CN102151278B - Use of 2-deoxy-D-glucose in prevention and treatment of viral diseases in livestock - Google Patents
Use of 2-deoxy-D-glucose in prevention and treatment of viral diseases in livestock Download PDFInfo
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- CN102151278B CN102151278B CN 200910303629 CN200910303629A CN102151278B CN 102151278 B CN102151278 B CN 102151278B CN 200910303629 CN200910303629 CN 200910303629 CN 200910303629 A CN200910303629 A CN 200910303629A CN 102151278 B CN102151278 B CN 102151278B
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Abstract
The invention discloses the use of 2-deoxy-D-glucose in prevention and treatment of viral diseases in livestock and relates to a method for preventing and treating livestock diseases, in particular to the use of 2-deoxy-D-glucose in the prevention and treatment of chicken infectious bursal disease, chicken newcastle disease and chicken infectious bronchitis. In the use, the 2-deoxy-D-glucose is applied into chicken through intramuscular injection or oral administration according to a ratio of 1.0 to 30 mg/Kg, and the prevention and treatment effect is observed. The medicine can relieve clinical symptoms of virus infection, promote sick livestock to have food, and has a treatment effective rate of over 75.5 percent for chicken infectious bronchitis and the like. The invention has the advantages that: (1) a medicine for preventing and treating viral diseases in livestock is developed for clinical medicine; (2) the medicine is free from toxic and side effects and can be used safely, the treatment effect of the medicine is exact, and the quality of the medicine is controllable; and (3) the medicine can be applied through intramuscular injection and oral administration and is insusceptible to arousing medicine resistance.
Description
Technical field
The present invention relates to a kind of method of preventing and treating poultry disease, particularly in control infectious bursal disease, Newcastle disease, the infectious bronchitis to the application of 2-deoxy-D-glucose.
Background technology
Infectious bursal disease, Newcastle disease, infectious bronchitis are three big main eqpidemic diseases of harm aviculture, in some more intensive areas of raising chickens, the own first place that replaces atypical newcastle disease and occupy infectious disease incidence is regardless of kind, laying hen, broiler, the assorted chicken of meat; No matter whether immunity, all might fall ill, these diseases cause the immunosuppressant of chickling, make the disease chicken to pathogen such as escherichia coli, adenovirus, Salmonella, chicken coccidiosis susceptible more, respond to inoculations such as horse Garrick vaccine, bursal disease vaccines descends, and therefore should disease cause huge harm to poultry husbandry.
In the recent period, numerous raisers generally react fowl disease be difficult to the control.The intractable respiratory tract disease that a variety of causes causes in the poultry breeding process now, mild influenza etc. cause chicken mortality rate height, and the rate of animals delivered to the slaughter-house is low.
2-deoxy-D-glucose (2-DEOXY-D-GLUCOSE) is natural antimetabolite class antibiotic, is off-white color or pale yellow crystals powder.It has multiple physiological and pharmacological effects such as can suppressing viral infection, culture propagation, pathogenic bacterium and growth of tumour cell.Have effects such as antiviral, antibiotic, antitumor, be used for pre-anti-virus and pathogenic bacterial infection etc., can prevent the microbial infectious disease of source of disease such as DNA viruses, RNA viruses.
2-deoxy-D-glucose and glucose are two kinds of materials, and its molecular structural formula is inequality.The pharmacological action of glucose effect: moisture and sugar in the energy added body have additional body fluid, energize, replenish effects such as blood glucose, heart tonifying diuresis, detoxifcation.Though 2-deoxy-D-glucose has the similar structure of glucose (2-deoxy-D-glucose lacks an oxygen atom than glucose), do not have the function of normal glucose, 2-deoxy-D-glucose has effects such as antiviral, antibiotic, anticancer, epilepsy.
The 2-deoxy-D-glucose mechanism of action is: viral homergy needs glucose, but virus can't be discerned, and the affinity to 2-deoxy-D-glucose is far longer than glucose (1000 times), so pathogen has preferentially been utilized 2-deoxy-D-glucose, can not finish tricarboxylic acid cycle, the blocking-up energy metabolism suppresses its growth and breeding, thereby plays antivirus action.Because of animal somatic cell can be discerned glucose and 2-deoxy-D-glucose, (, antibacterial the strongest to virus takes second place primary pathogen a 2-deoxy-D-glucose specific effect in evolving, parasite is weak), and it is harmless to the poultry body, be natural targeted drug, have multiple pharmacodynamics effects such as viral infection, tumor cell and the bacterial growth of inhibition.
At present, drug effect, the pharmacological research of the anti-Human virus of 2-deoxy-D-glucose (herpesvirus, hepatitis virus etc.) effect are a lot, but yet there are no report in research and development of products that is used for anti-avian viral disease and application about 2-deoxy-D-glucose.
