CN101011408A - Animal-used compound preparation for treating parasitic disease in or out of livestock and fowl body and preparation method thereof - Google Patents
Animal-used compound preparation for treating parasitic disease in or out of livestock and fowl body and preparation method thereof Download PDFInfo
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- CN101011408A CN101011408A CNA2007100514236A CN200710051423A CN101011408A CN 101011408 A CN101011408 A CN 101011408A CN A2007100514236 A CNA2007100514236 A CN A2007100514236A CN 200710051423 A CN200710051423 A CN 200710051423A CN 101011408 A CN101011408 A CN 101011408A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention relates to a method for preparing animal composite agent which can be used to treat parasitism of animal. The inventive agent comprises main drug and findings, wherein, the main drug is formed by two of following materials as 2-10 deals of edeine, 2-10 deals of avermectin, 50-250 deals of abendazole, 50-250 deals of bisbendazole, 50-250 deals of aofenzole, and 50-250 deals of alcaine decaris; and the findings are prepared from one or two of following materials as 1-2 deals of anti-oxidant, 0.1-0.2 deals of metal complex builder, 740-950 deals of injection dissolvent, 740-950 deals of stuff, 50-200 deals of disintegration agent, 10-50 deals of adhesive and 3-60 deals of lubricant. The invention develops a novel animal agent for treating the parasitism, while it all uses relative high-effect drugs, with stable agent, long storage time, controllable quality and accurate agent consumption.
Description
Technical field
The present invention relates to a kind of animal-used compound preparation and preparation technology thereof who treats parasitic disease in or out of livestock and fowl body.
Background technology
The hazardness of verminosis of animal is very big, not only has a strong impact on the growth of animal rate, and makes livestock products downgrade such as breast, meat, hair, leather, and quantity reduces.Some infecting both domestic animals and human parasitic disease can also directly threaten human beings'health and life security.The verminosis of animal treatment is untimely, can cause large quantities of domestic animal death, causes the tremendous economic loss to the raiser.At present, veterinary clinic is used for the treatment of the verminosis of animal medicine and is generally single preparations of ephedrine, and pest-resistant spectrum is narrower.Because the parasitic disease of poultry is most to belong to mixed infection, the parasite mixed infection of some or even different genera, thereby only can not satisfy the veterinary clinic needs to single or the effective antiparasitic of minority worm kind.For this reason, it is of crucial importance to develop a kind of broad-spectrum anti-parasite medicine.With two kinds in medicine ivermectin, avilamycin, Albendazole, Phenbendasol, oxfendazole, the levamisole hydrochloride be the new veterinary drug compound preparation that primary raw material is made, to gastrointestinal tract nematicide, taeniasis, trematodiasis in the treatment poultry body; External warble, grain leather fly larvae; Parasitic disease effects such as sheep nose fly larvae, psoroptes communis disease and Sarcoptes suis disease are remarkable.
Summary of the invention
The purpose of this invention is to provide a kind of animal-used compound preparation for the treatment of parasitic disease in or out of livestock and fowl body, dosage form comprises dosage forms such as injection, tablet, powder.
Another object of the present invention provides a kind of preparation technology who treats the animal-used compound preparation of parasitic disease in or out of livestock and fowl body, comprises the preparation technology of dosage forms such as injection, tablet, powder.
The present invention is achieved like this, it comprises principal agent and adjuvant, and wherein principal agent is formulated by two kinds in the following raw materials in part by weight medicine: ivermectin 2～10, avilamycin 2～10, Albendazole 50～250, Phenbendasol 50～250, oxfendazole 50～250, levamisole hydrochloride 50～250; Wherein adjuvant is formulated by following substances in parts by weight: antioxidant 1～2, metal chelating agent 0.1～0.2, solvent for injection 740～950, filler 740～950, disintegrating agent 50～200, binding agent 10～50, lubricant 3～60.
Described antioxidant is that in sodium sulfite, sodium sulfite, sodium formaldehyde sulphoxylate, the sodium thiosulfate one or more are used; Metal chelating agent is a disodiumedetate; Solvent for injection is that in propylene glycol, glycerol, glycerin methylal, the water for injection one or more are used; Filler is that in starch, dextrin, lactose, the calcium carbonate etc. one or more are used; Disintegrating agent is that in starch, the carboxymethyl cellulose etc. one or both are used; Binding agent is that in starch, dextrin, sodium carboxymethyl cellulose, the low-substituted hydroxypropyl cellulose etc. one or more are used; Lubricant is that in magnesium stearate, the Pulvis Talci one or both are used.
