CN101653597A - Compound poplar flower oral liquid for treating piglet yellow or white dysentery and preparation thereof - Google Patents
Compound poplar flower oral liquid for treating piglet yellow or white dysentery and preparation thereof Download PDFInfo
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- CN101653597A CN101653597A CN200810054223A CN200810054223A CN101653597A CN 101653597 A CN101653597 A CN 101653597A CN 200810054223 A CN200810054223 A CN 200810054223A CN 200810054223 A CN200810054223 A CN 200810054223A CN 101653597 A CN101653597 A CN 101653597A
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Abstract
The invention discloses a compound poplar flower oral liquid for treating piglet yellow or white dysentery and a preparation thereof, and aims to provide the compound poplar flower oral liquid which has a quick response to piglet yellow or white dysentery treatment, is effective and efficient and can reduce the drug resistance generated by bacteria and treat both symptoms and root causes, and thepreparation method which has a simple process and is easy to implement. Each 100 liters of the oral liquid comprises the following components by mass: 1 to 10 kilograms of poplar flower extract, 1 to10 kilograms of colistin sulfate, 0.05 to 0.5 kilogram of atropine sulfate, 0.01 kilogram of EDTA-2Na, 0.6 kilogram of sodium benzoate, and the balance of water. The compound poplar flower oral liquidis a compound preparation adopting the combination of Chinese medicaments and western medicaments, wherein the poplar flower and the colistin sulfate have a dual antibacterial effect; the atropine sulfate inhibits glandular secretion of intestinal tracts to reduce the water content of intestinal contents and can effectively reduce the drug resistance probability of escherichia coli; and thus, thecompound poplar flower oral liquid has a quick response to the piglet yellow or white dysentery treatment, is effective and efficient, and can obviously reduce the piglet death rate and improve the cure rate.
Description
Technical field
The present invention relates to a kind of compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet and preparation method thereof.
Background technology
Yellow and white dysentery of piglet is a kind of general type disease that piglet often sends out, be to cause by Escherichia coli, owing to be mainly in piglet, cause the characteristics that the course of disease is short, mortality rate is high, and have very strong infectiousness, the sow that carries disease germs usually is its source of infection, sick pig shows as diarrhoea, draw Huang, white, gray feces, because of dehydration, very fast death.
At present, because the distinctive physiological stage decision of living in of the particularity of yellow and white dysentery of piglet and sick pig, therapeutic effect is poor, the mortality rate height, and treat by other modes, as injection for curing, zest to piglet is bigger, can cause the part piglet faint from fear dead, stress is big; Powder is treated, and characteristics such as feeding and do not search for food owing to piglet is bad also determine its bad operation.And owing to use various medicines widely in recent years, bacterial drug resistance is serious, makes the weak effect of single drug, does not often reach therapeutic effect.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat yellow and white dysentery of piglet, and instant effect can prevent that antibacterial from producing drug resistance, the compound poplar flower oral liquid for the treatment of both the principal and secondary aspects of a disease.
It is simple that another object of the present invention provides a kind of technology, easily the above-mentioned preparation method that is used for the treatment of the compound poplar flower oral liquid of yellow and white dysentery of piglet that realizes.
The present invention is achieved through the following technical solutions:
A kind of compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet is characterized in that, the consisting of of every 100L oral liquid: poplar flower extract 1～10kg, colistin sulfate 1～10kg, atropine sulfate 0.05～0.5kg, EDTA-2Na 0.01kg, sodium benzoate 0.6kg, surplus is a water.Wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug.
A kind of above-mentioned preparation method that is used for the treatment of the compound poplar flower oral liquid of yellow and white dysentery of piglet is characterized in that, comprises the steps:
(1) water intaking 50L adds poplar flower extract 1～10kg, is stirred to whole dissolvings;
(2) water intaking 30L adds EDTA-2Na 0.01kg, sodium benzoate 0.6kg, colistin sulfate 1～10kg, atropine sulfate 0.05～0.5kg, is stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2, moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly makes the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet of the present invention after clear and bright.
The preferable of wherein every 100L oral liquid consists of: poplar flower extract 3～8kg, and colistin sulfate 3～6kg, atropine sulfate 0.1～0.3kg, EDTA-2Na 0.01kg, sodium benzoate 0.6kg, surplus is a water.
