CN103006660A - Sarafloxacin hydrochloride bactericide for silkworms and preparation method for capsules thereof - Google Patents
Sarafloxacin hydrochloride bactericide for silkworms and preparation method for capsules thereof Download PDFInfo
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- CN103006660A CN103006660A CN2012102822482A CN201210282248A CN103006660A CN 103006660 A CN103006660 A CN 103006660A CN 2012102822482 A CN2012102822482 A CN 2012102822482A CN 201210282248 A CN201210282248 A CN 201210282248A CN 103006660 A CN103006660 A CN 103006660A
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Abstract
The invention discloses a sarafloxacin hydrochloride bactericide for silkworms and a preparation method for capsules thereof. The bactericide consists of sarafloxacin hydrochloride, sucrose powder and sodium carbonate in a weight ratio of 1: (0.5-1.5): (1.5-2.5). The method comprises the following steps of: mixing the materials uniformly, preparing a soft material by using 50 to 90 weight percent ethanol solution as mucilage, granulating, drying, reshaping, mixing uniformly, filling into No.0 capsules, making plates by using aluminum plastic, and packing, wherein each capsule contains 0.1 gram of sarafloxacin hydrochloride. The results show that the water solubility, the quality stability and the controllability of the researched sarafloxacin hydrochloride capsules for the silkworms are obviously enhanced, and the capsules have an obvious prevention and control effect on bacterial silkworm septicemia caused by infection of bacillus such as bacillus thuringiensis or chromobacterium prodigiosum.
Description
Technical field
The present invention relates to the preparation method of antibacterial and capsule thereof.For example as the preparation method of broad-spectrum antiseptic medicament and capsule thereof, refer to that especially a kind of trade name is hydrochloric acid sarafloxacin antibacterial and capsule thereof are used in control by the silkworm of bacillus and the caused silkworm bacteremic septicemia of clever bacterium the preparation method that is used for of " inferior enlightening silkworm is rich ".
Background technology
The silkworm bacteremic septicemia refers to that antibacterial invades in the body fluid of silkworm body, Pupa bombycis and Bombycis mori, amount reproduction and along with the body fluid loop distribution to whole body, cause serious General Symptoms, this disease is divided into 2 kinds of constitutional and Secondary cases.The silkworm bacteremic septicemia happens occasionally in silkworm already produces, especially heavier in the high temperature humid season harm of autumn in summer, bring great economic loss to the silkworm raiser, the desirable antibacterials of screening development are used for silkworm and already produce one of important technique measure that is the realization high and stable yields, increases economic efficiency.Cause that the septicemic cemia pathogenetic bacteria of silkworm is of a great variety, such as septicaemia bacterium, husky thunder ferrum Salmonella, blue or green deteriorated blood pathogenic bacteria and streptococcus faecalis, the crystallinity toxin that the apoplectic stroke bacterium produces is nibbled lower meeting and is caused that silkworm poisons and the generation sotto disease, but the thalline of apoplectic stroke bacterium or spore are also more common aborning by the silkworm septicemia that traumatic infection causes.In the silkworm medicine of control silkworm bacteremic septicemia commonly used, most pharmaceutical agents example hydrochloric acid norfloxacin solution, the norfloxacin hydrochloride capsule, erythromycin thiocyanate capsule and erythromycin capsule etc. are better to the silkworm bacteremic septicemia prevention effect that bacillus category causes, but relatively poor to the silkworm bacteremic septicemia prevention effect that husky thunder ferrum Salmonella (being commonly called as clever bacterium on the silkworm industry) causes, and Ciprofloxacin Hydrochloride Capsules is directly to pour in the hard capsule case by raw material medicated powder, easily moisture absorption affects the quality stability of finished product drug effect, and norfloxacin hydrochloride, erythromycin, the medicines such as ciprofloxacin share crude drug for people and animals, should not be silkworm, poultry, multiplex between fowl, in order to avoid accelerate antibacterial said medicine is produced drug resistance, affect the human effect.
The present invention just is being based on above reason, the research and development of the antibacterial for silkworm of new high-efficiency broad spectrum are carried out in project verification, to control bacterial disease harm (particularly clever bacterium septicemia and bacillus category cause septicemia), make silkworm and mulberry production stable development, the stable silkworm district popular feelings, building a harmonious society has very great help, and will greatly promote the update of our province and national silkworm medicine product.
