CN105560446A - Medicinal preparation for preventing and curing mycoplasmosis of livestock and improving non-specific immunity and preparing method of medicinal preparation - Google Patents

Medicinal preparation for preventing and curing mycoplasmosis of livestock and improving non-specific immunity and preparing method of medicinal preparation Download PDF

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Publication number
CN105560446A
CN105560446A CN201610117166.0A CN201610117166A CN105560446A CN 105560446 A CN105560446 A CN 105560446A CN 201610117166 A CN201610117166 A CN 201610117166A CN 105560446 A CN105560446 A CN 105560446A
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parts
medicinal preparation
livestock
preparation
specific immunity
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CN201610117166.0A
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Inventor
黄静
周盛昌
肖丽萍
戴多亮
温庆琪
梁世仁
艾春香
吴有林
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Jiangxi Aoxin Biotechnology Co Ltd
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Jiangxi Aoxin Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004Monosaccharides having only carbon, hydrogen and oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/70Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Fodder In General (AREA)

Abstract

The invention discloses a medicinal preparation for preventing and curing mycoplasmosis of livestock and improving non-specific immunity. The medicinal preparation is prepared from the following materials in parts by weight: 15-30 parts of tilmicosin, 4-10 parts of epimedium folium, 4-10 parts of radix bupleuri, 8-18 parts of folium eriobotryae, 3-6 parts of fructo-oligose, 20-30 parts of medical stone and 15-25 parts of anhydrous dextrose. The invention further discloses a preparing method of the medicinal preparation. According to the medicinal preparation, all the components of the medicinal preparation are compatible and have the effects of promoting the tilmicosin to repair immune cells and improving the functions of the immune cells. Meanwhile, the growth of normal flora in intestines is protected and promoted, and the organism immunity function is enhanced. In addition, the preparing method is convenient to operate and easy to popularize and apply.

