CN102743407B - Oral liquid for treating infectious air sacculitis of chicken and preparation method thereof - Google Patents
Oral liquid for treating infectious air sacculitis of chicken and preparation method thereof Download PDFInfo
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- CN102743407B CN102743407B CN201210265248.1A CN201210265248A CN102743407B CN 102743407 B CN102743407 B CN 102743407B CN 201210265248 A CN201210265248 A CN 201210265248A CN 102743407 B CN102743407 B CN 102743407B
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Abstract
The invention provides oral liquid for treating infectious air sacculitis of a chicken and a preparation method of the oral liquid. Each 1,000L of oral liquid contains 3-10kg of ambroxol hydrochloride, 5-15L of phosphoric acid, 20-30kg of tilmicosin, 15-25g of analgin, 10-15kg of diammonium glycyrrhizinate, 15-25L of propylene glycol, 15-25ml of glycerol and the rest of water. Aiming at reasons for air sacculitis of the chicken, the oral liquid can achieve the effect of treating both principal and secondary aspect of disease by combination of drugs; and aiming at physiological characteristics of the chicken, the ambroxol hydrochloride is prepared into a water solution by an easily operated process and can be conveniently used, so that a quick treatment drug is provided for masses of breeding enterprises and the economic loss caused by the infectious air sacculitis is avoided.
Description
Technical field
The invention belongs to veterinary drug technical field, relate to a kind for the treatment of and cause compound medicine oral liquid of avian infectious airsacculitis and preparation method thereof by invasive organism mixed infections such as escherichia coli, mycoplasma, viruses.
Background technology
Along with China's aquaculture large-scale development; because cultivation density is excessive; breeding enterprise is not noted ventilation; cause the harmful gass such as Ammonia in Air gas, hydrogen sulfide too high; stimulate chicken respiratory cilium; cause mucosa injury, make the invasive organisms such as escherichia coli in air, mycoplasma, newcastle on respiratory mucosa, breed and enter body, and then make the organ generation pathological changes such as lungs, air bag, liver.
The clinical symptoms of avian infectious airsacculitis is: early stage cough, ataxia, after about 3～4 days, snore, swollen head, swollen eye, shed tears, after about 7 days, indivedual chickens be take mouth breathing as main, and the average age in days of falling ill is 15 age in days left and right, and 7 ages in days just have incidence the earliest, spirit is depressed, loss of appetite, even absolutely useless, thirsty wish strengthens, row's yellow-white loose stool, feather pine is random, tarnish, and pawl is dry unglazed.Dissect symptom: larynx and trachea be congested, hemorrhage, have mucus, and bronchus has thromboembolism, air bag muddiness, thicken, have yellow or the cheesy thing of yellow-white to adhere to.The middle and late stage of serious chicken group or morbidity, cuing open inspection symptom, to be mainly larynx hemorrhage, congested, trachea, bronchus diffuse hemorrhage, there is yellow cheesy exudate, Pulmonary hemorrhage edema has yellow cheesy thing to adhere to, air bag muddiness thickens, and liver has cellulose exudate to cover mostly, intestinal lymph island shape projection.
In recent years, avian infectious airsacculitis morbidity is more and more serious, in addition the vascularity of air bag is few, medicine be difficult to arrive, and chicken can not cough, and when the respiratory systems such as trachea have sputum, can only excrete by getting rid of first-class method, the dry thickness so once sputum becomes in respiratory system, be difficult to excrete, cause primary disease therapeutic effect not good, be easy to cause serious loss to breeding enterprise.
Summary of the invention
The present invention is directed to and bring out the multiple pathogenic factors employing of avian infectious airsacculitis drug regimen, develop a kind of oral liquid and preparation method for the treatment of avian infectious airsacculitis.
Special object of the present invention is for chicken respiratory system feature, develops a kind of technological operation is simple, cost performance is high ambroxol hydrochloride oral solution and preparation method.
The present invention is achieved through the following technical solutions:
Treat avian infectious airsacculitis oral liquid and it is characterized in that consisting of of every 100L oral liquid: ambroxol hydrochloride 3～10kg, phosphoric acid 5～15L, tilmicosin 20～30kg, dipyrone 15～25g, diammonium glycyrrhizinate 10～15kg, propylene glycol 15～25L, glycerol 15～25ml, surplus is water.
The better prescription of every 100L oral liquid is: ambroxol hydrochloride 3～8kg, and phosphoric acid 7～15L, tilmicosin 20～29kg, dipyrone 15～23g, diammonium glycyrrhizinate 10～15kg, propylene glycol 15～23L, glycerol 15～23ml, surplus is water.
The best prescription of every 100L oral liquid is: ambroxol hydrochloride 6kg, and phosphatase 11 0L, tilmicosin 25kg, dipyrone 20g, diammonium glycyrrhizinate 10kg, propylene glycol 15L, glycerol 15ml, surplus is water.
