CN103040848B - Medicinal composition for treating and preventing chicken proventriculitis and preparation method thereof - Google Patents
Medicinal composition for treating and preventing chicken proventriculitis and preparation method thereof Download PDFInfo
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- CN103040848B CN103040848B CN201110310168.9A CN201110310168A CN103040848B CN 103040848 B CN103040848 B CN 103040848B CN 201110310168 A CN201110310168 A CN 201110310168A CN 103040848 B CN103040848 B CN 103040848B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
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Abstract
The invention provides a medicinal composition for treating and preventing chicken proventriculitis, as well as a preparation method and application thereof in treating and preventing chicken proventriculitis. The medicinal composition consists of the following components in parts by weight: 5 to 25 parts of cimetidine, 5 to 15 parts of butafosfan, and the balance of vector. Therefore, the invention provides the medicinal composition for quickly treating chicken proventriculitis to the poultry cultivation industry, the death rate of chicken infected by proventriculitis in late-stage can be effectively reduced, the disease symptom can be quickly relieved, and the food consumption can be increased. The medicinal composition has a good treatment effect on chicken in late stage of attack, can be used for preventing relapse after drug withdrawal, so that the defect that an existing vaccine and other preventing and treating medicaments cannot be used for effectively treating late-stage infection of chicken proventriculitis can be overcome, and the loss of breeding industry brought by the diseases can be reduced.
Description
Technical field
The present invention relates to pharmaceutical composition of a kind for the treatment of and prevention chicken glandular stomach disease and preparation method thereof, refer to especially a kind of pharmaceutical composition containing cimetidine and butafosfan and preparation method thereof.
Background technology
Current, clinically taking glandular stomach enlargement, glandular stomach ulcer of nipple etc. as the chicken glandular stomach disease of principal character very general, research shows, causes this sick cause of disease may be: proventricular type infectious bronchitis virus, fowl arc reovirus virus or avian reticuloendotheliosis virus.Primary disease have a multiple inducement, excessive and the various stressors of bad feeding and management condition, stocking density all can increase the weight of the state of an illness, and primary disease is often and mixes or secondary infection with the disease such as escherichia coli, cholera, coccidiosis, blackhead, newcastle and chronic respiratory tract disease.This disease course of disease is longer, can reach about 20～60d, and morbidity age in days is less, and chicken group sickness rate, mortality rate are higher, the autumn in summer young bird higher than young sickness rate of spring.This disease has been brought sizable harm to aquaculture, infect later stage chicken group and occur that size is uneven, grow uneven phenomenon, morbidity chicken feed intake obviously declines, body weight is only 1/3 or 1/2 of healthy chicken, and this disease is mainly prevented and treated by injection glandular stomach inactivated vaccine at present, but this medicine onset is slower, therapeutic effect to infection later stage chicken group is poor, and after drug withdrawal, the state of an illness easily recurs.Therefore, provide a kind of rapid-action, effective to later stage treatment of infection, and prevent from the medicine of the treatment chicken glandular stomach disease of recurrence from becoming one of these those skilled in the art problem anxious to be resolved.
Summary of the invention
In view of this, main purpose of the present invention is to provide the pharmaceutical composition of a kind for the treatment of and prevention chicken glandular stomach disease, composed of the following components: cimetidine 5～25 weight portions, butafosfan 5～15 weight portions, surplus are carrier.
Preferably, pharmaceutical composition of the present invention, composed of the following components: cimetidine 15 weight portions, butafosfan 10 weight portions, surplus are carrier.
Preferably, carrier of the present invention is one or more of anhydrous glucose, sodium chloride or anhydrous sodium sulfate.
The preparation method that another object of the present invention is to the pharmaceutical composition that a kind for the treatment of and prevention chicken glandular stomach disease are provided, is made up of following steps:
1) by weight 5～25 parts take cimetidine, 5～15 parts take butafosfan, mix homogeneously by weight;
2) take by weight wherein a kind of carrier of anhydrous glucose, sodium chloride or anhydrous sodium sulfate, add to 100 parts, with above-mentioned steps 1) obtain compositions mix homogeneously and get final product.
Preferably, the preparation method of pharmaceutical composition of the present invention, is characterized in that, is made up of following steps:
1) by weight 15 parts take cimetidine, 10 parts take butafosfan, mix homogeneously by weight;
2) take by weight wherein a kind of carrier of anhydrous glucose, sodium chloride or anhydrous sodium sulfate, add to 100 parts, with above-mentioned steps 1) obtain compositions mix homogeneously and get final product.
The present invention also provides the purposes of a kind of pharmaceutical composition of the present invention in treatment and prevention chicken glandular stomach disease.
Preferably, pharmaceutical composition of the present invention is by mouth enteral administration.
