CN113854434A - Composition and application thereof in improving egg-laying poultry production performance - Google Patents
Composition and application thereof in improving egg-laying poultry production performance Download PDFInfo
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- CN113854434A CN113854434A CN202111144553.0A CN202111144553A CN113854434A CN 113854434 A CN113854434 A CN 113854434A CN 202111144553 A CN202111144553 A CN 202111144553A CN 113854434 A CN113854434 A CN 113854434A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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Abstract
The invention relates to the field of animal science, in particular to a composition and application thereof in improving the production performance of laying poultry. The composition comprises isochlorogenic acid, flavonoid glycoside and terpenoid glycoside, and can effectively improve the production performance of laying fowls, improve the quality of eggs, reduce the occurrence frequency of inferior eggs such as eggshells, blood eggs and eggshells, improve the health condition (especially including intestinal health) of the laying fowls and improve the economic benefit of breeding. Meanwhile, the composition is pure natural, has no toxic or side effect, and cannot cause the problems of flora imbalance, drug resistance enhancement, drug residue and the like. Therefore, the composition has a good application prospect in improving the production performance of the laying fowl.
Description
Technical Field
The invention relates to the field of animal science, in particular to a composition and application thereof in improving the production performance of laying poultry.
Background
With the development of modern egg-laying poultry intensive cultivation, the egg-laying poultry production performance becomes a constantly concerned problem for farmers and operators, and the high-density and high-intensity production enables the egg-laying poultry to be in a high-stress sensitive state, so that the immunity of the egg-laying poultry is reduced, the gastrointestinal tract digestion and absorption capacity is reduced, the egg-laying poultry production performance is clinically shown as reduced egg production rate, reduced egg quality, thin-shell eggs, spotted eggs, eggshell eggs and the like, and great economic loss is caused to the egg breeding industry.
The quality requirements of contemporary people on egg products are continuously improved, while the traditional antibiotics can improve the growth and immune functions of egg-laying poultry and improve the egg quality, but the excessive use of the antibiotics in the egg-laying poultry breeding industry brings about a plurality of side effects, such as the problems of flora imbalance, drug resistance enhancement, drug residue and the like, and even harms the health of livestock bodies and human beings. Therefore, the development of more novel safe and nontoxic medicines or feed additives which can effectively improve the production performance of laying fowls is urgently needed.
In CN113057260A, a feed additive for enhancing the anti-stress ability of breeding ducks in the egg producing period and a preparation method thereof are also disclosed, and the feed additive is specifically mentioned to comprise the following raw materials in percentage by weight: 3-5 parts of isochlorogenic acid, 1-3 parts of tributyrin, 2-4 parts of acetyl glucosamine benzoate and 6-9 parts of puffed chickpea powder. The additive is added into feed for breeding ducks, so that the body constitution, the resistance, the adaptability to external factor changes such as material change, illumination increase and the like of the breeding ducks and the anti-stress capability after egg laying can be effectively enhanced, and the overall duck breeding economic benefit is improved. However, the additive has no obvious effect on improving the production performance and intestinal health of the laying poultry, and particularly, the additive cannot effectively improve the quality of eggs and reduce bad eggs.
Disclosure of Invention
The invention aims to provide a safe, non-toxic and purely natural composition and application thereof in improving the production performance of laying poultry.
In order to achieve the purpose, the technical scheme of the invention is as follows:
the present invention provides a composition comprising:
a first component which is isochlorogenic acid; and
a second component which is a mixture of flavonoid glycosides and terpenoid glycosides;
wherein the mass ratio of the first component to the second component is (2-5): 1;
the mass ratio of the flavonoid glycoside to the terpenoid glycoside is (1-4): 1.
the invention unexpectedly discovers that when the isochlorogenic acid is compounded with the mixture of the flavonoid glycoside and the terpenoid glycoside in the proportion, the synergistic effect is achieved, and the production performance of the laying fowl can be obviously improved.