Sarafloxacin is the quinolones of veterinary's special use of FDA approval behind enrofloxacin, the husky star of single promise, it is the fluoroquinolones that first (August 18 nineteen ninety-five) is used for food animal by Food and Drug Administration (FDA) approval, this medicine has a broad antifungal spectrum, sterilizing power are strong, and gram positive bacteria, gram negative bacteria and Mycoplasma are had remarkable effect.At present, domestic-developed is used mainly is its hydrochlorate, be hydrochloric acid sarafloxacin.The dissolubility of hydrochloric acid sarafloxacin draws the dissolubility of copying star high than copying, can the multipath administration, and infiltration rate is fast in animal body, is the ideal medicament of control livestock and poultry.
Hydrochloric acid sarafloxacin is the animal specific antibacterials, has that antibacterial activity is strong, an efficient advantage such as rapid of has a broad antifungal spectrum, bactericidal action, but its water solublity is relatively poor.
Summary of the invention
The technical problem that solves: exist with antimicrobial agent for present silkworm or the wide not silkworm bacteremic septicemia that only bacillus category is caused of antimicrobial spectrum effectively but relatively poor to the microbial silkworm bacteremic septicemia of spirit prevention effect, or the pharmacodynamic stability of finished product not good enough, affect result of use, or crude drug provides the preparation method of a kind of silkworm usefulness hydrochloric acid sarafloxacin antibacterial and capsule thereof for people and animals share crude drug, cause antibacterial to produce the present situation that drug resistance affects the problem such as human effect using with between people and silkworm, poultry, fowl; We adopt hydrochloric acid sarafloxacin is primary raw material, adds a certain proportion of dilution cosolvent sucrose and sodium carbonate in prescription, carries out silkworm and tests with the production technology development of hydrochloric acid sarafloxacin capsule and to the control of silkworm bacteremic septicemia.The result shows, the silkworm of the present invention's development obviously strengthens with water solublity, quality stability and the controllability of hydrochloric acid sarafloxacin capsule, and the silkworm bacteremic septicemia that is caused by the bacillus cereus such as apoplectic stroke bacterium or the infection of clever bacterium is all had obvious prevention effect.
Technical scheme:
A kind of silkworm hydrochloric acid sarafloxacin antibacterial, this antibacterial by hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate by weight 1: (0.5～1.5): (1.5～2.5) form.
One of preferred scheme, this antibacterial is comprised of by weight 1: 0.5: 2.5 hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate.
Two of preferred scheme, this antibacterial is comprised of by weight 1: 1: 2 hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate.
Three of preferred scheme, this antibacterial is comprised of by weight 1: 1.5: 1.5 hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate.
A kind of silkworm hydrochloric acid sarafloxacin capsule, this capsule by hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate by weight 1: (0.5～1.5): behind (1.5～2.5) mixing again take 50%wt～90%wt alcoholic solution as mucilage soft material processed, behind granulation, oven dry, granulate, mixing, pour in the 0# capsule, plastic-aluminum plate-making packing is made hydrochloric sarafloxacin 0.1g in every capsules more at last.16 eye mesh screens are adopted in described granulation.60 ℃ of forced air dryings 2～4 hours are adopted in described oven dry, and water content must not surpass 6.0%.
The raw material hydrochloric acid sarafloxacin meets the middle quality standard requirement of version " Ministry of Agriculture's veterinary drug quality standard " in 2003, content 〉=98.0%; Adjuvant sucrose meets two middle quality standard requirements of the version Pharmacopoeia of the People's Republic of China in 2005; The adjuvant sodium carbonate meets " food additive sodium carbonate GB1886-1992 " quality standard requirement, content 〉=98.0%.
The silkworm of the present invention preparation method of hydrochloric acid sarafloxacin antibacterial and capsule thereof, its prescription and production technology are by the former powder of hydrochloric acid sarafloxacin and dilution cosolvent cane sugar powder and the sodium carbonate proportioning with weight ratio 1: 0.5～1.5: 1.5～2.5, mix homogeneously, take 50%～90% alcoholic solution as adhesive, pour into (the hydrochloric sarafloxacin 0.1g of every capsules) in the capsule after making soft material, oven dry (granule water content≤6.0%), granulate, mixing, polishing is also aluminum-plastic packaged.With in capsule 's content impouring 250～1000mL water, be sprayed on the Folium Mori blade face after the stirring and dissolving and feed silkworm during use, be used for control and infect caused silkworm bacteremic septicemia by bacillus or clever bacterium.
