CN103417571A - Composition for treating chicken mycoplasma respiratory infection and preparing method thereof - Google Patents
Composition for treating chicken mycoplasma respiratory infection and preparing method thereof Download PDFInfo
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- CN103417571A CN103417571A CN2013103911721A CN201310391172A CN103417571A CN 103417571 A CN103417571 A CN 103417571A CN 2013103911721 A CN2013103911721 A CN 2013103911721A CN 201310391172 A CN201310391172 A CN 201310391172A CN 103417571 A CN103417571 A CN 103417571A
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Abstract
The invention discloses a composition for treating chicken mycoplasma respiratory infection and a preparing method of the composition. The composition comprises, by weight, 1-10% of erythromycin thiocyanate, 40-90% of ammonium chloride and the balance anhydrous dextrose. According to the composition, the erythromycin thiocyanate is used as a main ingredient for resisting mycoplasmas, is effective in various mycoplasmas causing the chicken respiratory infection, is taken orally and can be absorbed, and can effectively treat mycoplasma infection of respiratory tracts; the ammonium chloride is an expectorant and enables sputum to be discharged easily through increase of sputum quantity, thereby facilitating removal of phlegm, enabling cheesy material and phlegm in tracheas to be diluted, dissolved and discharged out of the body, and keeping smooth breath. Through combination of the two medicines, the composition aims at pathogeny and also aims at symptomatic treatment, can effectively improve the cure rate, and reduces losses caused by respiratory disease characteristics.
Description
Technical field
The present invention relates to field of veterinary, relate to specifically a kind of composition and method of making the same that is used for the treatment of the mycoplasma gallinarum respiratory tract infection.
Background technology
The respiratory tract infection that mycoplasma gallinarum causes is the common disease of chicken, and cause of disease is mycoplasma, and main clinical manifestation is to occur more viscous liquid or Catarrhal secretions in nostril, nasal sinuses, trachea and lung, and tracheal wall is edema slightly.Along with the development of infecting, air bag is muddy gradually, occurs cheese shape exudate on airbag wall, during beginning as pearl, in bulk in heaps when serious, sick chicken is because respiratory tract stops up, hypopnea often, the serious death by suffocation that causes, bring great loss to the raiser.
Because the disease of primary disease shows many aspects, single drug, often do not reach therapeutic effect; The characteristics of respiratory tract disease are that when generally showing symptom, pathological changes has occurred respiratory tract, even after killing cause of disease, symptom still exists, and need the rehabilitation of certain hour ability; So single for cause of disease or etiological treatment medication, effect is not ideal.When sick chicken is ill, passive protective physical fitness is low, the impact of ambient conditions in addition, and for example the depollution of environment is not thorough, is easy to cause palindromia, results in greater loss.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, provides a kind of and can treat Chicken salpingitis, effective, reduces the mistaken diagnosis probability, improves the composition and method of making the same of cure rate.
The present invention is achieved through the following technical solutions:
A kind of compositions that is used for the treatment of the mycoplasma gallinarum respiratory tract infection, is characterized in that, following raw material, consists of by weight percentage: erythromycin thiocyanate 1～10%, and ammonium chloride 40～90%, surplus is anhydrous glucose.
The better composition of above-mentioned composition is by weight percentage: erythromycin thiocyanate 3～8%, and ammonium chloride 50～70%, surplus is anhydrous glucose.
The best of above-mentioned composition forms: erythromycin thiocyanate 4%, ammonium chloride 60%, anhydrous glucose 36%.
The above-mentioned preparation method that is used for the treatment of the compositions of mycoplasma gallinarum respiratory tract infection, is characterized in that, comprises the steps:
Get by weight percentage erythromycin thiocyanate 1～10%, ammonium chloride 40～90%, surplus is anhydrous glucose; After erythromycin thiocyanate is mixed to 30 minutes with anhydrous glucose, then mixture is mixed with ammonium chloride 1 hour, after mixing, obtain for treating the compositions of the respiratory tract infection that mycoplasma gallinarum causes.
The better composition of above-mentioned composition is by weight percentage: dimetridazole 18～25%, and ofloxacin 7～12%, vitamin e1～4%, surplus is anhydrous glucose.
The best of above-mentioned composition forms: dimetridazole 20%, ofloxacin 10%, vitamin E2 %, anhydrous glucose 68%.
