CN105726618A - Livestock and poultry compound medicine prepared from garden balsam stems and amikacin - Google Patents
Livestock and poultry compound medicine prepared from garden balsam stems and amikacin Download PDFInfo
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- CN105726618A CN105726618A CN201610103619.4A CN201610103619A CN105726618A CN 105726618 A CN105726618 A CN 105726618A CN 201610103619 A CN201610103619 A CN 201610103619A CN 105726618 A CN105726618 A CN 105726618A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- Animal Behavior & Ethology (AREA)
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Abstract
The invention relates to a livestock and poultry compound medicine prepared from garden balsam stems and amikacin. The livestock and poultry compound medicine is prepared from, by weight, 5-30 parts of amikacin and 10-160 parts of garden balsam stems. The raw materials are evenly mixed and then prepared into powder or tablets or oral liquid or particles, the compound medicine is added into livestock and poultry feed according to the feed adding amount of 0.1-7 g/kg for feeding, and the medicine resistance of bacteria to antibacterial medicine can be reversed so that the treatment effect of the antibacterial medicine can be improved, medication cost and medicine residues can be greatly reduced, higher economic benefits can be created for framers, and human food safety can be guaranteed.
Description
The present invention is invention entitled " a kind of compound recipe treating poultry coli-infection disease filed on 04 15th, 2014
Compositions ", the divisional application of Application No. 201410150091.7.
Technical field
The invention belongs to poultry coli-infection treatment technology field, particularly relate to a kind of containing Herba speranskiae tuberculatae with the poultry of amikacin
Fowl compound medicine.
Background technology
Escherichia coli are common conditioned pathogens, are also a kind of diseases often sent out, and it primary can cause chicken acute sepsis, abdomen
The multiple location severe infections such as film inflammation, hepatitis, pneumonia, enteritis, also can secondary or mixed send out in virosis, cause huge to aquaculture
Economic loss.Amoxicillin, ampicillin, ceftiofur, ceftriaxone, amoxicillin/clavulanate, ampicillin/
The beta-lactam nucleus class antibiotic such as sulbactam are the conventional important drugs preventing and treating this disease, along with cultivation scale intensive degree more comes
Bigger, medication is more and more spread unchecked, and its Resistant strain is the most, and the report about Drug Resistance of E. coli is the most more.Research card
Real, one of main mechanism of drug resistance is to produce beta-lactamase, especially extended spectrumβ-lactamase (Extended-
Spectrum β-lactamase, ESBLs), this enzyme can hydrolyze beta-lactam nucleus more by force and rapidly, makes this kind of antibiotic lose
Lose antibacterial activity.ESBLs is the main enzyme type of beta-lactamase, and it is not only to cephalo three generations and aztreonam drug resistance, and right
Aminoglycoside, quinolones and sulfonamides are crossing drug resistant, only to carbapenems, a mould alkenes medicaments insensitive.Many literary compositions
Offer it has been reported that colibacillary multi-drug resistant with produce ESBLs have substantial connection, both at home and abroad to more pay close attention to.Inventor
The detection of food animal source pathogenic bacterium ESBLs, extraction, enzyme are carried out recently to the percent hydrolysis of antibiotic and sulbactam, his azoles bar
Smooth and Chinese medicine the enzyme protection effect that presses down etc. is studied, and drug sensitive test colibacillary to part ESBLs shows, its multidrug resistant rate
Apparently higher than non-ESBLs bacterial strain.It addition, result also shows to produce ESBLs bacterial strain not only to third generation cephalosporins such as ceftiofurs
Serious drug resistance, and also antimicrobial drug drug resistance multiple to fluoroquinolones, aminoglycoside and sulfonamides, fosfomycin etc., in seriously
Multidrug resistant.Inventor is separated to resistance to fosfomycin in producing ESBLs bacterial strain and produces the escherichia coli of fosA3 drug resistant gene, more
The strong drug resistance of antibacterial.Colibacillary drug resistance causes raiser's drug cost to increase, and treatment extends the course for the treatment of, and poultry are dead
Rate increases, and brings bigger economic loss to production, and increases poultry drug residue risk.Therefore, actual production needs one badly
Kind to regardless of whether the escherichia coli of drug resistance can have a medicine of preferable therapeutical effect, and can shorten and treat the course for the treatment of, minimizing mortality rate,
Reduce economic loss and reduce drug residue, creating higher economic benefit for raiser, also ensure that the mankind's is healthy and safe.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Herba speranskiae tuberculatae and amikacin, and it can
Kill antibacterial quickly, overcome weak curative effect that antimicrobial drug treatment causes due to drug resistance problems, consumption is big, residual is high and cost is high
Defect, it is to avoid simple Chinese medicine sterilizing spectrum is narrow, sterilize slow problem.