Silkworm of the present invention is hydrochloric acid sarafloxacin with the primary raw material of hydrochloric acid sarafloxacin capsule and preparation method thereof, and chemical name is: fluoro-4 oxidations-Isosorbide-5-Nitrae-dihydro-7-(1-the piperazinyl)-3-quinoline carboxylic acid hydrochloride 1-(4-fluorophenyl)-6; English name: Sarafloxacin Hydrochloride; Molecular formula is: C
20H
17F
2N
3O
3HCl; Molecular weight is 421.84, and structural formula is:
The hydrochloric acid sarafloxacin prescription meets in the 2003 middle quality standard of version " Ministry of Agriculture's veterinary drug quality standard ", content 〉=98.0%; Adjuvant sucrose requires to meet two middle quality standards of in the 2005 version Pharmacopoeia of the People's Republic of China; The adjuvant sodium carbonate requires to meet " food additive sodium carbonate GB1886-1992 " standard, content 〉=98.0%.
Silkworm is write out a prescription with the hydrochloric acid sarafloxacin capsule:
Silkworm hydrochloric acid sarafloxacin capsule manufacture technique:
A. pulverize: sucrose is put in the pulverizer pulverized, cross 120 mesh sieves.
B. weigh batching: calculate actual inventory by prescription, and accurately take by weighing supplementary material.
C. system is wet: hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate are mixed, make soft material take 50%～90% alcoholic solution as adhesive, the shaping soft material is sent in the oscillating granulator granulated with 16 eye mesh screens.
D. dry: as the even stall with goods spread out on the ground for sale of the wet granular that makes to be entered drip pan, sent into the heated-air circulation oven drying 2～4 hours, make dried granule water content reach prescribed limit.
E. granulate, total mixed: dried particles is placed oscillating granulator, by 16 eye mesh screen granulate, will have suffered the granule of grain and put in the three dimension high efficiency mixing machine, make it mix homogeneously.
F. intermediate check: measure moisture and content.
G. capsule charge: with the dried particles fill in the 0# empty hard capsule.
H. polishing: the capsule that filling is good, polish with the medicine buffing machine.
I. aluminum-plastic packaged: as to carry out aluminum-plastic packaged with the plastic-aluminum Autoblisterpackagingmachine polished capsule.
J. outer package: behind Low Density Polyethylene bag of aluminum-plastic packaged overcoat of every plate, the sealing vanning.Clinical drug effect:
The present invention is used for the silkworm of control silkworm bacteremic septicemia and lists in table 1 and table 2 with hydrochloric acid sarafloxacin capsule and norfloxacin hydrochloride solution, Ciloxan to infected the septicemic cemia prevention effect contrast of the silkworm that causes by bacillus cereus or clever bacterium:
The septicemic cemia prevention effect of silkworm that table 1 silkworm infects bacillus cereus Bt with the hydrochloric acid sarafloxacin capsule
Annotate: (1) Bt high-concentration bacterial liquid count plate: I is 5.9 * 10
8Cfu/mL; II is 5.5 * 10
8Cfu/mL; III is 7.3 * 10
8Cfu/mL.Among the Bt, low concentration bacterium liquid is with high-concentration bacterial liquid successively 10 times of dilutions.
(2) sickness rate calculates: (together lower)
(3) 1. represent in the table to raise the medicine leaf 24 hours on the 1st day, respectively raised the medicine leaf 6 hours on the 2nd, 3 day, all the other times are raised common Folium Mori; 2. represented to raise every day the medicine leaf 6 hours, for three days on end, all the other times are raised common Folium Mori; 3. represent to raise the medicine leaf 24 hours on the 1st day, all the other times are raised common Folium Mori.(together lower)
The septicemic cemia prevention effect of silkworm that table 2 silkworm infects clever bacterium Sm with the hydrochloric acid sarafloxacin capsule
Annotate: Sm high-concentration bacterial liquid count plate: I is 3.1 * 10
8Cfu/mL; II is 1.4 * 10
8Cfu/mL; III is 2.2 * 10
8Cfu/mL.Among the Sm, low concentration bacterium liquid is with high-concentration bacterial liquid successively 10 times of dilutions.
