CN102743407A - Oral liquid for treating infectious air sacculitis of chicken and preparation method thereof - Google Patents
Oral liquid for treating infectious air sacculitis of chicken and preparation method thereof Download PDFInfo
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Abstract
The invention provides oral liquid for treating infectious air sacculitis of a chicken and a preparation method of the oral liquid. Each 1,000L of oral liquid contains 3-10kg of ambroxol hydrochloride, 5-15L of phosphoric acid, 20-30kg of tilmicosin, 15-25g of analgin, 10-15kg of diammonium glycyrrhizinate, 15-25L of propylene glycol, 15-25ml of glycerol and the rest of water. Aiming at reasons for air sacculitis of the chicken, the oral liquid can achieve the effect of treating both principal and secondary aspect of disease by combination of drugs; and aiming at physiological characteristics of the chicken, the ambroxol hydrochloride is prepared into a water solution by an easily operated process and can be conveniently used, so that a quick treatment drug is provided for masses of breeding enterprises and the economic loss caused by the infectious air sacculitis is avoided.
Description
Technical field
The invention belongs to the veterinary drug technical field, relate to a kind of treatment and cause compound medicine oral liquid of avian infectious airsacculitis and preparation method thereof by invasive organism mixed infections such as escherichia coli, mycoplasma, viruses.
Background technology
Along with China's aquaculture large-scale development; Because cultivation density is excessive, breeding enterprise is not noted ventilation, causes in the air harmful gas such as ammonia, hydrogen sulfide too high; Stimulate the chicken respiratory cilium; Cause mucosa injury, make invasive organisms such as escherichia coli in the air, mycoplasma, newcastle on respiratory mucosa, breed and get into body, and then make organ generation pathological changes such as lungs, air bag, liver.
The clinical symptoms of avian infectious airsacculitis is: early stage cough, ataxia, after about 3～4 days, snore, swollen head, swollen eye, shed tears, and indivedual chickens are main with mouth breathing after about 7 days; The average age in days of falling ill is about 15 ages in days, and 7 ages in days just have incidence the earliest, and spirit is depressed, loss of appetite; Even useless exhausted, thirsty desire strengthens, row's yellow-white loose stool; The feather pine is random, tarnish, and the pawl drying is unglazed.Dissect symptom: larynx and trachea be congested, hemorrhage, mucus is arranged, and bronchus has thromboembolism, the air bag muddiness, thickens, has yellow or the cheesy thing of yellow-white to adhere to.The middle and late stage of serious chicken crowd or morbidity; Cuing open the inspection symptom, to be mainly larynx hemorrhage, congested, and trachea, bronchus diffuse hemorrhage have yellow cheesy exudate; The hemorrhage edema of lungs has yellow cheesy thing to adhere to; The air bag muddiness thickens, and liver has the cellulose exudate to cover intestinal lymph island shape projection mostly.
In recent years, avian infectious airsacculitis morbidity is more and more serious, and the vascularity of air bag is few in addition; Medicine be difficult to arrive, and chicken can not cough, and when respiratory systems such as trachea have sputum, can only excrete through getting rid of first-class method; Dry thickness so in case sputum becomes in respiratory system; Be difficult to excrete, cause the primary disease therapeutic effect not good, be easy to cause serious loss to culturing enterprise.
Summary of the invention
The present invention is directed to and bring out the multiple pathogenic factors employing of avian infectious airsacculitis drug regimen, develop a kind of oral liquid and method for preparing of treating avian infectious airsacculitis.
Special purpose of the present invention is to chicken respiratory system characteristics, develops a kind of technological operation is simple, cost performance is high ambroxol hydrochloride oral solution and method for preparing.
The present invention realizes through following technical scheme:
A kind ofly treat avian infectious airsacculitis oral liquid and it is characterized in that consisting of of every 100L oral liquid: ambroxol hydrochloride 3～10kg, phosphoric acid 5～15L, tilmicosin 20～30kg; Dipyrone 15～25g, diammonium glycyrrhizinate 10～15kg, propylene glycol 15～25L; Glycerol 15～25ml, surplus is a water.
The preferable prescription of every 100L oral liquid is: ambroxol hydrochloride 3～8kg, and phosphoric acid 7～15L, tilmicosin 20～29kg, dipyrone 15～23g, diammonium glycyrrhizinate 10～15kg, propylene glycol 15～23L, glycerol 15～23ml, surplus is a water.