Summary of the invention
The objective of the invention is by the application of a kind of 2-deoxy-D-glucose in the control avian viral disease is provided, overcome deficiency of the prior art, reach bird flu, newcastle, infectious bursal disease, the infectious bronchitis of control birds, the purpose of infectious laryngotracheitis.
As follows for realizing the technical scheme that purpose of the present invention adopts:
A kind of 2-deoxy-D-glucose especially is included in the application in control infectious bursal disease, Newcastle disease, the infectious bronchitis in the application of the medicine of preparation control avian viral disease.
The 2-deoxy-D-glucose using dosage is 1.0～30mg/Kg body weight, every day 1-2 time.
The 2-deoxy-D-glucose using method is for can orally also injecting.
The every composition that uses in the above-mentioned preparation method is commercially available product, meets the relevant regulations of veterinary drug pharmaceutical raw material quality standard, and specification is a pharmaceutical grade.
The invention has the beneficial effects as follows: the clinical research confirmation 2-deoxy-D-glucose has excellent curative to avian viral disease, especially can remove clinical symptoms that viral infection causes, reduce the mortality rate of sick fowl, promote that disease fowl recovers to search for food, recovery from illness in general 5～7 days, evident in efficacy.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
Treatment to infectious bursal disease.
Therapeutic test makes chickling that infections chicken cloacal bursa take place with the method for artificial infection chicken's infectious bursa of Fabricius virus 54 SPF chickens in the artificial malicious model that causes a disease, and the while is divided into 3 groups, 18 every group at random.The A group is " 2-deoxy-D-glucose " treatment group, and the quality percentage composition of 2-deoxy-D-glucose is 30%; The B group is astragalus polysaccharides treatment group, and the quality percentage composition of astragalus polysaccharides is 30%; The C group is matched group, with the normal saline treatment, 3 groups of chickens is contaminated with infections chicken cloacal bursa virus simultaneously, every chicken is with the strong malicious collunarium 0.2ml of infections chicken cloacal bursa virus, after waiting clinical symptoms to occur, to A group injection " 2-deoxy-D-glucose " 1.0mg/Kg chicken body weight, once a day, B group chicken injection astragalus polysaccharides 1.0mg/Kg chicken body weight, once a day, C group chicken injection equal-volume normal saline, logotype 3-6 days, observe morbidity death and the pathological change of chicken then, and itemized record.
The artificial therapeutic effect that causes a disease
Behind the contamination 24h, test chicken begins to occur clinical symptoms: lassitude, to stand transfixed to the ground, and feather is fluffy and disorderly, and row's yellow green loose stool, diet reduce or are useless exhausted.After the medication, A group and B group chicken take a turn for the better since the 2d state of an illness, and 3d, 4d have dead chicken to occur, the basic rehabilitation of the chicken that survives behind the 5d, sb.'s illness took a turn for the worse after the 2nd day symptom occurring for the C group, begins to occur dead, 3-5d reaches dead peak, spontaneous recovery behind the not dead chicken 6d.2-deoxy-D-glucose treatment group and matched group difference is (P＜0.01) extremely significantly, illustrates that " 2-deoxy-D-glucose " has certain therapeutical effect to infections chicken cloacal bursa.
Three groups of therapeutic outcomes comparisons of table 1 (example, %)
| Group | The example number | Cure | Take a turn for the better | Effectively | Dead |
| The A group | 18 | 11(61％) | 5(28％) | 16(89％) | 2(11％) |
| The B group | 18 | 10(56％) | 4(22％) | 14(78％) | 4(22％) |
| The C group | 18 | 0 | 4(22％) | 4(22％) | 14(78％) |
Embodiment 2
The clinical treatment test.
Select typical infectious bronchitis morbidity chicken, 54 chickens are divided into 3 groups at random, A organizes oral 2-deoxy-D-glucose 30.0mg/Kg chicken body weight; B group oral administration astragalus polysaccharide 30.0mg/Kg chicken body weight.C organizes oral normal saline.
The avian infectious bronchopathy result of the test of table 2 " 2-deoxy-D-glucose " treatment
| Group | Quantity | The morbidity number | Death toll | Mortality rate | Significant figure | Effective percentage % |
| The A group | 18 | 18 | 3 | 16.7 | 15 | 83.3 |
| The B group | 18 | 18 | 5 | 27.8 | 13 | 72.2 |
| The C group | 18 | 18 | 14 | 77.8 | 4 | 22.2 |
By table 2 as seen, " 2-deoxy-D-glucose " test group effective percentage is 83.3%, and the effective percentage of oral normal saline group is 22.2%.As seen, 2-deoxy-D-glucose has good therapeutic effect to avian infectious bronchopathy.
Embodiment 3
The example of " 2-deoxy-D-glucose " treatment Newcastle disease.