Preparation technology of the present invention is: (1) process for preparation of injection: take by weighing two kinds of medicines in recipe quantity ivermectin, avilamycin, Albendazole, Phenbendasol, oxfendazole, the levamisole hydrochloride, add in an amount of solvent for injection stirring and dissolving, add recipe quantity antioxidant, metal chelating agent again, stirring and dissolving is added solvent for injection to full dose, regulate pH value, filter embedding, sterilized 30 minutes for 100 ℃, cooling, lamp inspection, lettering, packing, promptly; (2) tablet producing technology: respectively with ivermectin, avilamycin, the Albendazole, the Phenbendasol, the oxfendazole, levamisole hydrochloride is pulverized, cross 100 mesh sieves, standby, take by weighing recipe quantity binding agent adjuvant, add purified water and be mixed with 10% solution in right amount, as binding agent, standby, take by weighing the recipe quantity ivermectin, avilamycin, the Albendazole, the Phenbendasol, the oxfendazole, two kinds of fine drug powders in the levamisole hydrochloride and filler, disintegrating agent, the method mix homogeneously that increases progressively with equivalent, add binding agent and make soft material, granulate oven dry, granulate, add the recipe quantity lubricant, mixing, tabletting, check, packing, promptly; (3) powder preparation technology: respectively ivermectin, avilamycin, Albendazole, Phenbendasol, oxfendazole, levamisole hydrochloride are pulverized, cross 80 mesh sieves, standby, take by weighing two kinds of fine drug powders and filler in recipe quantity ivermectin, avilamycin, Albendazole, Phenbendasol, oxfendazole, the levamisole hydrochloride, the method mix homogeneously that increases progressively with equivalent, check, packing, promptly.
The animal-used compound preparation of the treatment parasitic disease in or out of livestock and fowl body of the present invention's development includes two kinds of pharmaceutical compositions in ivermectin, avilamycin, Albendazole, Phenbendasol, oxfendazole, the levamisole hydrochloride.Wherein ivermectin, avilamycin are novel wide spectrum, efficient, low toxicity antiparasitic, are used to prevent and treat sick and other parasitic insect diseases of gastrointestinal tract of livestock and fowls nematicide, warble, grain leather fly larvae, sheep nose fly larvae, psoroptes communis disease and Sarcoptes suis; Albendazole, Phenbendasol, oxfendazole are used for poultry nematicide, taeniasis and trematodiasis; Levamisole hydrochloride is mainly used to treat gastrointestinal tract of livestock and fowls nematicide, hoose and stephanurosis of swine.
Advantage of the present invention is: (1) develops a kind of veterinary drug novel formulation for the treatment of parasitic disease in or out of livestock and fowl body for veterinary clinic; (2) reasonable recipe, selected medicine are the efficient medicine of treatment verminosis of animal; (3) production technology advanced person, preparation stabilization, storage period is long; (4) safe in utilization, determined curative effect, quality controllable; (5) dosage is accurate, and is easy to use.
The specific embodiment
Embodiment one (injection)
Ivermectin 2g levamisole hydrochloride 50g
Preparation method of the present invention: take by weighing recipe quantity ivermectin, levamisole hydrochloride respectively, add in an amount of solvent for injection stirring and dissolving, add recipe quantity antioxidant, metal chelating agent again, stirring and dissolving is added solvent for injection to full dose, regulate pH value, filter embedding, sterilized 30 minutes for 100 ℃, cooling, lamp inspection, lettering, packing, promptly.
Embodiment two (injection)
Avilamycin 5g levamisole hydrochloride 125g
Preparation method of the present invention: take by weighing recipe quantity ivermectin, levamisole hydrochloride respectively, add in an amount of solvent for injection stirring and dissolving, add recipe quantity antioxidant, metal chelating agent again, stirring and dissolving is added solvent for injection to full dose, regulate pH value, filter embedding, sterilized 30 minutes for 100 ℃, cooling, lamp inspection, lettering, packing, promptly.
Embodiment three (tablet)
Avilamycin 2g Albendazole 50g
Preparation method of the present invention: respectively avilamycin, Albendazole are pulverized, cross 100 mesh sieves, standby, take by weighing the recipe quantity binding agent, add purified water and be mixed with 10% solution in right amount, as binding agent, standby, take by weighing recipe quantity avilamycin, Albendazole's fine powder and starch, dextrin, carboxymethyl cellulose,, add binding agent and make soft material with the method mix homogeneously that equivalent increases progressively, granulate oven dry, granulate, add recipe quantity magnesium stearate, Pulvis Talci, mixing, tabletting, check, packing, promptly.