Preferably, the mass ratio of the first component to the second component is (3-5): 1.
preferably, the mass ratio of the flavonoid glycoside to the terpenoid glycoside is (2-4): 1.
preferably, the composition has a better effect in improving the egg laying performance of laying fowls when the proportion of the first component is more than 50 wt.%, more preferably more than 70 wt.%, and even more preferably more than 80 wt.%, based on the total mass of the composition.
Preferably, the composition comprises the following components in parts by weight: 50-80 parts of isochlorogenic acid, 5-20 parts of flavonoid glycoside and 5-20 parts of terpenoid glycoside.
More preferably, the composition comprises the following components in parts by weight: 55-80 parts of isochlorogenic acid, 10-15 parts of flavonoid glycoside and 5-10 parts of terpenoid glycoside.
As a preferred embodiment, the composition comprises the following components in parts by weight: 80 parts of isochlorogenic acid, 15 parts of flavonoid glycoside and 5 parts of terpenoid glycoside.
Preferably, the isochlorogenic acid is selected from one or more of isochlorogenic acid A, isochlorogenic acid B and isochlorogenic acid C; more preferably, the isochlorogenic acid is prepared from (1-3) by mass: 1 of a mixture of isochlorogenic acid a and isochlorogenic acid C; further preferably, the isochlorogenic acid is prepared from the following components in a mass ratio of 2: 1 of iso-chlorogenic acid a and iso-chlorogenic acid C.
Preferably, the flavonoid glycoside is selected from one or more of flavonoids, flavonol compounds and isoflavonoids; more preferably, the flavonoid glycoside is prepared from (4-6) by mass: 1, wherein the flavonoids and the flavonols are both extracted from stevia rebaudiana; further preferably, the flavonoid glycoside is prepared from the following raw materials in a mass ratio of 5: 1 of flavonoids and flavonols.
In the present invention, the flavonoid and flavonol compounds are extracted from stevia rebaudiana Bertoni by conventional extraction methods, and the specific extraction method can be confirmed by those skilled in the art according to common knowledge.
Preferably, the terpenoid glycoside is stevioside.
The present invention also finds that when the specific selection of isochlorogenic acid, flavonoid glycoside and terpenoid glycoside is as defined above, the synergistic effect of the composition in enhancing egg laying performance and improving the intestinal health of laying fowl is further improved.
The invention also provides the use of the composition as described above in any of the following aspects:
(1) the application in improving the egg laying performance of the laying poultry;
(2) the application in improving the intestinal health of the laying fowl;
(3) the application of the feed additive, the animal feed or the medicine in preparing the feed additive, the animal feed or the medicine is used for improving the egg laying performance of laying poultry and/or improving the intestinal health of the laying poultry.
The specific expression of "improving the egg laying performance of laying poultry" referred to in the invention includes: improve the quality of eggs and reduce the frequency of inferior eggs (such as eggshells, blood eggs, thin eggshells and the like).
Preferably, the composition is administered to the laying fowl by the oral route.
For example, in a preferred embodiment, the composition is administered to the laying fowl by means of a dressing or drinking water.
Preferably, when the composition is administered for 7 ± 2 days, more preferably for 7 days, in a feeding cycle during the laying period of laying hens, it is more advantageous for the composition to exert its effect in improving the laying performance of the laying hens.
Preferably, the egg-laying period is a pre-egg-laying period or a post-egg-laying period.
Preferably, the feeding period is 2-3 months.
Preferably, the addition amount of the composition is 100-400mg/kg in every 1kg of the laying bird feed; preferably 100-300mg/kg, more preferably 200 +/-50 mg/kg, can obviously improve the intestinal health of the laying fowl.
The laying fowl mentioned in the invention is preferably laying hen or laying duck.
Furthermore, the invention also provides a medicine which contains the composition and pharmaceutically acceptable auxiliary components thereof.
Further, the invention also provides a feed or feed additive which contains the composition.
Preferably, the addition amount of the composition in the feed is 400mg/kg of 100-.
