CN101966186A - Composition for treating chicken escherichia coli infection and preparation method thereof - Google Patents
Composition for treating chicken escherichia coli infection and preparation method thereof Download PDFInfo
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- CN101966186A CN101966186A CN2010102364362A CN201010236436A CN101966186A CN 101966186 A CN101966186 A CN 101966186A CN 2010102364362 A CN2010102364362 A CN 2010102364362A CN 201010236436 A CN201010236436 A CN 201010236436A CN 101966186 A CN101966186 A CN 101966186A
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- amoxicillin
- ofloxacin
- escherichia coli
- composition
- taurine
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Abstract
The invention discloses a composition for treating chicken escherichia coli infection and a preparation method thereof, and aims to provide a composition for treating chicken escherichia coli infection and treating the root cause and symptoms of disease and a preparation method. The composition comprises the following components in percentage by weight: 5 to 15 percent of amoxicillin, 3 to 10 percent of ofloxacin, 3 to 10 percent of taurine, 5 percent of anhydrous sodium carbonate and the balance of anhydrous dextrose. The amoxicillin and the ofloxacin adopted in the composition can effectively kill escherichia coli aiming at etiology; the combination of the amoxicillin and the ofloxacin can reduce the probability of medicament resistance of the escherichia coli and improve the sensitivity, and also has good effect on other bacterial diseases secondarily infected by the escherichia coli; the taurine with anti-inflammatory effect has the effect of quickly diminishing inflammation caused by the escherichia coli; and the anhydrous sodium carbonate is used as a co-solvent so that the composition can be fully dissolved in water and is convenient to use. The medicaments are used together so that the composition can effectively resist etiology and clinical symptoms and treat both principal and secondary aspects of diseases aiming at the etiology and the diseases.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that chicken colibacillosis infects that is used for the treatment of.
Background technology
It is the common in recent years disease of chicken that chicken colibacillosis infects, cause of disease is escherichia coli etc., main clinical manifestation mainly shows as symptoms such as septicemia, pericarditis, perihepatitis, airsacculitis, salpingitis, peritonitis, escherichia coli granuloma, enteritis, it can seriously cause systemic infection, causes resistance decline and causes multiple disease.
It is that the escherichia coli drug resistance is serious, inflammatory reaction serious, secondary infection generally waits that this disease is treated topmost difficult point, add that escherichia coli are originally as resident bacterium in the body, at resistance decline or environment, stress wait disease takes place under the influence of factor, the user is selecting aspect medicine and the medication, often simple responding well to treatment is very poor, cause big batch death because of chemical sproof generation causes delaying with failing in time to diminish inflammation of treatment opportunity, economic loss is huge.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of chicken colibacillosis of can treating to infect, reduce the chemical sproof occurrence probability of escherichia coli, improving the composition and method of making the same of sensitivity.
The present invention is achieved through the following technical solutions:
A kind of compositions that is used for the treatment of the chicken colibacillosis infection is characterized in that, is made up of following raw material by weight percentage: amoxicillin 5～15%, and ofloxacin 3～10%, taurine 3～10%, natrium carbonicum calcinatum 5%, surplus is an anhydrous glucose.
A kind of preparation of compositions method that is used for the treatment of the chicken colibacillosis infection is characterized in that, comprises the steps: the amoxicillin; ofloxacin, taurine, natrium carbonicum calcinatum are after pulverize separately sieves; get amoxicillin 5～15% by weight percentage; ofloxacin 3～10%, taurine 3～10%, natrium carbonicum calcinatum 5%; surplus is an anhydrous glucose; fully mixed 1 hour, behind the mixing, promptly get the compositions that is used to treat the chicken colibacillosis infection.
Wherein, preferable consisting of by weight percentage: amoxicillin 8～12%, ofloxacin 4～7%, taurine 5～8%, natrium carbonicum calcinatum 5%, surplus is an anhydrous glucose.
Best group by weight percentage becomes: amoxicillin 10%, ofloxacin 5%, taurine 8%, natrium carbonicum calcinatum 5%, anhydrous glucose 72%.