The present invention has following technique effect:
Compositions of the present invention adopts the main component of erythromycin thiocyanate as anti-mycoplasma, to causing the multiple mycoplasma that chicken respiratory infects, all produce effect, its for oral administration can absorption, can be effectively for the mycoplasma infection of respiratory tract; Ammonium chloride is expectorant, and to the chemical irritation of mucosa, reflexive ground increases amount of expectoration, make sputum be easy to discharge, so be conducive to be difficult for a small amount of removing of gluing expectorant of expectoration, and make endotracheal caseous substance, sticky expectorant obtain the dilution dissolving, and excrete, keep smooth breathing.Two kinds of drug combinations, for cause of disease, symptomatic treatment, can effectively improve cure rate again, and reduce the loss that the characteristic of respiratory tract disease causes.
The specific embodiment
Below take and produce the 100kg compositions and the present invention is described in further detail as example.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1
Take erythromycin thiocyanate 1kg, ammonium chloride 90kg, anhydrous glucose 9kg, mix erythromycin thiocyanate 30 minutes with anhydrous glucose, and mixture mixes with ammonium chloride 60 minutes again, obtains for treating the compositions of the respiratory tract infection that mycoplasma gallinarum causes.
Embodiment 2
Take erythromycin thiocyanate 10kg, ammonium chloride 40kg, anhydrous glucose 50kg, mix erythromycin thiocyanate 30 minutes with anhydrous glucose, and mixture mixes with ammonium chloride 60 minutes again, obtains for treating the compositions of the respiratory tract infection that mycoplasma gallinarum causes.
Embodiment 3
Take erythromycin thiocyanate 3kg, ammonium chloride 70kg, anhydrous glucose 27kg, mix erythromycin thiocyanate 30 minutes with anhydrous glucose, and mixture mixes with ammonium chloride 60 minutes again, obtains for treating the compositions of the respiratory tract infection that mycoplasma gallinarum causes.
Embodiment 4
Take erythromycin thiocyanate 8kg, ammonium chloride 50kg, anhydrous glucose 42kg, mix erythromycin thiocyanate 30 minutes with anhydrous glucose, and mixture mixes with ammonium chloride 60 minutes again, obtains for treating the compositions of the respiratory tract infection that mycoplasma gallinarum causes.
Embodiment 5
Take erythromycin thiocyanate 5kg, ammonium chloride 55kg, anhydrous glucose 40kg, mix erythromycin thiocyanate 30 minutes with anhydrous glucose, and mixture mixes with ammonium chloride 60 minutes again, obtains for treating the compositions of the respiratory tract infection that mycoplasma gallinarum causes.
Embodiment 6
Take erythromycin thiocyanate 4kg, ammonium chloride 60kg, anhydrous glucose 36kg, mix erythromycin thiocyanate 30 minutes with anhydrous glucose, and mixture mixes with ammonium chloride 60 minutes again, obtains for treating the compositions of the respiratory tract infection that mycoplasma gallinarum causes.
Clinical trial:
1. laboratory animal:
Choose at random 1000 of ill chickens, body weight is about the 1kg left and right.
2. Experimental agents
The compositions our unit development of the embodiment of the present invention 6 preparations;
The mixture our unit laboratory preparation of 4% erythromycin thiocyanate powder and 96% anhydrous glucose;
The mixture our unit laboratory preparation of 60% ammonium chloride powders and 40% anhydrous glucose.
3. experimental technique:
Suffer from chicken by 1000 and be divided at random four groups by body weight, 250 every group.
The A group, for the blank group, does not give Drug therapy.
B group is treated with the mixture of the anhydrous glucose of 4% erythromycin thiocyanate powder and 96%, and usage: drink water: every 1L water 1g 2 times on the one, is used in conjunction 7.
The C group is treated with the mixture of the anhydrous glucose of 60% ammonium chloride powders and 40%, usage: drinking-water: every 1L water 1g 2 times on the one, is used in conjunction 7.
The D group is treated by the compositions of the embodiment of the present invention 6 preparations, usage: drinking-water: every 1L water 1g 2 times on the one, is used in conjunction 7.
After treatment starts, every day entry suffers from chicken health situation of change and dead animal distributes, and treats after 10 days and adds up therapeutic effect, wherein
After treatment starts, every day entry suffers from chicken health situation of change and dead animal distributes and egg production, and treat after 10 days and add up therapeutic effect, wherein:
Invalid: as after referring to 10 days, to suffer from the chicken symptom without obvious change, still keep the front symptom for the treatment of.
Effectively: after referring to 10 days, suffer from the chicken symptom and change, symptom is better than the effect before treatment.