According to the prevention effect result of the test, hydrochloric acid sarafloxacin 200mgL
-11., 2., 3. three kinds of administering modes and 100mgL
-11. administering mode has obvious prevention effect to the silkworm septicemia that bacillus cereus Bt infects, and compares no significant difference with control drug norfloxacin hydrochloride, ciprofloxacin.Hydrochloric acid sarafloxacin 800mgL
-1, 500mgL
-1, 400mgL
-11. administering mode has obvious prevention effect to the silkworm septicemia that is infected by clever bacterium Sm, with control drug ciprofloxacin 500mgL
-1Compare no significant difference, but obviously be better than control drug norfloxacin hydrochloride 500mgL
-1, ciprofloxacin 250mgL
-1
Medication: be used for control by the caused silkworm bacteremic septicemia of bacillus, get one of this product, porphyrize, adding water 1000mL(is that concentration is 100mgL
-1), after the stirring and dissolving, be sprayed on the positive and negative blade face of Folium Mori, take moistening as degree; After finding the disease silkworm, raise medicine leaf 24h on the 1st day, respectively raised medicine leaf 6h on the the 2nd, 3 day.Be used for control by the caused silkworm bacteremic septicemia of clever bacterium, get one of this product, porphyrize, adding water 250mL(is that concentration is 400mgL
-1), after the stirring and dissolving, be sprayed on the positive and negative blade face of Folium Mori, take moistening as degree; After finding the disease silkworm, raise medicine leaf 24h on the 1st day, respectively raised medicine leaf 6h on the the 2nd, 3 day.
Dissolubility and quality stability
(take embodiment 1 product as example):
The silkworm of the present invention preparation method of hydrochloric acid sarafloxacin antibacterial and capsule thereof, its every the silkworm content of hydrochloric acid sarafloxacin capsule, adding water 125～250mL can all dissolve.Its quality stability comprises that character, dissolubility, water content, content uniformity, content etc. are by the long-term stable experiment result as can be known, silkworm preserves under the room temperature air-proof condition with the hydrochloric acid sarafloxacin capsule, steady quality, its packing, character, discriminating, dissolubility, water content, content uniformity, content have no significant change within 24 months effect duration, meet the requirement of quality standard regulation, detailed data sees Table 3, table 4, table 5.Quality mainly examines or check index and detection method is summarized as follows: (1) character: range estimation, capsule 's content should be white to faint yellow particle powder; (2) dissolubility: the content that desirable this product is 1, add water 125～250mL, should all dissolve; (3) water content (being loss on drying): take phosphorus pentoxide as desiccant, 60 ℃ of drying under reduced pressure are to constant weight, water content should≤6.0%; (4) the content uniformity inspection should meet under the capsule item and stipulates; (5) content should be 90.0～110.0% of labelled amount (every hydrochloric sarafloxacin 0.1g) according to high effective liquid chromatography for measuring.
Table 3 silkworm hydrochloric acid sarafloxacin capsule (batch sample 1) quality long-term stable experiment testing result
Table 4 silkworm hydrochloric acid sarafloxacin capsule (batch sample 2) quality long-term stable experiment testing result
Table 5 silkworm hydrochloric acid sarafloxacin capsule (batch sample 3) quality long-term stable experiment testing result
Beneficial effect: silkworm is compared with hydrochloric acid sarafloxacin capsule and the antibacterial for silkworm of commonly using in the market, has novelty.And below commonly used antibacterial for silkworm such as example hydrochloric acid norfloxacin solution, Ciprofloxacin Hydrochloride Capsules, erythromycin capsule and erythromycin thiocyanate capsule exist at least in the market wherein one, binomial is not enough.1. silkworm is strong with the antibacterial activity of hydrochloric acid sarafloxacin capsule, bactericidal action is efficiently rapid, and the antibacterial of resting stage and trophophase is all had stronger bactericidal action.2. silkworm has broad-spectrum antibacterial action with the hydrochloric acid sarafloxacin capsule, no matter to being by the bacillus cereus such as apoplectic stroke bacterium or infecting the silkworm bacteremic septicemia that causes by clever bacterium all has significant prevention effect.3. silkworm is capsule with the hydrochloric acid sarafloxacin capsule, stable processing technique (through granulating process processing, capsule formulation, aluminum-plastic packaged), and quality controllability is strong.Its finished product efficacy stability, also more convenient transportation.4. silkworm is domestic with the supplementary material of hydrochloric acid sarafloxacin capsule, buys easily.Especially the crude drug hydrochloric acid sarafloxacin is the special-purpose antimicrobial drugs of poultry, has avoided people and animals to share the homogeneous raw material medicine, accelerates antibacterial it is produced drug resistance, affects the human effect.