Embodiment four (tablet)
Avilamycin 5g oxfendazole 125g
Preparation method of the present invention: respectively avilamycin, oxfendazole are pulverized, cross 100 mesh sieves, standby, take by weighing the recipe quantity binding agent, add purified water and be mixed with 10% solution in right amount, as binding agent, standby, take by weighing recipe quantity avilamycin, oxfendazole's fine powder and starch, dextrin, carboxymethyl cellulose,, add binding agent and make soft material with the method mix homogeneously that equivalent increases progressively, granulate oven dry, granulate, add recipe quantity magnesium stearate, Pulvis Talci, mixing, tabletting, check, packing, promptly.
Embodiment five (tablet)
Avilamycin 10g Phenbendasol 250g
Preparation method of the present invention: respectively avilamycin, Phenbendasol are pulverized, cross 100 mesh sieves, standby, take by weighing the recipe quantity binding agent, add purified water and be mixed with 10% solution in right amount, as binding agent, standby, take by weighing recipe quantity avilamycin, Phenbendasol's fine powder and starch, dextrin, carboxymethyl cellulose,, add binding agent and make soft material with the method mix homogeneously that equivalent increases progressively, granulate oven dry, granulate, add recipe quantity magnesium stearate, Pulvis Talci, mixing, tabletting, check, packing, promptly.
Embodiment six (powder)
Avilamycin 2g Phenbendasol 50g
Preparation method of the present invention: respectively avilamycin, Phenbendasol are pulverized, cross 80 mesh sieves, standby, take by weighing recipe quantity avilamycin, Phenbendasol's fine powder and starch, calcium carbonate, with the method mix homogeneously that equivalent increases progressively, check, packing, promptly.
Embodiment six (powder)
Avilamycin 5g Albendazole 125g
Preparation method of the present invention: respectively avilamycin, Albendazole are pulverized, cross 80 mesh sieves, standby, take by weighing recipe quantity avilamycin, Albendazole's fine powder and starch, calcium carbonate, with the method mix homogeneously that equivalent increases progressively, check, packing, promptly.
Embodiment seven (powder)
Avilamycin 10g Phenbendasol 250g
Preparation method of the present invention: respectively avilamycin, Phenbendasol are pulverized, cross 80 mesh sieves, standby, take by weighing recipe quantity avilamycin, Phenbendasol's fine powder and starch, calcium carbonate, with the method mix homogeneously that equivalent increases progressively, check, packing, promptly.
Result of study
1. animal-used compound preparation main pharmacodynamics research of the present invention
Animal-used compound preparation of the present invention is made up of two kinds of medicines in ivermectin, avilamycin, Albendazole, Phenbendasol, oxfendazole, the levamisole hydrochloride.Wherein ivermectin, avilamycin are novel wide spectrum, efficient, low toxicity antiparasitic, its mechanism of action is to promote presynaptic neuron to discharge y-aminobutyric acid (GABA), thereby open the chloride channel of GABA mediation, strengthen neurolemma to the CL-permeability, disturb the signal transmission between neuromuscular, make the loose paralysis of polypide, cause polypide dead or be excreted, be used to prevent and treat sick and other parasitic insect diseases of gastrointestinal tract of livestock and fowls nematicide, warble, grain leather fly larvae, sheep nose fly larvae, psoroptes communis disease and Sarcoptes suis; Albendazole, Phenbendasol, oxfendazole are the novel benzimidazoles anthelmintic of wide spectrum, efficient, low toxicity, medicine can combine with parasite cell tubulin, particularly combine with the dimer tubulin, thereby overslaugh the polymerization of tubulin in the microtubule assembling process, in addition, to the high selectivity effect of polypide, and performance is efficient, the parasiticide effect of low toxicity; Its Albendazole of levamisole hydrochloride, Phenbendasol, oxfendazole are used for poultry nematicide, taeniasis and trematodiasis; Parasympathetic and sympathetic ganglion that its anthelmintic action mechanism of levamisole hydrochloride is excited responsive anthelmintic, make polypide be in the neuromuscular depolarization of quiescent condition, cause that muscle continues contraction and causes paralysis, living worm body is discharged, be mainly used to treat gastrointestinal tract of livestock and fowls nematicide, hoose and stephanurosis of swine.Compound preparation of the present invention proves through clinical trial, and the curative effect of treatment parasitic disease in or out of livestock and fowl body obviously is better than the single preparations of ephedrine of its medicine.
