CN103989728B - It is a kind of to contain the livestock and poultry compound medicine containing pearl grass and beta-lactam class antimicrobial - Google Patents
It is a kind of to contain the livestock and poultry compound medicine containing pearl grass and beta-lactam class antimicrobial Download PDFInfo
- Publication number
- CN103989728B CN103989728B CN201410230412.4A CN201410230412A CN103989728B CN 103989728 B CN103989728 B CN 103989728B CN 201410230412 A CN201410230412 A CN 201410230412A CN 103989728 B CN103989728 B CN 103989728B
- Authority
- CN
- China
- Prior art keywords
- antimicrobial
- beta
- compound medicine
- grass
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to a kind of containing the livestock and poultry compound medicine containing pearl grass and beta-lactam class antimicrobial, it is made up of the raw material of following parts by weight：3 30 parts of beta-lactam class antimicrobial, it is careless 5 200 parts containing pearl.Beta-lactam class antimicrobial is Amoxicillin, Ceftriaxone Sodium or ceftiofur sodium.Research has shown that, is added in antimicrobial containing after pearl grass, can reverse bacterial to the drug resistance of antimicrobial, so as to improve the therapeutic effect of antimicrobial.Powder, tablet, oral liquid or granule is made in the compound medicine according to a conventional method, addition according to 0.1 7g main ingredients/kg feeds, which is added in animal and fowl fodder, to be fed, drug cost and medicament residue can be greatly reduced, higher economic benefit is created for raiser, while also ensure that food security.
Description
Technical field
Contain Guangxi the invention belongs to livestock and poultry Escherichia coli and salmonella infection treatment technology field, more particularly to one kind
Livestock and poultry compound medicine of the precious jade medicine containing pearl grass and beta-lactam antimicrobial.
Background technology
Fowl salmonellosis (Avian salmonellosis) is by one or more salmonellas in Salmonella
The general name of caused poultry disease.3 classes can be divided into according to the difference of pathogen antigen structure：White diarrhea, avian typhoid and fowl pair
Typhoid fever.Wherein white diarrhea and avian typhoid salmonella has host specificity, mainly causes chicken and turkey to fall ill；And avian paratyphoid is husky
Door Salmonella can then infect many animals and people extensively, be mankind's salmonella infection and food by poultry of its pollution and products thereof
One of main source of poisoning.Considerably complicated propagation circulation is commonly formed in fowl salmonellosis.Sick fowl is main with the fowl that carries disease germs
The infection sources, can infect poult, cause big portion by alimentary canal, respiratory tract or eye conjunctiva horizontal transmission after ovum vertical transmission
Divide death, poultry carries disease germs for a long time, the ovum that then output is carried disease germs, if hatching in this, as hatching egg, the generation that can be gone round and begun again
In generation, passes on from one to another, and it is difficult purification in chicken group to cause fowl salmonellosis, causes serious economic loss.Because salmonella is in chicken group
Middle pollution face is big, and is also easy to produce drug resistance, and immune effect of vaccine in the market is undesirable.Therefore, breeder flock quarantine, medicine
Thing control, environment disinfected purification, reinforcement feeding management and health and epidemic prevention are still control and prevent salmonella from entering food chain
Essential measure.Chick goes out after shell to drink 0.01% liquor potassic permanganate or other drugs carry out chemoprophylaxis in 1~2 day.The bacterium pair
Common drug produces drug resistance, and forcing must not be used alternatingly in production without various medicines, in the hope of preferably control drug-fast bacteria.
The current bacterium produces stronger drug resistance to aminoglycoside medicaments, and aminoglycoside inactive enzyme is to these antibacterials molecules
In it is some protection antibacterial activities necessary to group modified, it is greatly lowered with the ribosomal affinity of target site.
These inactive enzymes include aminoglycoside acyltransferase (AAC), aminoglycoside adenylyl transferase (AAD), aminoglycoside phosphorus
Sour transferase (APH), gland nucleotidyltransferase (ANT) etc..It is found that not in the drug-fast bacteria of many aminoglycosides at present
With the inactive enzyme of characteristic.