The best prescription of every 100L oral liquid is: ambroxol hydrochloride 6kg, and phosphatase 11 0L, tilmicosin 25kg, dipyrone 20g, diammonium glycyrrhizinate 10kg, propylene glycol 15L, glycerol 15ml, surplus is a water.
A kind of above-mentioned multifactor method for preparing of bringing out avian infectious airsacculitis oral liquid that is used to treat comprises the steps:
(1) water intaking 30～40L adds propylene glycol 15～25L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 3～10kg, stirring and dissolving;
(2) water intaking 40～50L adds phosphoric acid 5～15L, is heated to 50 ℃, stirs, and adds tilmicosin 20～30kg, and stirring and dissolving adds dipyrone 15～25g, and stirring and dissolving adds diammonium glycyrrhizinate 10～15kg, stirring and dissolving;
(3) earlier the solution in the step (2) is added in the solution in the step (1), stir, add glycerol 15～25ml, stir, regulate PH to 4 with citric acid;
(4) the solution with water polishing in the step (3) is to 100L, filters, and fill, sterilization promptly get the oral liquid of treating the avian infectious airsacculitis that multi-pathogenesis causes.
The present invention has following technique effect:
The present invention is a compound preparation, and tilmicosin is the special-purpose Macrocyclolactone lactone kind medicines of poultry, the for oral administration absorption soon, and apparent volume of distribution is big, and is high at respiratory system drug substrate concentrations such as lungs, is the medicine of treatment escherichia coli and mycoplasma; Diammonium glycyrrhizinate is the effective liquorice extract, and newcastle, infectiousness bronchus etc. is had good therapeutical effect; Ambroxol hydrochloride is a mucolytic drugs; Can significantly increase amount of expectoration; Reduce sputum viscosity, stimulate the generation and the secretion of respiratory system surfactants such as lung, help chicken the sputum in the respiratory systems such as trachea, bronchus is excreted; And can increase the blood drug level of curative drug in respiratory system such as tilmicosin, improve antibacterial effect; Dipyrone mainly is to be used for chicken because the fervescence that escherichia coli, mycoplasma and viral infection cause.The present invention is directed to the multiple reason that causes the chicken airsacculitis, adopt multiple medication combined use, can reach the effect of treating both the principal and secondary aspects of a disease.These article adopt a kind of maneuverable technology to process aqueous solution ambroxol hydrochloride to the physiological characteristics of chicken, and are easy to use, thereby for vast breeding enterprise a kind of quick curative drug are provided, and avoid the economic loss that causes because of the infectiousness airsacculitis.
The specific embodiment
Below in conjunction with instantiation to the detailed description of the invention.
Embodiment 1:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 3kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 20kg, and stirring and dissolving adds dipyrone 15Kg, and stirring and dissolving adds diammonium glycyrrhizinate 10kg, stirring and dissolving;
(3) earlier the solution in the step (2) is added in the solution in the step (1), stir, add glycerol 15ml, stir, regulate PH to 4 with citric acid;
(4) the solution with water polishing in the step (3) is to 100L, filters, and fill, sterilization promptly get the oral liquid of treating the avian infectious airsacculitis that multi-pathogenesis causes.
Embodiment 2:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 4kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 24kg, and stirring and dissolving adds dipyrone 20Kg, and stirring and dissolving adds diammonium glycyrrhizinate 10kg, stirring and dissolving;
(3) earlier the solution in the step (2) is added in the solution in the step (1), stir, add glycerol 15ml, stir, regulate PH to 4 with citric acid;
(4) the solution with water polishing in the step (3) is to 100L, filters, and fill, sterilization promptly get the oral liquid of treating the avian infectious airsacculitis that multi-pathogenesis causes.
Embodiment 3:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 6kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 25kg, and stirring and dissolving adds dipyrone 20Kg, and stirring and dissolving adds diammonium glycyrrhizinate 10kg, stirring and dissolving;
(3) earlier the solution in the step (2) is added in the solution in the step (1), stir, add glycerol 15ml, stir, regulate PH to 4 with citric acid;
(4) the solution with water polishing in the step (3) is to 100L, filters, and fill, sterilization promptly get the oral liquid of treating the avian infectious airsacculitis that multi-pathogenesis causes.