Above-mentionedly be used for the treatment of a multifactor preparation method of bringing out avian infectious airsacculitis oral liquid, comprise the steps:
(1) water intaking 30～40L adds propylene glycol 15～25L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 3～10kg, stirring and dissolving;
(2) water intaking 40～50L adds phosphoric acid 5～15L, is heated to 50 ℃, stirs, and adds tilmicosin 20～30kg, and stirring and dissolving, adds dipyrone 15～25g, and stirring and dissolving adds diammonium glycyrrhizinate 10～15kg, stirring and dissolving;
(3) first the solution in step (2) is added in the solution in step (1), stir, add glycerol 15～25ml, stir, with citric acid, regulate PH to 4;
(4) the solution with water polishing in step (3) is to 100L, filter, and fill, sterilizing obtains the oral liquid of the avian infectious airsacculitis that treatment multi-pathogenesis causes.
The present invention has following technique effect:
The present invention is compound preparation, and tilmicosin is the special-purpose Macrocyclolactone lactone kind medicines of poultry, for oral administration absorption soon, and apparent volume of distribution is large, high at respiratory system drug substrate concentrations such as lungs, is the medicine for the treatment of escherichia coli and mycoplasma; Diammonium glycyrrhizinate is effective liquorice extract, and newcastle, infectiousness bronchus etc. is had to good therapeutical effect; Ambroxol hydrochloride is mucolytic drugs, can significantly increase amount of expectoration, reduce sputum viscosity, stimulate generation and the secretion of the respiratory system surfactants such as lung, being conducive to chicken excretes the sputum in the respiratory systems such as trachea, bronchus, and can increase the blood drug level of the curative drugs such as tilmicosin in respiratory system, improve antibacterial effect; Dipyrone is mainly used for chicken because the fervescence that escherichia coli, mycoplasma and viral infection cause.The present invention is directed to the many reasons that causes chicken airsacculitis, adopt multi-medicament to combine use, can reach the effect for the treatment of both the principal and secondary aspects of a disease.This product, for the physiological characteristics of chicken, adopts a kind of maneuverable technique to make aqueous solution ambroxol hydrochloride, easy to use, thereby for vast breeding enterprise provides a kind of fast treating medicine, avoids the economic loss causing because of infectiousness airsacculitis.
The specific embodiment
Below in conjunction with instantiation to the detailed description of the invention.
Embodiment 1:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 3kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 20kg, and stirring and dissolving, adds dipyrone 15Kg, and stirring and dissolving adds diammonium glycyrrhizinate 10kg, stirring and dissolving;
(3) first the solution in step (2) is added in the solution in step (1), stir, add glycerol 15ml, stir, with citric acid, regulate PH to 4;
(4) the solution with water polishing in step (3) is to 100L, filter, and fill, sterilizing obtains the oral liquid of the avian infectious airsacculitis that treatment multi-pathogenesis causes.
Embodiment 2:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 4kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 24kg, and stirring and dissolving, adds dipyrone 20Kg, and stirring and dissolving adds diammonium glycyrrhizinate 10kg, stirring and dissolving;
(3) first the solution in step (2) is added in the solution in step (1), stir, add glycerol 15ml, stir, with citric acid, regulate PH to 4;
(4) the solution with water polishing in step (3) is to 100L, filter, and fill, sterilizing obtains the oral liquid of the avian infectious airsacculitis that treatment multi-pathogenesis causes.
Embodiment 3:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 6kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 25kg, and stirring and dissolving, adds dipyrone 20Kg, and stirring and dissolving adds diammonium glycyrrhizinate 10kg, stirring and dissolving;
(3) first the solution in step (2) is added in the solution in step (1), stir, add glycerol 15ml, stir, with citric acid, regulate PH to 4;
(4) the solution with water polishing in step (3) is to 100L, filter, and fill, sterilizing obtains the oral liquid of the avian infectious airsacculitis that treatment multi-pathogenesis causes.
Embodiment 4:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 4kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 25kg, and stirring and dissolving, adds dipyrone 20Kg, and stirring and dissolving adds diammonium glycyrrhizinate 15kg, stirring and dissolving;
(3) first the solution in step (2) is added in the solution in step (1), stir, add glycerol 15ml, stir, with citric acid, regulate PH to 4;
(4) the solution with water polishing in step (3) is to 100L, filter, and fill, sterilizing obtains the oral liquid of the avian infectious airsacculitis that treatment multi-pathogenesis causes.
Embodiment 5:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 6kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 25kg, and stirring and dissolving, adds dipyrone 20Kg, and stirring and dissolving adds diammonium glycyrrhizinate 14kg, stirring and dissolving;
(3) first the solution in step (2) is added in the solution in step (1), stir, add glycerol 15ml, stir, with citric acid, regulate PH to 4;
(4) the solution with water polishing in step (3) is to 100L, filter, and fill, sterilizing obtains the oral liquid of the avian infectious airsacculitis that treatment multi-pathogenesis causes.Clinical trial: according to embodiment 3, produce 100L avian infectious airsacculitis oral liquid for the treatment of, ambroxol hydrochloride 6kg, phosphatase 11 0L, tilmicosin 25kg, dipyrone 20g, diammonium glycyrrhizinate 10kg, propylene glycol 15L, glycerol 15ml, surplus is water.This prescription is as follows on the impact of broiler:
1, experimental animal:
Choose at random and suffer from 120 of infectiousness airsacculitis broiler, be divided at random 4 groups, 30 every group, body weight is at 1～2kg.