For solving above technical problem, the present invention by the following technical solutions: a kind of poultry containing Herba speranskiae tuberculatae and amikacin are used
Compound medicine, is made up of the raw material of following weight portion: amikacin 5-30 part, Herba speranskiae tuberculatae 10-160 part.
The dosage form of this compound is powder, tablet, oral liquid or granule.
The preparation method of above-mentioned compound medicine, pulverized 60 mesh sieves by Herba speranskiae tuberculatae, then mixed, routinely with the antimicrobial drug of powder
Method is prepared as powder, tablet, oral liquid or granule.
The drug resistance problems existed for current poultry coli-infection, inventor utilizes Guangxi Special Traditional Chinese Medicine Herba speranskiae tuberculatae with antibacterial
Medicine composition compound.Research proves, after antimicrobial drug adds Herba speranskiae tuberculatae, it is possible to the reverse bacterial drug resistance to antimicrobial drug,
Thus improve the therapeutic effect of antimicrobial drug.According to a conventional method this compound is made powder, tablet, oral liquid or granule,
Add in animal and fowl fodder according to the addition of 0.1-7g principal agent/kg feedstuff and feed, drug cost and medicine can be greatly reduced
Residual, creates higher economic benefit for raiser, also ensure that food safety simultaneously.
Detailed description of the invention
One, the Herba speranskiae tuberculatae drug resistance inversion Effect study to antimicrobial drug
Antimicrobial drug itself has the colibacillary effect for the treatment of, but has stronger owing to producing the escherichia coli of ESBLs drug resistant gene
Drug resistance, causes antimicrobial drug not show preferable therapeutic effect in the case of normal using dosage.
In order to verify the Herba speranskiae tuberculatae drug resistance inversion effect to antimicrobial drug, 96 orifice plates use microtest tube doubling dilution, first surveys
Determine antimicrobial drug to producing the minimal inhibitory concentration of e. coli strains of ESBLs and fosA3 drug resistant gene and Herba speranskiae tuberculatae to producing ESBLs
With the subinhibitory concentration of fosA3 drug resistant gene e. coli strains, add the Herba speranskiae tuberculatae of subinhibitory concentration the most in the medium again
Microtest tube doubling dilution is used to cultivate the minimal inhibitory concentration measuring antimicrobial drug；Continuous passage method is utilized to press down added with same Asia
Product ESBLs and fosA3 drug resistant gene e. coli strains is passed by the culture medium of bacteria concentration Herba speranskiae tuberculatae and same concentration antimicrobial drug
Culture, until the antimicrobial drug minimal inhibitory concentration observed with pass on before compared with diminish more than 4 times, Herba speranskiae tuberculatae can be judged as
Antibacterial medical instrument there is drug resistance inversion effect.Result of the test statistics is as shown in table 1:
Table 1 subinhibitory concentration (0.25g/mL) Herba speranskiae tuberculatae passes on to cause and produces ESBLs and fosA3 escherichia coli Western medicine MIC's
Change (μ g/mL).
As seen from the above table, antimicrobial drug all reduces more than 4 times to the minimal inhibitory concentration of antibiotic-resistance E. coli, i.e. can determine whether it is deep
Grass has drug resistance inversion effect to producing ESBLs and fosA3 drug resistant gene escherichia coli.