The best group of every 100L oral liquid becomes: poplar flower extract 5kg, and colistin sulfate 4kg, atropine sulfate 0.15kg, EDTA-2Na0.01kg, sodium benzoate 0.6kg, surplus is a water.
Wherein, institute's water preferably adopts purified water.The purity of above-mentioned used poplar flower extract is: the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug.
The present invention has following technique effect:
The present invention is for adopting the compound preparation of Integrative Chinese-Western, flower of poplar, colistin sulfate have dual antibacterial effect, add the inhibition glandular secretion of atropine sulfate to intestinal, reduce the intestinal contents moisture, and reaching quick therapeutic effect, the treatment yellow and white dysentery of piglet has the effect for the treatment of both the principal and secondary aspects of a disease.And the reasonable combination of flower of poplar and colistin sulfate can effectively reduce colibacillary drug resistance probability, and is more effective to yellow and white dysentery of piglet.Simultaneously, the present invention can reduce mortality rate because therapeutic process is accelerated, and improves cure rate, provides a kind of medicine fast and easily to the raiser.
The preparation method technology of the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
The purity of the poplar flower extract among the following embodiment is: the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug.
Embodiment 1
(1) gets purified water 50L, add poplar flower extract 1kg, be stirred to whole dissolvings.
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, colistin sulfate 10kg, atropine sulfate 0.5kg, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 is mended purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet of the present invention after clear and bright.
Embodiment 2
(1) gets purified water 50L, add poplar flower extract 10kg, be stirred to whole dissolvings.
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, colistin sulfate 1kg, atropine sulfate 0.05kg, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 is mended purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet of the present invention after clear and bright.
Embodiment 3
(1) gets purified water 50L, add poplar flower extract 3kg, be stirred to whole dissolvings.
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, colistin sulfate 6kg, atropine sulfate 0.3kg, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 is mended purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet of the present invention after clear and bright.
Embodiment 4
(1) gets purified water 50L, add poplar flower extract 8kg, be stirred to whole dissolvings.
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, colistin sulfate 3kg, atropine sulfate 0.1kg is stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 is mended purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet of the present invention after clear and bright.
Embodiment 5
(1) gets purified water 50L, add poplar flower extract 6kg, be stirred to whole dissolvings.
(2) get purified water 30L, add EDTA-2Na 0.01k g, sodium benzoate 0.6kg, colistin sulfate 5kg, atropine sulfate 0.25kg, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 is mended purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet of the present invention after clear and bright.
Embodiment 6
(1) gets purified water 50L, add poplar flower extract 5kg, be stirred to whole dissolvings.
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, colistin sulfate 4kg, atropine sulfate 0.15kg, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 is mended purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet of the present invention after clear and bright.
Clinical trial:
1. laboratory animal:
100 of the ill piglets of picked at random.
2. experiment medicine
The compound poplar flower oral liquid our unit development that is used for the treatment of yellow and white dysentery of piglet of the embodiment of the invention 6 preparations;
5% poplar flower oral liquid solution our unit prepared in laboratory;
4% colistin sulfate injection our unit prepared in laboratory.
3. experimental technique:
100 ill piglets are divided into four groups at random by body weight, 25 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 5% poplar flower oral liquid: gavage every 1kg body weight 0.2ml, 2 times on the one, logotype 3 days.
The C group is treated usage with 4% colistin sulfate injection: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 3 days.
The D group is treated usage with the oral liquid that is used for the treatment of yellow and white dysentery of piglet of the embodiment of the invention 6 preparations: gavage every 1kg body weight 0.2ml, 2 times on the one, logotype 2 days.
After the treatment beginning, every day, piglet health situation of change and dead animal distribution suffered from record, and treat and add up therapeutic effect after 4 days, wherein:
Invalid: after referring to 4 days, ill piglet symptom does not have obvious change, still keeps the preceding symptom of treatment.
Effectively: after referring to 4 days, ill piglet symptom changes, the effect before symptom is better than treating.