Escherichia coli are common conditioned pathogens, are also a kind of disease often sent out, and it primary can cause the acute sepsis of chicken
The multiple location severe infections such as disease, peritonitis, hepatitis, pneumonia, enteritis, also can it is secondary or it is mixed send out in virosis, caused to aquaculture
Huge economic loss.Amoxicillin, ampicillin, Ceftiofur, ceftriaxone, amoxicillin/clavulanate, ammonia benzyl west
The beta-lactam nucleus class antibiotic such as woods/Sulbactam is the conventional important drugs for preventing and treating the disease, with the cultivation intensive journey of scale
Degree is more and more big, and medication is more and more spread unchecked, and its antibody-resistant bacterium is more and more more, and the report on Drug Resistance of E. coli is also more.
Research confirms that one of main mechanism of resistance is to produce beta-lactamase, especially extended spectrumβ-lactamase (Extended-
Spectrum β-lactamase, ESBLs), the enzyme can be relatively strong and rapidly hydrolyzes beta-lactam nucleus, loses this kind of antibiotic
Antibacterial activity.ESBLs is the main enzyme type of beta-lactamase, and it is not only to cephalo three generations and AZT resistance, and to ammonia
Base glycoside, quinolones and sulfamido are in crossing drug resistant, only to Carbapenems, a mould alkenes medicaments insensitive.Many documents
It has been reported that the multi-drug resistant of Escherichia coli has substantial connection with producing ESBLs, it is more paid close attention to both at home and abroad.Inventor is most
Nearly detection, extraction, enzyme percent hydrolysis and Sulbactam, the Tazobactam Sodium to antibiotic for having carried out food animal source pathogenic bacteria ESBLs
And the research such as the suppression enzyme protection effect of Chinese medicine, the drug sensitive test to part ESBLs Escherichia coli shows that its multidrug resistant rate is bright
It is aobvious to be higher than non-ESBLs bacterial strains.In addition, result also shows that production ESBLs bacterial strains are not only tight to third generation cephalosporins such as Ceftiofurs
Weight resistance, and also to a variety of antimicrobial resistances such as fluoroquinolones, aminoglycoside and sulfamido, phosphonomycin, in serious
Multidrug resistant.Inventor is separated to the Escherichia coli that resistance to phosphonomycin produces fosA3 drug resistant genes in production ESBLs bacterial strains, more strengthens
The drug resistance of bacterium.
The drug resistance of salmonella and Escherichia coli causes the increase of raiser's drug cost, and treatment course extension, livestock and poultry are dead
Rate increase is died, larger economic loss is brought to production, and increase livestock and poultry medicament residue risk.Therefore, needed badly in actual production
A kind of pair regardless of whether the salmonella and Escherichia coli of resistance can have the medicine of preferable therapeutic action, and can shorten treatment treatment
Journey, reduces the death rate, reduces economic loss and reduction medicament residue, is that raiser creates higher economic benefit, also ensures people
The health and safety of class.
The content of the invention
Contain the livestock and poultry use containing pearl grass and beta-lactam antimicrobial the technical problem to be solved in the present invention is to provide a kind of
Compound medicine, it can kill bacterium quickly, weak curative effect, the consumption for overcoming antimicrobial treatment to be caused due to drug resistance problems
Greatly, the high and high defect of cost is remained, it is to avoid simple Chinese medicine sterilizing spectrum is narrow, the problem of sterilize slow.
To solve above technical problem, the present invention uses following technical scheme：One kind contains containing pearl grass and beta-lactam
The livestock and poultry compound medicine of antimicrobial, is made up of the raw material of following parts by weight：3-30 parts of beta-lactam antimicrobial, containing pearl grass 5-
200 parts.
Described beta-lactam antimicrobial is Amoxicillin, Ceftriaxone Sodium or ceftiofur sodium.
Further, described compound medicine is made up of the raw material of following parts by weight：Amoxicillin 3-20 parts and containing pearl grass
40-180 parts, or 3-25 parts of ceftiofur sodium and containing 30-190 parts of pearl grass.
