CN106166226A - A kind of Chinese medicine composition treating poultry airsacculitis - Google Patents

A kind of Chinese medicine composition treating poultry airsacculitis Download PDF

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Publication number
CN106166226A
CN106166226A CN201610652938.0A CN201610652938A CN106166226A CN 106166226 A CN106166226 A CN 106166226A CN 201610652938 A CN201610652938 A CN 201610652938A CN 106166226 A CN106166226 A CN 106166226A
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radix
parts
airsacculitis
chinese medicine
medicine composition
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王华伟
田玮
杨明凡
王明发
陈应健
高扬
陈荣弟
邹贵
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)

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Abstract

The invention belongs to Chinese veterinary drug preparation field, a kind of Chinese medicine composition treating poultry airsacculitis, it is made up of Radix Panacis Quinquefolii, Radix Scutellariae, Fructus Forsythiae, Radix Angelicae Sinensis, Radix Bupleuri, Cacumen Platycladi, Radix Notoginseng, Cordyceps, Rhizoma Polygonati, Gecko, Bulbus Fritillariae Uninbracteatae, Radix Ranunculi Ternati, Fructus Mume, Semen Armeniacae Amarum, Os Draconis, Herba Houttuyniae, Radix Glycyrrhizae.The present invention shows through many experiments room and clinical practice assay, and the feature such as this Chinese medicine formula is reasonable, technique is simple, steady quality, with low cost, toxic and side effects is little, the preventing and treating to airsacculitis has preferable effect, has huge market potential.

