CN104027369A - Plumbago zeylanica and norfloxacin containing compound composition for livestock and poultry - Google Patents
Plumbago zeylanica and norfloxacin containing compound composition for livestock and poultry Download PDFInfo
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- CN104027369A CN104027369A CN201410272411.6A CN201410272411A CN104027369A CN 104027369 A CN104027369 A CN 104027369A CN 201410272411 A CN201410272411 A CN 201410272411A CN 104027369 A CN104027369 A CN 104027369A
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Abstract
The invention relates to a plumbago zeylanica and norfloxacin containing compound composition for livestock and poultry. The compound composition is prepared from the following raw materials in parts by weight: 3-25 parts of norfloxacin and 30-190 parts of plumbago zeylanica. By preparing powder, tablets, oral liquids or granules through uniformly mixing the raw materials, and feeding in a manner of adding the powder, tablets, oral liquids or granules into a livestock and poultry feed according to the ratio of (0.1-7)g: 1kg, the antibacterial drug resistance of bacteria can be reversed, so that the treatment effect of antibacterial drugs is improved, the medication cost is greatly reduced, and higher economic benefit is created for farmers.
Description
The present invention is that the denomination of invention of application on 06 13rd, 2013 is " a kind of compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease ", the divisional application that application number is 201310233232.7.
Technical field
The present invention relates to a kind of poultry compound that contains Radix Plumbaginis Zeylanicae and norfloxacin.
Background technology
Escherichia coli are common conditioned pathogens, also be normal a kind of disease of sending out, can the former multiple location severe infections such as chicken acute sepsis, peritonitis, hepatitis, pneumonia, enteritis of having carried out the coffin upon burial, also can secondary or mixed in virosis, cause huge economic loss to aquaculture.Wherein amoxicillin, ampicillin, ceftiofur, ceftriaxone, amoxicillin/clavulanate, the beta-lactam lopps antibiotic such as ampicillin/sulbactam are the conventional important drugs of this disease of control, along with cultivation scale intensive degree is more and more large, medication is more and more spread unchecked, its Resistant strain is more and more many, more about Drug Resistance of E. coli report, one of main mechanism that studies confirm that at present drug resistance is to produce beta-lactamase, especially extended spectrumβ-lactamase (Extended-Spectrum β-lactamase, ESBLs), can be hydrolyzed more by force and fast beta-lactam nucleus, make this class antibiotic lose antibacterial activity.ESBLs is the main enzyme type of beta-lactamase, and ESBLs is not only to cephalo three generations and aztreonam drug resistance, and aminoglycoside, quinolones and sulfonamides are to crossing drug resistant, only to carbapenems, a mould alkene class medicaments insensitive.Current many documents have reported that colibacillary multi-drug resistant and generation ESBLs have substantial connection, comparatively pay close attention to it both at home and abroad.The detection, extraction, enzyme that the inventor has carried out chicken source pathogenic bacterium ESBLs presses down the researchs such as enzyme protection effect to antibiotic percent hydrolysis and sulbactam, Tazobactam Sodium and Chinese medicine.To part ESBLs, colibacillary drug sensitive test shows, its multidrug resistant rate is apparently higher than non-ESBLs bacterial strain.Result also shows to produce ESBLs bacterial strain not only to the serious drug resistance of the third generation cephalosporins such as ceftiofur in addition, and also to multiple antimicrobial drug drug resistances such as fluoroquinolones, aminoglycoside and sulfonamides, be serious multidrug resistant, colibacillary drug resistance causes to raiser's drug cost to be increased, extend the course for the treatment of of treatment, mortality of livestock increases, and brings higher expenses for medicine cost and economic loss to production.Therefore, suddenly in actual production waiting to need a kind of to no matter whether, the escherichia coli of drug resistance can have the medicine of better therapeutical effect, to shorten the course for the treatment of of treatment, reduce mortality rate, reduce economic loss, is that raiser creates higher economic benefit.