Description

A kind ofly prevent and treat the sick and pharmaceutical preparation improving non-specific immunity and preparation method thereof of livestock and poultry mycoplasma
Technical field
The present invention relates to the technical field of veterinary drug preparation, refer in particular to a kind of livestock and poultry mycoplasma of preventing and treating sick and improve the pharmaceutical preparation of non-specific immunity, relevant with preparation method with its formula.
Background technology
In recent years; along with the large-scale development of livestock and poultry breeding industry, introduce a fine variety frequently between different regions, country, various diseases day by day increases and the state of an illness becomes increasingly complex; especially the disease that causes of mycoplasma infection; almost throughout each plant, this sick mortality rate is very low, even can be not dead; but have a strong impact on the speed of growth or cause growth retardation; greatly reduce feed conversion rate, aquaculture cost is significantly increased, be a great problem in livestock and poultry cultivation production process for a long time always.Though have corresponding vaccine as one of preventive measure, because of a variety of causes, antibody horizontal is very undesirable.At present, except vaccine, conventional prophylactico-therapeutic measures is antibiotic, though obtain certain effect.But, its side effect unavoidable again: immunosuppressant and suppress the growth of profitable strain in intestinal.On the one hand, when making the poultry after medication carry out vaccine immunity, the antibody horizontal of generation is poor, even immuning failure; On the other hand, the profitable strain in animal and bird intestines is grown suppressed, upset intestinal to the absorption of nutrient substance and utilization, thus reduce feed conversion rate; In addition, after medication, though mycoplasma infection symptom alleviates, the function such as feed intake, gastrointestinal function is not also recovered in time, and the growth promoter of young stock fowl is obstructed, and increases aquaculture cost.
Summary of the invention
For solving the problem; the object of the present invention is to provide a kind of livestock and poultry mycoplasma of preventing and treating sick and improve the pharmaceutical preparation of non-specific immunity; the mutual compatibility of pharmaceutical preparation each component of the present invention has the effect promoting tilmicosin reparation immunocyte; strengthen its effect; protect simultaneously and promote the growth of enteral normal flora, enhancing human body immunity function.
The present invention also aims to provide a kind of livestock and poultry mycoplasma of preventing and treating sick and improve the preparation method of the pharmaceutical preparation of non-specific immunity.
For reaching above-mentioned purpose, solution of the present invention is:
Prevent and treat livestock and poultry mycoplasma sick and improve the pharmaceutical preparation of non-specific immunity, formulated by weight by following compatibility: tilmicosin 15-30 part, Herba Epimedii 4-10 part, Radix Bupleuri 4-10 part, Folium Eriobotryae 8-18 part, oligofructose 3-6 part, Maifanitum 20-30 part, anhydrous glucose 15-25 part.Wherein, Folium Eriobotryae is the cured leaf dried at dry place, below water content 5wt%.
Prevent and treat livestock and poultry mycoplasma sick and improve the preparation method of the pharmaceutical preparation of non-specific immunity, comprise the following steps:
Step one, takes Herba Epimedii, Radix Bupleuri, Folium Eriobotryae, oligofructose, Maifanitum, micronizing, crosses 150 mesh sieves, makes adjuvant;
Step 2, takes tilmicosin and fully mixs homogeneously with step one gained adjuvant;
Step 3, takes anhydrous glucose, stirs together with step 2 mixture, obtains pharmaceutical preparation of the present invention.
Adopt after such scheme, the present invention is a kind of to be prevented and treated the sick and pharmaceutical preparation improving non-specific immunity of livestock and poultry mycoplasma and is made up of Western medicine component and adjuvant component, and wherein, the existing sterilization of western medicine composition, antibacterial action, have again the effect of repairing immunocyte; Specially good effect is had to the livestock and poultry that mycoplasma etc. causes; Adjuvant composition has heat-clearing and toxic substances removing; pathogenic bacterium in absorption intestinal and toxin; protection intestinal mucosa; for intestinal beneficial microbes flora provides trophic factors, safeguards the ecological balance of intestinal beneficial flora; regulate poultry gastrointestinals function, improve the anti-stress ability of poultry, Promote immunity cell proliferation, strengthen the effect such as immunologic function of poultry.Therefore, compared with prior art, have the following advantages:
One, there is complementary facilitation in adjuvant of the present invention and the mutual compatibility of Western medicine, have efficient, quick-acting, safeguard the effects such as enteral microecological balance, Promote immunity cell proliferation, enhancing human body immunity power;