As seen from the above, the present invention provides a kind of pharmaceutical composition of rapid, effective treatment chicken glandular stomach disease for cultivating industry, pharmaceutical composition of the present invention can reduce the sick later stage chicken group's of infection of glandular stomach mortality rate, alleviate rapidly disease symptoms and increase feed intake, chicken group to the morbidity later stage has good therapeutical effect, and no longer recurrence after drug withdrawal, makes up existing vaccine and other control medicines and can not effectively treat the chicken glandular stomach deficiency of phase infection after being ill, reduces the loss that this disease is brought aquaculture.
Detailed description of the invention
For making the present invention easier to understand, below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment are only not used in and limit the scope of the invention for the present invention is described, in the following example, NM specific experiment method, carries out according to normal experiment method conventionally.
Embodiment 1 treats and prevents pharmaceutical composition of chicken glandular stomach disease and preparation method thereof
In the present embodiment, the pharmaceutical composition for the treatment of and prevention chicken glandular stomach disease is prepared as follows:
(1) by weight when 1g (every part for) takes cimetidine (purchased from Shijiazhuang Puli pharmaceutical Co. Ltd, content 99.0%) 5g, take by weight butafosfan (purchased from Hangzhou Foster Pharmaceutical, content 99.5%) 5g, mix homogeneously;
(2) take by weight anhydrous glucose 90g, mix homogeneously and get final product with above-mentioned (1) component.
Embodiment 2 treats and prevents pharmaceutical composition of chicken glandular stomach disease and preparation method thereof
In the present embodiment, the pharmaceutical composition for the treatment of and prevention chicken glandular stomach disease is prepared as follows:
(1) by weight when 1g (every part for) takes cimetidine (purchased from Shijiazhuang Puli pharmaceutical Co. Ltd, content 99.0%) 25g, take by weight butafosfan (purchased from Hangzhou Foster Pharmaceutical, content 99.5%) 15g, mix homogeneously;
(2) take by weight anhydrous sodium sulfate 60g, mix homogeneously and get final product with above-mentioned (1) component.
Embodiment 3 treats and prevents pharmaceutical composition of chicken glandular stomach disease and preparation method thereof
In the present embodiment, the pharmaceutical composition for the treatment of and prevention chicken glandular stomach disease is prepared as follows:
(1) by weight when 1g (every part for) takes cimetidine (purchased from Shijiazhuang Puli pharmaceutical Co. Ltd, content 99.0%) 15g, take by weight butafosfan (purchased from Hangzhou Foster Pharmaceutical, content 99.5%) 10g, mix homogeneously;
(2) take by weight sodium chloride 75g, mix homogeneously and get final product with above-mentioned (1) component.
Embodiment 4 treats and prevents pharmaceutical composition of chicken glandular stomach disease and preparation method thereof
In the present embodiment, the pharmaceutical composition for the treatment of and prevention chicken glandular stomach disease is prepared as follows:
(1) by weight when 1g (every part for) takes cimetidine (purchased from Shijiazhuang Puli pharmaceutical Co. Ltd, content 99.0%) 5g, take by weight butafosfan (purchased from Hangzhou Foster Pharmaceutical, content 99.5%) 15g, mix homogeneously;
(2) take by weight anhydrous glucose 80g, mix homogeneously and get final product with above-mentioned (1) component.
Embodiment 5 treats and prevents pharmaceutical composition of chicken glandular stomach disease and preparation method thereof
In the present embodiment, the pharmaceutical composition for the treatment of and prevention chicken glandular stomach disease is prepared as follows:
(1) by weight when 1g (every part for) takes cimetidine (purchased from Shijiazhuang Puli pharmaceutical Co. Ltd, content 99.0%) 25g, take by weight butafosfan (purchased from Hangzhou Foster Pharmaceutical, content 99.5%) 5g, mix homogeneously;
(2) take by weight anhydrous sodium sulfate 70g, mix homogeneously and get final product with above-mentioned (1) component.
The clinical practice of embodiment 6 pharmaceutical compositions of the present invention
1. incidence:
4530 of Luo Man laying hens, points of 3 hen houses are raised (A, B and C), 1510, every hen house, occurs that part chicken spirit is depressed, drop-head vertical fin while raising to 28 age in days, feather is fluffy and disorderly reduces phenomenon with feed intake, their early stage does not draw attention, and does not also treat, and occurs subsequently disease chicken growth retardation and stagnation behavior, raise to 35 only 160g～200g of age in days seasonal disease chicken body weight, and have chicken death condition.
2. clinical symptoms:
Originally sick chicken spirit is depressed, drop-head vertical fin, and wing is sagging, and feather is fluffy and disorderly not whole, later stage sick chicken minimizings of searching for food, growth retardation or stagnation, chicken body is pale, skeletonize, body weight is only 50% left and right of normal chicken body weight, arranges yellow green or green loose stool.
