CN103948656B - A kind of poultry compound medicine containing Herba Andrographis and fosfomycin - Google Patents
A kind of poultry compound medicine containing Herba Andrographis and fosfomycin Download PDFInfo
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- CN103948656B CN103948656B CN201410170969.3A CN201410170969A CN103948656B CN 103948656 B CN103948656 B CN 103948656B CN 201410170969 A CN201410170969 A CN 201410170969A CN 103948656 B CN103948656 B CN 103948656B
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Abstract
The present invention relates to a kind of poultry compound medicine containing Herba Andrographis and fosfomycin, be made up of the raw material of following weight portion: fosfomycin 3 30 parts, Herba Andrographis 10 170 parts.Powder, tablet, oral liquid or granule will be prepared as after raw material blending, add in animal and fowl fodder according to 0.1 7g/kg feedstuff addition and feed, can the reverse bacterial drug resistance to antimicrobial drug, thus improve the therapeutic effect of antimicrobial drug, drug cost and drug residue are greatly reduced, create higher economic benefit for raiser, and ensure the food safety of the mankind.
Description
Technical field
The invention belongs to poultry coli-infection treatment technology field, particularly relate to a kind of poultry containing Herba Andrographis and fosfomycin and use
Compound medicine.
Background technology
Escherichia coli are common conditioned pathogens, are also a kind of diseases often sent out, and it primary can cause chicken acute sepsis, abdomen
The multiple location severe infections such as film inflammation, hepatitis, pneumonia, enteritis, also can secondary or mixed send out in virosis, cause huge to aquaculture
Economic loss.Amoxicillin, ampicillin, ceftiofur, ceftriaxone, amoxicillin/clavulanate, ampicillin/
The beta-lactam nucleus class antibiotic such as sulbactam are the conventional important drugs preventing and treating this disease, along with cultivation scale intensive degree more comes
Bigger, medication is more and more spread unchecked, and its Resistant strain is the most, and the report about Drug Resistance of E. coli is the most more.Research card
Real, one of main mechanism of drug resistance is to produce beta-lactamase, especially extended spectrumβ-lactamase (Extended-
Spectrum β-lactamase, ESBLs), this enzyme can hydrolyze beta-lactam nucleus more by force and rapidly, makes this kind of antibiotic lose
Lose antibacterial activity.ESBLs is the main enzyme type of beta-lactamase, and it is not only to cephalo three generations and aztreonam drug resistance, and right
Aminoglycoside, quinolones and sulfonamides are crossing drug resistant, only to carbapenems, a mould alkenes medicaments insensitive.Many literary compositions
Offer it has been reported that colibacillary multi-drug resistant with produce ESBLs have substantial connection, both at home and abroad to more pay close attention to.Inventor
The detection of food animal source pathogenic bacterium ESBLs, extraction, enzyme are carried out recently to the percent hydrolysis of antibiotic and sulbactam, his azoles bar
Smooth and Chinese medicine the enzyme protection effect that presses down etc. is studied, and drug sensitive test colibacillary to part ESBLs shows, its multidrug resistant rate
Apparently higher than non-ESBLs bacterial strain.It addition, result also shows to produce ESBLs bacterial strain not only to third generation cephalosporins such as ceftiofurs
Serious drug resistance, and also antimicrobial drug drug resistance multiple to fluoroquinolones, aminoglycoside and sulfonamides, fosfomycin etc., in seriously
Multidrug resistant.Inventor is separated to resistance to fosfomycin in producing ESBLs bacterial strain and produces the escherichia coli of fosA3 drug resistant gene, more
The strong drug resistance of antibacterial.Colibacillary drug resistance causes raiser's drug cost to increase, and treatment extends the course for the treatment of, and poultry are dead
Rate increases, and brings bigger economic loss to production, and increases poultry drug residue risk.Therefore, actual production needs one badly
Kind to regardless of whether the escherichia coli of drug resistance can have a medicine of preferable therapeutical effect, and can shorten and treat the course for the treatment of, minimizing mortality rate,
Reduce economic loss and reduce drug residue, creating higher economic benefit for raiser, also ensure that the mankind's is healthy and safe.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Herba Andrographis and fosfomycin, and it can be very fast
Kill antibacterial, overcome weak curative effect that antimicrobial drug treatment causes due to drug resistance problems, consumption is big, residual is high and cost is high lacks
Fall into, it is to avoid simple Chinese medicine sterilizing spectrum is narrow, sterilize slow problem.
