiviral influenza medicine comprises one or more pharmaceutically acceptable carrier or drug excipients.
Pharmaceutically acceptable carrier or drug excipient are starch described in a kind of antiviral influenza medicine; Dextrin; Cyclodextrin; Sucrose; Lactose; Mannitol; Microcrystalline Cellulose; Silicon derivative; Cellulose family and derivant thereof; Alginate; Water; Ethanol; Propylene glycol; Glycerol; Gelatin; Polyvinylpyrrolidone; Polyoxyethylene sorbitan monoleate; Agar; Calcium carbonate; Calcium bicarbonate; Surfactant; Polyethylene Glycol; The phospholipid material; Kaolin; Pulvis Talci; Calcium stearate; In 27 kinds of materials of magnesium stearate any one or any several kinds.
A kind of dosage form of antiviral influenza medicine is: tablet, capsule, oral liquid, granule, electuary, pill, powder, suspensoid, powder, syrup.
A kind of method for preparing of antiviral influenza medicine, concrete preparation process is following:
(1), Ramulus Cinnamomi and Rhizoma Zingiberis Recens are added 4～8 times of water, soaked 0～2 hour, adopt steam distillation to extract 2～6 hours, obtain volatile oil and medicinal liquid is subsequent use;
(2), the medicinal residues that will extract behind volatile oil and the medicinal liquid mix with all the other medical materials, add 8～12 times of water, adopt steam distillation to extract 1～3 time; The each extraction 1～2 hour; The medicinal liquid that filter extracts, and the medicinal liquid that extracts in the subsequent use medicinal liquid in the step (1) and this step mixed, it is 1～1.2 that mixed medicinal liquid is concentrated into relative density; Through spray drying, obtain the extract of said antiviral influenza medicine;
(3), with the extract of antiviral influenza medicine and medicine acceptable carrier or drug excipient mixed by 1: 0.5～1: 2, an amount of with 60%～90% ethanol, it is dry to granulate, the volatile oil that adds extraction in the step (1) is processed antiviral influenza medicine.
Ramulus Cinnamomi and Rhizoma Zingiberis Recens add 4 times of water in a kind of step (1) of method for preparing of antiviral influenza medicine, soak 1 hour, extract 4 hours, obtain volatile oil and medicinal liquid is subsequent use; Step (2) Chinese medicine slag mixes with all the other medical materials, adds 8 times of water, extracts 2 times, extracts 2 hours at every turn, and it is 1.14～1.18 that mixed medicinal liquid is concentrated into relative density; Spray-dired condition is that intake air temperature is 170～180 ℃, and the air outlet temperature is 85 ℃～95 ℃, and the atomizing disk rotating speed is 20000 rev/mins; Extract is 1: 0.75～1: 0.90 with the mixed proportion of medicine acceptable carrier or drug excipient in the step (3), and concentration of alcohol is 65%, and the exsiccant temperature of granulating is 60～75 ℃, the adding mode of volatile oil for evenly spray add or enclose after add.
Ramulus Cinnamomi and Rhizoma Zingiberis Recens add 8 times of water in a kind of concrete preparation process of antiviral influenza medicine (1), do not soak, and extract 6 hours, obtain volatile oil and medicinal liquid is subsequent use; Step (2) Chinese medicine slag mixes with all the other medical materials, adds 10 times of water, extracts 3 times; The each extraction 1.5 hours, it is 1.14～1.15 that mixed medicinal liquid is concentrated into relative density, spray-dired condition is that intake air temperature is 175 ℃; The air outlet temperature is 90 ℃, and the atomizing disk rotating speed is 20000 rev/mins; Extract is 1: 0.75～1: 0.8 with the mixed proportion of medicine acceptable carrier or drug excipient in the step (3), and concentration of alcohol is 75%, and the exsiccant temperature of granulating is 65 ℃, the adding mode of volatile oil for evenly spray add or enclose after add.
The pharmacological action of seven flavor medicine material is following in the present invention's prescription:
Herba Ephedrae acrid in the mouth, little hardship, temperature.Return lung, urinary bladder channel.Main effect is the diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Pharmacological action: diaphoresis, diuresis, eliminate the phlegm, antitussive, relieving asthma, rising blood pressure, stimulating central nervous system system, analgesic, antiinflammatory, resisting pathogenic microbes etc.
