CN102319253A - Oral liquid for treating enteritis caused by avian escherichia coli and preparation method thereof - Google Patents
Oral liquid for treating enteritis caused by avian escherichia coli and preparation method thereof Download PDFInfo
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- CN102319253A CN102319253A CN201110188039A CN201110188039A CN102319253A CN 102319253 A CN102319253 A CN 102319253A CN 201110188039 A CN201110188039 A CN 201110188039A CN 201110188039 A CN201110188039 A CN 201110188039A CN 102319253 A CN102319253 A CN 102319253A
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- escherichia coli
- oral liquid
- poplar
- enteritis
- mequindox
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses an oral liquid for treating enteritis caused by avian escherichia coli and a preparation method thereof, and aims at providing an oral liquid which can be used for effectively and efficiently treating enteritis caused by avian escherichia coli, preventing bacteria from generating drug tolerance, and addressing both the symptoms and root causes, and a preparation method simple in process and easy for realization of the oral liquid. Each 100L of the oral liquid comprises 5kg of poplar flower extract, 3 to 10kg of mequindox, 4 to 15kg of neomycin sulfate, 6 to 20kg of sodium salicylate, and the balance of water. In the compound preparation by adopting combination of Chinese medicaments and western medicaments,the poplar flower has the function of eliminating dampness and stopping diarrhea, and is effective to enteritis; the mequindox and the neomycin sulfate are combined for use, thus the escherichia coli can be effectively resisted and the drug tolerance of the escherichia coli is greatly reduced; the sodium salicylate has a anti-inflammation function; and by virtue of combination of the medicaments, the enteritis caused by the avian escherichia coli can be treated with the efficacy of addressing both the symptoms and root causes, so that the curative rate can be improved, and a quick and convenient treatment medicament is provided to raising households.
Description
Technical field
The present invention relates to a kind of oral liquid that is used to treat the enteritis that avian escherichia coli causes and preparation method thereof.
Background technology
The microbial enteritis of avian Escherichia coli is a kind of general type disease that chicken often sends out, and is caused by Escherichia coli, and escherichia coli are resident bacterium in the chicken body; Most of not pathogenic, but under certain condition, it changes Escherichia coli into; And the serotype of pathogenic escherichia coli is a lot, and sick fowl mainly shows as diarrhoea, draws yellow, color feces such as yellowish green, greyish white; What have is water sample, band food-residue that has or complete indigestible feedstuff, and feces often pollutes around the anus; When serious even thromboembolism occurs, stop up anus, the dehydration of sick fowl is serious, high, the dead speed of mortality rate is fast.
At present; Because intensive culture is more and more in recent years, adds that medication is general, escherichia coli are more and more serious to the drug resistance of single medicine; The culturist usually produces drug resistance because understand pathogenic escherichia coli to which medicine, treats untimely and causes very big loss.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat the enteritis that avian escherichia coli causes, instant effect can reduce antibacterial and produce drug resistance, the oral liquid of treating both the principal and secondary aspects of a disease.
It is simple that another object of the present invention provides a kind of technology, the above-mentioned method for preparing that is used to treat the oral liquid of the enteritis that avian escherichia coli causes that realizes easily.
The present invention realizes through following technical proposals:
A kind of oral liquid that is used to treat the enteritis that avian escherichia coli causes is characterized in that, the consisting of of every 100L oral liquid: poplar flower extract 5kg, Mequindox 3～10kg, and polygynax 4～15kg, sodium salicylate 6～20kg, surplus is a water; Wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug in whole.
A kind of above-mentioned method for preparing that is used to treat the oral liquid of the enteritis that avian escherichia coli causes is characterized in that, comprises the steps:
(1) water intaking 30L adds poplar flower extract 5kg, is stirred to whole dissolvings; Add polygynax 4～15kg stirring and dissolving afterwards again; Wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug in whole;
(2) water intaking 40L adds sodium salicylate 6～20kg, Mequindox 3～10kg, stirring and dissolving;
(3) solution of combining step step (1) and step (2), moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly processes the oral liquid that is used to treat the enteritis that avian escherichia coli causes after clear and bright.
The preferable of wherein every 100L oral liquid consists of: poplar flower extract 5kg, Mequindox 4～7kg, and polygynax 6～12kg, sodium salicylate 8～14kg, surplus is a water.