Two, the adjuvant composition of employing, the pathogenic bacterium in absorption intestinal and toxin, protection intestinal mucosa, safeguards the ecological balance of intestinal beneficial flora, promotes immune cell propagation, improves the anti-stress ability of poultry, safe and reliable;
Three, reduce antibiotic to the interference effect of intestinal beneficial flora, remarkable to the sick prevention effect of livestock and poultry mycoplasma;
Four, there is the effect of unique raising body non-specific immunity.
Meanwhile, a kind ofly prevent and treat that livestock and poultry mycoplasma is sick and to improve the preparation method of the pharmaceutical preparation of non-specific immunity easy, easily apply.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment one
Prevent and treat livestock and poultry mycoplasma sick and improve the pharmaceutical preparation of non-specific immunity, formulated by weight by following compatibility: tilmicosin 15 parts, Herba Epimedii 4 parts, Radix Bupleuri 4 parts, Folium Eriobotryae 8 parts, oligofructose 3 parts, Maifanitum 20 parts, anhydrous glucose 15 parts.
Prevent and treat livestock and poultry mycoplasma sick and improve the preparation method of the pharmaceutical preparation of non-specific immunity, comprise the following steps:
One, take Herba Epimedii, Radix Bupleuri, Folium Eriobotryae, oligofructose, Maifanitum, micronizing, cross 150 mesh sieves, make adjuvant;
Two, take tilmicosin and fully mix homogeneously with step one gained adjuvant;
Three, take anhydrous glucose, stir together with step 2 mixture, obtain pharmaceutical preparation of the present invention.
Embodiment two
Prevent and treat livestock and poultry mycoplasma sick and improve the pharmaceutical preparation of non-specific immunity, formulated by weight by following compatibility: tilmicosin 15 parts, Herba Epimedii 4 parts, Radix Bupleuri 10 parts, Folium Eriobotryae 18 parts, oligofructose 6 parts, Maifanitum 20 parts, anhydrous glucose 30 parts.
Prevent and treat livestock and poultry mycoplasma sick and improve the preparation method of the pharmaceutical preparation of non-specific immunity, comprise the following steps:
One, take Herba Epimedii, Radix Bupleuri, Folium Eriobotryae, oligofructose, Maifanitum, micronizing, cross 150 mesh sieves, make adjuvant;
Two, take tilmicosin and fully mix homogeneously with step one gained adjuvant;
Three, take anhydrous glucose, stir together with step 2 mixture, obtain pharmaceutical preparation of the present invention.
Embodiment three
Prevent and treat livestock and poultry mycoplasma sick and improve the pharmaceutical preparation of non-specific immunity, formulated by weight by following compatibility: tilmicosin 30 parts, Herba Epimedii 10 parts, Radix Bupleuri 4 parts, Folium Eriobotryae 8 parts, oligofructose 5 parts, Maifanitum 25 parts, anhydrous glucose 28 parts.
Prevent and treat livestock and poultry mycoplasma sick and improve the preparation method of the pharmaceutical preparation of non-specific immunity, comprise the following steps:
One, take Herba Epimedii, Radix Bupleuri, Folium Eriobotryae, oligofructose, Maifanitum, micronizing, cross 150 mesh sieves, make adjuvant;
Two, take tilmicosin and fully mix homogeneously with step one gained adjuvant;
Three, take anhydrous glucose, stir together with step 2 mixture, obtain pharmaceutical preparation of the present invention.
Embodiment four
Prevent and treat livestock and poultry mycoplasma sick and improve the pharmaceutical preparation of non-specific immunity, formulated by weight by following compatibility: tilmicosin 20 parts, Herba Epimedii 8 parts, Radix Bupleuri 6 parts, Folium Eriobotryae 12 parts, oligofructose 5 parts, Maifanitum 25 parts, anhydrous glucose 20 parts.
Prevent and treat livestock and poultry mycoplasma sick and improve the preparation method of the pharmaceutical preparation of non-specific immunity, comprise the following steps:
One, take Herba Epimedii, Radix Bupleuri, Folium Eriobotryae, oligofructose, Maifanitum, micronizing, cross 150 mesh sieves, make adjuvant;
Two, take tilmicosin and fully mix homogeneously with step one gained adjuvant;
Three, take anhydrous glucose, stir together with step 2 mixture, obtain pharmaceutical preparation of the present invention.
Below for the present invention prevents and treats the sick result of the test of livestock and poultry mycoplasma:
One, the experiment of prevention livestock and poultry mycoplasma disease
Through the pig farm that test in laboratory mycoplasma is positive, random choose kind is identical, health status is close, it is consistent with management condition to raise, piglets 180 that is about 60 ages in days, be divided into 6 groups at random, be respectively test A, B, C, D, drug control group, matched group, often organize 30.Wherein, the preparation of the A group mixed feeding embodiment of the present invention one is tested; The preparation of the test B group mixed feeding embodiment of the present invention two; The preparation of the test C group mixed feeding embodiment of the present invention three, the preparation of the test D group mixed feeding embodiment of the present invention four, drug control group mixed feeding tilmicosin soluble powder (20% tilmicosin, adjuvant is anhydrous glucose), often organize and all add corresponding medicine 1kg/ ton feedstuff, feed continuously 5; Matched group does not add any medicine.