The present invention has following technique effect:
Compositions of the present invention adopts amoxicillin and ofloxacin at cause of disease, can effectively kill escherichia coli, and the combination of two kinds of medicines can reduce the chemical sproof occurrence probability of escherichia coli, improves sensitivity, and two kinds of medicines can both absorb, and can comprehensively be distributed in each tissue and the body fluid, can play good effect to the systemic infection of chicken colibacillosis, and both wide spectrums, other bacterial diseases to the escherichia coli secondary infection also have good effect; Taurine has good antiinflammatory action, and action time is fast, the inflammation that escherichia coli are caused has the effect of quick antiinflammatory, and this product avoids causing common antipyretic and anti-inflammatory medicine such as aminophenazone, dipyrone etc. to damage gastrointestinal mucosa in antiphlogistic process to the gastrointestinal tract not damaged; Natrium carbonicum calcinatum help solubilization to amoxicillin and ofloxacin, make this product can be soluble in water fully, easy to use concerning the raiser, avoid causing low light too high side effect that brings of feed intake of serious sick fowl feed intake and the not good situation of therapeutic effect because of colibacillosis.All medicines share and by rational proportion, at cause of disease, disease, make this product can effectively resist cause of disease and clinical symptoms thereof, and giving consideration to both the incidental and fundamental is easy to use, can treat chicken colibacillosis effectively and infect.
Preparation method of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
With the amoxicillin, ofloxacin, taurine, it is standby to cross No. 5 sieves behind the natrium carbonicum calcinatum pulverize separately.
Embodiment 1
Take by weighing the amoxicillin 5kg after sieving, ofloxacin 10kg, taurine 10kg, natrium carbonicum calcinatum 5kg, anhydrous glucose 70kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat the chicken colibacillosis infection.
Embodiment 2
Take by weighing the amoxicillin 15kg after sieving, ofloxacin 3kg, taurine 3kg, natrium carbonicum calcinatum 5kg, anhydrous glucose 74kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat the chicken colibacillosis infection.
Embodiment 3
Take by weighing the amoxicillin 8kg after sieving, ofloxacin 7kg, taurine 8kg, natrium carbonicum calcinatum 5kg, anhydrous glucose 72kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat the chicken colibacillosis infection.
Embodiment 4
Take by weighing the amoxicillin 12kg after sieving, ofloxacin 4kg, taurine 5kg, natrium carbonicum calcinatum 5kg, anhydrous glucose 74kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat the chicken colibacillosis infection.
Embodiment 5
Take by weighing the amoxicillin 9kg after sieving, ofloxacin 5.5kg, taurine 7.5kg, natrium carbonicum calcinatum 5kg, anhydrous glucose 73kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat the chicken colibacillosis infection.
Embodiment 6
Take by weighing the amoxicillin 10kg after sieving, ofloxacin 5kg, taurine 8kg, natrium carbonicum calcinatum 5kg, anhydrous glucose 72kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat the chicken colibacillosis infection.
Clinical trial:
1. laboratory animal:
1000 of the ill chickens of picked at random, body weight is about about 1kg.
2. experiment medicine
The compositions our unit development that is used for the treatment of the chicken colibacillosis infection of the embodiment of the invention 6 preparations;
10% amoxicillin soluble powder our unit prepared in laboratory;
5% ofloxacin soluble powder our unit prepared in laboratory.
3. experimental technique:
Suffer from chicken with 1000 and be divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 10% amoxicillin soluble powder: drinking-water, every 1L water 1g, 2 times on the one, logotype 5 days.
The C group is treated usage with 5% ofloxacin soluble powder: drinking-water, every 1L water 1g, 2 times on the one, logotype 5 days.
The D group is treated usage with the compositions that is used for the treatment of the chicken colibacillosis infection of the embodiment of the invention 6 preparations: drinking-water, every 1L water 1g, 1 time on the one, logotype 5 days.