Prescription of the present invention, production technology and clinical test of pesticide effectiveness result of study show, silkworm is reasonable with the prescription of hydrochloric acid sarafloxacin capsule, all obviously being better than the existing market like product at aspects such as curative effect, production technology, quality standard, safety, stability, is current comparatively desirable antibacterial for silkworm.Produce enlarging pilot scale and sericulture production practices proves, use silkworm of the present invention with the hydrochloric acid sarafloxacin capsule after, silkworm bacteremic septicemia sickness rate obviously descends, kind of an amount of cocoon production improves, economic results in society obviously increase.Therefore, the silkworm for control silkworm bacteremic septicemia of the present invention has popularizing value aborning with the hydrochloric acid sarafloxacin capsule, and market prospect is wide.
Description of drawings
Fig. 1 is silkworm hydrochloric acid sarafloxacin capsule process chart;
The specific embodiment
Below be embodiments of the invention, the actual use of the present invention is not limited to embodiment.
Embodiment 1: the silkworm hydrochloric acid sarafloxacin capsule and preparation method thereof that is used for control silkworm bacteremic septicemia
Adopt silkworm hydrochloric acid sarafloxacin capsule and preparation method thereof for control silkworm bacteremic septicemia of the present invention, silkworm with each component proportion in the hydrochloric acid sarafloxacin capsule prescription is: the former powder of hydrochloric acid sarafloxacin is 1: 0.5: 2.5 with the weight proportion of dilution cosolvent cane sugar powder, sodium carbonate; Be hydrochloric sarafloxacin 0.1g, cane sugar powder 0.05g, sodium carbonate 0.25g in every capsules.Its preparation method is that production technology is: take by weighing respectively supplementary material by the prescription inventory, mix homogeneously is made soft material take 90% alcoholic solution as adhesive, behind oven dry, granulate, the mixing, pours into after the assay was approved in the capsule through intermediate, and polishing is also aluminum-plastic packaged.With in the capsule 's content impouring 250mL water, be sprayed on the positive and negative blade face of Folium Mori (take moistening as degree) after the stirring and dissolving during use, then feed silkworm with the medicine leaf, be used for control and infect caused silkworm bacteremic septicemia by bacillus or clever bacterium.Carry out in rural area silkworm district and finish pilot scale.Pilot-scale is 25000, is used for raising the silkworm septicemia control of 2500 silkworm eggs.Pilot scale proves, after using silkworm of the present invention to carry out the control of silkworm bacteremic septicemia with the hydrochloric acid sarafloxacin capsule, silkworm septicemia annual loss rate is than not using the sericulture family to reduce by 4.0% percentage point, with control drug norfloxacin hydrochloride solution phase ratio, the flacherie loss rate reduces by 2.0% percentage point, particularly clever bacterium septicemia has no in for examination sericulture family substantially, and in without the contrast family of silkworm of the present invention with the hydrochloric acid sarafloxacin capsule, finding, sickness rate are arranged more than 1.5% during clever bacterium septicemia.After using silkworm with the hydrochloric acid sarafloxacin capsule, the amount of cocoon production increases, and average is produced 48.2 kilograms of cocoons (the highest is produced 54.5 kilograms of cocoons, and minimum is produced 35.5 kilograms of cocoons), and producing a cocoon on the specific surface on average improves about 5 kilograms, kind increases income 150 yuan.User's reflection, silkworm of the present invention is remarkable to the prevention effect that is infected caused silkworm bacteremic septicemia by bacillus or clever bacterium with the hydrochloric acid sarafloxacin capsule, especially the septicemic cemia therapeutic effect of silkworm spirit bacterium obviously is better than norfloxacin hydrochloride solution.This medicine is a kind of new antibacterial for silkworm, have that antibacterial activity is strong, the efficient advantage such as rapid of has a broad antifungal spectrum, bactericidal action, user's transportation, easy to use, drug price is moderate, especially the silkworm raiser uses this medicine can improve an amount of cocoon production, increase income, and is a kind of silkworm antimicrobial drug that is worthy to be popularized.