The best group of every 100L oral liquid becomes: poplar flower extract 5kg, Mequindox 5kg, and polygynax 8kg, sodium salicylate 10kg, surplus is a water.
Wherein, institute's water preferably adopts purified water.The purity of above-mentioned used poplar flower extract is: the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug in whole.
The present invention has following technique effect:
The present invention is for adopting the compound preparation of Integrative Chinese-Western, and flower of poplar, polygynax, Mequindox have multiple antibacterial effect.Flower of poplar has the function of removing dampness dysentery relieving, and is effective to enteritis; Mequindox and polygynax share has synergism, can effectively resist escherichia coli, and can significantly reduce colibacillary drug resistance; Sodium salicylate has anti-inflammatory properties.All medicines share, and the enteritis that the treatment avian escherichia coli causes has the effect that treating both the principal and secondary aspects of a disease is arranged, and can improve cure rate, to the raiser a kind of medicine fast and easily is provided, and avoids causing raiser's economic loss.
The method for preparing technology of the oral liquid that is used to treat the enteritis that avian escherichia coli causes of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Poplar flower extract among the following embodiment adopts the conventional method of announcing in the pharmacopeia to extract and obtains, and its purity is: the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug in whole.
Embodiment 1
(1) water intaking 30L adds poplar flower extract 5kg, is stirred to whole dissolvings; Add polygynax 4kg stirring and dissolving afterwards again.
(2) water intaking 40L adds sodium salicylate 20kg, Mequindox 10kg, stirring and dissolving.
(3) solution of combining step step (1) and step (2), moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly processes the oral liquid that is used to treat the enteritis that avian escherichia coli causes after clear and bright.
Embodiment 2
(1) water intaking 30L adds poplar flower extract 5kg, is stirred to whole dissolvings; Add polygynax 15kg stirring and dissolving afterwards again.
(2) water intaking 40L adds sodium salicylate 6kg, Mequindox 3kg, stirring and dissolving.
(3) solution of combining step step (1) and step (2), moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly processes the oral liquid that is used to treat the enteritis that avian escherichia coli causes after clear and bright.
Embodiment 3
(1) water intaking 30L adds poplar flower extract 5kg, is stirred to whole dissolvings; Add polygynax 12kg stirring and dissolving afterwards again.
(2) water intaking 40L adds sodium salicylate 8kg, Mequindox 4kg, stirring and dissolving.
(3) solution of combining step step (1) and step (2), moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly processes the oral liquid that is used to treat the enteritis that avian escherichia coli causes after clear and bright.
Embodiment 4
(1) water intaking 30L adds poplar flower extract 5kg, is stirred to whole dissolvings; Add polygynax 6kg stirring and dissolving afterwards again.
(2) water intaking 40L adds sodium salicylate 8kg, Mequindox 4kg, stirring and dissolving;
(3) solution of combining step step (1) and step (2), moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly processes the oral liquid that is used to treat the enteritis that avian escherichia coli causes after clear and bright.
Embodiment 5
(1) water intaking 30L adds poplar flower extract 5kg, is stirred to whole dissolvings; Add polygynax 7kg stirring and dissolving afterwards again.
(2) water intaking 40L adds sodium salicylate 12kg, Mequindox 6kg, stirring and dissolving;
(3) solution of combining step step (1) and step (2), moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly processes the oral liquid that is used to treat the enteritis that avian escherichia coli causes after clear and bright.
Embodiment 6
(1) water intaking 30L adds poplar flower extract 5kg, is stirred to whole dissolvings; Add polygynax 8kg stirring and dissolving afterwards again.
(2) water intaking 40L adds sodium salicylate 10kg, Mequindox 5kg, stirring and dissolving;
(3) solution of combining step step (1) and step (2), moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly processes the oral liquid that is used to treat the enteritis that avian escherichia coli causes after clear and bright.
Oral liquid of the present invention can be used for poultry such as chicken, duck, goose.Below to be example with the chicken carry out clinical trial to the oral liquid that is used to treat the enteritis that avian escherichia coli causes of the present invention.
1. laboratory animal:
1000 of the ill chickens of picked at random, average every 1kg.
2. experiment medicine
The oral liquid our unit development that is used to treat the microbial enteritis of avian Escherichia coli of the embodiment of the invention 6 preparations;
5% Mequindox oral liquid our unit prepared in laboratory;
8% neomycin sulfate oral solution our unit prepared in laboratory.