Ramulus Cinnamomi property of medicine temperature, ignorant hot sweet, current 12 warps.GUIXIN, lung, urinary bladder channel have the effect of diaphoresis expelling pathogenic factors from muscles, supporing yang activating QI, promoting the flow of QI-blood by warming the meridian.Pharmacological action: resisting pathogenic microbes, antipyretic-antalgic, antiinflammatory, antiallergic, blood vessel dilating inspires antiperspirant, and the cinnamic aldehyde in the Ramulus Cinnamomi can make the heat radiation increase regulate blood circulation and make blood flow to body surface by blood vessel dilating, strengthens the perspiration of Herba Ephedrae.
Semen Armeniacae Amarum has the effect of the antitussive of relievining asthma, loosening bowel to relieve constipation.Have eliminate the phlegm, antitussive, relieving asthma, modern pharmacology effect such as anti-inflammatory and antalgic, antitumor, immunomodulating, loosening bowel to relieve constipation.
Radix Glycyrrhizae Preparata is the Radix Glycyrrhizae of smoking with honey, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.Have antiinflammatory, antibiotic, antiviral, anticancer, immunomodulating, antitussive, pharmacological action such as eliminate the phlegm.
Fructus Jujubae has invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, the effect of the mitigation property of medicine.The Chang Peiwu Rhizoma Zingiberis Recens is transferred the regulating the function of middle-JIAO taste, to grow the antiperspirant source.Have the immunity of adjusting, antioxidation, hepatoprotective, antitumor.
The Rhizoma Zingiberis Recens property and flavor of peppery and warm has the cold expelling of inducing sweat, warming middle-JIAO to arrest vomiting, row hydrolysis poison, the effect of warming the lung to relieve cough.Pharmacological action has effects such as antioxidation, cholesterol reducing, antiinflammatory, resisting pathogenic microbes, antitumor, anti-kinetosis, blood sugar lowering, emesis.
The Gypsum Fibrosum nature and flavor are cold hot sweet light, have removing heat with drugs of pungent flavor and cold nature, the effect that relieving restlessness is quenched the thirst.Its modern pharmacology effect has refrigeration function, low dose of excited cardiovascular, improves muscle and peripheral nervous irritability, immunomodulating etc.
" pharmaceutically acceptable carrier " refers to the non-active ingredient in the pharmaceutical composition, for example: calcium carbonate, calcium phosphate, various sugar, starch, cyclodextrin, magnesium stearate, cellulose, magnesium carbonate, acrylate copolymer, methacrylate polymer, gel, water, Polyethylene Glycol, propylene glycol, ethylene glycol, Oleum Ricini, hydrogenated castor wet goods.
" drug excipient " refers to the additament except that principal agent in pharmaceutical preparation, also can be described as adjuvant.Like the adhesive in the tablet, filler, disintegrating agent, lubricant; Wine in the medicine pill, vinegar, medicine juice etc.; Substrate part in semi-solid preparation ointment, the cream; Antiseptic in the liquid preparation, antioxidant, correctives, aromatic, cosolvent, emulsifying agent, solubilizing agent, osmotic pressure regulator, coloring agent etc. all can be described as excipient.General requirement to excipient is a stable in properties; There is not incompatibility with principal agent; Do not have side effects, do not affect the treatment, not yielding, dry and cracked at normal temperatures, go mouldy, damage by worms, harmless, no physiological action; Do not produce chemistry or physical action, do not influence the assay of principal agent etc. with principal agent.
Medicine of the present invention is applicable to fever caused by exogenous pathogens disease, and popularity flu, common cold etc. have fever with aversion to cold, general aching, lossless, and differential diagnosis in tcm is an exterior cold serious symptom person best results.