After above medicine is mixed homogeneously with basal diet, take cafeteria feeding mode, every morning 8 point, observation at 8 in evening, record piglets breathes, status of cough and death toll, Continuous Observation 30 days, off-test.Result of the test is in table 1.
Equally, the same in the test method of certain macro rearing chicken field, result of the test is in table 2.
Test method: feed in advance under the same terms one week, weigh in the morning on an empty stomach, and keep a record.Start test, medicine 1kg/ ton feedstuff of the present invention, matched group does not add medicine, feeds continuously 5, every day viewing test pig clinical change, line item of going forward side by side.1 month experimental period, terminated, and weighed.
Curative effect judging standard: slight, for poultry have obvious and continuous 3 times within sneeze or cough.
Moderate, for poultry have obvious and the sneeze of continuous more than 3 times or cough.
Seriously, obviously for poultry have cough and pant continuously, and it is serious to become thin.
Clinical test results is as follows: test group, a situation arises for matched group respiratory tract disease
Table 1 pharmaceutical preparation of the present invention is to the preventive effect of porcine mycoplasmal disease
Respiratory symptom A group B group C group D group Drug control group Matched group
Test pig number 30 30 30 30 30 30
Nothing 27 28 30 29 17 10
Slightly 2 2 0 1 5 7
Moderate 1 0 0 0 5 8
Seriously 0 0 0 0 3 5
Sickness rate % 11.11 6.67 0 3.33 43.33 66.67
Table 2 pharmaceutical preparation of the present invention is to the preventive effect of mycoplasma gallinarum disease
Respiratory symptom A group B group C group D group Drug control group Matched group
Test chicken number 50 50 50 50 50 50
Nothing 47 50 49 29 13
Slightly 3 3 0 1 10 10
Moderate 1 0 0 0 6 12
Seriously 0 0 0 0 5 15
Sickness rate % 8.00 6.00 0 2.00 42.00 74.00
By observing, use the test pig of pharmaceutical preparation of the present invention, the overall mental status of chicken, diet situation to be better than similar drugs matched group and matched group, the sickness rate of respiratory tract disease is also starkly lower than similar drugs matched group and matched group.
Two, the experiment for the treatment of porcine mycoplasmal disease
Test drug: the embodiment of the present invention three pharmaceutical preparation, control drug (above-mentioned tilmicosin soluble powder preparation).
Experimental animal: natural occurrence, have breathe, the piglets of symptom of coughing, be positive through test in laboratory mycoplasma.Random choose kind is identical, raising is consistent with management condition, occurs the piglets 60 breathed, symptom of coughing is close, is divided into 3 groups at random, is respectively A, B, C group, often organizes 20.Wherein, the preparation of the test A group mixed feeding embodiment of the present invention three, test B group mixed feeding control drug preparation, often organize and all add corresponding medicine 1kg/ ton feedstuff, feed continuously 5, test C group is that morbidity matched group does not add any medicine, selects 20 else and makes normal healthy controls group.
After above medicine is mixed homogeneously with basal diet, take cafeteria feeding mode, every morning 8 point, observation at 8 in evening, record pig breathes, status of cough and death toll, Continuous Observation 20 days, off-test.
Weigh on an empty stomach before dispensing, and keep a record.Start test, medicine 1kg/ ton feedstuff of the present invention, morbidity matched group do not add medicine, feed continuously 5, every day viewing test pig clinical change, line item of going forward side by side.Experimental period on the 20th, terminates, and weighs.
Index of assessment of curative effect: mortality rate=dead pig/test pig number × 100%;
Cure rate=pig cures number/test pig number × 100%;
Relative growth rate=respectively organize weightening finish/health group weightening finish × 100%, result of the test is in table 3.
The test method for the treatment of respiratory disease of chicken: often group is 50, other method is with the test method of pig, and result of the test is in table 4.
Table 3 medicine of the present invention is to the sick therapeutic effect of porcine mycoplasmal
Group Experimental animal head number (head) Mortality rate/% Cure rate/% Weightening finish (kg) in 15 days Relative growth rate/%
Test A group 20 0 100 6.56±1.19 93.98
Test B group 20 2 90 4.0±1.12 57.3
Normal healthy controls group 20 0 6.98±1.05 100
Morbidity matched group 20 6 1.56±0.12 22.35
Table 4 medicine of the present invention is to the sick therapeutic effect of mycoplasma gallinarum
Group Test chicken (head) Mortality rate/% Cure rate/% Weightening finish (kg) in 15 days Relative growth rate/%
Test A group 50 0 100 8.25±1.19 94.18
Test B group 50 6 88 4.11±1.12 46.92
Normal healthy controls group 50 0 8.76±1.05 100
Morbidity matched group 50 18 2.31±0.12 26.37
From table 3, table 4, pharmaceutical preparation of the present invention, compared with similar drugs preparation, has significant curative effect to treatment livestock and poultry mycoplasma disease; And after curing, speed of weight increment recovers very fast.Consider from preparation cost, embodiment three is best of breed of the present invention.