Summary of the invention
The object of this invention is to provide a kind of poultry compound that contains Radix Plumbaginis Zeylanicae and norfloxacin, can kill quickly antibacterial, overcome large, the residual height of weak curative effect, consumption and the high defect of cost that antimicrobial drug treatment causes due to drug resistance problem.
The present invention is achieved through the following technical solutions above-mentioned purpose: a kind of poultry compound that contains Radix Plumbaginis Zeylanicae and norfloxacin, is made up of the raw material of following weight ratio: norfloxacin 3-25 part, Radix Plumbaginis Zeylanicae 30-190 part.
The compound method of described compound is: Radix Plumbaginis Zeylanicae is pulverized, cross after 60 mesh sieves, then put into blender with pulverous antimicrobial drug according to described parts by weight of raw materials ratio and mix, be prepared into powder, tablet, oral liquid or granule.
The beneficial effect that the present invention compared with prior art had is: in antimicrobial drug, add after Radix Plumbaginis Zeylanicae, can reverse the drug resistance of bacteria medicine, thereby the therapeutic effect that improves antimicrobial drug, significantly reduces drug cost, for raiser creates higher economic benefit.
Detailed description of the invention
Antimicrobial drug itself has the colibacillary effect for the treatment of, but because the escherichia coli that produce ESBLs drug resistant gene have stronger drug resistance, causes antimicrobial drug not show good therapeutic effect in normal using dosage situation.
In order to verify the drug resistance inversion effect of Radix Plumbaginis Zeylanicae to antimicrobial drug, inventor adopts microtest tube doubling dilution on 96 orifice plates, first measure antimicrobial drug to producing minimal inhibitory concentration and the subinhibitory concentration of Radix Plumbaginis Zeylanicae to product ESBLs e. coli strains of ESBLs e. coli strains, then in culture medium, added the Radix Plumbaginis Zeylanicae of subinhibitory concentration to reuse the minimal inhibitory concentration of microtest tube doubling dilution cultivation mensuration antimicrobial drug; Utilize continuous passage method in the culture medium that is added with same subinhibitory concentration Radix Plumbaginis Zeylanicae and same concentration antimicrobial drug to producing the cultivation of going down to posterity of ESBLs e. coli strains, until the antimicrobial drug minimal inhibitory concentration observing diminishes more than 4 times compared with before going down to posterity, can be judged as Radix Plumbaginis Zeylanicae has drug resistance inversion effect to antibacterial medical instrument.Result of the test statistics is as shown in the table:
Subinhibitory concentration Radix Plumbaginis Zeylanicae culture medium goes down to posterity and causes the variation (ug/ml) of producing ESBLs escherichia coli antimicrobial drug minimal inhibitory concentration
As seen from the above table, through continuous passage, during to the second filial generation, antimicrobial drug all reduces more than 4 times producing the colibacillary minimal inhibitory concentration of ESBLs, can be judged as Radix Plumbaginis Zeylanicae and have drug resistance inversion effect to producing ESBLs escherichia coli.
In order to further illustrate technical scheme of the present invention, inventor has carried out following specific embodiment:
Embodiment 1
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 3 parts of amoxicillin, 120 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 2
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 10 parts of amoxicillin, 90 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 3
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 14 parts of amoxicillin, 40 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 4
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 20 parts of amoxicillin, 200 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 5
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 13 parts of norfloxacins, 190 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 6
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 15 parts of norfloxacins, 85 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 7
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 3 parts of norfloxacins, 140 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 8
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 25 parts of norfloxacins, 30 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 9
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 20 parts of doxycyclines, 80 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 10
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 13 parts of doxycyclines, 10 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 11
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 7 parts of doxycyclines, 160 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 12
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 30 parts of doxycyclines, 110 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 13
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 11 parts of LIJUNJING, 5 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 14
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 20 parts of LIJUNJING, 10 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 15
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 3 parts of LIJUNJING, 45 parts of Radix Plumbaginis Zeylanicaes.