Described compound medicine is prepared into powder, tablet, oral liquid or granule.
The preparation method of described compound medicine is：The broken mesh sieve of mistake 60 of pearl grass meal will be contained, then it is mixed with powdered antimicrobial
It is even, powder, tablet, oral liquid or granule are prepared into according to a conventional method.
It is careless (Acalypha australis L.) containing pearl, also known as Acalypha australis, acalypha copperleaf, people amaranth, belong to Euphorbiaceae iron amaranth
Lepidium, draft is to suffruticose draft, and stem is very thin, and thick less than 3 millimeters, female flower bract is lobate, long up to 1 li greatly and in lobate
Rice, does not divide, and there is sawtooth at edge, and base portion is heart-shaped, is kidney shape when female flower is opened, and is clam during closure, wherein fruit is kept, therefore
There is the reputation of " Acalypha australis ", also therefore easily recognize.Originate in Guangxi various regions, be born in it is waste on the ground or village side compared with moistening at.Herb
Pan-fried water is for oral administration can to treat bacillary dysentery, diarrhoea etc..
The drug resistance problems existed for current livestock and poultry Escherichia coli and salmonella infection, inventor contains pearl using Chinese medicine
Grass constitutes compound medicine with antimicrobial.Research has shown that, is added in antimicrobial containing after pearl grass, can reverse bacterial to the resistance to of antimicrobial
The property of medicine, so as to improve the therapeutic effect of antimicrobial.According to a conventional method by the compound medicine be made powder, tablet, oral liquid or
Granula, is added in animal and fowl fodder according to the addition of 0.1-7g main ingredients/kg feeds and is fed, drug cost can be greatly reduced
And medicament residue, it is that raiser creates higher economic benefit, while also ensure that food security.
Embodiment
First, containing drug resistance inversion Effect study of the pearl grass to antimicrobial
Antimicrobial has the effect for the treatment of Escherichia coli and salmonella in itself, but due to producing the Escherichia coli of drug resistant gene
There is stronger drug resistance with salmonella, cause antimicrobial not show preferably to control in the case of normal dosage
Therapeutic effect.
1st, the resistance of Escherichia coli is suppressed to test after the grass containing pearl is mixed with antimicrobial
Microtest tube doubling dilution is used on 96 orifice plates, antimicrobial is first determined to production ESBLs and fosA3 resistance bases
The minimal inhibitory concentration of the e. coli strains of cause and the sub- suppression containing pearl grass to production ESBLs and fosA3 drug resistant gene e. coli strains
Bacteria concentration, the grass containing pearl that subinhibitory concentration is then added in the medium reuses microtest tube doubling dilution culture assay
The minimal inhibitory concentration of antimicrobial；Using continuous passage method added with same subinhibitory concentration careless and same concentration antimicrobial containing pearl
Culture medium in Secondary Culture is carried out to production ESBLs and fosA3 drug resistant genes e. coli strains, until the antimicrobial that observes is most
Small Mlc diminishes more than 4 times compared with before passage, you can be judged as that the grass containing pearl has drug resistance inversion effect to antibacterial medical instrument.Examination
Test result statistics as shown in table 1：
The subinhibitory concentration of table 1 (0.5g/mL) grass passage containing pearl causes production ESBLs and fosA3 Escherichia coli Western medicine MIC change
Change (mg/mL).
As seen from the above table, antimicrobial reduces more than 4 times to the minimal inhibitory concentration of antibiotic-resistance E. coli, you can judgement is
There is drug resistance inversion effect to production ESBLs and fosA3 drug resistant gene Escherichia coli containing pearl grass.
