CN101879172B - Compound preparation of ceftiofur sodium - Google Patents
Compound preparation of ceftiofur sodium Download PDFInfo
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- CN101879172B CN101879172B CN2010102254288A CN201010225428A CN101879172B CN 101879172 B CN101879172 B CN 101879172B CN 2010102254288 A CN2010102254288 A CN 2010102254288A CN 201010225428 A CN201010225428 A CN 201010225428A CN 101879172 B CN101879172 B CN 101879172B
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- ceftiofur sodium
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- salmonella
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Abstract
The invention relates to a compound preparation of ceftiofur sodium, in particular to the application of a compound preparation of ceftiofur sodium in preparing medicines for treating colibacillus or salmonella infection of chicken and swine. The compound preparation of ceftiofur sodium comprises the following formula in parts by weight: 0.5-8 parts of ceftiofur sodium, 0.5-6 parts of fosfomycin sodium, 1-3 parts of sulbactam sodium and 4-7 parts of enorfloxacin sodium. The formula can be prepared into a premixed agent, a drink agent or an injection in the using process. The applicant of the invention, by summarizing of many years of tests and according to the antibacterial synergy principle, prepares the compound preparation of ceftiofur sodium which effectively solves the drug tolerance problem of the colibacillus and salmonella, simultaneously improves the action effect and the field of application and improves the survival rate of livestock and fowl.
Description
Technical field
The present invention relates to compound preparation of ceftiofur sodium, the particularly application of compound preparation of ceftiofur sodium in the medicine of preparation treatment chicken and swine escherichia coli or Salmonella infection.
Background technology
Colibacillosis is that some bacterial strains by pathogenic ETEC cause the acute of poultry or chronic bacterial sexually transmitted disease.At present, this disease is paid attention to by people in public health as a kind of potential zoonosis day by day.Because its antigenicity is complicated, serotype is various, and clinical symptoms and pathological change are changeable, and many and viral disease and the concurrent or secondary of other bacterial diseasees, and particularly pig industry and poultry husbandry are brought sizable harm to livestock and poultry breeding industry.Can cause multiple different disease because cause of disease serotype is extremely many clinically; Common piglet pujos blancos, yellow scour of piglet on pig; Higher M & M is arranged; Main propagate through digestive tract, common e. coli septicemia, yolk peritonitis on chicken, main route of transmission comprises that digestive tract, respiratory tract, eggshell penetrate, copulation, through the egg vertical transmission etc.
Salmonellal acute infectious disease can be divided into gastroenteritis type (being that food is poisoned), typhoid fever type, septicemia type and the outer focal infection of intestinal according to clinical manifestation.Wherein common with the gastroenteritis type, can cause nausea, vomit, clinical syndrome such as stomachache, diarrhoea and heating.Be found that Salmonella choleraesuls in the Salmonella the earliest, isolated from the pig that suffers from hog cholera by U.S. bacteriologist D.E. Sa Meng (sramana) in 1885, hence obtain one's name.Salmonella is mainly animal pathogen; Can cause baby swine paratyphoid, Pullorum Disease, fowl typhoid etc.; But also can infect the mankind, become human conditioned pathogen, like Salmonella typhimurium, Salmonella enteritidis, Salmonella choleraesuls etc. through approach such as contaminated food products or water sources.Only the mankind are had pathogenic in the Salmonella like salmonella typhi, salmonella paratyphi etc.Food transmission is the main path of human Salmonella infection.At occurring in nature, Salmonella has animal host widely.Domestic animals such as poultry such as chicken, duck, goose and pig, cattle, sheep, horse, and various beasts, Fish, muroid all can carry disease germs, even also separablely from Cicadae and some insecticide go out Salmonella.This bacterium is present in the enteric cavity of these animals, but therefore all microbiological contaminations of its meat in poultry domestic animals slaughter, the course of processing sell after infected animal is butchered and more be prone to spread disease germs, eggs or egg products can be polluted equally.
A lot of antibiotic such as aminoglycoside, chloromycetin, quinolones all have certain curative effect to escherichia coli and Salmonella, but very easily produce drug resistance.In recent years, because these antibioticly a large amount of lack of standardizationly use and abuse, Resistant strain produces in a large number, often causes therapeutic effect not obvious.
Ceftiofur sodium is that special-purpose third generation cephalosporin antibacterial activity is extremely strong, to gram positive bacteria, negative bacterium and anaerobe, efficient be difficult for producing drug resistance, long half time, lasting medicine is arranged all.Since U.S. FDA in 1988 is ratified the injection ceftiofur sodium first and is used to treat the cattle respiratory system infection, its at home and abroad veterinary clinic use extensive day by day.
