CN103690952A - Compound drug for treating livestock and poultry escherichia coli infected diseases - Google Patents
Compound drug for treating livestock and poultry escherichia coli infected diseases Download PDFInfo
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- CN103690952A CN103690952A CN201310617988.1A CN201310617988A CN103690952A CN 103690952 A CN103690952 A CN 103690952A CN 201310617988 A CN201310617988 A CN 201310617988A CN 103690952 A CN103690952 A CN 103690952A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses a compound drug for treating livestock and poultry escherichia coli infected diseases. The compound drug comprises the following raw materials in parts by weight: 3-30 parts of an antibacterial drug, and 5-200 parts of longtube ground ivy herb. The Guangxi characteristic traditional Chinese medicine longtube ground ivy herb and the antibacterial drug are utilized to form the compound drug; researches prove that after longtube ground ivy herb is added into the antibacterial drug, the drug resistance of bacteria to the antibacterial drug can be reversed, so as to enhance the treatment effect of the antibacterial drug. The compound drug is made into powder, tablets, an oral liquid or granules by a conventional method, is used for feeding by being added into a livestock and poultry feed according to the addition amount of 0.1-7 g/kg, can greatly reduce the drug using cost and drug residues, creates higher economic benefits for farmers, and besides, also ensures foodstuff safety.
Description
Technical field
The invention belongs to poultry coli-infection treatment technology field, relate in particular to a kind of compound medicine for the treatment of poultry coli-infection disease.
Background technology
Escherichia coli are common conditioned pathogens, also be normal a kind of disease of sending out, its multiple location severe infections such as chicken acute sepsis, peritonitis, hepatitis, pneumonia, enteritis of can formerly having carried out the coffin upon burial, also can secondary or mixed sending out in virosis, to aquaculture, causes huge economic loss.The beta-lactam lopps antibiotic such as amoxicillin, ampicillin, ceftiofur, ceftriaxone, amoxicillin/clavulanate, ampicillin/sulbactam are the conventional important drugs of this disease of control, along with cultivation scale intensive degree is more and more large, medication is more and more spread unchecked, its Resistant strain is more and more many, also more about the report of Drug Resistance of E. coli.Studies confirm that, one of main mechanism of drug resistance is to produce beta-lactamase, especially extended spectrumβ-lactamase (Extended-Spectrum β-lactamase, ESBLs), this enzyme can be more by force and is hydrolyzed rapidly beta-lactam nucleus, makes this class antibiotic lose antibacterial activity.ESBLs is the main enzyme type of beta-lactamase, and it is not only to cephalo three generations and aztreonam drug resistance, and aminoglycoside, quinolones and sulfonamides are to crossing drug resistant, only to carbapenems, a mould alkene class medicaments insensitive.Many documents have reported colibacillary multi-drug resistant and have produced ESBLs and have substantial connection, both at home and abroad to comparatively pay close attention to.The detection, extraction, enzyme that inventor has carried out food animal source pathogenic bacterium ESBLs recently presses down the researchs such as enzyme protection effect to antibiotic percent hydrolysis and sulbactam, Tazobactam Sodium and Chinese medicine; to part ESBLs, colibacillary drug sensitive test shows, its multidrug resistant rate is apparently higher than non-ESBLs bacterial strain.In addition, result also shows to produce ESBLs bacterial strain not only to the serious drug resistance of the third generation cephalosporins such as ceftiofur, and also to multiple antimicrobial drug drug resistance such as fluoroquinolones, aminoglycoside and sulfonamides, fosfomycin etc., is serious multidrug resistant.Inventor is separated to the escherichia coli that tolerate P-levels mycin produces fosA3 drug resistant gene in producing ESBLs bacterial strain, has more strengthened the drug resistance of antibacterial.Colibacillary drug resistance causes raiser's drug cost to increase, and treatment extends the course for the treatment of, and mortality of livestock increases, and to production, brings larger economic loss, and increases poultry drug residue risk.Therefore, in actual production, need a kind of to no matter whether, the escherichia coli of drug resistance can have the medicine of better therapeutical effect badly, and can shorten treatment course for the treatment of, reduce mortality rate, reducing economic loss and reduce drug residue, is that raiser creates higher economic benefit, also ensures that the mankind's is healthy and safe.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of compound medicine for the treatment of poultry coli-infection disease, it can kill antibacterial quickly, overcome antimicrobial drug treatment due to large, the residual height of weak curative effect, consumption and the high defect of cost that drug resistance problem causes, avoided that simple Chinese medicine sterilizing spectrum is narrow, slow problem sterilizes.
