CN105617383A - Compound livestock and poultry drug containing garden balsam stems and beta-lactam antibacterial drug - Google Patents
Compound livestock and poultry drug containing garden balsam stems and beta-lactam antibacterial drug Download PDFInfo
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- CN105617383A CN105617383A CN201610104184.5A CN201610104184A CN105617383A CN 105617383 A CN105617383 A CN 105617383A CN 201610104184 A CN201610104184 A CN 201610104184A CN 105617383 A CN105617383 A CN 105617383A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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Abstract
The invention relates to a compound livestock and poultry drug containing garden balsam stems and a beta-lactam antibacterial drug.The compound livestock and poultry drug is prepared from, by weight, 3-30 parts of the beta-lactam antibacterial drug and 5-200 parts of garden balsam stems.The raw materials are mixed to be uniform and then prepared into powder or tablets or oral liquid or granules, the drug is added into livestock and poultry feed for feeding according to the feeding dosing amount of 0.1-7 g/kg, the drug resistance of bacteria to the antibacterial drug can be reversed, therefore, the treating effect of the antibacterial drug is improved, the drug cost and drug residues are significantly reduced, the higher economic benefit is created for raising households, and the food safety of human beings is guaranteed.
Description
The denomination of invention that the present invention is application on 04 15th, 2014 is " a kind of compound treating livestock and poultry coli-infection disease ", and application number is point case application of 201410150091.7.
Technical field
The invention belongs to livestock and poultry coli-infection treatment technology field, particularly relate to a kind of containing the livestock and poultry compound medicine of Tuberculate Speranskia Herb and beta-lactam antimicrobial drug.
Background technology
Intestinal bacteria are common conditioned pathogens, also it is the normal a kind of disease sent out, it can former have been carried out the coffin upon burial many positions severe infections such as chicken acute sepsis, peritonitis, hepatitis, pneumonia, enteritis, also can secondary or mixed send out in virus disease, cause huge financial loss to aquaculture. The beta-lactam lopps microbiotic such as amoxycilline Trihydrate bp, Ampicillin Trihydrate, ceftiofur, ceftriaxone, amoxicillin/clavulanate, Ampicillin Trihydrate/Sulbactam are the conventional important drugs of this disease of control, along with the cultivation intensive degree of scale is more and more big, medication is more and more spread unchecked, its Resistant strain is more and more many, and the report about intestinal bacteria resistance is also more. Research confirms, one of main mechanism of resistance produces ��-lactamase, especially extended spectrum��-lactamase (Extended-Spectrum ��-lactamase, ESBLs), this enzyme can be hydrolyzed beta-lactam nucleus more by force and fast, makes this kind of microbiotic lose anti-microbial activity. ESBLs is the main enzyme type of ��-lactamase, and it is correct spore three generations and aztreonam resistance not only, and is crossing drug resistant to aminoglycoside, quinolones and sulfamido, only to carbapenems, a mould alkene class medicaments insensitive. ESBLs has substantial connection to the multi-drug resistant that intestinal bacteria reported by many documents with producing, both at home and abroad to comparatively pay close attention to. Contriver has carried out the detection of food animal source pathogenic bacterium ESBLs recently, extraction, enzyme press down the researchs such as enzyme provide protection to the percent hydrolysis of microbiotic and Sulbactam, Tazobactam Sodium and Chinese medicine; the drug sensitive test of part ESBLs intestinal bacteria being shown, its multidrug resistant rate is obviously higher than non-ESBLs bacterial strain. In addition, result also shows to produce ESBLs bacterial strain not only to the serious resistance of the third generation cephalosporins such as ceftiofur, and also to multiple antimicrobial drug resistance such as fluoroquinolones, aminoglycoside and sulfamido, phosphonomycin etc., in serious multidrug resistant. Contriver is separated to the intestinal bacteria of resistance to phosphonomycin product fosA3 drug resistant gene producing in ESBLs bacterial strain, more strengthen the resistance of bacterium. The resistance of intestinal bacteria causes raiser's drug cost to increase, and treatment extends the course for the treatment of, and mortality of livestock increases, and brings bigger financial loss to production, and increases livestock and poultry drug residue risk. Therefore, the intestinal bacteria needing a kind of resistance to no matter whether in actual production badly can have the medicine of better therapeutic action, and can shorten treatment course for the treatment of, reduce mortality ratio, reduce financial loss and reduce drug residue, for raiser creates higher economic benefit, also ensure that the mankind's is healthy and safe.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of containing the livestock and poultry compound medicine of Tuberculate Speranskia Herb and beta-lactam antimicrobial drug, it can kill bacterium quickly, overcome the weak curative effect that antimicrobial drug treatment causes due to drug resistance problems, the defect that consumption is big, residual is high and cost is high, avoid the problem that simple Chinese medicine sterilizing spectrum is narrow, sterilization is slow.