A kind of antiviral influenza of the present invention medicine and preparation method thereof has following advantage: 1, evident in efficacy; Medicine of the present invention is to improve a kind of medicine of treating viral influenza that obtains according to traditional classical side's Daqinglong Tang, and it is evident in efficacy that this prescription is used to treat viral influenza, particularly to the hyperpyrexia heat symptom-complex; It is fast to bring down a fever; Relapse rate is low, and is evident in efficacy, receives patient's high evaluation.2, can use on a large scale, the Daqinglong Tang drug effect in the classics side is high violent, is difficult to appropriateness and grasps; Usually can only vary with each individual, medicine of the present invention has overcome this defective, through classics side is improved; It can be used on a large scale, to realize the industrialized development of Chinese medicine classic prescriptions.3, taking convenience, determined curative effect, quality controllable, the present invention has overcome that traditional prescription need decoct and many defectives of causing, has obtained pharmaceutical preparation, patient's taking convenience through solvent extraction, drying, technology such as concentrate; The medicament that the present invention processes is observed through clinical use, and is evident in efficacy; Because the influence that traditional decoct can receive amount of water, decoct many factors such as number of times, time; Can influence drug effect; The present invention adopts steam distillation to extract medicament extract adding appropriate excipients and processes pharmaceutical preparation, makes drug quality be guaranteed, efficacy stability.4, pharmaceutical production technological process of the present invention is simple, and the active substance basis of its extract is clear and definite, and quality standard is controlled, has reduced production cost, has practiced thrift the energy, and non-environmental-pollution has reduced the potential safety hazard in producing, and is applicable to industrialization production.
Description of drawings
Preparation technology's flow chart of a kind of antiviral cold medicine of Fig. 1 the present invention.
The specific embodiment
Through embodiment the present invention is done further explanation below.
Embodiment 1
A kind of antiviral influenza medicine comprises following material: Herba Ephedrae 10g, Ramulus Cinnamomi 10g, Radix Glycyrrhizae Preparata 6g, Semen Armeniacae Amarum 10g, Rhizoma Zingiberis Recens 10g, Fructus Jujubae 20g, Gypsum Fibrosum 20g.
Method for preparing:
At first each 10g of Ramulus Cinnamomi Rhizoma Zingiberis Recens is added 8 times of water, do not soak, adopt steam distillation to extract 6 hours, it is subsequent use to collect volatile oil and medicinal liquid;
The medicinal residues that then will extract behind volatile oil and the medicinal liquid mix with all the other medical materials, add 10 times of water, adopt steam distillation to extract 3 times, extract 1.5 hours at every turn, filter to obtain medicinal liquid and the subsequent use combining medicine extracted, leave standstill, filter; Filtrating is concentrated into relative density between 1.1 to 1.2,, obtains the extract of said antiviral influenza medicine through spray drying (drying condition is 175 ℃ of intake air temperatures, 90 ℃ of air outlet temperature, 20000 rev/mins of atomizing disk rotating speeds);
The mixed of at last extract and the dextrin of antiviral influenza medicine being pressed 1: 0.8 is granulated with 75% ethanol in right amount, 60 ℃ of dryings, and spray adds the subsequent use volatile oil of extraction and processes antiviral influenza medicine.
Embodiment 2
A kind of antiviral influenza medicine comprises following material: Herba Ephedrae 8g, Ramulus Cinnamomi 8g, Radix Glycyrrhizae Preparata 5g, Semen Armeniacae Amarum 8g, Rhizoma Zingiberis Recens 8g, Fructus Jujubae 18g, Gypsum Fibrosum 18g.
Method for preparing
At first each 8g of Ramulus Cinnamomi Rhizoma Zingiberis Recens is added 4 times of water, soaked 1 hour, adopt steam distillation to extract 4 hours, it is subsequent use to collect volatile oil and medicinal liquid;
Then, the medicinal residues behind extraction volatile oil and the medicinal liquid are mixed with all the other medical materials, add 8 times of water, adopt steam distillation to extract 2 times, extracted 2 hours at every turn, filter the medicinal liquid and the subsequent use combining medicine that obtain extraction, leave standstill, filter; Filtrating is concentrated into relative density between 1.14 to 1.18,, obtains the extract of said antiviral influenza medicine through spray drying (drying condition is 170 ℃ of intake air temperatures, 85 ℃ of air outlet temperature, 20000 rev/mins of atomizing disk rotating speeds);
At last,, granulate in right amount with 60% ethanol with the mixed that the extract and the mannitol of antiviral influenza medicine are pressed 1: 0.75,65 ℃ of dryings, spray adds the subsequent use volatile oil of extraction and processes antiviral influenza medicine.