2. the main pharmacokinetic studies of animal-used compound preparation of the present invention
The fine most tissues that is distributed to of energy after this product enters and absorbs in the body, apparent volume of distribution in animal body (Vd) is big, and the bioavailability height has the long half-life most of animals.This product is mainly discharged from feces.
3. the clinical application effect of animal-used compound preparation of the present invention
Animal-used compound preparation of the present invention is by implementing treatment to pig natural infection gastrointestinal tract nematicide case.The experimental animal grouping:
(1) the drug test group is established compound preparation low dose group, middle dosage group, high dose group respectively.
(2) medicine matched group single preparations of ephedrine matched group.
(3) positive controls infects not administration group
(4) the blank group does not infect not administration group
Show by clinical trial; animal-used compound preparation of the present invention can effectively be treated Gaster Sus domestica intestinal nematodes disease; alleviate it because of the various symptoms suffering from the gastrointestinal tract nematicide and rise and the degree of pathological changes; appetite and the spirit of protection pig are quickened its rehabilitation, its treatment gastrointestinal tract nematicide drug effect; compare with control drug; curative effect strengthens, and is better than similar folk prescription medicine, is the ideal medicament of treatment parasitic disease in or out of livestock and fowl body on the veterinary clinic.
Claims (3)
1, a kind of animal-used compound preparation for the treatment of parasitic disease in or out of livestock and fowl body, it comprises principal agent and adjuvant, it is characterized in that principal agent is formulated by two kinds in the following raw materials in part by weight medicine: ivermectin 2～10, avilamycin 2～10, Albendazole 50～250, Phenbendasol 50～250, oxfendazole 50～250, levamisole hydrochloride 50～250; Adjuvant is formulated by following substances in parts by weight: antioxidant 1～2, metal chelating agent 0.1～0.2, solvent for injection 740～950, filler 740～950, disintegrating agent 50～200, binding agent 10～50, lubricant 3～60.
2,, it is characterized in that described antioxidant is that in sodium sulfite, sodium sulfite, sodium formaldehyde sulphoxylate, the sodium thiosulfate one or more are used according to the animal-used compound preparation of claims 1 described treatment parasitic disease in or out of livestock and fowl body; Metal chelating agent is a disodiumedetate; Solvent for injection is that in propylene glycol, glycerol, glycerin methylal, the water for injection one or more are used; Filler is that in starch, dextrin, lactose, the calcium carbonate etc. one or more are used; Disintegrating agent is that in starch, the carboxymethyl cellulose etc. one or more are used; Binding agent is that in starch, dextrin, sodium carboxymethyl cellulose, the low-substituted hydroxypropyl cellulose etc. one or more are used; Lubricant is that in magnesium stearate, the Pulvis Talci one or both are used.
3, a kind of preparation technology of animal-used compound preparation of claims 1 described treatment parasitic disease in or out of livestock and fowl body, it comprises injection, tablet, the preparation technology of dosage forms such as powder, it is characterized in that processing step is: (1) process for preparation of injection: take by weighing the recipe quantity ivermectin, avilamycin, the Albendazole, the Phenbendasol, the oxfendazole, two kinds of medicines in the levamisole hydrochloride, add in an amount of solvent for injection, stirring and dissolving adds recipe quantity antioxidant again, metal chelating agent, stirring and dissolving, add solvent for injection to full dose, regulate pH value, filter embedding, sterilized 30 minutes for 100 ℃, cooling, lamp inspection, lettering, packing, promptly; (2) tablet producing technology: respectively with ivermectin, avilamycin, the Albendazole, the Phenbendasol, the oxfendazole, levamisole hydrochloride is pulverized, cross 100 mesh sieves, standby, take by weighing the recipe quantity binding agent, add purified water and be mixed with 10% solution in right amount, as binding agent, standby, take by weighing the recipe quantity ivermectin, avilamycin, the