But along with the frequent and heavy dose of use of the use of ceftiofur sodium; Make the ceftiofur sodium effect render a service and reduce, even produce drug resistance, influenced the application of ceftiofur sodium; Especially particularly serious to the drug resistance of escherichia coli and Salmonella, and do not have fine solution now.The applicant is through Test Summary for many years; And according to antibacterials synergism principle, compatibility compound preparation of ceftiofur sodium, it has solved the drug resistance problem of escherichia coli and Salmonella effectively; And improve action effect and range of application simultaneously, improved the survival rate of domestic animals and fowls.
Summary of the invention
The technical problem that solves
The present invention is directed to the escherichia coli of ceftiofur sodium and the drug resistance of Salmonella, problems such as action effect reduction provide a kind of compound preparation of ceftiofur sodium, and the application in the medicine of preparation treatment chicken and swine escherichia coli or Salmonella infection.
Technical scheme
Technical solution of the present invention is: a kind of compound preparation of ceftiofur sodium, fill a prescription as follows:
By weight, ceftiofur sodium 0.5-8 part, fosfomycin sodium 0.5-6 part, sulbactam sodium 1-3 part, Enrofloxacin Base sodium 4-7 part.Above-mentioned prescription can be made into pre-mixing agent, drinking agent or injection in use.
Method for using:
1. spice final concentration: prevention 80ppm, treatment 160ppm (in the ceftiofur sodium net content) connects 3 days.
2. the final concentration of drinking water: prevention 40ppm, treatment 80ppm (in the ceftiofur sodium net content) connects 3 days.
3. inject consumption: per kilogram of body weight 3-5mg (in the ceftiofur sodium net content), every day 1 time, logotype 3 days (every 0.1mg of chicken subcutaneous injection in age on the 1st～0.2mg).
Beneficial effect
The applicant is through Test Summary for many years, and according to antibacterials synergism principle, compatibility compound preparation of ceftiofur sodium; Thereby the treatment of many target spots causes disease with prevention escherichia coli and Salmonella; And under similar dosage, improved its antibacterial activity, and overcome the drug resistance problem of escherichia coli and Salmonella with folk prescription; And range of application has improved the survival rate of domestic animal simultaneously.
The specific embodiment
Embodiment 1
A kind of compound preparation of ceftiofur sodium, ceftiofur sodium 1g, fosfomycin sodium 2.5g, sulbactam sodium 2g, Enrofloxacin Base sodium 3g.
Embodiment 2
A kind of compound preparation of ceftiofur sodium, ceftiofur sodium 0.5g, fosfomycin sodium 0.5g, sulbactam sodium 1g, Enrofloxacin Base sodium 4g.
Embodiment 3
A kind of compound preparation of ceftiofur sodium, ceftiofur sodium 8g, fosfomycin sodium 6g, sulbactam sodium 3g, Enrofloxacin Base sodium 7g.
Embodiment 4
A kind of compound preparation of ceftiofur sodium, ceftiofur sodium 6g, fosfomycin sodium 4g, sulbactam sodium 2.5g, Enrofloxacin Base sodium 6g.
Embodiment 5
A kind of compound preparation of ceftiofur sodium, ceftiofur sodium 4g, fosfomycin sodium 3g, sulbactam sodium 2.0g, Enrofloxacin Base sodium 5g.
Embodiment 6
With the compound preparation of embodiment 1-5, the clinical data of treatment treatment chicken colibacillosis and Salmonella infection:
Case one, in August, 2009, Shi Gangzhen stone port, Tongzhou District, Nantong City, Jiangsu Province occupies the 10000 plumage Luo Man laying hens that Zhang raises, and is normal always before 250 ages in days, and 251 ages in days are found minority chicken sneeze; Do not take effect in 5 days with enrofloxacin drinking-water, the jumpbogroup morbidity, snore appears in trachea, and beginning is fragmentary dead; Laying eggs begins to descend, and uses tylosin drinking-water instead 5 days, and respiratory symptom disappears basically; But death rolls up, about about 50 of every day, egg drop reduction about about 20%; After veterinary station laboratory, Tongzhou District is diagnosed as coli-infection, use the treatment of compound preparation of ceftiofur sodium 80ppm (in the ceftiofur sodium net content) drinking-water instead, the state of an illness was controlled in 3 days; No longer include new sick chicken and occur, death descends significantly after 5 days, stops death after 7 days.