For solving above technical problem, the present invention by the following technical solutions: the compound medicine for the treatment of poultry coli-infection disease, comprises the raw material of following weight portion: antimicrobial drug 3-30 part, Radix seu Folium Gaultheriae Forrestii 5-200 part.
Antimicrobial drug is a kind of in beta-lactam, fluoroquinolones, Tetracyclines, aminoglycoside, carbadox class, polypeptide class, amide alcohols antimicrobial drug or fosfomycin.
Beta-lactam antimicrobial drug is amoxicillin, ceftriaxone sodium or ceftiofur sodium; Fluoroquinolone antibacterial agent is norfloxacin; Aminoglycoside antimicrobial drug is amikacin; Carbadox class antimicrobial drug is LIJUNJING; Amide alcohols is florfenicol; Polypeptide class antimicrobial drug is colistin.
The compound medicine of above-mentioned treatment poultry coli-infection disease, the raw material that comprises following weight portion: amoxicillin 3-20 part and Radix seu Folium Gaultheriae Forrestii 40-180 part, or norfloxacin 3-25 part and Radix seu Folium Gaultheriae Forrestii 30-190 part, or amikacin 5-30 part and Radix seu Folium Gaultheriae Forrestii 10-160 part, or LIJUNJING 3-20 part and Radix seu Folium Gaultheriae Forrestii 10-180 part, or colistin 3-30 part and Radix seu Folium Gaultheriae Forrestii 15-170 part, or florfenicol 5-30 part and Radix seu Folium Gaultheriae Forrestii 10-170 part, or fosfomycin 7-30 part and Radix seu Folium Gaultheriae Forrestii 10-170 part.
The dosage form of this compound medicine is powder, tablet, oral liquid or granule.
The preparation method of the compound medicine of above-mentioned treatment poultry coli-infection disease, pulverized 60 mesh sieves by Radix seu Folium Gaultheriae Forrestii, then mixed with pulverous antimicrobial drug, was prepared into according to a conventional method powder, tablet, oral liquid or granule.
The drug resistance problem existing for current poultry coli-infection, inventor utilizes Guangxi Special Traditional Chinese Medicine Radix seu Folium Gaultheriae Forrestii and antimicrobial drug to form compound medicine.Studies have shown that, in antimicrobial drug, add after Radix seu Folium Gaultheriae Forrestii, can reverse the drug resistance of bacteria medicine, thereby improve the therapeutic effect of antimicrobial drug.According to a conventional method this compound medicine is made to powder, tablet, oral liquid or granule, according to 0.1-7g principal agent (Radix seu Folium Gaultheriae Forrestii and the antimicrobial drug)/addition of kg feedstuff, add in animal and fowl fodder and feed, can significantly reduce drug cost and drug residue, for raiser creates higher economic benefit, also guaranteed food safety simultaneously.
The specific embodiment
One, the drug resistance inversion effect research of Radix seu Folium Gaultheriae Forrestii to antimicrobial drug
Antimicrobial drug itself has the colibacillary effect for the treatment of, but has stronger drug resistance owing to producing the escherichia coli of ESBLs drug resistant gene, causes antimicrobial drug not show good therapeutic effect in normal using dosage situation.
In order to verify the drug resistance inversion effect of Radix seu Folium Gaultheriae Forrestii to antimicrobial drug, on 96 orifice plates, adopt microtest tube doubling dilution, first measure antimicrobial drug to producing minimal inhibitory concentration and the subinhibitory concentration of Radix seu Folium Gaultheriae Forrestii to product ESBLs and fosA3 drug resistant gene e. coli strains of the e. coli strains of ESBLs and fosA3 drug resistant gene, then in culture medium, added the Radix seu Folium Gaultheriae Forrestii of subinhibitory concentration to reuse the minimal inhibitory concentration that microtest tube doubling dilution is cultivated mensuration antimicrobial drug; Utilize continuous passage method in the culture medium that is added with same subinhibitory concentration Radix seu Folium Gaultheriae Forrestii and same concentration antimicrobial drug to producing the cultivation of going down to posterity of ESBLs and fosA3 drug resistant gene e. coli strains, until the antimicrobial drug minimal inhibitory concentration observing with go down to posterity before compare and diminish more than 4 times, can be judged as Radix seu Folium Gaultheriae Forrestii has drug resistance inversion effect to antibacterial medical instrument.Result of the test statistics is as shown in table 1:
Table 1 subinhibitory concentration (0.25g/mL) Radix seu Folium Gaultheriae Forrestii goes down to posterity and causes
Produce the variation (μ g/mL) of ESBLs and fosA3 escherichia coli Western medicine MIC.