Embodiment 2: the silkworm hydrochloric acid sarafloxacin capsule and preparation method thereof that is used for control silkworm bacteremic septicemia
Adopt silkworm hydrochloric acid sarafloxacin capsule and preparation method thereof for control silkworm bacteremic septicemia of the present invention, silkworm with each component proportion in the hydrochloric acid sarafloxacin capsule prescription is: the former powder of hydrochloric acid sarafloxacin is 1: 1: 2 with the weight proportion of dilution cosolvent cane sugar powder, sodium carbonate; Be hydrochloric sarafloxacin 0.1g, cane sugar powder 0.1g, sodium carbonate 0.2g in every capsules.Its preparation method is that production technology is: take by weighing respectively supplementary material by the prescription inventory, mix homogeneously is made soft material take 75% alcoholic solution as adhesive, behind oven dry, granulate, the mixing, pours into after the assay was approved in the capsule through intermediate, and polishing is also aluminum-plastic packaged.With in the capsule 's content impouring 1000mL water, be sprayed on the positive and negative blade face of Folium Mori (take moistening as degree) after the stirring and dissolving during use, then feed silkworm with the medicine leaf, be used for control and infect caused silkworm bacteremic septicemia by bacillus or clever bacterium.Carry out in rural area silkworm district and finish pilot scale.Pilot-scale is 1000, is used for raising the silkworm septicemia control of 121.5 silkworm eggs.Pilot scale proves, after using silkworm of the present invention to carry out the control of silkworm bacteremic septicemia with the hydrochloric acid sarafloxacin capsule, silkworm septicemia annual loss rate is than not using the sericulture family to reduce by 3.54% percentage point, with control drug norfloxacin hydrochloride solution phase ratio, the flacherie loss rate reduces by 1.56% percentage point.After using silkworm with the hydrochloric acid sarafloxacin capsule, average is produced 45.25 kilograms of cocoons (the highest is produced 54.4 kilograms of cocoons, and minimum is produced 32.5 kilograms of cocoons), and producing a cocoon on the specific surface on average improves about 5 kilograms, kind increases income 110 yuan.User's reflection, silkworm of the present invention hydrochloric acid sarafloxacin capsule, antibacterial activity is strong, has a broad antifungal spectrum, bactericidal action are efficiently rapid, remarkable to the prevention effect that infected the silkworm bacteremic septicemia cause by bacillus, the silkworm that causes is septicemic cemia also certain prophylactic treatment effect to being infected by clever bacterium.This medicine is a kind of new antibacterial for silkworm, and antibacterial action is extensive; Silkworm raiser's use cost is relatively low; Its crude drug hydrochloric acid sarafloxacin is the special-purpose antibacterials of poultry, is difficult for producing drug resistance; As capsule, stable processing technique (through granulating process processing, capsule formulation, aluminum-plastic packaged), quality controllability is strong, the finished product efficacy stability.The silkworm raiser can increase income after using this medicine, has aborning popularizing value, can obtain preferably economic results in society, should declare early operation.