Claims (2)

1. prevent and treat livestock and poultry mycoplasma sick and improve the pharmaceutical preparation of non-specific immunity, it is characterized in that: formulated by weight by following compatibility: tilmicosin 15-30 part, Herba Epimedii 4-10 part, Radix Bupleuri 4-10 part, Folium Eriobotryae 8-18 part, oligofructose 3-6 part, Maifanitum 20-30 part, anhydrous glucose 15-25 part.
2. a kind of livestock and poultry mycoplasma of preventing and treating as claimed in claim 1 is sick and improve the pharmaceutical preparation of non-specific immunity, it is characterized in that preparation method comprises the following steps:
Step one, takes Herba Epimedii, Radix Bupleuri, Folium Eriobotryae, oligofructose, Maifanitum, micronizing, crosses 150 mesh sieves, makes adjuvant;
Step 2, takes tilmicosin and fully mixs homogeneously with step one gained adjuvant;
Step 3, takes anhydrous glucose, stirs, obtain pharmaceutical preparation together with step 2 mixture.
CN201610117166.0A 2016-03-02 2016-03-02 Medicinal preparation for preventing and curing mycoplasmosis of livestock and improving non-specific immunity and preparing method of medicinal preparation Pending CN105560446A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105902639A (en) * 2016-06-16 2016-08-31 福建傲农生物科技集团股份有限公司 Pharmaceutical preparation for prevention and treatment of chronic respiratory diseases of livestock and poultry and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103006892A (en) * 2012-12-28 2013-04-03 北京大北农动物保健科技有限责任公司 Medicine composition for preventing and treating porcine viral diseases, and premix and batch with composition
CN104083729A (en) * 2014-07-31 2014-10-08 刘吉山 Medicine for preventing and treating mixed infection of fur-bearing animals as well as preparation method and application of medicine
CN104523888A (en) * 2014-12-25 2015-04-22 北京资源亚太饲料科技有限公司 Pharmaceutical composition for preventing and treating respiratory tract diseases of poultry and preparation method and application of pharmaceutical composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103006892A (en) * 2012-12-28 2013-04-03 北京大北农动物保健科技有限责任公司 Medicine composition for preventing and treating porcine viral diseases, and premix and batch with composition
CN104083729A (en) * 2014-07-31 2014-10-08 刘吉山 Medicine for preventing and treating mixed infection of fur-bearing animals as well as preparation method and application of medicine
CN104523888A (en) * 2014-12-25 2015-04-22 北京资源亚太饲料科技有限公司 Pharmaceutical composition for preventing and treating respiratory tract diseases of poultry and preparation method and application of pharmaceutical composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105902639A (en) * 2016-06-16 2016-08-31 福建傲农生物科技集团股份有限公司 Pharmaceutical preparation for prevention and treatment of chronic respiratory diseases of livestock and poultry and preparation method thereof

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Application publication date: 20160511