Cure: after referring to 10 days, transference cure, suffer from chicken and get well.Its numeral is included in significant digits.
Symptom is arranged: after referring to 10 days, suffer from chicken and still have certain symptom, before its Symptoms is better than treatment or without change, suffers from chicken and do not cure during end.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in the table.
4. conclusion:
The result of the test statistical analysis, the embodiment of the present invention 6 is used for the treatment of combination treatment group, 4% erythromycin thiocyanate treated powder group and the 60% ammonium chloride powders treatment group of the respiratory tract infection that mycoplasma gallinarum causes and matched group difference extremely significantly (P<0.01).Curative effect of the present invention is better than other two kinds of medicines.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (6)
1. be used for the treatment of the compositions of mycoplasma gallinarum respiratory tract infection, it is characterized in that, formed by following raw material by weight percentage: erythromycin thiocyanate 1～10%, ammonium chloride 40～90%, surplus is anhydrous glucose.
2. the compositions that is used for the treatment of the mycoplasma gallinarum respiratory tract infection according to claim 1 is characterized in that consisting of of each compositions in weight percentage: erythromycin thiocyanate 3～8%, and ammonium chloride 50～70%, surplus is anhydrous glucose.
3. the compositions that is used for the treatment of the mycoplasma gallinarum respiratory tract infection according to claim 1, is characterized in that consisting of of each compositions in weight percentage: erythromycin thiocyanate 4%, ammonium chloride 60%, anhydrous glucose 36%.
4. be used for the treatment of as claimed in claim 1 the preparation method of the compositions of mycoplasma gallinarum respiratory tract infection, it is characterized in that, comprise the steps: to get by weight percentage erythromycin thiocyanate 1～10%, ammonium chloride 40～90%, surplus is anhydrous glucose; After erythromycin thiocyanate is mixed to 30 minutes with anhydrous glucose, then mixture is mixed with ammonium chloride 1 hour, after mixing, obtain for treating the compositions of the respiratory tract infection that mycoplasma gallinarum causes.
5. the preparation method that is used for the treatment of the compositions of mycoplasma gallinarum respiratory tract infection according to claim 4 is characterized in that consisting of of each compositions in weight percentage: erythromycin thiocyanate 3～8%, and ammonium chloride 50～70%, surplus is anhydrous glucose.
6. the preparation method that is used for the treatment of the compositions of mycoplasma gallinarum respiratory tract infection according to claim 4, is characterized in that consisting of of each compositions in weight percentage: erythromycin thiocyanate 4%, ammonium chloride 60%, anhydrous glucose 36%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103911721A CN103417571A (en) | 2013-08-30 | 2013-08-30 | Composition for treating chicken mycoplasma respiratory infection and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103911721A CN103417571A (en) | 2013-08-30 | 2013-08-30 | Composition for treating chicken mycoplasma respiratory infection and preparing method thereof |
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| Publication Number | Publication Date |
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| CN103417571A true CN103417571A (en) | 2013-12-04 |
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| CN2013103911721A Pending CN103417571A (en) | 2013-08-30 | 2013-08-30 | Composition for treating chicken mycoplasma respiratory infection and preparing method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083430A (en) * | 2014-07-28 | 2014-10-08 | 山东省动物疫病预防与控制中心 | Drug for treating mink mycoplasma respiratory disease |
| CN106176613A (en) * | 2016-08-30 | 2016-12-07 | 瑞普（天津）生物药业有限公司 | A kind of slow release erythromycin thiocyanate soluble powder for animals and preparation method thereof |
| CN113197862A (en) * | 2021-04-16 | 2021-08-03 | 山东亚康药业股份有限公司 | High-content erythromycin thiocyanate soluble powder and preparation method thereof |
-
2013
- 2013-08-30 CN CN2013103911721A patent/CN103417571A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083430A (en) * | 2014-07-28 | 2014-10-08 | 山东省动物疫病预防与控制中心 | Drug for treating mink mycoplasma respiratory disease |
| CN106176613A (en) * | 2016-08-30 | 2016-12-07 | 瑞普（天津）生物药业有限公司 | A kind of slow release erythromycin thiocyanate soluble powder for animals and preparation method thereof |
| CN113197862A (en) * | 2021-04-16 | 2021-08-03 | 山东亚康药业股份有限公司 | High-content erythromycin thiocyanate soluble powder and preparation method thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131204 |
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| WD01 | Invention patent application deemed withdrawn after publication |