Based on the technical scheme, the invention has the following beneficial effects:
the composition can effectively improve the production performance of the laying poultry, improve the egg quality, reduce the occurrence frequency of inferior eggs such as eggshells, blood eggs, thin eggshells and the like, improve the health condition (particularly including intestinal health) of the laying poultry and improve the economic benefit of cultivation. Meanwhile, the composition is pure natural, has no toxic or side effect, and cannot cause the problems of flora imbalance, drug resistance enhancement, drug residue and the like. Therefore, the composition has a good application prospect in improving the production performance of the laying fowl.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
In order to facilitate the comparison effect, the isochlorogenic acid mentioned in the following examples is 2 by mass: 1 of a mixture of isochlorogenic acid A and isochlorogenic acid C, wherein the flavonoid glycosides are all mixed according to a mass ratio of 5: 1 (both flavonoids and flavonols are extracted from stevia rebaudiana by a conventional extraction method), and the terpenoid glycosides are stevioside (purchased from a commercial source), and the effects of the invention can be achieved as long as the used components are within the range defined by the content of the invention.
In order to facilitate the comparison effect, the same general ration is used in the following examples, and the specific formula is shown in table 1 below.
TABLE 1 basic diet formula and nutritional ingredients
The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or instruments used are conventional products available from regular distributors, not indicated by the manufacturer.
Example 1
The embodiment provides a composition, which is composed of the following components in parts by weight: 80 parts of isochlorogenic acid, 15 parts of flavonoid glycoside and 5 parts of terpenoid glycoside.
The embodiment further provides a feed which comprises common daily ration and the composition, wherein the composition accounts for 0.01 percent of the total mass of the feed. During preparation, the composition is added into feed and mixed evenly to obtain the feed.
Example 2
This example provides a feed comprising a normal ration and the composition of example 1, wherein the composition comprises 0.02% of the total mass of the feed. During preparation, the composition is added into feed and mixed evenly to obtain the feed.
Example 3
This example provides a feed comprising a normal ration and the composition of example 1, wherein the composition comprises 0.04% of the total mass of the feed. During preparation, the composition is added into feed and mixed evenly to obtain the feed.
Example 4
The embodiment provides a composition, which is composed of the following components in parts by weight: 50 parts of isochlorogenic acid, 5 parts of flavonoid glycoside and 5 parts of terpenoid glycoside.
The embodiment further provides a feed which comprises common daily ration and the composition, wherein the composition accounts for 0.02% of the total mass of the feed. During preparation, the composition is added into feed and mixed evenly to obtain the feed.
Example 5
The embodiment provides a composition, which is composed of the following components in parts by weight: 80 parts of isochlorogenic acid, 20 parts of flavonoid glycoside and 20 parts of terpenoid glycoside.
The embodiment further provides a feed which comprises common daily ration and the composition, wherein the composition accounts for 0.02% of the total mass of the feed. During preparation, the composition is added into feed and mixed evenly to obtain the feed.
Example 6
The embodiment provides a composition, which is composed of the following components in parts by weight: 80 parts of isochlorogenic acid, 20 parts of flavonoid glycoside and 5 parts of terpenoid glycoside.
The embodiment further provides a feed which comprises common daily ration and the composition, wherein the composition accounts for 0.02% of the total mass of the feed. During preparation, the composition is added into feed and mixed evenly to obtain the feed.
Comparative example 1
This comparative example provides a feed which differs from example 2 only in that the flavonoid glycoside is replaced by an equal amount of terpenoid glycoside in the composition.
Comparative example 2
The present comparative example provides a feed which differs from example 2 only in that the formulation of the composition is different, and the composition of the present comparative example consists of the following components in parts by weight: 30 parts of isochlorogenic acid, 30 parts of flavonoid glycoside and 40 parts of terpenoid glycoside.
Test examples the effect of the composition of the present invention on the prevention and treatment of diseases of laying fowl
1 materials and methods
1.1 test drugs
The feed in the examples was a normal ration.