Embodiment 3
A kind of antiviral influenza medicine comprises following material: Herba Ephedrae 12g, Ramulus Cinnamomi 12g, Radix Glycyrrhizae Preparata 7g, Semen Armeniacae Amarum 12g, Rhizoma Zingiberis Recens 12g, Fructus Jujubae 22g, Gypsum Fibrosum 22g.
Method for preparing
At first Ramulus Cinnamomi and Rhizoma Zingiberis Recens are added 6 times of water, soaked 2 hours, extracted 2 hours, obtain volatile oil and medicinal liquid is subsequent use;
Then will remain medicinal residues and mix, add 12 times of water, and adopt steam distillation to extract 1 time, extract 1 hour, filter the medicinal liquid and the subsequent use combining medicine that obtain extraction, and leave standstill, filter with all the other medical materials; Filtrating is concentrated into relative density between 1.14 to 1.15,, obtains the extract of said antiviral influenza medicine through spray drying (drying condition is 180 ℃ of intake air temperatures, 95 ℃ of air outlet temperature, 20000 rev/mins of atomizing disk rotating speeds);
With the extract of antiviral influenza medicine and sucrose and lactose mixed, granulate in right amount at last with 90% ethanol by 1: 2,75 ℃ of dryings, spray adds the subsequent use volatile oil of extraction and processes antiviral influenza medicine.
Embodiment 4
A kind of antiviral influenza medicine comprises following material: Herba Ephedrae 8g, Ramulus Cinnamomi 8g, Radix Glycyrrhizae Preparata 7g, Semen Armeniacae Amarum 8g, Rhizoma Zingiberis Recens 8g, Fructus Jujubae 22g, Gypsum Fibrosum 22g.
Embodiment 5
A kind of antiviral influenza medicine comprises following material: Herba Ephedrae 12g, Ramulus Cinnamomi 12g, Radix Glycyrrhizae Preparata 5g, Semen Armeniacae Amarum 12g, Rhizoma Zingiberis Recens 12g, Fructus Jujubae 18g, Gypsum Fibrosum 18g.
Through concrete experimental example in the following table medicine of the present invention is used to treat viral beneficial effect of catching a cold and does further elaboration:
Table 1
The medicament that patient takes after mixing it with water in the table 1 is the graininess electuary of antiviral influenza medicine of the present invention; 30 different patients have different separately diseases in the table 1, after taking medicine of the present invention, and most of recovery from illness; 4 patients are only arranged also with the symptom of having a stuffy nose, coughing; But also all brought down a fever or do not have aversion to cold, this shows, it is remarkable that medicament of the present invention is used to treat virus flu effect.
Claims (10)
1. an antiviral influenza medicine is characterized in that said medicine comprises following material by weight: 8 ~ 12 parts in Herba Ephedrae, 8 ~ 12 parts of Ramulus Cinnamomi, 5 ~ 7 parts of Radix Glycyrrhizae Preparatas, 8 ~ 12 parts of Semen Armeniacae Amarums, 8 ~ 12 parts in Rhizoma Zingiberis Recens, 18 ~ 22 parts in Fructus Jujubae, 18 ~ 22 parts in Gypsum Fibrosum.
2. according to the said a kind of antiviral influenza medicine of claim 1, it is characterized in that said medicine comprises following material by weight: 10 parts in Herba Ephedrae, 10 parts of Ramulus Cinnamomi, 6 parts of Radix Glycyrrhizae Preparatas, 10 parts of Semen Armeniacae Amarums, 10 parts in Rhizoma Zingiberis Recens, 20 parts in Fructus Jujubae, 20 parts in Gypsum Fibrosum.
3. according to the said a kind of antiviral influenza medicine of claim 1, it is characterized in that said medicine comprises following material by weight: 8 parts in Herba Ephedrae, 8 parts of Ramulus Cinnamomi, 7 parts of Radix Glycyrrhizae Preparatas, 8 parts of Semen Armeniacae Amarums, 8 parts in Rhizoma Zingiberis Recens, 22 parts in Fructus Jujubae, 22 parts in Gypsum Fibrosum.