Description

A kind of Chinese medicine composition treating poultry airsacculitis
Technical field
The invention belongs to Chinese veterinary drug preparation field, a kind of Chinese medicine composition treating poultry airsacculitis.
Background technology
Poultry airsacculitis occurred more universal in recent years, even presents in some cultivation City Regions and concentrates showing of morbidity As, chicken group just presents fall ill serious, course of disease length, fatality rate feature high, refractory once fall ill, and particularly 15 ages in days are to going out The chicken group in hurdle stage is relatively common, and spring in time of the year when autumn changes into winter to the coming year is the multiple phase of this disease.Airsacculitis is most commonly that clinically The airsacculitis that coli-infection causes: sick chicken spirit is depressed, dyspnea has sound, cough.Cut open the visible air bag of inspection muddy, Having a large amount of muddy transudate, severe one airbag wall thickens, and has the cheesy grumeleuse differed in size.In addition to escherichia coli, newcastle The cause of diseases such as virus, infectious bursa diseases virus, infectious bronchitis pathogenic bacteria, infective rhinitis's virus, mycoplasma, aspergillosis Microorganism, after infecting broiler, can cause airsacculitis.Owing to airbag wall is the thinnest, internal layer is simple squamous epithelium, is all in opening Place is ciliated columnar epithelium, and outer layer is simple epithelium consecutive with serous coat, is fibrous connective tissue between two-layer epithelium, contains Elastic fiber, not only structure is thin, and blood vessel seldom, the thinnest.So, after airsacculitis occurs, after injection, drinking-water, spice, The absorption of medicine is difficult to reach effective blood drug level, is difficult to kill to the microorganism on air bag, and therefore effect is the most reliable.And And along with the generation of bacterial drug resistance, simple dependence antibiotic can not realize the treatment to airsacculitis.
Summary of the invention
It is an object of the invention to be to overcome above-mentioned technical deficiency and provide that a kind of production technology is simple, extraction ratio is high, matter Measure the Chinese medicine composition for the treatment of poultry airsacculitis stable, with low cost, evident in efficacy.
Weight proportion formula of the present invention is:
Radix Panacis Quinquefolii 10--25 part Radix Scutellariae 10--25 part Fructus Forsythiae 15 25 parts
Radix Angelicae Sinensis 10--25 part Radix Bupleuri 10--25 part Cacumen Platycladi 15 25 parts
5 15 parts of Cordyceps 2---10 part Rhizoma Polygonati 10--25 parts of Radix Notoginseng
5-15 portions of Radix Ranunculi Ternatis of 20 30 portions of Bulbus Fritillariae Uninbracteataes of Gecko 15 25 parts
5-15 parts of Os Draconis 10--25 parts of Fructus Mume 10--25 part Semen Armeniacae Amarum
5-15 parts of 25 35 portions of Radix Glycyrrhizaes of Herba Houttuyniae
Chinese medicinal preparation method of the present invention is as follows:
Weighing various raw material by described weight ratio, then pulverized 120 mesh with pulverizer, mix homogeneously is.
The usage of the present invention and consumption: every 100kg feedstuff adds this product 1000g, is used in conjunction 5～7 days.
The present invention shows through many experiments room and clinical practice assay, and this Chinese medicine formula is reasonable, technique simple, quality The feature such as stable, with low cost, toxic and side effects is little, the preventing and treating to airsacculitis has preferable effect, has huge market potential.
Detailed description of the invention
Weight proportion formula of the present invention is:
Radix Panacis Quinquefolii 10--25 part Radix Scutellariae 10--25 part Fructus Forsythiae 15 25 parts
Radix Angelicae Sinensis 10--25 part Radix Bupleuri 10--25 part Cacumen Platycladi 15 25 parts
5 15 parts of Cordyceps 2---10 part Rhizoma Polygonati 10--25 parts of Radix Notoginseng
5-15 portions of Radix Ranunculi Ternatis of 20 30 portions of Bulbus Fritillariae Uninbracteataes of Gecko 15 25 parts
5-15 parts of Os Draconis 10--25 parts of Fructus Mume 10--25 part Semen Armeniacae Amarum
5-15 parts of 25 35 portions of Radix Glycyrrhizaes of Herba Houttuyniae
Chinese medicinal preparation method of the present invention is as follows:
Weighing various raw material by described weight ratio, then pulverized 120 mesh with pulverizer, mix homogeneously is.
Toxicity test
Select SD rat, give the powder of the embodiment of the present invention 2 of variable concentrations (18.0,6.0,2.0g crude drug/kg), often It gavage once, continuous 90 days, last be administered latter 24 hours respectively group live and kill 1/2 animal (male and female half and half), remaining 1/2 moves Thing is lived after continuing to observe 2 weeks and is killed.The outward appearance of animal, general behavior, food ration, body weight change is observed, after administration 90 during test It and drug withdrawal within 2 weeks, carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the inspection of the index such as histopathology Look into.
Result of the test shows: the Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, outward appearance body Levy, behavioral activity, food-intake and body weight increase change the most without exception；Three dosage groups and matched group hematological examination, blood life Chemistry, urine biochemical analysis all between normal range, group without significant difference；Each group main organs histopathological examination has no bright Aobvious abnormal.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively the 180 of clinical medicine dose, 60, 20 times, according to the Chinese medicine preparation of the result of the test present invention in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) Even within 90 days, being administered and have no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no delay Property toxic reaction, the dose safety of Chinese medicine preparation clinical practice of the prompting present invention is higher.
Application test and effect
1, in order to verify the Chinese medicine composition of the present invention effect to treatment poultry airsacculitis, test, carry out with conventional medicament Contrast, studies its therapeutic effect, and test is carried out at certain chicken house of Henan Shangqiu City.This chicken house 20 age in days meat of in December, 2012 There is death in chicken, dissects and find, tracheal strips has yellow embolus, and air bag is muddy, pulmonary's large-area hemorrhage, and essence occur in other chickens God is depressed, and dyspnea has the symptoms such as sound, cough, is airsacculitis after diagnosing.Selecting 1200 ill chickens is experimental subject, It is randomly divided into three experimental grouies, three groups of disease chicken comparing difference not statistically significants in terms of state of an illness weight, each experimental group 400 Only, use the powder 1(embodiment group one of embodiment 1 respectively), the powder 2(embodiment group two of embodiment 2) and conventional medicament (right
According to group) treat.The using method of powder 1 and powder 2 is: every 100g powder is watered 200kg, uses 4 continuously My god, conventional medicament selects Nuo Dakang, and using method, for be dissolved in drinking water by Nuo Dakang, uses 4 days continuously.Test is 8 My god, note every day observing and record the situation of chicken, including the mental status, search for food, breathing situation, death etc..Test the 5th day system Meter mortality rate and effective percentage, the chicken do not fully recovered starts to proceed treatment from test on the 6th day, statistics death after off-test Rate and effective percentage.Wherein effective percentage be symptom take a turn for the better significant figure and recovery from illness recovery from illness number summation account for test total chicken number hundred Proportion by subtraction.
Result is as shown in table 1 and table 2.
The 5th day each experimental group curative effect comparision table tested by table 1
Each experimental group curative effect comparision table after table 2 off-test
Data from table 1 with table 2: compared with conventional medicament, use the embodiment of the present invention 1 and the medicine of embodiment 2 Carry out treating chicken airsacculitis and there is the advantage that therapeutic effect is good, healing time is short and reduces chicken mortality rate.
2, the foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (2)