Albendazole, the Phenbendasol, the oxfendazole, two kinds of fine drug powders in the levamisole hydrochloride and starch, dextrin, carboxymethyl cellulose, the method mix homogeneously that increases progressively with equivalent, add binding agent and make soft material, granulate oven dry, granulate, add the recipe quantity magnesium stearate, Pulvis Talci, mixing, tabletting, check, packing, promptly; (3) powder preparation technology: respectively ivermectin, avilamycin, Albendazole, Phenbendasol, oxfendazole, levamisole hydrochloride are pulverized, cross 80 mesh sieves, standby, take by weighing a kind of in two kinds of fine drug powders in recipe quantity ivermectin, avilamycin, Albendazole, Phenbendasol, oxfendazole, the levamisole hydrochloride and starch, the calcium carbonate, the method mix homogeneously that increases progressively with equivalent, check, packing, promptly.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100514236A CN101011408A (en) | 2007-01-29 | 2007-01-29 | Animal-used compound preparation for treating parasitic disease in or out of livestock and fowl body and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007100514236A CN101011408A (en) | 2007-01-29 | 2007-01-29 | Animal-used compound preparation for treating parasitic disease in or out of livestock and fowl body and preparation method thereof |
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| CN101011408A true CN101011408A (en) | 2007-08-08 |
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| CNA2007100514236A Pending CN101011408A (en) | 2007-01-29 | 2007-01-29 | Animal-used compound preparation for treating parasitic disease in or out of livestock and fowl body and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283856A (en) * | 2011-06-30 | 2011-12-21 | 山东恩康药业有限公司 | Veterinary compound ivermectin liposome medicine and preparation method thereof |
| CN102743403A (en) * | 2012-06-26 | 2012-10-24 | 格特生物制药（天津）有限公司 | Parasite expelling tablet for domestic animals and preparation method thereof |
| CN103340884A (en) * | 2013-07-18 | 2013-10-09 | 成都乾坤动物药业有限公司 | Wettable fenbendazole ivermectin powder |
| CN106902206A (en) * | 2017-03-14 | 2017-06-30 | 滁州新源农业科技有限公司 | A kind of pulvis and preparation method for preventing and treating pig epidermis parasite |
| CN109223857A (en) * | 2018-11-23 | 2019-01-18 | 句容市茅山风景区鼎源畜禽养殖场 | A kind of knob raising goat preventing and treating verminosis medicament and preparation method thereof |
| CN110638761A (en) * | 2018-06-08 | 2020-01-03 | 上海莫息生物科技有限公司 | Avermemycin soluble powder and preparation method thereof |
| CN111514157A (en) * | 2020-05-13 | 2020-08-11 | 吉林吉力生物技术研究有限公司 | Application of composition in preparation of veterinary anti-parasitic drug, veterinary anti-parasitic transdermal solution and preparation method thereof |
-
2007
- 2007-01-29 CN CNA2007100514236A patent/CN101011408A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283856A (en) * | 2011-06-30 | 2011-12-21 | 山东恩康药业有限公司 | Veterinary compound ivermectin liposome medicine and preparation method thereof |
| CN102283856B (en) * | 2011-06-30 | 2012-11-21 | 山东恩康药业有限公司 | Veterinary compound ivermectin liposome medicine and preparation method thereof |
| CN102743403A (en) * | 2012-06-26 | 2012-10-24 | 格特生物制药（天津）有限公司 | Parasite expelling tablet for domestic animals and preparation method thereof |
| CN103340884A (en) * | 2013-07-18 | 2013-10-09 | 成都乾坤动物药业有限公司 | Wettable fenbendazole ivermectin powder |
| CN103340884B (en) * | 2013-07-18 | 2015-07-22 | 成都乾坤动物药业有限公司 | Wettable fenbendazole ivermectin powder |
| CN106902206A (en) * | 2017-03-14 | 2017-06-30 | 滁州新源农业科技有限公司 | A kind of pulvis and preparation method for preventing and treating pig epidermis parasite |
| CN110638761A (en) * | 2018-06-08 | 2020-01-03 | 上海莫息生物科技有限公司 | Avermemycin soluble powder and preparation method thereof |
| CN110638761B (en) * | 2018-06-08 | 2022-05-24 | 上海莫息生物科技有限公司 | Avermectin soluble powder and preparation method thereof |
| CN109223857A (en) * | 2018-11-23 | 2019-01-18 | 句容市茅山风景区鼎源畜禽养殖场 | A kind of knob raising goat preventing and treating verminosis medicament and preparation method thereof |
| CN111514157A (en) * | 2020-05-13 | 2020-08-11 | 吉林吉力生物技术研究有限公司 | Application of composition in preparation of veterinary anti-parasitic drug, veterinary anti-parasitic transdermal solution and preparation method thereof |
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Open date: 20070808 |