4. according to the said a kind of antiviral influenza medicine of claim 1, it is characterized in that said medicine comprises following material by weight: 12 parts in Herba Ephedrae, 12 parts of Ramulus Cinnamomi, 5 parts of Radix Glycyrrhizae Preparatas, 12 parts of Semen Armeniacae Amarums, 12 parts in Rhizoma Zingiberis Recens, 18 parts in Fructus Jujubae, 18 parts in Gypsum Fibrosum.
5. according to the said a kind of antiviral influenza medicine of claim 1 ~ 4, it is characterized in that said medicine comprises one or more pharmaceutically acceptable carrier or drug excipients.
6. according to the said a kind of antiviral influenza medicine of claim 5, it is characterized in that said pharmaceutically acceptable carrier or drug excipient are any one or any several kinds in starch, dextrin, cyclodextrin, sucrose, lactose, mannitol, microcrystalline Cellulose, silicon derivative, cellulose family and derivant thereof, alginate, water, ethanol, propylene glycol, glycerol, gelatin, polyvinylpyrrolidone, polyoxyethylene sorbitan monoleate, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, 27 kinds of materials of magnesium stearate.
7. any one antiviral influenza medicine according to claim 6 is characterized in that said pharmaceutical dosage form is: tablet, capsule, oral liquid, granule, electuary, pill, powder, suspensoid, powder, syrup.
8. the method for preparing of the described a kind of antiviral influenza medicine of claim 7, concrete preparation process is following:
(1), Ramulus Cinnamomi and Rhizoma Zingiberis Recens are added 4 ~ 8 times of water, soaked 0 ~ 2 hour, adopt steam distillation to extract 2 ~ 6 hours, obtain volatile oil and medicinal liquid is subsequent use;
(2), the medicinal residues that will extract behind volatile oil and the medicinal liquid mix with all the other medical materials, add 8 ~ 12 times of water, adopt steam distillation to extract 1 ~ 3 time; The each extraction 1 ~ 2 hour; The medicinal liquid that filter extracts, and the medicinal liquid that extracts in the subsequent use medicinal liquid in the step (1) and this step mixed, it is 1 ~ 1.2 that mixed medicinal liquid is concentrated into relative density; Through spray drying, obtain the extract of said antiviral influenza medicine;
(3), with the mixed that the extract of antiviral influenza medicine and medicine acceptable carrier or drug excipient are pressed 1:0.5 ~ 1:2, an amount of with 60% ~ 90% ethanol, it is dry to granulate, and adds the volatile oil that extracts in the step (1) and processes antiviral influenza medicine.
9. method for preparing according to claim 8 is characterized in that: Ramulus Cinnamomi and Rhizoma Zingiberis Recens add 4 times of water in the said step (1), soak 1 hour, extract 4 hours, obtain volatile oil and medicinal liquid is subsequent use; Step (2) Chinese medicine slag mixes with all the other medical materials, adds 8 times of water, extracts 2 times, extracts 2 hours at every turn, and it is 1.14 ~ 1.18 that mixed medicinal liquid is concentrated into relative density; Spray-dired condition is that intake air temperature is 170 ~ 180 ℃, and the air outlet temperature is 85 ℃ ~ 95 ℃, and the atomizing disk rotating speed is 20000 rev/mins; Extract is 1:0.75 ~ 1:0.90 with the mixed proportion of medicine acceptable carrier or drug excipient in the step (3), and concentration of alcohol is 65%, and the exsiccant temperature of granulating is 60 ~ 75 ℃, the adding mode of volatile oil for evenly spray add or enclose after add.