As seen from the above table, antimicrobial drug all reduces more than 4 times the colibacillary minimal inhibitory concentration of drug resistance, can judge that Radix seu Folium Gaultheriae Forrestii has drug resistance inversion effect to producing ESBLs and fosA3 drug resistant gene escherichia coli.
Two, the application example of compound medicine of the present invention
Above-described embodiment 1-embodiment 20 is prepared in accordance with the following methods: Radix seu Folium Gaultheriae Forrestii was pulverized after 60 mesh sieves, as basic material, again with pulverous antimicrobial drug by weight ratio put into blender and mix, according to a conventional method, embodiment 2,3,6,9,15 and 19 is prepared into powder; Embodiment 1,5,10,16 and 18 is prepared into tablet, and embodiment 7,11,13 and 17 is prepared into oral liquid; Embodiment 4,8,12,14 and 20 is prepared into granule.
Formula and the product of table 2 embodiment 1-20
Inventor obtains compound medicine product by above-described embodiment and has carried out following experiment:
1, the efficacy experiment of the compound medicine product of embodiment 1-4 gained to chicken escherichia coil disease
Clinical symptoms: Nanning chicken house, 30 Day-old Broiler Chickens, there is fragmentary death in chicken group, cuts open the indivedual chickens of inspection and occur the pathological change of bag pericardium liver, typical bacillus coli feature.
Laboratory diagnosis: get pathologic liver and dye sheet, Gram’s staining, micro-Microscopic observation, the gram negative bacilli of red color visible; Tentatively be judged as bacillus coli.By escherichia coli, cultivate, biochemical test is differentiated, judges that chicken infects for bacillus coli, and pcr amplification, proves and produce the ESBLs drug resistant gene that has TEM type.
Test therapeutic regimen: morbidity chicken group is divided into 6 groups of administrations, use embodiment 1 according to the addition administration of 3.8g/kg feedstuff for first group, use embodiment 2 according to the addition administration of 2g/kg feedstuff for second group, use embodiment 3 according to the addition administration of 0.8g/kg feedstuff for the 3rd group, use embodiment 4 according to the addition administration of 2g/kg feedstuff for the 4th group; The 5th group with amoxicillin powder according to the addition administration of 0.2g/kg feedstuff, the 6th group with the thick powder of Radix seu Folium Gaultheriae Forrestii according to the addition administration of 1.8g/kg feedstuff; Above six groups of therapeutic regimens all continue to use 5 days.
Effect feedback: after the chicken group medication of first group to the 4th group, sick chicken feed intake rises, and no longer occurs dead chicken, continues to use 3 days, and chicken group be almost recovered; The chicken group medication of the 5th group is after 2 days, and chicken group majority is still unhealthy, still has indivedual chicken deaths, continues to use 3 days, and chicken death phenomenon is not still effectively controlled; The chicken group medication of the 6th group is after 2 days, and chicken group does not have too large remarkable improvement, continues to use 3 days, and chicken death phenomenon is not still effectively controlled.Visible, the compound medicine curative effect that contains Radix seu Folium Gaultheriae Forrestii is better than folk prescription.
2, the efficacy experiment of the compound medicine product of embodiment 5-8 gained to the meat-type duck diarrhoea of 20 ages in days
Clinical symptoms: Guangxi Yulin duck field, 15 age in days meat-type duck, duck group draws watery stools, has obvious indigested feedstuff in feces.A duck group material feeding is not but long, and the serious duck appearance foot gradually of suffering from diarrhoea is individually soft slowly dead.