Embodiment 3: the silkworm hydrochloric acid sarafloxacin capsule and preparation method thereof that is used for control silkworm bacteremic septicemia
Adopt silkworm hydrochloric acid sarafloxacin capsule and preparation method thereof for control silkworm bacteremic septicemia of the present invention, silkworm with each component proportion in the hydrochloric acid sarafloxacin capsule prescription is: the former powder of hydrochloric acid sarafloxacin is 1: 1.5: 1.5 with the weight proportion of dilution cosolvent cane sugar powder, sodium carbonate; Be hydrochloric sarafloxacin 0.1g, cane sugar powder 0.15g, sodium carbonate 0.15g in every capsules.Its preparation method is that production technology is: take by weighing respectively supplementary material by the prescription inventory, mix homogeneously is made soft material take 60% alcoholic solution as adhesive, behind oven dry, granulate, the mixing, pours into after the assay was approved in the capsule through intermediate, and polishing is also aluminum-plastic packaged.With in the capsule 's content impouring 500mL water, be sprayed on the positive and negative blade face of Folium Mori (take moistening as degree) after the stirring and dissolving during use, feed silkworm with the medicine leaf, be used for control and infect caused silkworm bacteremic septicemia by bacillus or clever bacterium.Carry out in rural area silkworm district and finish pilot scale.Pilot-scale is 1000, is used for raising the silkworm septicemia control of 42 silkworm eggs.Pilot scale proves, after using silkworm of the present invention to carry out the control of silkworm bacteremic septicemia with the hydrochloric acid sarafloxacin capsule, the septicemic cemia sickness rate of silkworm descends to some extent, spring, the flacherie loss rate was than not using the sericulture family to reduce by 3.2% percentage point, compare with control drug erythromycin thiocyanate capsule, the flacherie loss rate reduces by 1.4% percentage point.After using silkworm to use the hydrochloric acid sarafloxacin capsule, on average open and produce 49.1 kilograms of cocoons, a product cocoon balanced growth 4.7% is opened to plant and is increased income 50.31 yuan, and the silkworm raiser increases income 2100 yuan, realizes more than 6.2 ten thousand yuan of economic results in society.User's reflection, silkworm of the present invention is better with hydrochloric acid sarafloxacin capsule water-soluble, have obvious prevention effect to infecting caused silkworm bacteremic septicemia by bacillus or clever bacterium, especially the septicemic cemia therapeutic effect of silkworm spirit bacterium significantly is better than the existing medicine of the same type in market.Silkworm of the present invention hydrochloric acid sarafloxacin capsule preparation method thereof, its stable processing technique, quality controllability is strong, and water solublity obviously is better than the former powder of hydrochloric acid sarafloxacin.This medicine is a kind of new antibacterial for silkworm, and antibacterial action is powerful, has a broad antifungal spectrum, bactericidal action are efficiently rapid; Crude drug is the animal specific antibacterials, is difficult for producing drug resistance; Silkworm raiser transportation, easy to use, cost is relatively low; Using and can improve kind of an amount of cocoon production behind this medicine, increase silkworm raiser's income, receive praises from customers, is current comparatively desirable antibacterial for silkworm, and market application foreground is wide, be worthy to be popularized.
Embodiment 4: the silkworm hydrochloric acid sarafloxacin capsule and preparation method thereof that is used for control silkworm bacteremic septicemia
Adopt silkworm hydrochloric acid sarafloxacin capsule and preparation method thereof for control silkworm bacteremic septicemia of the present invention, silkworm with each component proportion in the hydrochloric acid sarafloxacin capsule prescription is: the former powder of hydrochloric acid sarafloxacin is 1: 0.5: 2.5 with the weight proportion of dilution cosolvent cane sugar powder, sodium carbonate; Be hydrochloric sarafloxacin 0.1g, cane sugar powder 0.05g, sodium carbonate 0.25g in every capsules.Its preparation method is that production technology is: take by weighing respectively supplementary material by the prescription inventory, mix homogeneously is made soft material take 50% alcoholic solution as adhesive, behind oven dry, granulate, the mixing, pours into after the assay was approved in the capsule through intermediate, and polishing is also aluminum-plastic packaged.With in the capsule 's content impouring 1000mL water, be sprayed on the positive and negative blade face of Folium Mori (take moistening as degree) after the stirring and dissolving during use, feed silkworm with the medicine leaf, be used for control and infect caused silkworm bacteremic septicemia by bacillus or clever bacterium.Carry out in rural area silkworm district and finish pilot scale.Pilot-scale is 1000, is used for raising the silkworm septicemia control of 87 silkworm eggs.Pilot scale proves, after using silkworm of the present invention to carry