2nd, the resistance of salmonella is suppressed to test after the grass containing pearl is mixed with antimicrobial
Microtest tube doubling dilution is used on 96 orifice plates, minimum of the antimicrobial to resistance salmonella strain is first determined
Mlc and containing pearl grass to the subinhibitory concentration of resistance salmonella strain, containing for subinhibitory concentration is then added in the medium
Pearl grass reuses the minimal inhibitory concentration of microtest tube doubling dilution culture assay antimicrobial；Added using continuous passage method
Have in the culture medium of same subinhibitory concentration careless and same concentration antimicrobial containing pearl and Secondary Culture carried out to salmonella persister,
Until the antimicrobial minimal inhibitory concentration observed diminishes more than 4 times compared with before passage, you can be judged as the grass containing pearl to antibacterial
Medical instrument has drug resistance inversion effect.Result of the test statistics is as shown in table 2：
The subinhibitory concentration of table 2 (0.5g/mL) grass passage containing pearl causes resistance salmonella Western medicine MIC change (mg/mL).
As seen from the above table, antimicrobial reduces more than 4 times to the minimal inhibitory concentration of resistance salmonella, you can judgement is
The grass containing pearl has drug resistance inversion effect to resistance salmonella.
2nd, the application example of compound medicine of the present invention
Embodiment 1- embodiments 8 are prepared according to the formula of table 3 and following methods：It will contain after the broken mesh sieve of mistake 60 of pearl grass meal, as
Basic material, then mixing in blender is put into powdered antimicrobial ratio by weight, according to a conventional method, by compound medicine
It is prepared into formulation products.
The embodiment 1-8 of table 3 formula and preparation formulation
| Numbering | Antimicrobial | Containing pearl grass | Formulation |
| Embodiment 1 | Amoxicillin 3g | 120g | Tablet |
| Embodiment 2 | Amoxicillin 10g | 90g | Powder |
| Embodiment 3 | Amoxicillin 14g | 40g | Oral liquid |
| Embodiment 4 | Amoxicillin 20g | 180g | Granule |
| Embodiment 5 | Ceftiofur sodium 13g | 190g | Tablet |
| Embodiment 6 | Ceftiofur sodium 15g | 85g | Powder |
| Embodiment 7 | Ceftiofur sodium 3g | 5g | Oral liquid |
| Embodiment 8 | Ceftiofur sodium 25g | 30g | Granule |
Above-described embodiment acquisition compound medicine product has been carried out following experiment by inventor：
1st, efficacy experiment of the compound medicine product obtained by embodiment 1-4 to chicken bacillus coli
Clinical symptoms：There is fragmentary death in Nanning chicken house, 27 Day-old Broiler Chickens, chicken group, and the indivedual chickens of cut open inspection are wrapped
Pericardium liver pathological change, typical bacillus coli feature.
Laboratory diagnosis：Pathologic liver is taken to contaminate piece, Gram's staining, micro- Microscopic observation, it is seen that red gram-negative
Property bacillus；Tentatively it is judged as bacillus coli.Cultivated by Escherichia coli, biochemical test differentiates, judge that chicken infection is big
Enterobacteria disease, PCR amplifications, it was demonstrated that production has the ESBLs drug resistant genes of TEM types.
Test therapeutic regimen：Morbidity chicken group is divided into 6 groups of administrations, first group with addition of the embodiment 1 according to 7g/kg feeds
Amount administration, second group is administered with embodiment 2 according to the addition of 2g/kg feeds, and the 3rd group is raised with embodiment 3 according to 0.8g/kg
The addition administration of material, the 4th group is administered with embodiment 4 according to the addition of 2g/kg feeds；5th group is used Amoxicillin pulvis
It is administered according to the addition of 0.2g/kg feeds, the 6th group is administered with the thick powder of the grass containing pearl according to the addition of 4g/kg feeds；With
Upper six groups of therapeutic regimens are persistently used 5 days.
Staining effect：After first group to the 4th group of chicken group's medication, diseased chicken feed intake rises, and dead chicken no longer occurs, continues
Using 3 days, chicken group was almost recovered；After 5th group of chicken group's medication 2 days, chicken group is most still unhealthy, still there is indivedual chicken deaths, after
Continuous to use 3 days, chicken death phenomenon is still without being effectively controlled；After 6th group of chicken group's medication 2 days, chicken group is without too big bright
It is aobvious to take on a new look, it is continuing with 3 days, chicken death phenomenon is still without being effectively controlled.It can be seen that, the compound medicine curative effect containing the grass containing pearl
Better than folk prescription.