Embodiment 4:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 4kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 25kg, and stirring and dissolving adds dipyrone 20Kg, and stirring and dissolving adds diammonium glycyrrhizinate 15kg, stirring and dissolving;
(3) earlier the solution in the step (2) is added in the solution in the step (1), stir, add glycerol 15ml, stir, regulate PH to 4 with citric acid;
(4) the solution with water polishing in the step (3) is to 100L, filters, and fill, sterilization promptly get the oral liquid of treating the avian infectious airsacculitis that multi-pathogenesis causes.
Embodiment 5:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 6kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 25kg, and stirring and dissolving adds dipyrone 20Kg, and stirring and dissolving adds diammonium glycyrrhizinate 14kg, stirring and dissolving;
(3) earlier the solution in the step (2) is added in the solution in the step (1), stir, add glycerol 15ml, stir, regulate PH to 4 with citric acid;
(4) the solution with water polishing in the step (3) is to 100L, filters, and fill, sterilization promptly get the oral liquid of treating the avian infectious airsacculitis that multi-pathogenesis causes.Clinical trial: produce 100L avian infectious airsacculitis oral liquid of treatment according to embodiment 3, ambroxol hydrochloride 6kg, phosphatase 11 0L, tilmicosin 25kg, dipyrone 20g, diammonium glycyrrhizinate 10kg, propylene glycol 15L, glycerol 15ml, surplus is a water.This prescription is following to the influence of broiler:
1, experimental animal:
Picked at random is suffered from 120 of infectiousness airsacculitis broiler, is divided into 4 groups at random, and 30 every group, body weight is at 1～2kg.
2, experiment medicine:
The avian infectious airsacculitis oral liquid of a kind of treatment of the embodiment of the invention 3 preparations; The tilmicosin oral liquid: water 80ml, add phosphatase 11 0ml and be heated to 50 ℃, add tilmicosin 25g, stirring and dissolving, water complements to 100ml.
Ambroxol hydrochloride oral liquid: water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 6kg, and the stirring and dissolving water is supplied 100ml.
3, experimental technique:
1 group is blank group, not medicament.
2 group of 25% tilmicosin solution treated usage: 100ml tilmicosin solution (25%) is converted water 300kg, once-a-day, concentrates to use up logotype 4 days in 3 hours.
3 group of 6% ambroxol hydrochloride solution is treated usage: 100mk ambroxol hydrochloride solution (6%) is converted water 300kg, once-a-day, concentrates to use up logotype 4 days in 3 hours.
4 groups with the avian infectious airsacculitis oral liquid of a kind of treatment of the present invention, and usage: 100ml converts water 300kg, once-a-day, concentrates to use up logotype 4 days in 3 hours.
After the treatment beginning, write down disease fowl respiratory tract situation every day and distribute, treat and add up therapeutic effect after 4 days, wherein with dead
Invalid: after referring to 4 days, sick fowl symptom has the situation of increasing the weight of or dead or not alleviation (bronchus still has thromboembolism, air bag that cheesy thing is arranged) of Respiratory symptoms.
Effectively: after referring to 4 days, sick fowl symptom changes, and symptom is controlled or with respect to having obviously and alleviate before the treatment.
Cure: after referring to 4 days, transference cure, the sick fowl mental status and feed intake are recovered normal condition.Its digital packets is contained in the significant digits.
Symptom is arranged during end: after referring to treat 4 days, sick fowl still has certain symptom, and the performance of its symptom is superior to before the treatment or does not have change, and sick fowl is cured fully, and its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1:
Table 1: each organizes therapeutic effect
4, conclusion:
Through statistical analysis, a kind of oral liquid, 25% tilmicosin oral liquid, 6% ambroxol hydrochloride oral liquid treatment group and matched group difference of treating avian infectious airsacculitis is (P＜0.01) extremely significantly from the result of the test of table 1.Therapeutic effect of the present invention is this product treating both the principal and secondary aspects of a disease than 25% tilmicosin oral liquid and the good main cause of 6% ambroxol hydrochloride oral liquid, and the various microbiological factors that cause avian infectious airsacculitis are all had good therapeutical effect.And 25% tilmicosin oral liquid effect is better than 6% ambroxol hydrochloride oral liquid, can effectively alleviate death though 6% ambroxol hydrochloride is described for avian infectious airsacculitis, and the medicine that has only adding simultaneously to effect a permanent cure just can reach good therapeutic effect.