Case two, in December, 2009, the blue laying hen in 4800 plumages sea of bank town Dong Chang village Wang raising, 3 age in days sudden onset are ridden the Tongzhou District by the Nantong City, Jiangsu Province; Dead sharply rising; The plumage more than 300 of dying in heaven during to 5 ages in days, chicken crowd Non Apparent Abnormality is invalid with multiple antibiotics; The veterinary station laboratory is diagnosed as septic Pullorum Disease (Salmonella infection) through the Tongzhou District; Use compound preparation of ceftiofur sodium 80ppm (in the ceftiofur sodium net content) drinking-water treatment instead, the state of an illness was controlled in 3 days, promptly stopped death on the 5th day.
Case three, in February, 2010,3000 plumage AA chickens of bridge town stone bridge village Shen raising are mended in sky, Haimen City, Jiangsu Province, grab back to find promptly that the part chicken is afraid of cold to beat and pile; The back is dead constantly to be increased, and the plumage more than 500 of dying in heaven during to 3 ages in days does not take effect with amikacin and ofloxacin drinking-water; The veterinary station laboratory is diagnosed as the septic colibacillosis through Haimen City; Use compound preparation of ceftiofur sodium 80ppm (in the ceftiofur sodium net content) drinking-water treatment instead, the state of an illness was controlled in 3 days, promptly stopped death on the 5th day.
Use compound preparation of ceftiofur sodium treatment chicken crowd nearly 60 ten thousand plumages similar with above symptom over nearly 3 years, cure rate is more than 98%.
Embodiment 7
With the compound preparation of embodiment 1-5, the clinical data of compound preparation of ceftiofur sodium treatment swine escherichia coli and Salmonella infection:
Case one, in December, 2008; It is a kind of disease of characteristic with diarrhoea, heating with than high mortality that 120 commodity piglets of Tongzhou District, Nantong city wooden bridge village, yellow sky osmanthus stone raising are taken place a kind of; Fail disease controlling with amikacin, amoxicillin, cefalexin etc., dead successively 20 bulls infect after veterinary station laboratory, Tongzhou District is diagnosed as baby swine paratyphoid (Salmonella infection); Use compound preparation of ceftiofur sodium every kg body weight intramuscular injection 4mg (in the ceftiofur sodium net content); Once a day, logotype promptly stopped to have loose bowels and is dead in 3 days, consolidated after 2 days and cured.
Case one, in February, 2009; One circle of certain raising of Shi Gangzhen Luan Dian village, Tongzhou District, Nantong City, the Jiangsu Province Yin Dynasty is from numerous piglet, and 7 ages in days begin to draw yellow dung, acute death; It is little to use multiple antibiotics effect; The veterinary station laboratory is diagnosed as yellow scour of piglet (coli-infection) through the Tongzhou District, uses compound preparation of ceftiofur sodium every kg body weight intramuscular injection 4mg (in the ceftiofur sodium net content), stops to have loose bowels and death after the injection once again in the 2nd day.
Case three, in March, 2010, a circle of Tongzhou District, Nantong City, Jiangsu Province Liu Qiaozhen Dong Bakou village Wu raising is from numerous piglet, and 32 ages in days begin to draw white dung; Use multiple antibiotics and do not take effect, delay and to take a turn for the better in more than 10 day, become thin; Growth retardation; Fragmentary dead, the veterinary station laboratory is diagnosed as piglet pujos blancos (coli-infection) through the Tongzhou District, uses compound preparation of ceftiofur sodium every kg body weight intramuscular injection 4mg (in the ceftiofur sodium net content); Once a day, logotype promptly stopped to have loose bowels and is dead in 3 days.
Reference examples 1
The clinical control data of ceftiofur sodium folk prescription treatment chicken colibacillosis and Salmonella infection
Case one, in January, 2010, the 1800 plumages grass Sanhuang chicken of the season village, bank town village Lee raising, 2 age in days sudden onset are ridden the Tongzhou District by the Nantong City, Jiangsu Province; God is depressed for the part chicken essence, does not eat, and wing hangs down; Cheep, the plumage more than 80 of dying in heaven during to 4 ages in days, the veterinary station laboratory is diagnosed as septic Pullorum Disease (Salmonella infection) through the Tongzhou District; Use the former powder 80ppm drinking-water of ceftiofur sodium, dead decline in the 1st day the 2nd day is not obvious, the 3rd day still dead plumage more than 10; After slowly descend, dead plumage more than 160 altogether during drug withdrawal in the 6th day still had fragmentary death in back the day.
Case two, in May, 2010, sky, Haimen City, Jiangsu Province is mended the town and is mended the 2000 plumage AA chickens that southern village Chen raises, and discovery part chicken is afraid of cold and beats heap during 30 ages in days; The back is dead constantly to be increased, the plumage more than 50 of dying in heaven during to 35 ages in days, and the veterinary station laboratory is diagnosed as colibacillosis through Haimen City; Use the former powder 80ppm drinking-water of ceftiofur sodium instead; Dead decline in the 1st day the 2nd day is not obvious, and death in the 3rd day slowly descends, and is total to dead plumage more than 120 during drug withdrawal in the 7th day; The back still had fragmentary death in the day, when 50 ages in days are delivered for sale, did not stop yet.