For solve above technical problem, the present invention by the following technical solutions: a kind of poultry compound recipe containing Herba Andrographis and fosfomycin
Medicine, is made up of the raw material of following weight portion: fosfomycin 3-30 part, Herba Andrographis 10-170 part.
Described compound medicine is prepared as powder, tablet, oral liquid or granule.
The preparation method of described compound medicine is: Herba Andrographis pulverized 60 mesh sieves, then mixes with the antimicrobial drug of powder, presses
Conventional method is prepared as powder, tablet, oral liquid or granule.
The drug resistance problems existed for current poultry coli-infection, inventor utilizes Guangxi Special Traditional Chinese Medicine Herba Andrographis with antibacterial
Medicine composition compound medicine.Research proves, after antimicrobial drug adds Herba Andrographis, it is possible to the reverse bacterial drug resistance to antimicrobial drug, from
And improve the therapeutic effect of antimicrobial drug.According to a conventional method this compound medicine is made powder, tablet, oral liquid or granule, press
Add in animal and fowl fodder according to the addition of 0.1-7g principal agent/kg feedstuff and feed, drug cost can be greatly reduced and medicine is residual
Stay, create higher economic benefit for raiser, also ensure that food safety simultaneously.
Detailed description of the invention
One, the Herba Andrographis drug resistance inversion Effect study to antimicrobial drug
Antimicrobial drug itself has the colibacillary effect for the treatment of, but has stronger owing to producing the escherichia coli of ESBLs drug resistant gene
Drug resistance, causes antimicrobial drug not show preferable therapeutic effect in the case of normal using dosage.
In order to verify the Herba Andrographis drug resistance inversion effect to antimicrobial drug, 96 orifice plates use microtest tube doubling dilution, first surveys
Determine antimicrobial drug to producing the minimal inhibitory concentration of e. coli strains of ESBLs and fosA3 drug resistant gene and Herba Andrographis to producing ESBLs
With the subinhibitory concentration of fosA3 drug resistant gene e. coli strains, add the Herba Andrographis of subinhibitory concentration the most in the medium again
Microtest tube doubling dilution is used to cultivate the minimal inhibitory concentration measuring antimicrobial drug；Continuous passage method is utilized to press down added with same Asia
Product ESBLs and fosA3 drug resistant gene e. coli strains is passed by the culture medium of bacteria concentration Herba Andrographis and same concentration antimicrobial drug
Culture, until the antimicrobial drug minimal inhibitory concentration observed with pass on before compared with diminish more than 4 times, Herba Andrographis can be judged as
Antibacterial medical instrument there is drug resistance inversion effect.Result of the test statistics is as shown in table 1:
Table 1 subinhibitory concentration (0.25g/mL) Herba Andrographis passes on and causes the change producing ESBLs and fosA3 escherichia coli Western medicine MIC.
As seen from the above table, antimicrobial drug all reduces more than 4 times to the minimal inhibitory concentration of antibiotic-resistance E. coli, i.e. can determine whether it is punching
Lotus has drug resistance inversion effect to producing ESBLs and fosA3 drug resistant gene escherichia coli.
Two, the application example of compound medicine of the present invention
Prepare embodiment 1-embodiment 4 in accordance with the following methods: after Herba Andrographis was pulverized 60 mesh sieves, based on raw material, then with
The antimicrobial drug of powder mixes during ratio puts into blender by weight, according to a conventional method, compound medicine is prepared as formulation products.