Claims (4)
1. the avian infectious airsacculitis oral liquid of treatment is characterized in that the consisting of of every 100L oral liquid: ambroxol hydrochloride 3～10kg; Phosphoric acid 5～15L, tilmicosin 20～30kg, dipyrone 15～25g; Diammonium glycyrrhizinate 10～15kg; Propylene glycol 15～25L, glycerol 15～25ml, surplus is a water.
2. the avian infectious airsacculitis oral liquid of a kind of treatment as claimed in claim 1 is characterized in that, the consisting of of every 100L oral liquid: ambroxol hydrochloride 3～8kg; Phosphoric acid 7～15L, tilmicosin 20～29kg, dipyrone 15～23g; Diammonium glycyrrhizinate 10～15kg; Propylene glycol 15～23L, glycerol 15～23ml, surplus is a water.
3. the avian infectious airsacculitis oral liquid of a kind of treatment as claimed in claim 1 is characterized in that, the consisting of of every 100L oral liquid: ambroxol hydrochloride 6kg, phosphatase 11 0L; Tilmicosin 25kg, dipyrone 20g, diammonium glycyrrhizinate 10kg; Propylene glycol 15L, glycerol 15ml, surplus is a water.
One kind the treatment avian infectious airsacculitis oral liquid method for preparing, it is characterized in that:
(1) water intaking 30～40L adds propylene glycol 15～25L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 3～10kg, stirring and dissolving;
(2) water intaking 40～50L adds phosphoric acid 5～15L, is heated to 50 ℃, stirs, and adds tilmicosin 20～30kg, and stirring and dissolving adds dipyrone 15～25g, and stirring and dissolving adds diammonium glycyrrhizinate 10～15kg, stirring and dissolving;
(3) earlier the solution in the step (2) is added in the solution in the step (1), stir, add glycerol 15～25ml, stir, regulate PH to 4;
(4) the solution with water polishing in the step (3) filters to 100L, fill, and sterilization promptly gets the oral liquid of treating avian infectious airsacculitis.
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| CN201210265248.1A CN102743407B (en) | 2012-07-30 | 2012-07-30 | Oral liquid for treating infectious air sacculitis of chicken and preparation method thereof |
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| CN102743407B CN102743407B (en) | 2014-03-26 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012332A (en) * | 2015-07-02 | 2015-11-04 | 河北科恒生物科技有限公司 | Compound tilmicosin phosphate-ambroxol nanoemulsion preparation |
| CN106166226A (en) * | 2016-08-11 | 2016-11-30 | 王华伟 | A kind of Chinese medicine composition treating poultry airsacculitis |
| CN108653205A (en) * | 2018-07-26 | 2018-10-16 | 日照市牧邦畜牧科技有限公司 | A kind of long stable effect compound tilmicosin solution and its preparation process |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327365A (en) * | 2011-07-07 | 2012-01-25 | 天津生机集团股份有限公司 | Oral liquid for treating air sacculitis caused by colibacillosis of chicken and preparation method thereof |
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2012
- 2012-07-30 CN CN201210265248.1A patent/CN102743407B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327365A (en) * | 2011-07-07 | 2012-01-25 | 天津生机集团股份有限公司 | Oral liquid for treating air sacculitis caused by colibacillosis of chicken and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012332A (en) * | 2015-07-02 | 2015-11-04 | 河北科恒生物科技有限公司 | Compound tilmicosin phosphate-ambroxol nanoemulsion preparation |
| CN106166226A (en) * | 2016-08-11 | 2016-11-30 | 王华伟 | A kind of Chinese medicine composition treating poultry airsacculitis |
| CN108653205A (en) * | 2018-07-26 | 2018-10-16 | 日照市牧邦畜牧科技有限公司 | A kind of long stable effect compound tilmicosin solution and its preparation process |
| CN108653205B (en) * | 2018-07-26 | 2021-02-26 | 日照市牧邦畜牧科技有限公司 | Stable long-acting compound tilmicosin solution |
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| CN102743407B (en) | 2014-03-26 |
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