2nd, efficacy experiment of the compound medicine product obtained by embodiment 5-8 to the meat duck diarrhoea of 22 ages in days
Clinical symptoms：Liuzhou duck, 22 age in days meat ducks, duck group, which draws to have in watery stools, excrement, not to disappear significantly
The feed of change.Duck group's material feeding but not long, it is soft slowly dead that pin gradually occurs in serious duck of suffering from diarrhoea individually.
Cut open inspection lesion：The duck that dies of illness dehydration is than more serious, and indivedual ducks are still very big, duck liver enlargement, hyperemia, the liver of part duck
There are white films on dirty, air bag is muddy, tentative diagnosis is Escherichia coli or duck oromeningitis.
Test therapeutic regimen：Fall ill duck group's point six groups of administrations, first group with addition of the embodiment 5 according to 3g/kg feeds
Administration, second group is administered with embodiment 6 according to the addition of 1.3g/kg feeds, and the 3rd group is raised with embodiment 7 according to 0.5g/kg
The addition administration of material, the 4th group is administered with embodiment 8 according to the addition of 0.45g/kg feeds；5th group is used ceftiofur sodium
Pulvis is administered according to the addition of 0.2g/kg feeds, and the 6th group is given with the thick powder of the grass containing pearl according to the addition of 5g/kg feeds
Medicine；Six groups of therapeutic regimens of the above are persistently used 5 days.
Using effect is fed back：After first group to the 4th group medication 2 days, sick duck no longer draws watery stools, formed stools, no longer
There is dead duck, be continuing with 3 days, duck group is almost recovered；After 5th group of medication 2 days, duck group's DeGrain is many or draw water
Sample excrement, containing indigested feed, is continuing with 3 days, somewhat takes a turn for the better, but without well thoroughly, dilute watery stools are still
Occur, use the compound medicine of the gained of embodiment 6 instead, be continuing with 2 days, be just almost recovered, reuse 1 day, excrement all switchs to
Normally；After 6th group of medication 2 days, duck is continuing with 3 days without too big remarkable improvement, and the duck phenomena of mortality are still without being had
Effect control.It can be seen that, the curative effect that the compound medicine containing the grass containing pearl is suffered from diarrhoea to duck is better than folk prescription.
3rd, embodiment 1-4 obtains efficacy experiment of the compound medicine product to Salmonella gallinarum disease
Clinical symptoms：There is diarrhea, row's white, pasty state loose stool, anus in Nanning chicken house, 16 age in days laying hens, chicken group
The fine hair faecal contamination of surrounding, there is lime sample lump, and what is had sends the shriek of pain, there is the phenomena of mortality.The indivedual chickens of cut open inspection
Hepatomegaly is in kermesinus to darkviolet, or slightly khaki, matter is crisp fragile, and surface is dispersed in or gathered the downright bad point of greyish white, lark,
Sometimes it is red blutpunkte, typical salmonella genius morbi.
Laboratory diagnosis：Pathologic liver is taken to contaminate piece, Gram's staining, micro- Microscopic observation, it is seen that red gram-negative
Property bacillus；Tentatively it is judged as salmonella disease.Cultivated by salmonella, biochemical test differentiates, judge chicken infection for sand
Door Salmonella disease, drug sensitive test result is judged as persister salmonella according to NCCLS standards.
Test therapeutic regimen：Morbidity chicken group is divided into 6 groups of administrations, first group with addition of the embodiment 1 according to 7g/kg feeds
Amount administration, second group is administered with embodiment 2 according to the addition of 2g/kg feeds, and the 3rd group is raised with embodiment 3 according to 0.8g/kg
The addition administration of material, the 4th group is administered with embodiment 4 according to the addition of 2g/kg feeds；5th group is used Amoxicillin pulvis
It is administered according to the addition of 0.2g/kg feeds, the 6th group is administered with the thick powder of the grass containing pearl according to the addition of 4g/kg feeds；With
Upper six groups of therapeutic regimens are persistently used 5 days.