Embodiment 16
A compound that contains Radix Plumbaginis Zeylanicae treatment poultry coli-infection disease, is made up of the raw material of following weight ratio: 20 parts of LIJUNJING, 180 parts of Radix Plumbaginis Zeylanicaes.
Above-described embodiment 1-embodiment 16 is prepared in accordance with the following methods: Radix Plumbaginis Zeylanicae was pulverized after 60 mesh sieves, as basic material, then with pulverous antimicrobial drug by weight ratio put into blender and mix, and embodiment 2,6,9 and 15 is prepared into powder; Embodiment 1,5,10 and 16 is prepared into tablet, and embodiment 3,7,11 and 13 is prepared into oral liquid; Embodiment 4,8,12 and 14 is prepared into granule.
For the beneficial effect that illustrates that better the present invention can obtain, inventor has carried out following Application Example.
Application Example 1
The efficacy experiment of the compound of embodiment 1-embodiment 4 gained to chicken escherichia coil disease:
Clinical symptoms: Guangxi Yulin chicken house, 20 Day-old Broiler Chickens, there is fragmentary death in chicken group, cuts open the indivedual chickens of inspection and occur the pathological change of bag pericardium liver, typical bacillus coli feature.
Laboratory diagnosis: get pathologic liver and dye sheet, Gram’s staining, micro-Microscopic observation, the gram negative bacilli of red color visible; Tentatively be judged as bacillus coli.Cultivate by escherichia coli, biochemical test is differentiated, judges that chicken infects for bacillus coli, and pcr amplification, proves to produce the ESBLs drug resistant gene that has TEM type.
Test therapeutic regimen: morbidity chicken group is divided into 6 groups of administrations, use embodiment 1 according to the addition administration of 3.8g/kg feedstuff for first group, use embodiment 2 according to the addition administration of 2g/kg feedstuff for second group, use embodiment 3 according to the addition administration of 0.2g/kg feedstuff for the 3rd group, use embodiment 4 according to the addition administration of 1g/kg feedstuff for the 4th group; The 5th group with amoxicillin powder according to the addition administration of 0.2g/kg feedstuff, the 6th group with the thick powder of Radix Plumbaginis Zeylanicae according to the addition administration of 8g/kg feedstuff; Above six groups of therapeutic regimens all continue to use 5 days.
Effect feedback: after the chicken group medication of first group to the 4th group, sick chicken feed intake rises, and no longer occurs dead chicken, continues to use 3 days, and chicken group be almost recovered; The chicken group medication of the 5th group is after 2 days, and chicken group majority is still unhealthy, still has indivedual chicken deaths, continues to use 3 days, and chicken death phenomenon is not still effectively controlled; The chicken group medication of the 6th group is after 2 days, and chicken group does not have too large remarkable improvement, continues to use 3 days, and chicken death phenomenon is not still effectively controlled.The visible compound curative effect that contains Radix Plumbaginis Zeylanicae is better than folk prescription.
Application Example 2
The efficacy experiment of the meat-type duck diarrhoea of the compound of embodiment 5-embodiment 8 gained to 20 ages in days:
Clinical symptoms: duck field, Nanning, 20 age in days meat-type duck, duck group draws watery stools, has obvious indigested feedstuff in feces.A duck group material feeding is not but long, and the serious duck appearance foot gradually of suffering from diarrhoea is individually soft slowly dead.
Cut open inspection pathological changes: the duck that dies of illness dehydration is more serious, indivedual ducks are still very large, duck liver enlargement, hyperemia, and adularescent film on the liver of part duck, air bag muddiness, tentative diagnosis is escherichia coli or duck oromeningitis.
Test therapeutic regimen: morbidity duck group divides six groups of administrations, use embodiment 5 according to the addition administration of 2g/kg feedstuff for first group, use embodiment 6 according to the addition administration of 1g/kg feedstuff for second group, use embodiment 7 according to the addition administration of 0.5g/kg feedstuff for the 3rd group, use embodiment 8 according to the addition administration of 0.2g/kg feedstuff for the 4th group; The 5th group with norfloxacin powder according to the addition administration of 0.15g/kg feedstuff, the 6th group with the thick powder of Radix Plumbaginis Zeylanicae according to the addition administration of 7g/kg feedstuff; Above six groups of therapeutic regimens all continue to use 5 days.
