CN101879218A - Compound shuanghuanglian oral solution used for treating cold of dog and preparation method thereof - Google Patents
Compound shuanghuanglian oral solution used for treating cold of dog and preparation method thereof Download PDFInfo
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- CN101879218A CN101879218A CN2009100687446A CN200910068744A CN101879218A CN 101879218 A CN101879218 A CN 101879218A CN 2009100687446 A CN2009100687446 A CN 2009100687446A CN 200910068744 A CN200910068744 A CN 200910068744A CN 101879218 A CN101879218 A CN 101879218A
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Abstract
The invention discloses compound shuanghuanglian oral solution used for controlling the cold of a dog and a preparation method thereof, and aims to provide compound shuanghuanglian oral solution used for treating the cold of a dog, which has the advantages of convenient use, high cure rate, quick response and treatment of both principal and secondary aspect of disease, and a preparation method thereof, which has the advantages of simple process and easy implementation. Each 100L of oral solution comprises 0.05 to 5kg of baicalin, 0.5 to 10kg of honey suckle and weeping forsythia extract, 0.1 to 5kg of clindamycin hydrochloride, 5 to 20kg of glucose, 0.2 to 5kg of analginum, 0.005 to 0.05kg of chlortrimeton, 0.1 to 5kg of ribavirin, 0.1kg of sodium glutamate and 0.1kg of sodium hydroxide. The compound shuanghuanglian oral solution is a compound preparation; the honey suckle and weeping forsythia extract, the baicalin, the ribavirin, and the clindamycin hydrochloride have the effect of inhibiting viruses and bacteria so as to control the cold; and by combining the glucose for supplementing energy, the antipyretic and anti-inflammatory analginum, the anti-allergic chlortrimeton and the sodium glutamate for improving the taste and smell of the oral solution, the cold of the dog is multilaterally treated.
Description
Technical field
The present invention relates to a kind of compound shuanghuanglian oral solution that is used for the treatment of cold of dog and preparation method thereof.
Background technology
Cold of dog is a kind of commonly encountered diseases, cause by cold virus, sick dog mainly shows as fever, depressed, the shaking chill of spirit, appetite descend even are useless exhausted, surveying the anus temperature can be above 40 ℃, cough, stream nose liquid, symptom such as shed tears, pilosity be born in change in weather or serious, the sick dog resistance of outside stimulus under degradation.Sick dog causes diseases such as pneumonia often because of other antibacterials of resistance problem secondary such as infection such as streptococcus, streptococcus pneumoniae
At present, the medicine of treatment cold of dog such as common SHUANGHUANGLIAN KOUFUYE, ribavirin oral solution etc. can only be from the treatments of single aspect, SHUANGHUANGLIAN KOUFUYE has heat-clearing and toxic substances removing, flu there is certain curative effect, but relief of symptoms fast, and can not prevent the secondary bacterial infection.Ribavirin oral solution has only the simple function that suppresses virus, but does not reach other symptoms of control and secondary bacterial infection problem.
In addition from China's present situation, present vast foster dog fan's professional standards are low, add that present common pet clinic lacks relevant phenomenons such as professional, cause golden hour of when treatment, incuring loss through delay dog, increase its stress, and bring very big puzzlement for vast foster dog fan.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, a kind of treatment cold of dog that is mainly used in to be provided, and is easy to use, the compound shuanghuanglian oral solution for the treatment of both the principal and secondary aspects of a disease.
It is simple that another object of the present invention provides a kind of technology, easily the preparation method of the compound shuanghuanglian oral solution of realizing.
The present invention is achieved through the following technical solutions:
A kind of compound shuanghuanglian oral solution that is used for the treatment of cold of dog, it is characterized in that, make in the raw material of every 100L oral liquid: baicalin 0.05～5kg, double flower forsythia extract 0.5～10kg, Clindamycin Hydrochloride 0.1～5kg, glucose 5～20kg, dipyrone 0.2～5kg, chlorphenamine 0.005～0.05kg, ribavirin 0.1～5kg, sodium glutamate 0.1kg, sodium hydroxide 0.1kg, surplus be purified water.
The preferable of raw material of making every 100L oral liquid consists of: baicalin 0.8～3kg, double flower forsythia extract 0.8～5kg, Clindamycin Hydrochloride 0.2～2kg, glucose 7～15kg, dipyrone 1～4kg, chlorphenamine 0.01～0.03kg, ribavirin 0.3～2kg, sodium glutamate 0.1kg, sodium hydroxide 0.1kg, surplus be purified water.
The best group of making the raw material of every 100L oral liquid becomes: baicalin 1.2kg, double flower forsythia extract 1kg, Clindamycin Hydrochloride 0.5kg, glucose 10kg, dipyrone 3kg, chlorphenamine 0.02kg, ribavirin 0.5kg, sodium glutamate 0.1kg, sodium hydroxide 0.1kg, surplus be purified water.
Wherein, double flower forsythia extract is Flos Lonicerae and Fructus Forsythiae according to parts by weight is that 1: 2 ratio adopts the method for water extract-alcohol precipitation to extract to obtain, and the 1g double flower forsythia extract is equivalent to the 50g crude drug in whole.
A kind of above-mentioned preparation method that is used for the treatment of the compound shuanghuanglian oral solution of cold of dog is characterized in that this oral liquid prepares by following method:
(1) gets purified water 30L, add sodium hydroxide 0.1kg, after the dissolving, add baicalin 0.05～5kg again, after the stirring and dissolving, add double flower forsythia extract 0.5～10kg again, stirring and dissolving;
(2) get purified water 30L, add glucose 5～20kg, dipyrone 0.2～5kg, chlorphenamine 0.005～0.05kg successively, stirring and dissolving;
(3) get purified water 10L, add sodium glutamate 0.1kg, Clindamycin Hydrochloride 0.1～5kg, ribavirin 0.1～5kg successively, stirring and dissolving;
(4) three kinds of solution that obtain in combining step (1), step (2) and the step (3), adding purified water to 100L, is that 10% sodium hydroxide or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 5.0～7.0 and promptly got dog of the present invention and use compound shuanghuanglian oral solution with mass percent concentration.
The present invention has following technique effect:
The oral liquid of treatment cold of dog of the present invention adopts the Chinese medicine and western medicine compound preparation, double flower forsythia extract, baicalin, ribavirin, Clindamycin Hydrochloride has the virus of inhibition, the function of antibacterial, make flu controlled, glucose in conjunction with makeup energy, the antipyretic and anti-inflammatory dipyrone, antianaphylactic chlorphenamine, and the sodium glutamate that improves oral liquid taste and abnormal smells from the patient, from antibiotic, antiviral, bring down a fever, antiallergic, calm, many-sided comprehensive consideration treatment cold of dog such as extra-nutrition, it is fast to respond well to treatment, can disease controlling show effect, reduce irritability, and can prevent the generation of secondary infection disease, reduce the misery of disease dog, treating both the principal and secondary aspects of a disease.And, easy to use by oral medication, alleviate the puzzlement of supporting the dog fan.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Employed double flower forsythia extract be Flos Lonicerae and Fructus Forsythiae according to parts by weight is that 1: 2 ratio adopts water extract-alcohol precipitation to extract to obtain among the present invention, and the 1g double flower forsythia extract is equivalent to crude drug in whole 50g.Sodium glutamate is a food grade materials.
Embodiment 1
(1) gets purified water 30L, add sodium hydroxide 0.1kg, after the dissolving, add baicalin 0.05 again, after the stirring and dissolving, add double flower forsythia extract 10kg again, stirring and dissolving.
(2) get purified water 30L, dissolve glucose 20kg, dipyrone 0.2kg, chlorphenamine 0.005 stirring and dissolving successively.
(3) get purified water 10L, dissolve sodium glutamate 0.1kg, Clindamycin Hydrochloride 0.1kg, ribavirin 5kg successively.
(4) merge the solution that above step 1, step 2 and step 3 obtain, adding purified water to 100L, is that 10% sodium hydroxide or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 5.0～7.0 and promptly got dog of the present invention and use compound shuanghuanglian oral solution with mass percent concentration.
(5) after pH value meets the requirements, use the suitable vessel fill, 100 ℃ of flowing steam sterilizations 30 minutes.
Embodiment 2
(1) gets purified water 30L, add sodium hydroxide 0.1kg, after the dissolving, add baicalin 5kg again, after the stirring and dissolving, add double flower forsythia extract 0.5kg again, stirring and dissolving.
(2) get purified water 30L, dissolve glucose 5kg successively, dipyrone 5kg, chlorphenamine 0.05kg stirring and dissolving.
(3) get purified water 10L, dissolve sodium glutamate 0.1kg, Clindamycin Hydrochloride 5kg, ribavirin 5kg successively.
(4) merge the solution that above step 1, step 2 and step 3 obtain, adding purified water to 100L, is that 10% sodium hydroxide or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 5.0～7.0 and promptly got dog of the present invention and use compound shuanghuanglian oral solution with mass percent concentration.
(5) after pH value meets the requirements, use the suitable vessel fill, 100 ℃ of flowing steam sterilizations 30 minutes.
Embodiment 3
(1) gets purified water 30L, add sodium hydroxide 0.1kg, after the dissolving, add baicalin 0.8kg again, after the stirring and dissolving, add double flower forsythia extract 5kg again, stirring and dissolving.
(2) get purified water 30L, dissolve glucose 15kg successively, dipyrone 1kg, chlorphenamine 0.03kg stirring and dissolving.
(3) get purified water 10L, dissolve sodium glutamate 0.1kg, Clindamycin Hydrochloride 2kg, ribavirin 0.3kg successively.
(4) merge the solution that above step 1, step 2 and step 3 obtain, adding purified water to 100L, is that 10% sodium hydroxide or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 5.0～7.0 and promptly got dog of the present invention and use compound shuanghuanglian oral solution with mass percent concentration.
(5) after pH value meets the requirements, use the suitable vessel fill, 100 ℃ of flowing steam sterilizations 30 minutes.
Embodiment 4
(1) gets purified water 30L, add sodium hydroxide 0.1kg, after the dissolving, add baicalin 3kg again, after the stirring and dissolving, add double flower forsythia extract 0.8kg again, stirring and dissolving.
(2) get purified water 30L, dissolve glucose 7kg successively, dipyrone 4kg, chlorphenamine 0.01kg stirring and dissolving.
(3) get purified water 10L, dissolve sodium glutamate 0.1kg, Clindamycin Hydrochloride 0.2kg, ribavirin 2kg successively.
(4) merge the solution that above step 1, step 2 and step 3 obtain, adding purified water to 100L, is that 10% sodium hydroxide or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 5.0～7.0 and promptly got dog of the present invention and use compound shuanghuanglian oral solution with mass percent concentration.
(5) after pH value meets the requirements, use the suitable vessel fill, 100 ℃ of flowing steam sterilizations 30 minutes.
Embodiment 5
(1) gets purified water 30L, add sodium hydroxide 0.1kg, after the dissolving, add baicalin 1.5kg again, after the stirring and dissolving, add double flower forsythia extract 0.9kg again, stirring and dissolving.
(2) get purified water 30L, dissolve glucose 9kg successively, dipyrone 3.5kg, chlorphenamine 0.015kg stirring and dissolving.
(3) get purified water 10L, dissolve sodium glutamate 0.1kg, Clindamycin Hydrochloride 0.6kg, ribavirin 0.8kg successively.
(4) merge the solution that above step 1, step 2 and step 3 obtain, adding purified water to 100L, is that 10% sodium hydroxide or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 5.0～7.0 and promptly got dog of the present invention and use compound shuanghuanglian oral solution with mass percent concentration.
(5) after pH value meets the requirements, use the suitable vessel fill, 100 ℃ of flowing steam sterilizations 30 minutes.
Embodiment 6
(1) gets purified water 30L, add sodium hydroxide 0.1kg, after the dissolving, add baicalin 1.2kg again, after the stirring and dissolving, add double flower forsythia extract 1kg again, stirring and dissolving.
(2) get purified water 30L, dissolve glucose 10kg successively, dipyrone 3kg, chlorphenamine 0.02kg stirring and dissolving.
(3) get purified water 10L, dissolve sodium glutamate 0.1kg, Clindamycin Hydrochloride 0.5kg, ribavirin 0.5kg successively.
(4) merge the solution that above step 1, step 2 and step 3 obtain, adding purified water to 100L, is that 10% sodium hydroxide or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 5.0～7.0 and promptly got dog of the present invention and use compound shuanghuanglian oral solution with mass percent concentration.
(5) after pH value meets the requirements, use the suitable vessel fill, 100 ℃ of flowing steam sterilizations 30 minutes.
Clinical trial:
1. laboratory animal:
100 of the ill one-tenth of picked at random dogs.
2. experiment medicine:
The compound shuanghuanglian oral solution our unit development that is used for the treatment of cold of dog of the embodiment of the invention 6 preparations;
SHUANGHUANGLIAN KOUFUYE our unit prepared in laboratory;
0.5% ribavirin solution our unit prepared in laboratory.
3. experimental technique:
Suffer from dog with 100 and be divided into four groups at random by body weight, 25 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with SHUANGHUANGLIAN KOUFUYE: oral, and every 1kg body weight 1ml, 2 times on the one, logotype 5 days.
The C group is treated usage with 0.5% ribavirin solution: oral, and every 1kg body weight 1ml, 2 times on the one, logotype 5 days.
The D group is treated usage with the compound shuanghuanglian oral solution that is used for the treatment of cold of dog of the embodiment of the invention 6 preparations: oral, and every 1kg body weight 1ml, 1 time on the one, logotype 5 days.
After the treatment beginning, every day, the distribution of dog health situation of change suffered from record, and treat after the 7th day and add up therapeutic effect, wherein:
Invalid: as after referring to 7 days, to suffer from the dog symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the dog symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from dog and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from dog and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from dog and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the compound shuanghuanglian oral solution treatment group that is used for the treatment of cold of dog, SHUANGHUANGLIAN KOUFUYE treatment group and the 0.5% ribavirin solution group of the embodiment of the invention 6 and matched group difference is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1 (C group data have problem)
Claims (5)
1. compound shuanghuanglian oral solution that is used for the treatment of cold of dog, it is characterized in that, make in the raw material of every 100L oral liquid: baicalin 0.05～5kg, double flower forsythia extract 0.5～10kg, Clindamycin Hydrochloride 0.1～5kg, glucose 5～20kg, dipyrone 0.2～5kg, chlorphenamine 0.005～0.05kg, ribavirin 0.1～5kg, sodium glutamate 0.1kg, sodium hydroxide 0.1kg, surplus be purified water.
2. the compound shuanghuanglian oral solution that is used for the treatment of cold of dog according to claim 1, it is characterized in that, make in the raw material of every 100L oral liquid: baicalin 0.8～3kg, double flower forsythia extract 0.8～5kg, Clindamycin Hydrochloride 0.2～2kg, glucose 7～15kg, dipyrone 1～4kg, chlorphenamine 0.01～0.03kg, ribavirin 0.3～2kg, sodium glutamate 0.1kg, sodium hydroxide 0.1kg, surplus be purified water.
3. the compound shuanghuanglian oral solution that is used for the treatment of cold of dog according to claim 1, it is characterized in that, make in the raw material of every 100L oral liquid: baicalin 1.2kg, double flower forsythia extract 1kg, Clindamycin Hydrochloride 0.5kg, glucose 10kg, dipyrone 3kg, chlorphenamine 0.02kg, ribavirin 0.5kg, sodium glutamate 0.1kg, sodium hydroxide 0.1kg, surplus be purified water.
4. according to each described compound shuanghuanglian oral solution that is used for the treatment of cold of dog in the claim 1 to 3, it is characterized in that, described double flower forsythia extract is Flos Lonicerae and Fructus Forsythiae according to parts by weight is that 1: 2 ratio adopts the method for water extract-alcohol precipitation to extract to obtain, and the 1g double flower forsythia extract is equivalent to the 50g crude drug in whole.
5. described preparation method that is used for the treatment of the compound shuanghuanglian oral solution of cold of dog of claim 1 is characterized in that this oral liquid prepares by following method:
(1) gets purified water 30L, add sodium hydroxide 0.1kg, after the dissolving, add baicalin 0.05～5kg again, after the stirring and dissolving, add double flower forsythia extract 0.5～10kg again, stirring and dissolving;
(2) get purified water 30L, add glucose 5～20kg, dipyrone 0.2～5kg, chlorphenamine 0.005～0.05kg successively, stirring and dissolving;
(3) get purified water 10L, add sodium glutamate 0.1kg, Clindamycin Hydrochloride 0.1～5kg, ribavirin 0.1～5kg successively, stirring and dissolving;
(4) three kinds of solution that obtain in combining step (1), step (2) and the step (3), adding purified water to 100L, is that 10% sodium hydroxide or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 5.0～7.0 and promptly got dog of the present invention and use compound shuanghuanglian oral solution with mass percent concentration.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068452A (en) * | 2011-01-26 | 2011-05-25 | 中国药科大学 | Antiviral medicinal composition |
| CN108272900A (en) * | 2018-04-02 | 2018-07-13 | 邹方昕 | A kind of Chinese medicine composition for treating rheumatoid arthritis |
| CN108606998A (en) * | 2016-12-13 | 2018-10-02 | 河南后羿实业集团有限公司 | It is a kind of to be used to inhibit drug of bacterium infection and preparation method thereof |
-
2009
- 2009-05-05 CN CN2009100687446A patent/CN101879218A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068452A (en) * | 2011-01-26 | 2011-05-25 | 中国药科大学 | Antiviral medicinal composition |
| CN102068452B (en) * | 2011-01-26 | 2012-11-28 | 中国药科大学 | Antiviral medicinal composition |
| CN108606998A (en) * | 2016-12-13 | 2018-10-02 | 河南后羿实业集团有限公司 | It is a kind of to be used to inhibit drug of bacterium infection and preparation method thereof |
| CN108272900A (en) * | 2018-04-02 | 2018-07-13 | 邹方昕 | A kind of Chinese medicine composition for treating rheumatoid arthritis |
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Application publication date: 20101110 |