Cut open inspection pathological changes: the duck that dies of illness dehydration is more serious, indivedual ducks are still very large, duck liver enlargement, hyperemia, and adularescent film on the liver of part duck, air bag is muddy, and tentative diagnosis is escherichia coli or duck oromeningitis.
Test therapeutic regimen: morbidity duck group divides six groups of administrations, use embodiment 5 according to the addition administration of 2g/kg feedstuff for first group, use embodiment 6 according to the addition administration of 1g/kg feedstuff for second group, use embodiment 7 according to the addition administration of 1g/kg feedstuff for the 3rd group, use embodiment 8 according to the addition administration of 0.2g/kg feedstuff for the 4th group; The 5th group with norfloxacin powder according to the addition administration of 0.15g/kg feedstuff, the 6th group with the thick powder of Radix seu Folium Gaultheriae Forrestii according to the addition administration of 1.8g/kg feedstuff; Above six groups of therapeutic regimens all continue to use 5 days.
Result of use feedback: first group to the 4th group medication is after 2 days, and sick duck is no longer drawn watery stools, feces is shaped, and no longer occurs dead duck, continues to use 3 days, and duck group be almost recovered; The 5th group of medication is after 2 days, and duck group DeGrain, much still draws watery stools, contain indigested feedstuff, continue to use 3 days some improvement a little, but not good thorough, rare watery stools still occurs, raiser cannot drug withdrawal to these two groups of ducks, have to use the compound medicine of embodiment 6 gained instead, continue to use 2 days, just be almost recovered, re-use 1 day, feces all transfers to normally; The 6th group of medication is after 2 days, and duck does not have too large remarkable improvement, continues to use 3 days, and the duck phenomena of mortality are not still effectively controlled.Visible, the compound medicine that contains Radix seu Folium Gaultheriae Forrestii is better than folk prescription to the curative effect of duck diarrhoea.
3, the efficacy experiment of the compound medicine product of embodiment 9-12 gained to the meat-type duck diarrhoea of 25 ages in days
Clinical symptoms: duck field, Guigang, Guangxi, 25 age in days meat-type duck, duck group draws watery stools, has obvious indigested feedstuff in feces.Indivedual serious duck appearance feet gradually of suffering from diarrhoea are soft slowly dead.
Cut open inspection pathological changes: the duck that dies of illness dehydration is more serious, indivedual ducks are still very large, duck liver enlargement, hyperemia, and adularescent film on the liver of part duck, air bag is muddy, and tentative diagnosis is escherichia coli or duck oromeningitis.
Test therapeutic regimen: morbidity duck group divides six groups of administrations, use embodiment 9 according to the addition administration of 1.5g/kg feedstuff for first group, use embodiment 10 according to the addition administration of 0.2g/kg feedstuff for second group, use embodiment 11 according to the addition administration of 2g/kg feedstuff for the 3rd group, use embodiment 12 according to the addition administration of 0.7g/kg feedstuff for the 4th group; The 5th group with amikacin powder according to the addition administration of 0.2g/kg feedstuff, the 6th group with the thick powder of Radix seu Folium Gaultheriae Forrestii according to the addition administration of 1.8g/kg feedstuff; Above six groups of therapeutic regimens all continue to use 5 days.
Result of use feedback: first group to the 4th group medication is after 3 days, and sick duck is no longer drawn watery stools, feces is shaped, and no longer occurs dead duck, continues to use 2 days, and duck group be almost recovered; The 5th group of medication is after 3 days, duck group DeGrain, much still draw watery stools, contain indigested feedstuff, continue to use 2 days, some improvement a little, but thoroughly not good, rare watery stools still occurs, raiser uses the compound medicine of embodiment 9 gained instead, continue to use 3 days, feces all transfers to normally; The 6th group of medication is after 3 days, and duck does not have too large remarkable improvement, continues to use 2 days, and the duck phenomena of mortality are not still effectively controlled.Visible, the compound medicine that contains Radix seu Folium Gaultheriae Forrestii is better than folk prescription to the curative effect of duck diarrhoea.
4, the efficacy experiment of the compound medicine product of embodiment 13-16 gained to the piglet diarrhea of 50 ages in days
Clinical symptoms: Guangxi Yulin pig farm, 50 age in days piglets, this swinery after wean is turn-taked, starts to occur diarrhoea, draws watery stools, feces contains indigested feedstuff, pig material feeding but be exactly not grow, indivedual serious diarrhea of pigs dehydrations are dead, do not occur symptoms of emesis, raiser uses multi-medicament, and ideal effect does not all appear in treatment.