Staining effect：After first group to the 4th group of chicken group's medication, diseased chicken feed intake rises, and dead chicken no longer occurs, continues
Using 3 days, chicken group was almost recovered；After 5th group of chicken group's medication 2 days, chicken group is most still unhealthy, still there is indivedual chicken deaths, after
Continuous to use 3 days, chicken death phenomenon is still without being effectively controlled；After 6th group of chicken group's medication 2 days, chicken group is without too big bright
It is aobvious to take on a new look, it is continuing with 3 days, chicken death phenomenon is still without being effectively controlled.It can be seen that, the compound medicine curative effect containing the grass containing pearl
Better than folk prescription.
Claims (4)
1. a kind of contain the livestock and poultry compound medicine containing pearl grass and beta-lactam antimicrobial, it is characterised in that by following weight
The raw material composition of part：3-30 parts of beta-lactam antimicrobial, containing 5-200 parts of pearl grass.
2. according to claim 1 contain the livestock and poultry compound medicine containing pearl grass and beta-lactam antimicrobial, its feature
It is, described beta-lactam antimicrobial is Amoxicillin, Ceftriaxone Sodium or ceftiofur sodium.
3. according to claim 1 contain the livestock and poultry compound medicine containing pearl grass and beta-lactam antimicrobial, its feature
It is, described compound medicine is made up of the raw material of following parts by weight：Amoxicillin 3-20 parts and containing 40-180 parts of pearl grass, or head
3-25 parts of spore ceftiofur sodium and containing 30-190 parts of pearl grass.
4. according to claim 1 contain the livestock and poultry compound medicine containing pearl grass and beta-lactam antimicrobial, its feature
It is, described compound medicine is prepared into powder, tablet, oral liquid or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410230412.4A CN103989728B (en) | 2014-05-28 | 2014-05-28 | It is a kind of to contain the livestock and poultry compound medicine containing pearl grass and beta-lactam class antimicrobial |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410230412.4A CN103989728B (en) | 2014-05-28 | 2014-05-28 | It is a kind of to contain the livestock and poultry compound medicine containing pearl grass and beta-lactam class antimicrobial |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103989728A CN103989728A (en) | 2014-08-20 |
| CN103989728B true CN103989728B (en) | 2017-07-21 |
Family
ID=51304229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410230412.4A Active CN103989728B (en) | 2014-05-28 | 2014-05-28 | It is a kind of to contain the livestock and poultry compound medicine containing pearl grass and beta-lactam class antimicrobial |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103989728B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306422A (en) * | 2014-11-07 | 2015-01-28 | 广西大学 | Balsamiferou Blumea herb and beta-lactam antibacterial drug containing compound medicine for livestock and poultry |
| CN106176895A (en) * | 2016-08-22 | 2016-12-07 | 广西大学 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amoxicillin |
| CN106236879A (en) * | 2016-08-22 | 2016-12-21 | 广西大学 | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and ceftiofur sodium |
| CN106265880A (en) * | 2016-08-22 | 2017-01-04 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae and ceftiofur sodium |
| CN106214742A (en) * | 2016-08-22 | 2016-12-14 | 广西大学 | A kind of poultry compound medicine containing Cortex Cinnamomi and ceftiofur sodium |
| CN106138318A (en) * | 2016-08-22 | 2016-11-23 | 广西大学 | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and amoxicillin |
| CN106138184A (en) * | 2016-08-22 | 2016-11-23 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae and amoxicillin |
| CN106266056A (en) * | 2016-09-21 | 2017-01-04 | 广西大学 | A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amoxicillin |
| CN106266053A (en) * | 2016-09-21 | 2017-01-04 | 广西大学 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and amoxicillin |
| CN106309634A (en) * | 2016-09-21 | 2017-01-11 | 广西大学 | Composite medicine containing cinnamon, cherokee rose fruit and ceftiofur sodium for beasts and birds |