3. experimental technique:
1000 ill chickens are divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 5% Mequindox oral liquid: drinking-water, every 1L water 1ml, one day 2 times, logotype 5 days.
The C group is treated usage with 8% neomycin sulfate oral solution: drinking-water, every 1L water 1ml, one day 2 times, logotype 5 days.
D group is treated usage with the oral liquid that is used to treat the microbial enteritis of avian Escherichia coli of the embodiment of the invention 6 preparations: drink water every 1L water 1ml, one day 2 times, logotype 5 days.
After the treatment beginning, write down ill chicken health situation of change and dead animal every day and distribute, treat and add up therapeutic effect after 7 days, wherein:
Invalid: after referring to 7 days, ill chicken symptom does not have obvious change, still keeps the preceding symptom of treatment.
Effectively: after referring to 7 days, ill chicken symptom changes, the effect before symptom is superior to treating.
Cure: after referring to 7 days, transference cure, ill chicken gets well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, ill chicken still has certain symptom, and its symptom performance is superior to before the treatment or does not have change, and ill chicken is not cured.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1.
4. conclusion:
Through statistical analysis, oral liquid treatment group, 5% Mequindox oral liquid treatment group and 8% neomycin sulfate oral solution group and the matched group difference that the embodiment of the invention 6 is used to treat the enteritis that avian escherichia coli causes is (P＜0.01) extremely significantly from the result of the test of table 1.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
Claims (4)
1. oral liquid that is used to treat the enteritis that avian escherichia coli causes; It is characterized in that the consisting of of every 100L oral liquid: poplar flower extract 5kg, Mequindox 3～10kg, polygynax 4～15kg; Sodium salicylate 6～20kg; Surplus is a water, and wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug in whole.
2. the oral liquid that is used to treat the enteritis that avian escherichia coli causes according to claim 1; It is characterized in that the consisting of of every 100L oral liquid: poplar flower extract 5kg, Mequindox 4～7kg, polygynax 6～12kg; Sodium salicylate 8～14kg, surplus is a water; Wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug in whole.
3. the oral liquid that is used to treat the enteritis that avian escherichia coli causes according to claim 1 is characterized in that, the consisting of of every 100L oral liquid: poplar flower extract 5kg, Mequindox 5kg, and polygynax 8kg, sodium salicylate 10kg, surplus is a water; Wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug in whole.
4. the described method for preparing that is used to treat the oral liquid of the enteritis that avian escherichia coli causes of a claim 1 is characterized in that, comprises the steps:
(1) water intaking 30L adds poplar flower extract 5kg, is stirred to whole dissolvings; Add polygynax 4～15kg stirring and dissolving afterwards again; Wherein, the 1g poplar flower extract is equivalent to 20g flower of poplar crude drug in whole;
(2) water intaking 40L adds sodium salicylate 6～20kg, Mequindox 3～10kg, stirring and dissolving;
(3) solution of combining step step (1) and step (2), moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly processes the oral liquid that is used to treat the enteritis that avian escherichia coli causes after clear and bright.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110188039A CN102319253A (en) | 2011-07-06 | 2011-07-06 | Oral liquid for treating enteritis caused by avian escherichia coli and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110188039A CN102319253A (en) | 2011-07-06 | 2011-07-06 | Oral liquid for treating enteritis caused by avian escherichia coli and preparation method thereof |
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| CN102319253A true CN102319253A (en) | 2012-01-18 |
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| CN201110188039A Pending CN102319253A (en) | 2011-07-06 | 2011-07-06 | Oral liquid for treating enteritis caused by avian escherichia coli and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973702A (en) * | 2012-08-23 | 2013-03-20 | 郑州后羿制药有限公司 | Piglet yellow and white scour treatment compound traditional Chinese medicine composition and preparation method thereof |
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2011
- 2011-07-06 CN CN201110188039A patent/CN102319253A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973702A (en) * | 2012-08-23 | 2013-03-20 | 郑州后羿制药有限公司 | Piglet yellow and white scour treatment compound traditional Chinese medicine composition and preparation method thereof |
| CN102973702B (en) * | 2012-08-23 | 2014-12-17 | 郑州后羿制药有限公司 | Piglet yellow and white scour treatment compound traditional Chinese medicine composition and preparation method thereof |
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Application publication date: 20120118 |