After the treatment beginning, every day, the treatment of record trouble chicken health situation of change was added up therapeutic effect after 7 days, wherein:
Invalid: as after referring to 7 days, to suffer from the chicken symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the chicken symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from chicken and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from chicken and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from chicken and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 preparation be used for the treatment of chicken colibacillosis treatment of infection group, 10% amoxicillin soluble powder treatment group and 5% ofloxacin soluble powder group and matched group difference extremely remarkable (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | Symptom chicken number is arranged during end | Dead number of elements |
| A | Matched group | 250 | 0 | 0 | 78 | 172 |
| B | 10% amoxicillin treated powder group | 123 | 127 | 82 | 76 | 92 |
| C | 5% ofloxacin soluble powder treatment group | 132 | 118 | 96 | 68 | 86 |
| D | The combination treatment that is used for the treatment of the chicken colibacillosis infection of the embodiment of the invention 6 | 31 | 219 | 206 | 18 | 26 |
Claims (6)
1. one kind is used for the treatment of the compositions that chicken colibacillosis infects, and it is characterized in that, is made up of following raw material by weight percentage: amoxicillin 5～15%, and ofloxacin 3～10%, taurine 3～10%, natrium carbonicum calcinatum 5%, surplus is an anhydrous glucose.
2. the compositions that is used for the treatment of the chicken colibacillosis infection according to claim 1; it is characterized in that, form by following raw material by weight percentage: amoxicillin 8～12%, ofloxacin 4～7%; taurine 5～8%, natrium carbonicum calcinatum 5%, surplus are anhydrous glucose.
3. the compositions that is used for the treatment of the chicken colibacillosis infection according to claim 1 is characterized in that, is made up of following raw material by weight percentage: amoxicillin 10%, ofloxacin 5%, taurine 8%, natrium carbonicum calcinatum 5%, anhydrous glucose 72%.
4. a claim 1 is described is used for the treatment of the preparation of compositions method that chicken colibacillosis infects; it is characterized in that; after comprising the steps: amoxicillin, ofloxacin, taurine, sodium carbonate pulverize separately crossed 5# sieve; get amoxicillin 5～15% by weight percentage, ofloxacin 3～10%, taurine 3～10%, natrium carbonicum calcinatum 5%; surplus is an anhydrous glucose; fully mixed 1 hour, behind the mixing, promptly get the compositions that chicken colibacillosis infects that is used for the treatment of of the present invention.
5. the compositions that is used for the treatment of the chicken colibacillosis infection according to claim 4; it is characterized in that, form by following raw material by weight percentage: amoxicillin 8～12%, ofloxacin 4～7%; taurine 5～8%, natrium carbonicum calcinatum 5%, surplus are anhydrous glucose.
6. the compositions that is used for the treatment of the chicken colibacillosis infection according to claim 4 is characterized in that, is made up of following raw material by weight percentage: amoxicillin 10%, ofloxacin 5%, taurine 8%, natrium carbonicum calcinatum 5%, anhydrous glucose 72%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102364362A CN101966186A (en) | 2010-07-26 | 2010-07-26 | Composition for treating chicken escherichia coli infection and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102364362A CN101966186A (en) | 2010-07-26 | 2010-07-26 | Composition for treating chicken escherichia coli infection and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101966186A true CN101966186A (en) | 2011-02-09 |
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| CN2010102364362A Pending CN101966186A (en) | 2010-07-26 | 2010-07-26 | Composition for treating chicken escherichia coli infection and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006660A (en) * | 2012-08-09 | 2013-04-03 | 江苏科技大学 | Sarafloxacin hydrochloride bactericide for silkworms and preparation method for capsules thereof |
-
2010
- 2010-07-26 CN CN2010102364362A patent/CN101966186A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006660A (en) * | 2012-08-09 | 2013-04-03 | 江苏科技大学 | Sarafloxacin hydrochloride bactericide for silkworms and preparation method for capsules thereof |
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Application publication date: 20110209 |
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| WD01 | Invention patent application deemed withdrawn after publication |