1. the Chinese medicine composition treating poultry airsacculitis, it is characterised in that it is to be prepared from the following raw materials in parts by weight:
Radix Panacis Quinquefolii 10--25 part Radix Scutellariae 10--25 part Fructus Forsythiae 15 25 parts
Radix Angelicae Sinensis 10--25 part Radix Bupleuri 10--25 part Cacumen Platycladi 15 25 parts
5 15 parts of Cordyceps 2---10 part Rhizoma Polygonati 10--25 parts of Radix Notoginseng
5-15 portions of Radix Ranunculi Ternatis of 20 30 portions of Bulbus Fritillariae Uninbracteataes of Gecko 15 25 parts
5-15 parts of Os Draconis 10--25 parts of Fructus Mume 10--25 part Semen Armeniacae Amarum
5-15 parts of 25 35 portions of Radix Glycyrrhizaes of Herba Houttuyniae.
The preparation method of a kind of Chinese medicine composition treating poultry airsacculitis the most according to claim 1, it is characterised in that: Weighing various raw material by described weight ratio, then pulverized 120 mesh with pulverizer, mix homogeneously is.
CN201610652938.0A 2016-08-11 2016-08-11 A kind of Chinese medicine composition treating poultry airsacculitis Pending CN106166226A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102247390A (en) * 2011-07-12 2011-11-23 河南牧翔动物药业有限公司 Medicine for treating bacterial air sacculitis in livestock and preparation method thereof
CN102743407A (en) * 2012-07-30 2012-10-24 山东迅达康兽药有限公司 Oral liquid for treating infectious air sacculitis of chicken and preparation method thereof
CN103417884A (en) * 2013-08-08 2013-12-04 陕西冠嘉高科生物技术有限公司 Drug for treating chicken airsacculitis and preparation method of drug
CN103520467A (en) * 2013-10-14 2014-01-22 裴毅 Chinese medicinal composition for treating air sacculitis of broilers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102247390A (en) * 2011-07-12 2011-11-23 河南牧翔动物药业有限公司 Medicine for treating bacterial air sacculitis in livestock and preparation method thereof
CN102743407A (en) * 2012-07-30 2012-10-24 山东迅达康兽药有限公司 Oral liquid for treating infectious air sacculitis of chicken and preparation method thereof
CN103417884A (en) * 2013-08-08 2013-12-04 陕西冠嘉高科生物技术有限公司 Drug for treating chicken airsacculitis and preparation method of drug
CN103520467A (en) * 2013-10-14 2014-01-22 裴毅 Chinese medicinal composition for treating air sacculitis of broilers

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