Cut open inspection pathological changes: after cuing open inspection, Intestinum Sus domestica wall is poor, especially small intestinal rear end and colon position, intestinal mucosa comes off, and intestinal wall is congested, hemorrhage.
Laboratory diagnosis: get pathologic liver and dye sheet, Gram’s staining, micro-Microscopic observation, the gram negative bacilli of red color visible; Tentatively be judged as bacillus coli.By escherichia coli, cultivate, biochemical test is differentiated, judges that chicken infects for bacillus coli, and pcr amplification, proves and produce ESBLs drug resistant gene and the fosA3 drug resistant gene that has CTX-M type.
Test therapeutic regimen: morbidity swinery is divided 6 groups of administrations, use embodiment 13 according to the addition administration of 0.3g/kg feedstuff for first group, use embodiment 14 according to the addition administration of 0.3g/kg feedstuff for second group, use embodiment 15 according to the addition administration of 3g/kg feedstuff for the 3rd group, use embodiment 16 according to the addition administration of 1g/kg feedstuff for the 4th group; The 5th group with LIJUNJING powder according to the addition administration of 0.2g/kg feedstuff, the 6th group with the thick powder of Radix seu Folium Gaultheriae Forrestii according to the addition administration of 1.9g/kg feedstuff; Above six groups of therapeutic regimens all continue to use 5 days.
Result of use feedback: first group to the 4th group medication is after 2 days, and swinery is no longer drawn watery stools, feces is shaped, and no longer contains feedstuff in feces, continues to use 3 days swinery recovery from illness; The 5th group of medication is after 2 days, and swinery is still unhealthy, continue to use 3 days, substantially get well, but still draw pasty state feces individually, but drug withdrawal is after 3 days, and recurrence appears in swinery; The 6th group of medication is after 2 days, and swinery, without remarkable improvement, continues to use 3 days, and swinery continues to have loose bowels, and all the other are also more serious individually.Visible, the compound medicine that contains Radix seu Folium Gaultheriae Forrestii is better than folk prescription LIJUNJING and folk prescription Radix seu Folium Gaultheriae Forrestii to swinery curative effect.
5, the efficacy experiment of the compound medicine product of embodiment 17-20 gained to the piglet diarrhea of 50 ages in days
Clinical symptoms: pig farm, Guigang, Guangxi, 50 age in days piglets, this swinery after wean is turn-taked, starts to occur diarrhoea, draws watery stools, feces contains indigested feedstuff, pig material feeding but be exactly not grow, indivedual serious diarrhea of pigs dehydrations are dead, do not occur symptoms of emesis, raiser uses multi-medicament, and ideal effect does not all appear in treatment.
Cut open inspection pathological changes: after cuing open inspection, Intestinum Sus domestica wall is poor, especially small intestinal rear end and colon position, intestinal mucosa comes off, and intestinal wall is congested, hemorrhage.
Laboratory diagnosis: get pathologic liver and dye sheet, Gram’s staining, micro-Microscopic observation, the gram negative bacilli of red color visible; Tentatively be judged as bacillus coli.By escherichia coli, cultivate, biochemical test is differentiated, judges that chicken infects for bacillus coli, and pcr amplification, proves and produce ESBLs drug resistant gene and the fosA3 drug resistant gene that has OXA type.
Test therapeutic regimen: morbidity swinery is divided 6 groups of administrations, use embodiment 17 according to the addition administration of 3g/kg feedstuff for first group, use embodiment 18 according to the addition administration of 4g/kg feedstuff for second group, use embodiment 19 according to the addition administration of 0.4g/kg feedstuff for the 3rd group, use embodiment 20 according to the addition administration of 2g/kg feedstuff for the 4th group; The 5th group with florfenicol powder according to the addition administration of 0.3g/kg feedstuff, the 6th group with the thick powder of Radix seu Folium Gaultheriae Forrestii according to the addition administration of 1.8g/kg feedstuff; Above six groups of therapeutic regimens all continue to use 5 days.