For solving above technical problem, the present invention is by the following technical solutions: a kind of containing the livestock and poultry compound medicine of Tuberculate Speranskia Herb and beta-lactam antimicrobial drug, comprise the raw material of following weight part: beta-lactam antimicrobial drug 3-30 part, Tuberculate Speranskia Herb 5-200 part, beta-lactam antimicrobial drug is amoxycilline Trihydrate bp, ceftriaxone sodium or ceftiofur sodium.
The weight ratio of above-mentioned compound medicine is preferably: amoxycilline Trihydrate bp 3-20 part and Tuberculate Speranskia Herb 40-180 part.
The formulation of this compound is powder, tablet, oral liquid or granule.
The preparation method of above-mentioned compound medicine, pulverized Tuberculate Speranskia Herb 60 order sieves, then mixed even with pulverous antimicrobial drug, be prepared into powder, tablet, oral liquid or granule according to a conventional method.
For the drug resistance problems that current livestock and poultry coli-infection exists, contriver utilizes Guangxi characteristic Chinese medicine Tuberculate Speranskia Herb and antimicrobial drug composition compound. Research proves, after adding Tuberculate Speranskia Herb in antimicrobial drug, it is possible to reverse bacterial is to the resistance of antimicrobial drug, thus improves the result for the treatment of of antimicrobial drug. According to a conventional method this compound is made powder, tablet, oral liquid or granule, add in animal and fowl fodder according to the addition of 0.1-7g main medicine/kg feed and feed, can much slower drug cost and drug residue, for raiser creates higher economic benefit, also ensure that food safety simultaneously.
Embodiment
One, Tuberculate Speranskia Herb is to the drug resistance inversion Effect study of antimicrobial drug
Antimicrobial drug itself has the effect for the treatment of intestinal bacteria, but has stronger resistance owing to producing the intestinal bacteria of ESBLs drug resistant gene, causes antimicrobial drug not show good result for the treatment of in normal using dosage situation.
In order to verify that Tuberculate Speranskia Herb is to the drug resistance inversion effect of antimicrobial drug, 96 orifice plates adopt microtest tube doubling dilution, first determining antimicrobial drug to producing the minimal inhibitory concentration of e. coli strains of ESBLs and fosA3 drug resistant gene and Tuberculate Speranskia Herb to the sub-Mlc producing ESBLs and fosA3 drug resistant gene e. coli strains, the Tuberculate Speranskia Herb then adding sub-Mlc in the medium reuses microtest tube doubling dilution and cultivates the minimal inhibitory concentration measuring antimicrobial drug; Utilize continuous passage method, in the substratum being added with same sub-Mlc Tuberculate Speranskia Herb and same concentration antimicrobial drug, product ESBLs and fosA3 drug resistant gene e. coli strains is carried out Secondary Culture, until the antimicrobial drug minimal inhibitory concentration observed diminishes more than 4 times compared with before going down to posterity, can be judged as that antibacterial medical instrument is had drug resistance inversion effect by Tuberculate Speranskia Herb. Test-results statistics is as shown in table 1:
The change (�� g/mL) that sub-Mlc (0.25g/mL) Tuberculate Speranskia Herb of table 1 is gone down to posterity and causes and produce ESBLs and fosA3 intestinal bacteria Western medicine MIC.
As seen from the above table, the minimal inhibitory concentration of antibiotic-resistance E. coli is all reduced more than 4 times by antimicrobial drug, can judge that product ESBLs and fosA3 drug resistant gene intestinal bacteria are had drug resistance inversion effect by Tuberculate Speranskia Herb.
Two, the application example of compound of the present invention
Prepare embodiment 1-embodiment 4 in accordance with the following methods: pulverized by Tuberculate Speranskia Herb after 60 orders sieve, based on raw material, then with pulverous antimicrobial drug by weight ratio to put into mixing tank mixed even, according to a conventional method, embodiment 2,3 is prepared into powder; Embodiment 1 is prepared into tablet, and embodiment 4 is prepared into granule.
The formula of table 2 embodiment 1-4 and product
Contriver by the compound product of embodiment 1-4 gained to the efficacy experiment of chicken escherichia coil disease.
Clinical symptom: Guangxi Yulin Ji Chang, age on the 25th broiler chicken, there is fragmentary death in chicken group, cut open inspection indivedual chicken bag pericardium liver pathological change there is, typical bacillus coli feature.
Laboratory diagnosis: get pathologic liver dye sheet, gramstaining, basis of microscopic observation, it is seen that red gram negative bacillus; Tentatively it is judged as bacillus coli. Being cultivated by intestinal bacteria, biochemical test differentiates, judges that chicken infects as bacillus coli, pcr amplification, proves to produce the ESBLs drug resistant gene having TEM type.