1.2 test animals
The test chicken flock is 840 feathers of 480-day-old Hailan brown laying hens, which are averagely divided into 7 groups, the groups of the examples 1 to 6 are sequentially fed with the feed of the examples 1 to 6 respectively, the control group is fed with common ration, other epidemic prevention measures are not taken, and other feeding environments are consistent. The test period was 7 days.
1.3 statistical determination of indices
Production index
During the test period, the daily egg number, egg weight, number of stored eggs and number of bad eggs (sand shell eggs, blood eggs and shell-broken eggs) of each group of laying hens are recorded every day, and the egg laying rate, average egg weight, death rate, bad egg rate and the like of the laying hens are counted.
② egg quality
During the test period, 20 eggs are randomly extracted from each group from the 0 th day and the 7 th day respectively, the thickness of the eggshell is measured on the big end, the small end and the middle part of the eggshell by a micrometer, and the average value is obtained.
1.4 calculation method
Laying rate is 100% per egg laying number/chicken;
average egg weight is the total weight of eggs laid per day/number of eggs laid per day;
bad egg rate is 100% per total egg per day;
the eggshell egg rate is 100% of eggshell egg number/total egg number per day;
the blood egg rate is 100% per total number of eggs per day;
the shell-breaking egg rate is the number of shell-breaking eggs/total number of eggs per day 100%;
the mortality rate is 100% of the total number of dead chicks in the test period.
2 results of the test
TABLE 2 comparison of laying hen productivity and eggshell thickness
TABLE 3 Effect of feed additives on Husky eggs
| Group of | Before treatment (%) | After treatment (%) |
| EXAMPLE 1 group | 62.39 | 23.85 |
| EXAMPLE 2 group | 62.73 | 20.91 |
| EXAMPLE 3 group | 62.96 | 23.15 |
| EXAMPLE 4 group | 61.47 | 22.02 |
| EXAMPLE 5 group | 62.96 | 24.07 |
| EXAMPLE 6 group | 63.64 | 20.91 |
| Control group | 63.30 | 63.30 |
TABLE 4 Effect of feed additives on blood eggs
| Group of | Before treatment (%) | After treatment (%) |
| EXAMPLE 1 group | 6.42 | 3.67 |
| EXAMPLE 2 group | 7.27 | 1.82 |
| EXAMPLE 3 group | 7.41 | 2.78 |
| EXAMPLE 4 group | 8.26 | 2.75 |
| EXAMPLE 5 group | 7.41 | 3.70 |
| EXAMPLE 6 group | 6.36 | 1.82 |
| Control group | 7.34 | 7.34 |
TABLE 5 Effect of feed additives on shell-broken eggs
As can be seen from tables 2, 3, 4 and 5, compared with the control group, the production performance of the laying hens in each example group is improved, the egg quality is obviously improved, and the composition provided by the invention can improve the production performance of the laying hens and improve the egg quality, and has no negative influence on the laying rate.
Meanwhile, the effect of the feed in the comparative example is verified by referring to the method, and the result shows that the effect test data of the feed in each embodiment has more outstanding advantages compared with the comparative example.
The results show that the feed added with the composition can effectively improve the egg laying performance of laying poultry, improve the egg quality, reduce the number of sand shell eggs, blood eggs and thin shell eggs and improve the health condition of the laying poultry. The amount of the composition of the present invention added to the feed is preferably 200 mg/kg.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. A composition characterized in that it comprises:
a first component which is isochlorogenic acid; and
a second component which is a mixture of flavonoid glycosides and terpenoid glycosides;
wherein the mass ratio of the first component to the second component is (2-5): 1;
the mass ratio of the flavonoid glycoside to the terpenoid glycoside is (1-4): 1.
2. the composition according to claim 1, wherein the mass ratio of the first component to the second component is (3-5): 1; and/or
The mass ratio of the flavonoid glycoside to the terpenoid glycoside is (2-4): 1;
the proportion of the first component is preferably 50 wt.% or more, more preferably 70 wt.% or more, and still more preferably 80 wt.% or more, based on the total mass of the composition.