3. pathological change:
Cut open the visible glandular stomach enlargement of inspection as ball, be creamy white, glandular stomach wall edema is turned up, and finger pressure can flow out serosity liquid, and glandular stomach mucosal erosion is hemorrhage, and glandular stomach nipple is outstanding, profile is unclear, mucosal bleeding and ulcer.Muscular stomach atrophy, the serious atrophy of thymus, spleen and fabricius bursa.Intestinal is without food but be full of water liquid, intestinal wall attenuation, and like transparence, intestinal has hemorrhagic inflammation in various degree.According to clinical symptoms with cut open inspection pathological changes situation, and describe symptom contrast with documents and materials " avian infectious glandular stomach disease " (Chen Dehua, Chinese veterinary's magazine, 05 phase in 1999), diagnosis primary disease is chicken glandular stomach disease.
4. Drug therapy situation:
A hen house in feedstuff by the 0.1% weight batch mixing pharmaceutical composition of the present invention that embodiment 3 makes of throwing something and feeding; B hen house in feedstuff by the 0.015% weight batch mixing cimetidine (purchased from Shijiazhuang Puli pharmaceutical Co. Ltd) of throwing something and feeding; C hen house in feedstuff by the 0.01% weight batch mixing butafosfan (purchased from Hangzhou Foster Pharmaceutical) of throwing something and feeding.
A, B, each hen house of C are admixed test drug in material in proportion, and free choice feeding during whole treatment, freely drinks water, and does well every day to clean.During treatment, observe each hen house chicken group state, record the dead quantity of chicken and feed intake.
The grouping of table 1. experimental animal and drug dose
5. result of the test:
The dead quantity of each group chicken accumulative total during table 2. treatment
The average feed intake of each group chicken during table 3. treatment
Result shows: respectively organize after medication treatment, through X 2 test, A the hen house chicken cumulative mortality of 10 days is significantly less than B, a C hen house (P < 0.05), and feed intake is apparently higher than B, a C hen house.After medication 10 days, A the hen house chicken group mental status is good, and feed intake is recovered normal level substantially; Though B, C hen house chicken group mental status makes moderate progress before treating, indivedual sick chickens are still spiritual depressed, and feed intake is still starkly lower than the normal chicken of this age in days level of on average searching for food.Above result shows that medicine of the present invention can effectively treat chicken glandular stomach disease, and the effect using separately with respect to cimetidine or butafosfan is more obvious.After A hen house disease cured, start to lay eggs to chicken and do not infect again glandular stomach disease.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (7)
1. a pharmaceutical composition for treatment and prevention chicken glandular stomach disease, is characterized in that, composed of the following components: cimetidine 5～25 weight portions, butafosfan 5～15 weight portions, surplus are carrier.
2. pharmaceutical composition according to claim 1, is characterized in that, composed of the following components: cimetidine 15 weight portions, butafosfan 10 weight portions, surplus are carrier.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that, described carrier is one or more of anhydrous glucose, sodium chloride or anhydrous sodium sulfate.
4. a preparation method for the pharmaceutical composition for the treatment of and prevention chicken glandular stomach disease, is characterized in that, is made up of following steps:
1) by weight 5～25 parts take cimetidine, 5～15 parts take butafosfan, mix homogeneously by weight;
2) take by weight wherein a kind of carrier of anhydrous glucose, sodium chloride or anhydrous sodium sulfate, add to 100 parts, with above-mentioned steps 1) obtain compositions mix homogeneously and get final product.
5. the preparation method of pharmaceutical composition according to claim 4, is characterized in that, is made up of following steps:
1) by weight 15 parts take cimetidine, 10 parts take butafosfan, mix homogeneously by weight;
2) take by weight wherein a kind of carrier of anhydrous glucose, sodium chloride or anhydrous sodium sulfate, add to 100 parts, with above-mentioned steps 1) obtain compositions mix homogeneously and get final product.
6. the purposes in the medicine of preparation treatment and prevention chicken glandular stomach disease according to the pharmaceutical composition described in claim 1-3 any one.
7. purposes according to claim 6, is characterized in that, described pharmaceutical composition is per os enteral administration.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110310168.9A CN103040848B (en) | 2011-10-13 | 2011-10-13 | Medicinal composition for treating and preventing chicken proventriculitis and preparation method thereof |
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| CN201110310168.9A CN103040848B (en) | 2011-10-13 | 2011-10-13 | Medicinal composition for treating and preventing chicken proventriculitis and preparation method thereof |
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| CN103040848B true CN103040848B (en) | 2014-06-18 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647883A (en) * | 2009-09-17 | 2010-02-17 | 天津市慧瑞动物药业有限公司 | Chinese-Western compound preparation for treating infective proventriculitis of chicken and preparation method thereof |
| CN101966178A (en) * | 2010-07-26 | 2011-02-09 | 天津生机集团股份有限公司 | Composition for treating chicken proventriculitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647883A (en) * | 2009-09-17 | 2010-02-17 | 天津市慧瑞动物药业有限公司 | Chinese-Western compound preparation for treating infective proventriculitis of chicken and preparation method thereof |
| CN101966178A (en) * | 2010-07-26 | 2011-02-09 | 天津生机集团股份有限公司 | Composition for treating chicken proventriculitis and preparation method thereof |
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