Test therapeutic regimen: morbidity chicken group is divided into 6 groups of administrations, first group with the addition administration of embodiment 1 according to 3.8g/kg feed, 2nd group with the addition administration of embodiment 2 according to 2g/kg feed, 3rd group with the addition administration of embodiment 3 according to 0.8g/kg feed, the 4th group with the addition administration of embodiment 4 according to 2g/kg feed; 5th group with the addition administration of amoxycilline Trihydrate bp pulvis according to 0.2g/kg feed, the 6th group with the addition administration of the thick powder of Tuberculate Speranskia Herb according to 3.7g/kg feed; Above six groups of therapeutic regimens all continue to use 5 days.
Staining effect: after chicken group's medication of first group to the 4th group, sick chicken food consumption rises, and dead chicken no longer occurs, continues to use 3 days, and chicken group fully recover substantially; Chicken group's medication of the 5th group is after 2 days, and chicken group's majority is still unhealthy, still has indivedual chicken death, continues to use 3 days, and chicken death phenomenon is not still effectively controlled; Chicken group's medication of the 6th group is after 2 days, and chicken group does not have too big remarkable improvement, continues to use 3 days, and chicken death phenomenon is not still effectively controlled. Visible, the compound curative effect containing Tuberculate Speranskia Herb is better than folk prescription.
Claims (2)
1. one kind contains the livestock and poultry compound medicine of Tuberculate Speranskia Herb and beta-lactam antimicrobial drug, it is characterised in that, it is made up of the raw material of following weight ratio: beta-lactam antimicrobial drug 3-30 part, Tuberculate Speranskia Herb 5-200 part; Described beta-lactam antimicrobial drug is ceftriaxone sodium, amoxycilline Trihydrate bp or ceftiofur sodium.
2. according to claim 1 containing the livestock and poultry compound medicine of Tuberculate Speranskia Herb and beta-lactam antimicrobial drug, it is characterised in that, it is made up of the raw material of following weight ratio: amoxycilline Trihydrate bp 3-20 part, Tuberculate Speranskia Herb 40-180 part.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410150091.7A CN103908670B (en) | 2014-04-15 | 2014-04-15 | A kind of compound treating poultry coli-infection disease |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410150091.7A Division CN103908670B (en) | 2014-04-15 | 2014-04-15 | A kind of compound treating poultry coli-infection disease |
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| Publication Number | Publication Date |
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| CN105617383A true CN105617383A (en) | 2016-06-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610104184.5A Pending CN105617383A (en) | 2014-04-15 | 2014-04-15 | Compound livestock and poultry drug containing garden balsam stems and beta-lactam antibacterial drug |
| CN201410150091.7A Active CN103908670B (en) | 2014-04-15 | 2014-04-15 | A kind of compound treating poultry coli-infection disease |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410150091.7A Active CN103908670B (en) | 2014-04-15 | 2014-04-15 | A kind of compound treating poultry coli-infection disease |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343160A (en) * | 2015-12-11 | 2016-02-24 | 广西南宁市桃源兽药厂 | Compound composition resisting livestock and poultry escherichia coli |
| CN105343159A (en) * | 2015-12-11 | 2016-02-24 | 广西南宁市桃源兽药厂 | Compound preparation capable of reversing drug resistance of germs to beta-lactam antibacterial drug |
| KR102489659B1 (en) * | 2020-07-20 | 2023-01-18 | 경북대학교 산학협력단 | Composition of antimicrobial complex for animal comprising amphenicols and aminoglycosides |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127507A (en) * | 2013-03-18 | 2013-06-05 | 广西大学 | Holly bark containing compound composition for treating escherichia coli infected diseases of livestock and poultry |
| CN103690952A (en) * | 2013-11-27 | 2014-04-02 | 广西大学 | Compound drug for treating livestock and poultry escherichia coli infected diseases |
-
2014
- 2014-04-15 CN CN201610104184.5A patent/CN105617383A/en active Pending
- 2014-04-15 CN CN201410150091.7A patent/CN103908670B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127507A (en) * | 2013-03-18 | 2013-06-05 | 广西大学 | Holly bark containing compound composition for treating escherichia coli infected diseases of livestock and poultry |
| CN103690952A (en) * | 2013-11-27 | 2014-04-02 | 广西大学 | Compound drug for treating livestock and poultry escherichia coli infected diseases |
Non-Patent Citations (3)
| Title |
|---|
| 王德志等: "中草药抑制耐药性大肠杆菌的研究进展", 《中国畜牧兽医》 * |
| 王思芦等: "中药消除致病性大肠杆菌耐药性研究进展", 《中国畜牧兽医》 * |
| 王芳等: "透骨草提取物的抑菌效果研究", 《辽宁中医杂志》 * |
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| Publication number | Publication date |
|---|---|
| CN103908670A (en) | 2014-07-09 |
| CN103908670B (en) | 2016-08-31 |
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