Reference examples 2
The clinical control data of ceftiofur sodium folk prescription treatment swine escherichia coli and Salmonella infection
Case one, in November, 2009,80 commodity piglets of Tongzhou District, Nantong city yellow sky Jin Bei village season raising generate heat suddenly, diarrhoea, dead 2, and the veterinary station laboratory is diagnosed as baby swine paratyphoid (Salmonella infection) and infects through the Tongzhou District; Use ceftiofur sodium injectable powder every kg body weight intramuscular injection 4mg (in the ceftiofur sodium net content), once a day, logotype 3 days; No longer heating; But still have loose bowels, dead again 2, it is no longer dead to use 2 days again; But still have loose bowels, after use florfenicol 3 days instead and cure.
Case two, in February, 2010, a circle of the Tongzhou District San Yu of Nantong City, Jiangsu Province town Heng Xing village Cui raising is from numerous piglet, and 28 ages in days begin to draw white dung; Feed intake descends, and hair is contrary, becomes thin; Growth retardation, the veterinary station laboratory is diagnosed as piglet pujos blancos (coli-infection) through the Tongzhou District, uses ceftiofur sodium injectable powder every kg body weight intramuscular injection 4mg (in the ceftiofur sodium net content); Once a day, logotype was not seen and is clearly better dead 1 in 3 days; Reuse was still had loose bowels in 2 days, promptly used florfenicol instead and cured in 5 days.
Claims (5)
1. a compound preparation of ceftiofur sodium is characterized in that being made up of ceftiofur sodium 1g, fosfomycin sodium 2.5g, sulbactam sodium 2g and Enrofloxacin Base sodium 3g.
2. a compound preparation of ceftiofur sodium is characterized in that being made up of ceftiofur sodium 0.5g, fosfomycin sodium 0.5g, sulbactam sodium 1g and Enrofloxacin Base sodium 4g.
3. a compound preparation of ceftiofur sodium is characterized in that being made up of ceftiofur sodium 8g, fosfomycin sodium 6g, sulbactam sodium 3g and Enrofloxacin Base sodium 7g.
4. a compound preparation of ceftiofur sodium is characterized in that being made up of ceftiofur sodium 6g, fosfomycin sodium 4g, sulbactam sodium 2.5g and Enrofloxacin Base sodium 6g.
5. a compound preparation of ceftiofur sodium is characterized in that being made up of ceftiofur sodium 4g, fosfomycin sodium 3g, sulbactam sodium 2.0g and Enrofloxacin Base sodium 5g.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102254288A CN101879172B (en) | 2010-07-13 | 2010-07-13 | Compound preparation of ceftiofur sodium |
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| CN2010102254288A CN101879172B (en) | 2010-07-13 | 2010-07-13 | Compound preparation of ceftiofur sodium |
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| CN101879172A CN101879172A (en) | 2010-11-10 |
| CN101879172B true CN101879172B (en) | 2012-07-18 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102319219A (en) * | 2011-09-30 | 2012-01-18 | 四川金瑞克动物药业有限公司 | Chitosan nanoparticle preparation of ceftiofur sodium, and preparation method thereof |
| NZ702087A (en) | 2012-06-29 | 2016-12-23 | Bayer Animal Health Gmbh | Pharmaceutical compositions and treatment of mastitis |
| CN103251634A (en) * | 2013-05-27 | 2013-08-21 | 关卫 | Fosfomycin sodium/sulbactam sodium injection |
| CN104800220B (en) * | 2015-03-11 | 2017-03-29 | 四川成康动物药业有限公司 | It is a kind of to be used to release the endotoxic medicament composing prescription of Endophytic bacteria |
| CN107519174A (en) * | 2017-09-13 | 2017-12-29 | 南通荣成医药化工有限公司 | A kind of new compound preparation of ceftiofur sodium |
| CN107569489A (en) * | 2017-09-13 | 2018-01-12 | 南通荣成医药化工有限公司 | A kind of compound preparation of ceftiofur sodium |
| CN107595852A (en) * | 2017-09-13 | 2018-01-19 | 南通荣成医药化工有限公司 | A kind of new compound preparation of ceftiofur sodium |
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Non-Patent Citations (2)
| Title |
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| 张新华.兽药使用的误区及禽病临床合理用药.《家禽科学》.2007,6-9. * |
| 武博达等.不同配比头孢噻呋与舒巴坦的体外抗菌活性比较.《河南畜牧兽医》.2008,第29卷6-7. * |
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