Cure: after referring to 4 days, transference cure, ill piglet gets well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 4 days, ill piglet still has certain symptom, and its symptom performance is better than before the treatment or does not have change, and ill piglet is not cured.Its numeral has been included in the numeral of invalid number and effective number.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 is used for the treatment of compound poplar flower oral liquid treatment group, 5% poplar flower oral liquid treatment group and the 4% colistin sulfate injection group of yellow and white dysentery of piglet and matched group difference extremely significantly (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number | Effective number | Cure a number | A symptom piglet number is arranged during end | A dead number |
| ??A | Matched group | ??25 | ??0 | ??0 | ??2 | ??23 |
| ??B | The treatment of 5% poplar flower oral liquid | ??12 | ??13 | ??8 | ??7 | ??10 |
| ??C | 4% colistin sulfate injection for treating | ??10 | ??15 | ??10 | ??5 | ??10 |
| ??D | The compound poplar flower oral liquid treatment that is used for the treatment of yellow and white dysentery of piglet of the embodiment of the invention 6 | ??3 | ??22 | ??19 | ??3 | ??3 |
Claims (6)
1, a kind of compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet is characterized in that, the consisting of of every 100L oral liquid: poplar flower extract 1～10kg, colistin sulfate 1～10kg, atropine sulfate 0.05～0.5kg, EDTA-2Na 0.01kg, sodium benzoate 0.6kg, surplus is a water; Wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug.
2, the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet according to claim 1, it is characterized in that, consisting of of every 100L oral liquid: poplar flower extract 3～8kg, colistin sulfate 3～6kg, atropine sulfate 0.1～0.3kg, EDTA-2Na 0.01kg, sodium benzoate 0.6kg, surplus is a water; Wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug.
3, the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet according to claim 1 is characterized in that, the consisting of of every 100L oral liquid: poplar flower extract 5kg, colistin sulfate 4kg, atropine sulfate 0.15kg, EDTA-2Na0.01kg, sodium benzoate 0.6kg, surplus is a water; Wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug.
4, the described preparation method that is used for the treatment of the compound poplar flower oral liquid of yellow and white dysentery of piglet of a kind of claim 1 is characterized in that, comprises the steps:
(1) water intaking 50L adds poplar flower extract 1～10kg, is stirred to whole dissolvings; Wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug;
(2) water intaking 30L adds EDTA-2Na 0.01kg, sodium benzoate 0.6kg, colistin sulfate 1～10kg, atropine sulfate 0.05～0.5kg, is stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2, moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly makes the compound poplar flower oral liquid that is used for the treatment of yellow and white dysentery of piglet of the present invention after clear and bright.
5, the preparation method that is used for the treatment of the compound poplar flower oral liquid of yellow and white dysentery of piglet according to claim 4, it is characterized in that, poplar flower extract 3～8kg in every 100L oral liquid, colistin sulfate 3～6kg, atropine sulfate 0.1～0.3kg, EDTA-2Na 0.01kg, sodium benzoate 0.6kg, surplus is a purified water.
6, the compound poplar flower oral liquid preparation method that is used for the treatment of yellow and white dysentery of piglet according to claim 4, it is characterized in that, poplar flower extract 5kg in every 100L oral liquid, colistin sulfate 4kg, atropine sulfate 0.15kg, EDTA-2Na0.01kg, sodium benzoate 0.6kg, surplus is a purified water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810054223A CN101653597A (en) | 2008-08-22 | 2008-08-22 | Compound poplar flower oral liquid for treating piglet yellow or white dysentery and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810054223A CN101653597A (en) | 2008-08-22 | 2008-08-22 | Compound poplar flower oral liquid for treating piglet yellow or white dysentery and preparation thereof |
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| CN101653597A true CN101653597A (en) | 2010-02-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200810054223A Pending CN101653597A (en) | 2008-08-22 | 2008-08-22 | Compound poplar flower oral liquid for treating piglet yellow or white dysentery and preparation thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377607A (en) * | 2016-11-08 | 2017-02-08 | 河南中盛动物药业有限公司 | Compound poplar flower oral liquid and preparation method thereof |
| CN107308439A (en) * | 2017-07-06 | 2017-11-03 | 山东中牧兽药有限公司 | A kind of compound poplar flower oral liquid and preparation method thereof |
-
2008
- 2008-08-22 CN CN200810054223A patent/CN101653597A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377607A (en) * | 2016-11-08 | 2017-02-08 | 河南中盛动物药业有限公司 | Compound poplar flower oral liquid and preparation method thereof |
| CN107308439A (en) * | 2017-07-06 | 2017-11-03 | 山东中牧兽药有限公司 | A kind of compound poplar flower oral liquid and preparation method thereof |
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Open date: 20100224 |