3. Composition according to claim 1 or 2, characterized in that it comprises the following components in parts by weight: 50-80 parts of isochlorogenic acid, 5-20 parts of flavonoid glycoside and 5-20 parts of terpenoid glycoside;
preferably, the composition comprises the following components in parts by weight: 55-80 parts of isochlorogenic acid, 10-15 parts of flavonoid glycoside and 5-10 parts of terpenoid glycoside;
more preferably, the composition comprises the following components in parts by weight: 80 parts of isochlorogenic acid, 15 parts of flavonoid glycoside and 5 parts of terpenoid glycoside.
4. The composition of claim 1 or 2, wherein the isochlorogenic acid is selected from one or more of isochlorogenic acid A, isochlorogenic acid B, isochlorogenic acid C; preferably, the isochlorogenic acid is prepared from (1-3) by mass: 1 of a mixture of isochlorogenic acid a and isochlorogenic acid C;
and/or the flavonoid glycoside is selected from one or more of flavonoid compounds, flavonol compounds and isoflavone compounds; more preferably, the flavonoid glycoside is prepared from (4-6) by mass: 1, wherein the flavonoids and the flavonols are both extracted from stevia rebaudiana;
and/or the terpenoid glycoside is stevioside.
5. Use of the composition of any one of claims 1-4 in any one of:
(1) the application in improving the egg laying performance of the laying poultry;
(2) the use in the preparation of a feed additive, animal feed or medicament for use in improving the egg laying performance and/or improving the intestinal health of laying birds;
preferably, the laying poultry is laying hens or laying ducks.
6. The use according to claim 5, wherein the composition is administered to laying birds by the oral route;
the composition is preferably applied to the laying fowl by means of a dressing or drinking water.
7. The use according to claim 6, wherein the composition is administered to laying birds during the laying period according to a feeding cycle of 7 ± 2 days;
preferably, the egg-laying period is the egg-laying prophase or the egg-laying anaphase;
preferably the feeding period is 2-3 months.
8. The use according to claim 6 or 7, characterized in that the composition is added in an amount of 100-400mg/kg, preferably 100-300mg/kg, more preferably 200 ± 50mg/kg per 1kg of the layer feed.
9. A pharmaceutical product comprising a composition as claimed in any one of claims 1 to 4 together with pharmaceutically acceptable auxiliary ingredients.
10. A feed or feed additive, characterized in that it contains a composition according to any one of claims 1 to 4.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111144553.0A CN113854434A (en) | 2021-09-28 | 2021-09-28 | Composition and application thereof in improving egg-laying poultry production performance |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111144553.0A CN113854434A (en) | 2021-09-28 | 2021-09-28 | Composition and application thereof in improving egg-laying poultry production performance |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109265346A (en) * | 2018-09-30 | 2019-01-25 | 晨光生物科技集团股份有限公司 | The industrialized utilization method and its chlorogenic acid and steviol glycoside of a kind of STEVIA REBAUDIANA |
| CN109419833A (en) * | 2017-08-30 | 2019-03-05 | 石任兵 | A kind of antihypelipidemic active substance and its preparation and application |
| CN113057260A (en) * | 2021-03-22 | 2021-07-02 | 江苏中煤长江生物科技有限公司 | Feed additive for enhancing anti-stress capability of breeding ducks in egg producing period and preparation method thereof |
-
2021
- 2021-09-28 CN CN202111144553.0A patent/CN113854434A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109419833A (en) * | 2017-08-30 | 2019-03-05 | 石任兵 | A kind of antihypelipidemic active substance and its preparation and application |
| CN109265346A (en) * | 2018-09-30 | 2019-01-25 | 晨光生物科技集团股份有限公司 | The industrialized utilization method and its chlorogenic acid and steviol glycoside of a kind of STEVIA REBAUDIANA |
| CN113057260A (en) * | 2021-03-22 | 2021-07-02 | 江苏中煤长江生物科技有限公司 | Feed additive for enhancing anti-stress capability of breeding ducks in egg producing period and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 邱光忠等: ""甜叶菊提取物"对蛋鸡生产性能的影响" * |
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