Result of use feedback: first group to the 4th group medication is after 2 days, and sick duck is no longer drawn watery stools, feces is shaped, and no longer occurs dead duck, continues to use 3 days, and duck group be almost recovered; The 5th group of medication is after 2 days, and duck group DeGrain, much still draws watery stools, contain indigested feedstuff, continue to use 3 days, some improvement a little, but not good thorough, rare watery stools still occurs, raiser cannot drug withdrawal to these two groups of ducks, have to use the compound of embodiment 6 gained instead, continue to use 2 days, just be almost recovered, re-use 1 day, feces all transfers to normally; The 6th group of medication is after 2 days, and duck does not have too large remarkable improvement, continues to use 3 days, and the duck phenomena of mortality are not still effectively controlled.The visible compound that contains Radix Plumbaginis Zeylanicae is better than folk prescription to the curative effect of duck diarrhoea.
Application Example 3
The efficacy experiment of the meat-type duck diarrhoea of the compound of embodiment 9-12 gained to 15 ages in days:
Clinical symptoms: duck field, Liuzhou, 15 age in days meat-type duck, duck group draws watery stools, has obvious indigested feedstuff in feces.Indivedual serious duck appearance feet gradually of suffering from diarrhoea are soft slowly dead.
Cut open inspection pathological changes: the duck that dies of illness dehydration is more serious, indivedual ducks are still very large, duck liver enlargement, hyperemia, and adularescent film on the liver of part duck, air bag muddiness, tentative diagnosis is escherichia coli or duck oromeningitis.
Test therapeutic regimen: morbidity duck group divides six groups of administrations, use embodiment 9 according to the addition administration of 1g/kg feedstuff for first group, use embodiment 10 according to the addition administration of 0.35g/kg feedstuff for second group, use embodiment 11 according to the addition administration of 4.7g/kg feedstuff for the 3rd group, use embodiment 12 according to the addition administration of 0.3g/kg feedstuff for the 4th group; The 5th group with doxycycline powder according to the addition administration of 0.2g/kg feedstuff, the 6th group with the thick powder of Radix Plumbaginis Zeylanicae according to the addition administration of 4.5g/kg feedstuff; Above six groups of therapeutic regimens all continue to use 5 days.
Result of use feedback: first group to the 4th group medication is after 3 days, and sick duck is no longer drawn watery stools, feces is shaped, and no longer occurs dead duck, continues to use 2 days, and duck group be almost recovered; The 5th group of medication is after 3 days, duck group DeGrain, much still draw watery stools, contain indigested feedstuff, continue to use 2 days, some improvement a little, but thoroughly not good, rare watery stools still occurs, raiser uses the compound of embodiment 12 gained instead, continue to use 3 days, feces all transfers to normally; The 6th group of medication is after 3 days, and duck does not have too large remarkable improvement, continues to use 2 days, and the duck phenomena of mortality are not still effectively controlled.The visible compound that contains Radix Plumbaginis Zeylanicae is better than folk prescription to the curative effect of duck diarrhoea.
Application Example 4
The efficacy experiment of the piglet diarrhea of embodiment 13-embodiment 16 compounds to 40 ages in days:
Clinical symptoms: pig farm, Nanning, 40 age in days piglets, this swinery after wean is turn-taked, starts to occur diarrhoea, draws watery stools, feces contains indigested feedstuff, pig material feeding but be exactly not grow, indivedual serious diarrhea of pigs dehydrations are dead, do not occur symptoms of emesis, raiser uses multi-medicament, and ideal effect does not all appear in treatment.
Cut open inspection pathological changes: after cuing open inspection, Intestinum Sus domestica wall is poor, especially small intestinal rear end and colon position, intestinal mucosa comes off, intestinal wall hyperemia, hemorrhage.