October in 2008 Tianjin plant on the 10th laying hen, same symptoms appears successively: swollen eye socket, cough, snore, the reduction of searching for food, laying rate descends, found later on that the chicken death rate rises on October 13, dead fast, feed intake descends fast, 10-20 of per 1000 chickens death every day, about 60/day of the most serious death.
At above-mentioned phenomenon, the 2-deoxy-D-glucose intramuscular injection is used in suggestion, press 25mg/ chicken use, logotype 2-3 days, cooperates multidimensional electrolyte etc. can control death rapidly in addition, the chicken group state that refreshes.
Analyze: through cuing open the inspection diagnosis: Newcastle disease.
Sum up: similar symptom, early find to carry out intramuscular injection by a 2-deoxy-D-glucose 25mg/ chicken by early treatment, once a day, logotype 2-3 days.Facts have proved that the 2-deoxy-D-glucose may command state of an illness reduces mortality rate.
Embodiment 4
The using method of prevention chicken viral diarrheal 2-deoxy-D-glucose is: with 2-deoxy-D-glucose is that 0.1～10.0% ratio is evenly admixed in the premix material by weight percentage, and premix material is for premix material commonly used, and is on sale on the market.Allow chicken free choice feeding, observation prevent chicken viral diarrheal effect.
Animal experiment: chicken viral diarrhoea takes place in Wuqing, Tianjin county chicken house throughout the year, and is poor through containing antibiotic feedstuff preventive effect such as ciprofloxacin lactate, so use the feedstuff that contains 2-deoxy-D-glucose to be used to prevent chicken viral to suffer from diarrhoea.The chick of 90 20 ages in days of this chicken house is divided into three groups of A, B, C, and 30 every group have been carried out 10 days prevention chicken diarrhea contrast tests.The A group is admixed 0.2% 2-deoxy-D-glucose by weight 0.1% ratio in feedstuff, the B group is admixed ciprofloxacin lactate by weight 0.2% ratio in feedstuff, does not contain the premix material of medicine in the C group feedstuff.Result of the test is that the protective rate of A group reaches 100.0%, and the B group only is 84.0%, and the C group only is 61.0%.The result shows that 2-deoxy-D-glucose can effectively be prevented and treated chicken viral diarrhoea.
2-deoxy-D-glucose mainly has significant advantage to the prevention and the treatment of avian viral disease.Studies confirm that: 2-deoxy-D-glucose also has remarkable therapeutical effect to the chicken model and the infectious bronchitis morbidity chicken of artificial infection chicken's infections chicken cloacal bursa virus.Simultaneously, 2-deoxy-D-glucose can effectively be prevented and treated chicken viral diarrhoea.As seen, 2-deoxy-D-glucose is the natural drug of treatment avian viral disease.
2-deoxy-D-glucose mainly has significant advantage to the prevention and the treatment of treatment avian viral disease.Studies confirm that: 2-deoxy-D-glucose has remarkable therapeutical effect to infectious bursal disease, Newcastle disease, infectious bronchitis, and chicken viral diarrhoea is had preventive effect.As seen, 2-deoxy-D-glucose is the natural drug of control avian viral disease.
Above-mentioned with reference to the embodiment detailed description that the application in preparation control avian viral disease medicine is carried out to this 2-deoxy-D-glucose; be illustrative rather than determinate; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (2)
1. the application of 2-deoxy-D-glucose in the medicine of preparation control avian viral disease, described avian viral disease is infectious bursal disease, Newcastle disease and infectious bronchitis, wherein the using dosage of 2-deoxy-D-glucose is 1.0～30mg/Kg body weight, every day 1-2 time.
2. the application of 2-deoxy-D-glucose according to claim 1 in the medicine of preparation control avian viral disease, it is characterized in that: described pharmaceutical dosage form is peroral dosage form or injection type.
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| CN 200910303629 CN102151278B (en) | 2009-06-25 | 2009-06-25 | Use of 2-deoxy-D-glucose in prevention and treatment of viral diseases in livestock |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868157A (en) * | 1987-10-05 | 1989-09-19 | Merck & Co., Inc. | Dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives as host resistance enhancers in AIDS-immunocompromised hosts and methods of use |
| CN1422156A (en) * | 2000-02-14 | 2003-06-04 | 法马西亚公司 | Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections |
| CN1580063A (en) * | 2003-08-12 | 2005-02-16 | 上海迪赛诺医药科技开发有限公司 | 2-desoxy-D-ribose synthesizing method |
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- 2009-06-25 CN CN 200910303629 patent/CN102151278B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868157A (en) * | 1987-10-05 | 1989-09-19 | Merck & Co., Inc. | Dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives as host resistance enhancers in AIDS-immunocompromised hosts and methods of use |
| CN1422156A (en) * | 2000-02-14 | 2003-06-04 | 法马西亚公司 | Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections |
| CN1580063A (en) * | 2003-08-12 | 2005-02-16 | 上海迪赛诺医药科技开发有限公司 | 2-desoxy-D-ribose synthesizing method |
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