Two, the application example of compound of the present invention
Prepare embodiment 1-embodiment 4 in accordance with the following methods: after Herba speranskiae tuberculatae was pulverized 60 mesh sieves, based on raw material, then with
The antimicrobial drug of powder mixes during ratio puts into blender by weight, is prepared as preparation according to a conventional method.
The formula of table 2 embodiment 1-4 and product
The efficacy experiment that the meat-type duck of 30 ages in days is suffered from diarrhoea by the compound product of embodiment 1-4 gained:
Clinical symptoms: Guangxi Qinzhou duck field, 30 age in days meat-type duck, duck group draws watery stools, has the most indigested in feces
Feedstuff.Indivedual serious ducks of suffering from diarrhoea gradually occur that foot is soft slowly dead.
Cuing open inspection pathological changes: the duck that dies of illness dehydration ratio is more serious, indivedual ducks are the biggest, duck liver enlargement, hyperemia, the liver of part duck
On have a white films, air bag is muddy, and tentative diagnosis is escherichia coli or duck oromeningitis.
Test therapeutic regimen: morbidity duck group divides six groups of administrations, gives according to the addition of 1.5g/kg feedstuff by embodiment 1 for first group
Medicine, second group with embodiment 2 according to 0.2g/kg feedstuff addition be administered, the 3rd group by embodiment 3 according to 2g/kg feedstuff
Addition be administered, the 4th group with embodiment 4 according to 0.7g/kg feedstuff addition be administered；Use amikacin powder for 5th group
Being administered according to the addition of 0.2g/kg feedstuff, the 6th group is administered according to the addition of 2.0g/kg feedstuff with the thick powder of Herba speranskiae tuberculatae；
Above six groups of therapeutic regimens the most persistently use 5 days.
Using effect is fed back: after first group to the 4th group medication 3 days, sick duck no longer draws watery stools, formed stools, no longer goes out
Now dead duck, is continuing with 2 days, and duck group be almost recovered；After 5th group of medication 3 days, duck group's DeGrain, the most still draws
Watery stools, containing indigested feedstuff, is continuing with 2 days, somewhat takes a turn for the better, but the best thorough, dilute watery stools
Or occurring, raiser uses the compound of embodiment 1 gained instead, is continuing with 3 days, and feces all transfers to normally；The
After six groups of medications 3 days, duck does not has the biggest remarkable improvement, is continuing with 2 days, and the duck phenomena of mortality are still without being effectively controlled.
Visible, the curative effect that duck is suffered from diarrhoea by compound containing Herba speranskiae tuberculatae is better than folk prescription.
Claims (1)
1. one kind contains Herba speranskiae tuberculatae and the poultry compound medicine of amikacin, it is characterised in that former by following weight ratio
Material composition: amikacin 5-30 part, Herba speranskiae tuberculatae 10-160 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610103619.4A CN105726618A (en) | 2014-04-15 | 2014-04-15 | Livestock and poultry compound medicine prepared from garden balsam stems and amikacin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610103619.4A CN105726618A (en) | 2014-04-15 | 2014-04-15 | Livestock and poultry compound medicine prepared from garden balsam stems and amikacin |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410150091.7A Division CN103908670B (en) | 2014-04-15 | 2014-04-15 | A kind of compound treating poultry coli-infection disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105726618A true CN105726618A (en) | 2016-07-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610103619.4A Pending CN105726618A (en) | 2014-04-15 | 2014-04-15 | Livestock and poultry compound medicine prepared from garden balsam stems and amikacin |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690952A (en) * | 2013-11-27 | 2014-04-02 | 广西大学 | Compound drug for treating livestock and poultry escherichia coli infected diseases |
-
2014
- 2014-04-15 CN CN201610103619.4A patent/CN105726618A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690952A (en) * | 2013-11-27 | 2014-04-02 | 广西大学 | Compound drug for treating livestock and poultry escherichia coli infected diseases |
Non-Patent Citations (2)
| Title |
|---|
| 王思芦等: "中药消除致病性大肠杆菌耐药性研究进展", 《中国畜牧兽医》 * |
| 王芳等: "透骨草提取物的抑菌效果研究", 《辽宁中医杂志》 * |
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Application publication date: 20160706 |
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