Result of use feedback: first group to the 4th group medication is after 2 days, and swinery is no longer drawn watery stools, feces is shaped, and no longer contains feedstuff in feces, continues to use 3 days swinery recovery from illness; The 5th group of medication is after 2 days, and swinery is still unhealthy, continue to use 3 days, substantially get well, but still draw pasty state feces individually, but drug withdrawal is after 3 days, and recurrence appears in swinery; The 6th group of medication is after 2 days, and swinery, without remarkable improvement, continues to use 3 days, and swinery continues to have loose bowels, and all the other are also more serious individually.Visible, the compound medicine that contains Radix seu Folium Gaultheriae Forrestii is better than folk prescription florfenicol and folk prescription Radix seu Folium Gaultheriae Forrestii to swinery curative effect.
Claims (6)
1. treat a compound medicine for poultry coli-infection disease, it is characterized in that comprising the raw material of following weight portion: antimicrobial drug 3-30 part, Radix seu Folium Gaultheriae Forrestii 5-200 part.
2. the compound medicine for the treatment of according to claim 1 poultry coli-infection disease, is characterized in that: described antimicrobial drug is a kind of in beta-lactam, fluoroquinolones, Tetracyclines, aminoglycoside, carbadox class, polypeptide class, amide alcohols antimicrobial drug or fosfomycin.
3. the compound medicine for the treatment of poultry coli-infection disease according to claim 2, is characterized in that: described beta-lactam antimicrobial drug is amoxicillin, ceftriaxone sodium or ceftiofur sodium; Described fluoroquinolone antibacterial agent is norfloxacin; Described aminoglycoside antimicrobial drug is amikacin; Described carbadox class antimicrobial drug is LIJUNJING; Described amide alcohols is florfenicol; Described polypeptide class antimicrobial drug is colistin.
4. the compound medicine for the treatment of according to claim 3 poultry coli-infection disease, it is characterized in that comprising the raw material of following weight portion: amoxicillin 3-20 part and Radix seu Folium Gaultheriae Forrestii 40-180 part, or norfloxacin 3-25 part and Radix seu Folium Gaultheriae Forrestii 30-190 part, or amikacin 5-30 part and Radix seu Folium Gaultheriae Forrestii 10-160 part, or LIJUNJING 3-20 part and Radix seu Folium Gaultheriae Forrestii 10-180 part, or colistin 3-30 part and Radix seu Folium Gaultheriae Forrestii 15-170 part, or florfenicol 5-30 part and Radix seu Folium Gaultheriae Forrestii 10-170 part, or fosfomycin 7-30 part and Radix seu Folium Gaultheriae Forrestii 10-170 part.
5. the compound medicine for the treatment of according to claim 5 poultry coli-infection disease, the dosage form that it is characterized in that this compound medicine is powder, tablet, oral liquid or granule.
6. described in claim 1, treat the preparation method of the compound medicine of poultry coli-infection disease, it is characterized in that Radix seu Folium Gaultheriae Forrestii to pulverize 60 mesh sieves, then mix with pulverous antimicrobial drug, be prepared into according to a conventional method powder, tablet, oral liquid or granule.
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| CN103908670A (en) * | 2014-04-15 | 2014-07-09 | 广西大学 | Compound composition for treating livestock escherichia coli infection disease |
| CN103948692A (en) * | 2014-05-14 | 2014-07-30 | 广西南宁市桃源兽药厂 | Red paeonia/amikacin-containing compound medicine for livestock and fowl |
| CN103977088A (en) * | 2014-05-14 | 2014-08-13 | 广西大学 | Compound medicine containing radix paeoniae rubrathe and fluoroquinolones antibacterial drug used for livestock and poultry |
| CN104306421A (en) * | 2014-11-07 | 2015-01-28 | 广西大学 | Balsamiferou Blumea herb and florfenicol containing compound medicine for livestock and poultry |
| CN104337847A (en) * | 2014-11-12 | 2015-02-11 | 中国农业科学院哈尔滨兽医研究所 | Compound medicine containing bracken and fosfomycin for livestock |
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| CN104337847B (en) * | 2014-11-12 | 2017-12-19 | 中国农业科学院哈尔滨兽医研究所 | A kind of livestock and poultry compound medicine containing phoenix-tail fern and phosphonomycin |
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