The formula of table 2 embodiment 1-4 and preparation dosage form
| Numbering | Antimicrobial drug | Herba Andrographis | Dosage form |
| Embodiment 1 | Fosfomycin 18g | 130g | Powder |
| Embodiment 2 | Fosfomycin 3g | 50g | Tablet |
| Embodiment 3 | Fosfomycin 9g | 10g | Oral liquid |
| Embodiment 4 | Fosfomycin 30g | 170g | Granule |
Inventor, by the compound medicine product of above-described embodiment 1-4 gained, carries out efficacy experiment to the meat-type duck diarrhoea of 35 ages in days.
Clinical symptoms: duck group draws watery stools, has obvious indigested feedstuff in feces.The duck that diarrhoea is serious individually is gradually
Occur that foot is soft slowly dead.
Cuing open inspection pathological changes: the duck that dies of illness dehydration ratio is more serious, indivedual ducks are the biggest, duck liver enlargement, hyperemia, the liver of part duck
On have a white films, air bag is muddy, and tentative diagnosis is escherichia coli or duck oromeningitis.
Test therapeutic regimen: morbidity duck group divides six groups of administrations, and first group is administered according to the addition of 1g/kg feedstuff by embodiment 1,
Second group is administered according to the addition of 2g/kg feedstuff by embodiment 2, the 3rd group by embodiment 3 according to the interpolation of 2g/kg feedstuff
Amount is administered, and the 4th group is administered according to the addition of 1g/kg feedstuff by embodiment 4；5th group with fosfomycin powder according to 0.1g/kg
The addition of feedstuff is administered, and the 6th group is administered according to the addition of 7g/kg feedstuff with the thick powder of Herba Andrographis；Use prescription for above six groups
Case the most persistently uses 5 days.
Using effect is fed back: after first group to the 4th group medication 3 days, sick duck no longer draws watery stools, formed stools, no longer goes out
Now dead duck, is continuing with 2 days, and duck group be almost recovered；After 5th group of medication 3 days, duck group's DeGrain, the most still draws
Watery stools, containing indigested feedstuff, is continuing with 2 days, somewhat takes a turn for the better, but the best thorough, dilute watery stools
Or occurring, raiser uses the compound medicine of embodiment 1 gained instead, is continuing with 3 days, and feces all transfers to normally；6th
After group medication 3 days, duck does not has the biggest remarkable improvement, is continuing with 2 days, and the duck phenomena of mortality are still without being effectively controlled.
Visible, the curative effect that duck is suffered from diarrhoea by compound medicine containing Herba Andrographis is better than folk prescription.
Claims (2)
1. one kind contains Herba Andrographis and the poultry compound medicine of fosfomycin, it is characterised in that be made up of the raw material of following weight portion:
Fosfomycin 3-30 part, Herba Andrographis 10-170 part.
Poultry compound medicine containing Herba Andrographis and fosfomycin the most according to claim 1, it is characterised in that described answers
Side's medicine is prepared as powder, tablet, oral liquid or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410170969.3A CN103948656B (en) | 2014-04-25 | 2014-04-25 | A kind of poultry compound medicine containing Herba Andrographis and fosfomycin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410170969.3A CN103948656B (en) | 2014-04-25 | 2014-04-25 | A kind of poultry compound medicine containing Herba Andrographis and fosfomycin |
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| CN103948656A CN103948656A (en) | 2014-07-30 |
| CN103948656B true CN103948656B (en) | 2016-08-31 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435038A (en) * | 2014-11-07 | 2015-03-25 | 广西大学 | Balsamiferou blumea herb and mequindox containing compound medicine for livestock and poultry |
| CN104435040A (en) * | 2014-11-07 | 2015-03-25 | 广西大学 | Balsamiferou blumea herb and fosfomycin containing compound medicine for livestock and poultry |
| CN104337847B (en) * | 2014-11-12 | 2017-12-19 | 中国农业科学院哈尔滨兽医研究所 | A kind of livestock and poultry compound medicine containing phoenix-tail fern and phosphonomycin |
| CN106176910A (en) * | 2016-08-22 | 2016-12-07 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae and fosfomycin |
| CN106109547A (en) * | 2016-08-22 | 2016-11-16 | 广西大学 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and fosfomycin |
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