out the control of silkworm bacteremic septicemia with the hydrochloric acid sarafloxacin capsule, the septicemic cemia sickness rate of silkworm descends to some extent, spring, the flacherie loss rate was than not using the sericulture family to reduce by 0.8% percentage point, with control drug norfloxacin hydrochloride solution phase ratio, the flacherie loss rate reduces by 0.6% percentage point.After the use silkworm is used the hydrochloric acid sarafloxacin capsule, 48.5 kilograms of product cocoons, balanced growth 5.8% is opened to plant and is increased income 61.02 yuan, and the silkworm raiser increases income 0.53 ten thousand yuan, more than 12.6 ten thousand yuan of realization economic results in society.User's reflection, silkworm of the present invention hydrochloric acid sarafloxacin capsule and preparation method thereof, its water-soluble is better, and drug residue is less; Its stable processing technique, quality controllability is strong; Silkworm is remarkable to the prevention effect that is infected caused silkworm bacteremic septicemia by bacillus or clever bacterium with the hydrochloric acid sarafloxacin capsule, particularly the septicemic cemia prophylactic treatment successful of silkworm spirit bacterium is better than norfloxacin hydrochloride solution.Silkworm is a kind of new desirable silkworm antimicrobial drug with the hydrochloric acid sarafloxacin capsule, compare with market similar medicine commonly used, have that antibacterial activity is strong, the efficient advantage such as rapid of has a broad antifungal spectrum, bactericidal action, no matter to being to infect caused silkworm bacteremic septicemia by bacillus or by clever bacterium obvious prevention effect is all arranged; Its crude drug hydrochloric acid sarafloxacin is the special-purpose antibacterials of poultry, has avoided people and animals to share the homogeneous raw material medicine and has caused antibacterial to produce drug resistance, affect the human effect; This medicine is moderate, silkworm raiser's transportation, easy to use, finished product efficacy stability, use can improve an amount of cocoon production behind this medicine, increase silkworm raiser's income, economic results in society are obvious, be a kind of antibacterial for silkworm that is worthy to be popularized, have broad application prospects aborning, wish to put into production as early as possible.User's reflection, silkworm of the present invention with its unique production technology and antibiotic prophylaxis effect, has produced huge economic benefit and social benefit with hydrochloric acid sarafloxacin capsule and preparation method thereof, is worthy to be popularized.
Claims (8)
1. silkworm hydrochloric acid sarafloxacin antibacterial, it is characterized in that this antibacterial by hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate by weight 1: (0.5～1.5): (1.5～2.5) form.
2. silkworm according to claim 1 hydrochloric acid sarafloxacin antibacterial is characterized in that this antibacterial is comprised of by weight 1: 0.5: 2.5 hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate.
3. silkworm according to claim 1 hydrochloric acid sarafloxacin antibacterial is characterized in that this antibacterial is comprised of by weight 1: 1: 2 hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate.
4. silkworm according to claim 1 hydrochloric acid sarafloxacin antibacterial is characterized in that this antibacterial is comprised of by weight 1: 1.5: 1.5 hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate.
5. silkworm hydrochloric acid sarafloxacin capsule, it is characterized in that this capsule by hydrochloric acid sarafloxacin, cane sugar powder and sodium carbonate by weight 1: (0.5～1.5): behind (1.5～2.5) mixing again take 50%wt～90%wt alcoholic solution as mucilage soft material processed, behind granulation, oven dry, granulate, mixing, pour in the 0# capsule, plastic-aluminum plate-making packing is made hydrochloric sarafloxacin 0.1g in every capsules more at last.
6. described silkworm hydrochloric acid sarafloxacin capsule according to claim 5 is characterized in that described granulation adopts 16 eye mesh screens.
7. described silkworm hydrochloric acid sarafloxacin capsule according to claim 5 is characterized in that described oven dry adopts 60 ℃ of forced air dryings 2～4 hours, and water content must not surpass 6.0%.
8. silkworm according to claim 1 hydrochloric acid sarafloxacin antibacterial is characterized in that the raw material hydrochloric acid sarafloxacin meets the middle quality standard requirement of version " Ministry of Agriculture's veterinary drug quality standard " in 2003, content 〉=98.0%; Adjuvant sucrose meets two middle quality standard requirements of the version Pharmacopoeia of the People's Republic of China in 2005; The adjuvant sodium carbonate meets " food additive sodium carbonate GB1886-1992 " quality standard requirement, content 〉=98.0%.
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| CN101966186A (en) * | 2010-07-26 | 2011-02-09 | 天津生机集团股份有限公司 | Composition for treating chicken escherichia coli infection and preparation method thereof |
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