| CN106266057A (en) * | 2016-09-21 | 2017-01-04 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae, Fructus Rosae Laevigatae and amoxicillin |
| CN106109579A (en) * | 2016-09-21 | 2016-11-16 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae, Cortex Cinnamomi and amoxicillin |
| CN106236884A (en) * | 2016-09-21 | 2016-12-21 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae, Fructus Rosae Laevigatae and ceftiofur sodium |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02204495A (en) * | 1989-02-02 | 1990-08-14 | Maruzen Kasei Co Ltd | Method for extracting licorice hydrophobic flavonoid |
-
2014
- 2014-05-28 CN CN201410230412.4A patent/CN103989728B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02204495A (en) * | 1989-02-02 | 1990-08-14 | Maruzen Kasei Co Ltd | Method for extracting licorice hydrophobic flavonoid |
Non-Patent Citations (2)
| Title |
|---|
| 铁苋菜联用思密达治疗小儿秋季腹泻118例报告;甘炳天;《右江民族医学院学报》;20021230;第24卷(第06期);第871页 * |
| 黄藤素、没食子酸增加β-内酰胺类抗生素对产ESBLs大肠埃希菌的敏感性及其作用机理初步探讨;罗芬芳;《中国优秀硕士学位论文全文数据库》;20140215(第2期);第V-VI、24-25、27-30页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103989728A (en) | 2014-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103989728B (en) | It is a kind of to contain the livestock and poultry compound medicine containing pearl grass and beta-lactam class antimicrobial | |
| CN103948930B (en) | A kind of poultry compound medicine containing Radix Paeoniae Rubra and beta-lactam antimicrobial drug | |
| CN103690952B (en) | The compound medicine for the treatment of poultry coli-infection disease | |
| CN103977090B (en) | A kind of poultry compound medicine containing Radix Paeoniae Rubra and florfenicol | |
| CN103989725A (en) | Acalypha australis L. and amikacin containing compound medicine for livestock and poultry | |
| CN103961421A (en) | Compound medicine containing radix paeoniae rubra and mequindox for livestock and poultry | |
| CN103977089B (en) | A kind of poultry compound medicine containing Radix Paeoniae Rubra and fosfomycin | |
| CN103989731A (en) | Acalypha australis L. and florfenicol containing compound medicine for livestock and poultry | |
| CN103989729A (en) | Acalypha australis L. and sulfamonomethoxine sodium containing compound medicine for livestock and poultry | |
| CN103933086A (en) | Creat/amikacin-containing compound medicine for livestock and fowl | |
| CN103989727A (en) | Acalypha australis L. and mequindox containing compound medicine for livestock and poultry | |
| CN103948692B (en) | A kind of livestock and poultry compound medicine containing the radix paeoniae rubrathe and amikacin | |
| CN103989730A (en) | Acalypha australis L. and fluoroquinolone antibacterial medicine containing compound medicine for livestock and poultry | |
| CN103948691B (en) | A kind of poultry compound medicine containing Radix Paeoniae Rubra and sulfamonomethoxine sodium | |
| CN103989726A (en) | Acalypha australis L. and fosfomycin containing compound medicine for livestock and poultry | |
| CN104306420A (en) | Balsamiferou blumea herb and sulfamonomethoxine sodium containing compound medicine for livestock and poultry | |
| CN103977088A (en) | Compound medicine containing radix paeoniae rubrathe and fluoroquinolones antibacterial drug used for livestock and poultry | |
| CN104337847B (en) | A kind of livestock and poultry compound medicine containing phoenix-tail fern and phosphonomycin | |
| CN103908670B (en) | A kind of compound treating poultry coli-infection disease | |
| CN104435012A (en) | Pteris multifida and florfenicol-containing compound drug for livestock and poultry | |
| CN104367601A (en) | Compound medicine containing herba pteridis multifidae and mequindox for livestock and poultry | |
| CN103933543A (en) | Method for treating Escherichia coli infection diseases by using creat and colimycin | |
| CN104306422A (en) | Balsamiferou Blumea herb and beta-lactam antibacterial drug containing compound medicine for livestock and poultry | |
| CN104027370B (en) | A kind of livestock and poultry compound containing Plumbago zeylanica and LIJUNJING | |
| CN104435038A (en) | Balsamiferou blumea herb and mequindox containing compound medicine for livestock and poultry |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant |