CN101669911B - Dicazuril soluble powder and preparation method thereof - Google Patents
Dicazuril soluble powder and preparation method thereof Download PDFInfo
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- CN101669911B CN101669911B CN2009100659427A CN200910065942A CN101669911B CN 101669911 B CN101669911 B CN 101669911B CN 2009100659427 A CN2009100659427 A CN 2009100659427A CN 200910065942 A CN200910065942 A CN 200910065942A CN 101669911 B CN101669911 B CN 101669911B
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- diclazuril
- soluble powder
- dicazuril
- polyvinylpyrrolidone
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Abstract
The invention discloses a dicazuril soluble powder which is prepared from the following components by weight percent: 50-69.5 percent of dicazuril, 30-49.5 percent of polyvinylpyrrolidone and 0.5-2 percent of antioxygen. The invention also discloses a preparation method of the dicazuril soluble powder. The polyvinylpyrrolidone in the dicazuril soluble powder has excellent physiological inertress and biocompatibility so that the dicazuril can be evenly dissolved in water to form cleared homogeneous solution for killing coccidium in carcass, thereby being more convenient and effective in clinical use. Besides, compared with pharmaceutical solution, the dicazuril soluble powder has the characteristics of easy preservation and convenient transportation.
Description
Technical field
The present invention relates to a kind of diclazuril soluble powder, also relate to a kind of preparation method of diclazuril soluble powder simultaneously.
Background technology
Diclazuril belongs to triazine benzene acetonitrile chemical compound, can be tender to chicken, heap type, murder by poisoning, Bu Shi, Eimeria maxima etc. have splendid killing action, it is a kind of anticoccidial drug of novel, efficient, low toxicity, its antibiotics index at above-mentioned five kinds of coccidiosiss is respectively 200,200,197,193,183, can disturb the division and the metabolic function of mitochondrial respiratory of polypide somatic cell nuclear after the medication, can act on the commitment of coccidiosis zygoblast and first generation schizont, kill coccidian oocyst, so be commonly used for the coccidiosis of control poultry.Mainly contain dosage forms such as diclazuril pre-mixing agent, suspension type powder, solution in the market, the subject matter that this series products exists is to mix the back with drinking water because the diclazuril dissolubility is extremely low, and medicine generation sedimentation causes chicken can not fully drink the medicine of capacity.Because the clinical using dosage of diclazuril is low, be difficult to mix homogeneously when spice uses, certainly will influence anticoccidial effect like this.
Summary of the invention
The diclazuril that the purpose of this invention is to provide a kind of solubility.
Another object of the present invention provides a kind of preparation method of diclazuril soluble powder.
In order to realize above purpose, the technical scheme that diclazuril soluble powder of the present invention is adopted is: a kind of diclazuril soluble powder, form by following components in weight percentage: diclazuril 50～69.5%, polyvinylpyrrolidone 30～49.5%, antioxidant 0.5～2%.
Described antioxidant is a kind of or its combination in any of sodium sulfite, sodium thiosulfate, edta salt apoplexy due to endogenous wind.
The preparation method of diclazuril soluble powder of the present invention is: a kind of preparation method of diclazuril soluble powder: get antioxidant and be dissolved in water, add ethanol and polyvinylpyrrolidone heating for dissolving again, add diclazuril in 50-70 ℃, the regulator solution pH value is 8.0-9.5, reclaim ethanol, drying is pulverized, and makes the diclazuril soluble powder.
Described antioxidant is a kind of or its combination in any of sodium sulfite, sodium thiosulfate, edta salt apoplexy due to endogenous wind.
In the preparation method of diclazuril soluble powder of the present invention, the water and the ethanol that add are solvent, and its consumption can be with each material dissolution as long as satisfy, and purpose is that each material is fully mixed, and to adopt ethanol be the recovery that solvent can make things convenient for solvent, reduces exsiccant cost simultaneously.
Polyvinylpyrrolidone in the diclazuril soluble powder of the present invention can increase the dissolubility of diclazuril, and polyvinylpyrrolidone has good physiology inertia, do not participate in the metabolism of animal body, has good biocompatibility again, skin, mucosa, eye etc. are not formed any stimulation, safe in utilization, but also can reduce viscosity after the diclazuril soluble powder dissolving, be beneficial to and feedstuff or drinking-water uniform mixing, improve the blended uniformity; Antioxidant can be selected sodium sulfite, sodium thiosulfate or edta salt class for use, can also multiplely use simultaneously, wherein the edta salt class comprises the EDTA disodium salt, EDTA calcium salt etc., can play preventing that the diclazuril soluble powder is oxidized rotten, make soluble powder be convenient to preserve.
Diclazuril soluble powder of the present invention in use, being dissolved in water stirs, and forms settled solution, according to dosage and feedstuff or drinking-water uniform mixing, eats for domestic animal again, can kill the intravital coccidiosis of domestic animal.In using process for preparation, the diclazuril soluble powder is dissolved in the water uniformly, and the precipitation of medicine can not take place, and the solution of diclazuril after the dissolving can mix with feedstuff or drinking-water uniformly, makes poultry can take in the medicine of q.s.And diclazuril soluble powder of the present invention compares pharmaceutical solutions, has the advantages that to be easy to preserve convenient transportation.Using method and dosage: diclazuril soluble powder of the present invention mixes drink in diclazuril: every 1L water, 0.5～1mg when the chicken poultry is used.
The specific embodiment
Embodiment 1
The diclazuril soluble powder of present embodiment is made up of following components in weight percentage: diclazuril 50%, polyvinylpyrrolidone (k30) 49.5%, sodium sulfite 0.5%.
The preparation method of the diclazuril soluble powder of present embodiment is: get sodium sulfite according to proportioning and add the suitable quantity of water dissolving, the polyvinylpyrrolidone and the adequate amount of ethanol that add formula ratio again, heated and stirred makes it dissolving, after 50 ℃, add diclazuril, the regulator solution pH value is 8.7, and ethanol, lyophilization are reclaimed in distilling under reduced pressure, pulverize, make the diclazuril soluble powder.
Embodiment 2
The diclazuril soluble powder of present embodiment, form by following components in weight percentage: diclazuril 59%, polyvinylpyrrolidone (k30) 39%, sodium sulfite 1%, EDTA-2Na 1%.
The preparation method of the diclazuril soluble powder of present embodiment is: get sodium sulfite and EDTA-2Na according to proportioning and add the suitable quantity of water dissolving, the polyvinylpyrrolidone and the adequate amount of ethanol that add formula ratio again, heated and stirred makes it dissolving, after 60 ℃, add diclazuril, the regulator solution pH value is 8.0, and ethanol, lyophilization are reclaimed in distilling under reduced pressure, pulverize, make the diclazuril soluble powder.
Embodiment 3
The diclazuril soluble powder of present embodiment is made up of following components in weight percentage: diclazuril 69.5%, polyvinylpyrrolidone (k30) 30%, sodium thiosulfate 0.5%.
The preparation method of the diclazuril soluble powder of present embodiment is: get sodium thiosulfate according to proportioning and add the suitable quantity of water dissolving, the polyvinylpyrrolidone and the adequate amount of ethanol that add formula ratio again, heated and stirred makes it dissolving, after 70 ℃, add diclazuril, the regulator solution pH value is 9.5, and ethanol, lyophilization are reclaimed in distilling under reduced pressure, pulverize, make the diclazuril soluble powder.
Embodiment 4
The diclazuril soluble powder of present embodiment is made up of following components in weight percentage: diclazuril 65%, polyvinylpyrrolidone (k30) 34%, sodium sulfite 1%.
The preparation method of the diclazuril soluble powder of present embodiment is: get sodium sulfite according to proportioning and add the suitable quantity of water dissolving, the polyvinylpyrrolidone and the adequate amount of ethanol that add formula ratio again, heated and stirred makes it dissolving, after 70 ℃, add diclazuril, the regulator solution pH value is 9.5, and ethanol, lyophilization are reclaimed in distilling under reduced pressure, pulverize, make the diclazuril soluble powder.
The raw material that relates among the embodiment 1-4 is commercially available product.
Embodiments of the invention are the non-limiting technical scheme of the present invention in order to explanation only; wherein antioxidant can also adopt sodium thiosulfate and edta salt class to use jointly; wherein the edta salt class can also adopt the EDTA calcium salt; this all is the replacement that is equal to technical scheme of the present invention; be conspicuous for those skilled in the art, should fall into protection scope of the present invention.
Claims (1)
1. a diclazuril soluble powder is characterized in that: be made up of following components in weight percentage: diclazuril 50～69.5%, polyvinylpyrrolidone 30～49.5%, antioxidant 0.5～2%; Described antioxidant is a kind of or its combination in any of sodium sulfite, sodium thiosulfate, edta salt apoplexy due to endogenous wind; Its preparation method is as follows: get antioxidant and be dissolved in water, add ethanol and polyvinylpyrrolidone heating for dissolving again, in 50-70 ℃ of adding diclazuril, the regulator solution pH value is 8.0-9.5, reclaims ethanol, and drying is pulverized, and makes the diclazuril soluble powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2009100659427A CN101669911B (en) | 2009-08-26 | 2009-08-26 | Dicazuril soluble powder and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100659427A CN101669911B (en) | 2009-08-26 | 2009-08-26 | Dicazuril soluble powder and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101669911A CN101669911A (en) | 2010-03-17 |
| CN101669911B true CN101669911B (en) | 2011-09-28 |
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| CN2009100659427A Expired - Fee Related CN101669911B (en) | 2009-08-26 | 2009-08-26 | Dicazuril soluble powder and preparation method thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670616B (en) * | 2012-05-25 | 2013-07-03 | 鼎正动物药业（天津）有限公司 | Novel diclazuril preparation and preparation method thereof |
| CN105534912A (en) * | 2014-10-31 | 2016-05-04 | 瑞普（天津）生物药业有限公司 | High-stability valnemulin hydrochloride soluble powder and uses thereof |
| CN105708856B (en) * | 2016-03-17 | 2018-08-07 | 广州格雷特生物科技有限公司 | It is a kind of to be used to prevent pharmaceutical composition and its preparation of the chicken coccidiasis containing attapulgite |
| CN106377509A (en) * | 2016-10-10 | 2017-02-08 | 朱隆娅 | Diclazuril granules and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004585A (en) * | 1996-02-05 | 1999-12-21 | Bayer Aktiengesellschaft | Granular composition of a triazine compound |
| CN101152184A (en) * | 2007-09-06 | 2008-04-02 | 浙江大学 | Diclazuril effervescence patch for birds |
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2009
- 2009-08-26 CN CN2009100659427A patent/CN101669911B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004585A (en) * | 1996-02-05 | 1999-12-21 | Bayer Aktiengesellschaft | Granular composition of a triazine compound |
| CN101152184A (en) * | 2007-09-06 | 2008-04-02 | 浙江大学 | Diclazuril effervescence patch for birds |
Non-Patent Citations (3)
| Title |
|---|
| 戴述诚.地克珠利可溶性粉的简化制备及检测.《中国动物保健》.2004,第40页第1.1栏至1.2栏. * |
| 邱家军等.0. 5 %地克珠利可溶性粉的制备及检测.《中国兽药杂志》.2003,第37卷(第1期),第24页第1.1栏至第1.2栏. * |
| 马小平等.地克珠利可溶性粉的工艺研究.《兽药与饲料添加剂》.2004,第9卷(第6期),第18页第1.2栏. * |
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| CN101669911A (en) | 2010-03-17 |
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Address after: 451162 Zhengzhou economic comprehensive experimentation area, Zhengzhou air port, Henan, Xingang Province Patentee after: Henan Hou Yi Industry Group Co., Ltd. Address before: 451161, Henan, Zhengzhou, Zhengzhou air port, Xingang Avenue East Patentee before: Zhengzhou Houyi Pharmaceutical Co., Ltd. |
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Granted publication date: 20110928 Termination date: 20170826 |