2, Experimental agents:
The embodiment of the present invention 3 preparation a kind of treats avian infectious airsacculitis oral liquid; Tilmicosin oral liquid: water 80ml, add phosphatase 11 0ml to be heated to 50 ℃, add tilmicosin 25g, stirring and dissolving, water complements to 100ml.
Ambroxol hydrochloride oral liquid: water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 6kg, and stirring and dissolving water is supplied 100ml.
3, experimental technique:
1 group is blank group, without medicine.
2 group of 25% tilmicosin solution treated, usage: 100ml tilmicosin solution (25%) is watered 300kg, once-a-day, concentrates and is finished for 3 hours, is used in conjunction 4.
3 group of 6% ambroxol hydrochloride solution is treated, usage: 100mk ambroxol hydrochloride solution (6%) is watered 300kg, once-a-day, concentrates and is finished for 3 hours, is used in conjunction 4 days.
With the present invention is a kind of, treat avian infectious airsacculitis oral liquid for 4 groups, usage: 100ml is watered 300kg, once-a-day, concentrates and is finished for 3 hours, is used in conjunction 4.
After treatment starts, every day entry sick fowl respiratory tract situation and dead distribution, treat and add up therapeutic effect after 4 days, wherein
Invalid: refer to after 4 days, sick fowl symptom has the situation of increasing the weight of or death or Respiratory symptoms not to alleviate (bronchus still has thromboembolism, air bag to have cheesy thing).
Effective: refer to after 4 days, sick fowl symptom changes, symptom is controlled or with respect to having obviously and alleviate before treatment.
Cure: refer to after 4 days, transference cure, the sick fowl mental status and feed intake are recovered normal condition.Its digital packets is contained in significant digits.
During end, have symptom: refer to treat after 4 days, sick fowl still has certain symptom, before its Symptoms is better than treatment or without change, sick fowl is cured completely, and its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1:
Table 1: each organizes therapeutic effect
4, conclusion:
From the result of the test statistical analysis of table 1, a kind of oral liquid, 25% tilmicosin oral liquid, 6% ambroxol hydrochloride oral liquid treatment group and matched group difference for the treatment of avian infectious airsacculitis is (P < 0.01) extremely significantly.Therapeutic effect of the present invention is this product treating both the principal and secondary aspects of a disease than 25% tilmicosin oral liquid and the good main cause of 6% ambroxol hydrochloride oral liquid, to causing that the various microbiological factors of avian infectious airsacculitis have good therapeutical effect.And 25% tilmicosin oral liquid effect is better than 6% ambroxol hydrochloride oral liquid, although illustrate that 6% ambroxol hydrochloride can effectively alleviate death for avian infectious airsacculitis, only have and add the medicine effecting a permanent cure simultaneously, just can reach good therapeutic effect.
Claims (2)
1. the avian infectious airsacculitis oral liquid for the treatment of, is characterized in that: the consisting of of every 100L oral liquid: ambroxol hydrochloride 6kg, phosphoric acid 8L, tilmicosin 25kg, dipyrone 20kg, diammonium glycyrrhizinate 10kg, propylene glycol 15L, glycerol 15ml, the citric acid of the amount of adjusting pH to 4, surplus is water.
2. described in claim 1, treat the preparation method of avian infectious airsacculitis oral liquid, it is characterized in that:
(1) water intaking 30L adds propylene glycol 15L, is heated to 70 ℃, stirs, and adds ambroxol hydrochloride 6kg, stirring and dissolving;
(2) water intaking 40L adds phosphoric acid 8L, is heated to 50 ℃, stirs, and adds tilmicosin 25kg, and stirring and dissolving, adds dipyrone 20kg, and stirring and dissolving adds diammonium glycyrrhizinate 10kg, stirring and dissolving;
(3) first the solution in step (2) is added in the solution in step (1), stir, add glycerol 15ml, stir, with Fructus Citri Limoniae acid for adjusting pH to 4;
(4) the solution with water polishing in step (3), to 100L, filters, fill, and sterilizing obtains the oral liquid of the avian infectious airsacculitis for the treatment of.
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| CN105012332A (en) * | 2015-07-02 | 2015-11-04 | 河北科恒生物科技有限公司 | Compound tilmicosin phosphate-ambroxol nanoemulsion preparation |
| CN106166226A (en) * | 2016-08-11 | 2016-11-30 | 王华伟 | A kind of Chinese medicine composition treating poultry airsacculitis |
| CN108653205B (en) * | 2018-07-26 | 2021-02-26 | 日照市牧邦畜牧科技有限公司 | Stable long-acting compound tilmicosin solution |
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| CN102327365A (en) * | 2011-07-07 | 2012-01-25 | 天津生机集团股份有限公司 | Oral liquid for treating air sacculitis caused by colibacillosis of chicken and preparation method thereof |
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| CN102327365A (en) * | 2011-07-07 | 2012-01-25 | 天津生机集团股份有限公司 | Oral liquid for treating air sacculitis caused by colibacillosis of chicken and preparation method thereof |
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