10. method for preparing according to claim 8 is characterized in that: Ramulus Cinnamomi and Rhizoma Zingiberis Recens add 8 times of water in the said step (1), do not soak, and extract 6 hours, obtain volatile oil and medicinal liquid is subsequent use; Step (2) Chinese medicine slag mixes with all the other medical materials, adds 10 times of water, extracts 3 times; The each extraction 1.5 hours, it is 1.14 ~ 1.15 that mixed medicinal liquid is concentrated into relative density, spray-dired condition is that intake air temperature is 175 ℃; The air outlet temperature is 90 ℃, and the atomizing disk rotating speed is 20000 rev/mins; The mixed proportion of extract and medicine acceptable carrier or drug excipient is 1:0.75 ~ 1:0.8 in the step (3), and concentration of alcohol is 75%, and the exsiccant temperature of granulating is 65 ℃, and the adding mode of volatile oil adds for evenly spraying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210135030 CN102631658B (en) | 2012-05-03 | 2012-05-03 | Antiviral influenza drug and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210135030 CN102631658B (en) | 2012-05-03 | 2012-05-03 | Antiviral influenza drug and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102631658A true CN102631658A (en) | 2012-08-15 |
| CN102631658B CN102631658B (en) | 2013-03-20 |
Family
ID=46616342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210135030 Expired - Fee Related CN102631658B (en) | 2012-05-03 | 2012-05-03 | Antiviral influenza drug and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102631658B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069477A (en) * | 2014-07-26 | 2014-10-01 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine oral liquid for preventing and treating chicken avian influenza and preparation method thereof |
| CN105194634A (en) * | 2015-10-29 | 2015-12-30 | 张结莲 | Traditional Chinese medicine composition for abating fever of children and preparation method of traditional Chinese medicine composition |
| CN105982936A (en) * | 2015-05-29 | 2016-10-05 | 西藏大学 | Waldheimia glabra volatile oil and application thereof in pharmacy |
| CN108404078A (en) * | 2018-04-26 | 2018-08-17 | 海南斯达制药有限公司 | A kind of preparation method of osmanthus Huang composition |
| CN111588828A (en) * | 2020-05-27 | 2020-08-28 | 李燕 | Chinese medicinal preparation for treating new coronavirus and viral diseases, and its preparation method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083381A (en) * | 1993-05-31 | 1994-03-09 | 东北制药集团公司沈阳第一制药厂 | Cordierite electuary and preparation method thereof |
| CN1465389A (en) * | 2002-06-21 | 2004-01-07 | 南京凯优科贸有限公司 | Daqinglong decoction and preparation thereof |
| CN101647997A (en) * | 2009-09-30 | 2010-02-17 | 吉林龙鑫药业有限公司 | Influenza Shufeng capsule and preparation method and quality control method thereof |
| CN102100888A (en) * | 2009-12-17 | 2011-06-22 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of new integrative formulation of major green-blue dragon decoction |
-
2012
- 2012-05-03 CN CN 201210135030 patent/CN102631658B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083381A (en) * | 1993-05-31 | 1994-03-09 | 东北制药集团公司沈阳第一制药厂 | Cordierite electuary and preparation method thereof |
| CN1465389A (en) * | 2002-06-21 | 2004-01-07 | 南京凯优科贸有限公司 | Daqinglong decoction and preparation thereof |
| CN101647997A (en) * | 2009-09-30 | 2010-02-17 | 吉林龙鑫药业有限公司 | Influenza Shufeng capsule and preparation method and quality control method thereof |
| CN102100888A (en) * | 2009-12-17 | 2011-06-22 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of new integrative formulation of major green-blue dragon decoction |
Non-Patent Citations (7)
| Title |
|---|
| 《中国药师》 20120205 李娜 等 "HPLC法测定大青龙汤颗粒剂中盐酸麻黄碱和盐酸伪麻黄碱的含量" 230-232 1-10 第15卷, 第2期 * |
| 《中药新药与临床药理》 20051130 翟华强 等 "大青龙颗粒治疗感冒风寒表实兼郁热证的临床研究" 452-453 1-10 第16卷, 第6期 * |
| 《河南中医》 20120331 邓倩 等 "大青龙汤加减治疗感冒高热35例" 283-284 1-10 第32卷, 第3期 * |
| 李娜 等: ""HPLC法测定大青龙汤颗粒剂中盐酸麻黄碱和盐酸伪麻黄碱的含量"", 《中国药师》, vol. 15, no. 2, 5 February 2012 (2012-02-05), pages 230 - 232 * |
| 柯雪帆: "《伤寒论选读》", 30 April 2001, article ""伤寒论选读"", pages: 59-62 * |
| 翟华强 等: ""大青龙颗粒治疗感冒风寒表实兼郁热证的临床研究"", 《中药新药与临床药理》, vol. 16, no. 6, 30 November 2005 (2005-11-30), pages 452 - 453 * |