Laboratory diagnosis: get pathologic liver and dye sheet, Gram’s staining, micro-Microscopic observation, the gram negative bacilli of red color visible; Tentatively be judged as bacillus coli.Cultivate by escherichia coli, biochemical test is differentiated, judges that Infection in Piglets is bacillus coli, and pcr amplification proves to produce the ESBLs drug resistant gene that has OXA type.
Test therapeutic regimen: morbidity swinery is divided 6 groups of administrations, use embodiment 13 according to the addition administration of 0.3g/kg feedstuff for first group, use embodiment 14 according to the addition administration of 0.3g/kg feedstuff for second group, use embodiment 15 according to the addition administration of 2g/kg feedstuff for the 3rd group, use embodiment 16 according to the addition administration of 2g/kg feedstuff for the 4th group; The 5th group with LIJUNJING powder according to the addition administration of 0.2g/kg feedstuff, the 6th group with the thick powder of Radix Plumbaginis Zeylanicae according to the addition administration of 3g/kg feedstuff; Above six groups of therapeutic regimens all continue to use 5 days.
Result of use feedback: first group to the 4th group medication is after 2 days, and swinery is no longer drawn watery stools, feces is shaped, and no longer contains feedstuff in feces, continues to use 3 days swinery recovery from illness; The 5th group of medication is after 2 days, and swinery is still unhealthy, continues to use 3 days, substantially get well, but still draw pasty state feces individually, but drug withdrawal is after 3 days, and recurrence appears in swinery; The 6th group of medication is after 2 days, and swinery, without remarkable improvement, continues to use 3 days, and swinery continues to have loose bowels, and all the other are also more serious individually.The visible compound that contains Radix Plumbaginis Zeylanicae is better than folk prescription LIJUNJING and folk prescription Radix Plumbaginis Zeylanicae to swinery curative effect.
Claims (1)
1. a poultry compound that contains Radix Plumbaginis Zeylanicae and norfloxacin, is characterized in that, is made up of the raw material of following weight ratio: norfloxacin 3-25 part, Radix Plumbaginis Zeylanicae 30-190 part.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410272411.6A CN104027369A (en) | 2013-06-13 | 2013-06-13 | Plumbago zeylanica and norfloxacin containing compound composition for livestock and poultry |
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| CN201410272411.6A CN104027369A (en) | 2013-06-13 | 2013-06-13 | Plumbago zeylanica and norfloxacin containing compound composition for livestock and poultry |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2013102332327A Division CN103301463A (en) | 2013-06-13 | 2013-06-13 | Compound composition containing plumbago zeylanica for treating livestock and poultry escherichia coli infection diseases |
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| CN104027369A true CN104027369A (en) | 2014-09-10 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109549A (en) * | 2016-08-22 | 2016-11-16 | 广西大学 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and norfloxacin |
| CN106166173A (en) * | 2016-08-22 | 2016-11-30 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae and norfloxacin |
| CN106176942A (en) * | 2016-08-22 | 2016-12-07 | 广西大学 | A kind of poultry compound medicine containing Cortex Cinnamomi and norfloxacin |
| CN106265920A (en) * | 2016-09-21 | 2017-01-04 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae, Cortex Cinnamomi and norfloxacin |
-
2013
- 2013-06-13 CN CN201410272411.6A patent/CN104027369A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| IQBAL AHMAD: "In vitro efficacy of bioactive extracts of 15 medicinal plants against ESbL-producing multidrug-resistant enteric bacteria", 《MICROBIOLOGICAL RESEARCH》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109549A (en) * | 2016-08-22 | 2016-11-16 | 广西大学 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and norfloxacin |
| CN106166173A (en) * | 2016-08-22 | 2016-11-30 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae and norfloxacin |
| CN106176942A (en) * | 2016-08-22 | 2016-12-07 | 广西大学 | A kind of poultry compound medicine containing Cortex Cinnamomi and norfloxacin |
| CN106265920A (en) * | 2016-09-21 | 2017-01-04 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae, Cortex Cinnamomi and norfloxacin |
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