| 邓倩 等: ""大青龙汤加减治疗感冒高热35例"", 《河南中医》, vol. 32, no. 3, 31 March 2012 (2012-03-31), pages 283 - 284 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069477A (en) * | 2014-07-26 | 2014-10-01 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine oral liquid for preventing and treating chicken avian influenza and preparation method thereof |
| CN105982936A (en) * | 2015-05-29 | 2016-10-05 | 西藏大学 | Waldheimia glabra volatile oil and application thereof in pharmacy |
| CN105194634A (en) * | 2015-10-29 | 2015-12-30 | 张结莲 | Traditional Chinese medicine composition for abating fever of children and preparation method of traditional Chinese medicine composition |
| CN108404078A (en) * | 2018-04-26 | 2018-08-17 | 海南斯达制药有限公司 | A kind of preparation method of osmanthus Huang composition |
| CN111588828A (en) * | 2020-05-27 | 2020-08-28 | 李燕 | Chinese medicinal preparation for treating new coronavirus and viral diseases, and its preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102631658B (en) | 2013-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102836290A (en) | Chinese herbal tea for preventing and treating flu | |
| CN102631658B (en) | Antiviral influenza drug and preparation method thereof | |
| CN101181393A (en) | Chinese medicine preparation for curing common cold and producing method thereof | |
| CN103860941A (en) | Traditional Chinese medicine for treating schizophrenia and preparation method thereof | |
| CN104352587A (en) | Ointment for treating rhinitis | |
| CN102772591B (en) | Hollow, ventilation and double-layer traditional Chinese medicine suppository for treating rhinitis and production method of traditional Chinese medicine suppository | |
| CN103432559A (en) | Traditional Chinese medicine composition for treating spanomenorrhea and dysmenorrhea caused by blood stasis and preparation method and application thereof | |
| CN103623280B (en) | A kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease | |
| CN104474104A (en) | Traditional Chinese medicine composition for preventing and treating infectious rhinitis of chicken and preparation method thereof | |
| CN115486488A (en) | Tea drink composition for common food and application thereof | |
| CN105343660A (en) | Traditional Chinese medicinal preparation for treating peripheral vertigo and preparation method of traditional Chinese medicinal preparation | |
| CN101708230B (en) | Anti-drug medicine and preparation method thereof | |
| CN104887950A (en) | Mastitis treatment traditional Chinese medicine compound | |
| CN104606661A (en) | Traditional Chinese medicinal galactagogue for treating hypogalactia after cesarean delivery and preparation method of galactagogue | |
| CN104173830A (en) | Medicament for reconciling interior syndromes and relieving exterior syndromes for high fever of cold in winter and preparation method thereof | |
| CN109464640A (en) | Conditioning alopecia is lived again the edible medicine and preparation method thereof of blackening hair | |
| CN101983712A (en) | Novel medicament for treating coronary heart disease | |
| CN105267895A (en) | Medicine for treating bovine postpartum blood stasis type placenta retension and preparing method thereof | |
| CN105454577A (en) | Christina loosestrife herbal tea dropping pills and preparation method thereof | |
| CN105362371A (en) | Traditional Chinese medicine preparation for treating onychomycosis and preparation method thereof | |
| CN104824233A (en) | Loquat leaf liquorice health-preserving herbal tea beverage and preparation method | |
| CN104606638A (en) | Medicine for treating damp-heat type acute eczema and preparation method thereof | |
| CN104940431A (en) | Ligusticum wallichii tea modulating agent | |
| CN115192680A (en) | Preparation method and efficacy of medicine for treating influenza | |
| CN115211479A (en) | Tea drink composition based on edible and medicinal Chinese medicinal materials and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130320 Termination date: 20190503 |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| RR01 | Reinstatement of patent right |
Former decision: termination of patent right due to unpaid annual fee Former decision publication date: 20200424 |
|
| RR01 | Reinstatement of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130320 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |