CN103340884B - Wettable fenbendazole ivermectin powder - Google Patents
Wettable fenbendazole ivermectin powder Download PDFInfo
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- CN103340884B CN103340884B CN201310302905.XA CN201310302905A CN103340884B CN 103340884 B CN103340884 B CN 103340884B CN 201310302905 A CN201310302905 A CN 201310302905A CN 103340884 B CN103340884 B CN 103340884B
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Abstract
The invention provides wettable fenbendazole ivermectin powder which is prepared from the following raw materials and auxiliary materials in parts by weight: 2.5-10 parts of fenbendazole, 0.1-0.8 part of ivermectin, 0.5-3 parts of magnesium stearate, 43.9-74 parts of powdered sugar, 3-11 parts of sodium dodecyl sulfate, 0-8 parts of xanthan gum, 0.6-1 part of fresh milk essence, 0.6-1 part of saccharin sodium and 10-30 parts of sodium citrate. The invention also provides a preparation method and application of the wettable fenbendazole ivermectin powder. The wettable fenbendazole ivermectin powder significantly improves the dispersity of the ivermectin and fenbendazole in water to ensure that the ivermectin and the fenbendazole can be uniformly distributed in the water for a long time to facilitate clinical water drinking and administration; and wettable fenbendazole ivermectin powder has a food calling function, namely that the fenbendazole ivermectin powder has a food calling function when used on faunas with sensitive tastes, such as pigs and the like. The wettable fenbendazole ivermectin powder is simple in preparation process, low in production cost and suitable for industrial large-scale production.
Description
Technical field
The present invention relates to a kind of wettable fenbendazole ivermectin powder and its production and use.
Background technology
Since the forties in 20th century, the research and development of anthelmintic are always burning hot abnormal, obtain gratifying achievement therebetween; Particularly 1976 Avermectins medicine (Avermectins) discovery, opened especially anthelmintic research new era.This compounds has the nematicide and arthropod that parasitize animal extremely strong kills effect, thus makes antiCerbB2 monoclonal antibodies dosage drop to μ g/kg level by mg/kg level.Commercial in this kind of medicine at present have avilamycin (Avermectin, AVM), ivermectin (Ivermectin, IVM), doractin (Doramectin, DRM), acetylamino evericin (Eprinomectin, EPM, has another name called her and composes rhzomorph, Ai Purui rhzomorph), selamectin (Selamectin, SLM) and moxidectin (Moxidectin or Milbemycin, MXD, has another name called Moses Dinke, moxidectin) etc.Due to anthelmintic activity and the higher safety of its excellence, Avermectins medicine is regarded as the most excellent, most widely used anthelmintic for animals at present, is achievement in research the most outstanding in anti-parasite medicine research in recent years; But good medicine is still needed and is mixed with excellent preparation its drug effect can be made to be given full play to.Therefore be a Hot Contents studying of novel chiral synthon in the last few years to the preparation research of such medicine and exploitation.AVM powder, tablet, capsule, injection and dashing agent are developed now, IVM powder, tablet, paste, oral liquid, slow release bolus, injection and dashing agent, the injection of doractin injection and dashing agent and Ai Purui rhzomorph and dashing agent.
Because Avermectins medicine is never poison, its mechanism is the GABA receptor acting on parasite synapse or neuromuscular synapse, and the information transmission of teleneuron in interference polypide, finally causes polypide to benumb dead.And the GABA mediator do not existed in the polypides such as platyhelminthes, antibacterial and actinomycetes and thalline as neural impulse, so Avermectins has Strong pest-expellant effect to nematicide and epizoa and other arthropod, but very micro-to trematodiasis, cestode effect, or do not have an active function.Facts have proved, anti-to Avermectins and fenbendazole etc. trematodiasis, the good compatibility of drugs of cestode effect are used, the deficiency of two kinds of medicines in pest-resistant spectrum can be made up, make its pest-resistant spectrum wider, usefulness is higher, alleviates people for driving away the trouble of multiple parasite and multiple dosing simultaneously.In China market, commercial Related product has fenbendazole ivermectin sheet etc.Although these preparations meet the demand expanding pest-resistant spectrum, clinical practice but exist to jumpbogroup animals administer difficulty and feedstuff is difficult to mix homogeneously or cannot the shortcoming of mix homogeneously.Therefore, when clinical practice, animal is usually uneven and occur unsatisfactory curative effect or occur side reaction and even the situation such as poisoning because taking in medicine.In order to avoid the generation of this situation, develop a kind of be easy to uniformity of dosage Avermectins and fenbendazole compound product very necessary.
The present invention is directed to existing Avermectins and the awkward shortcoming of fenbendazole compound product, provide one can be dispersed in water, by drinking water or being sprayed at the fenbendazole ivermectin powder of the mode administration on feedstuff.
Summary of the invention
The object of the present invention is to provide a kind of wettable fenbendazole ivermectin powder, and its production and use.
The invention provides a kind of wettable fenbendazole ivermectin powder, it is prepared from by the supplementary material of following weight proportion:
Fenbendazole 2.5 ~ 10 parts, ivermectin 0.1 ~ 0.8 part, magnesium stearate 0.5 ~ 3 part, Icing Sugar 43.9 ~ 74 parts, sodium lauryl sulphate 3 ~ 11 parts, xanthan gum 0 ~ 8 part, fresh milk essence 0.6 ~ 1 part, saccharin sodium 0.6 ~ 1 part, sodium citrate 10 ~ 30 parts.
Wherein, it is prepared from by the supplementary material of following weight proportion:
Fenbendazole 2.5 ~ 5 parts, ivermectin 0.2 ~ 0.8 part, magnesium stearate 0.5 ~ 2.5 part, Icing Sugar 54.5 ~ 74 parts, sodium lauryl sulphate 3 ~ 9 parts, xanthan gum 2 ~ 8 parts, fresh milk essence 0.6 ~ 0.9 part, saccharin sodium 0.6 ~ 0.9 part, sodium citrate 10 ~ 25 parts.
Further, it is prepared from by the supplementary material of following weight proportion:
Fenbendazole 3 ~ 5 parts, ivermectin 0.2 ~ 0.6 part, magnesium stearate 1.5 ~ 2.5 parts, Icing Sugar 54.5 ~ 67.5 parts, sodium lauryl sulphate 5 ~ 9 parts, xanthan gum 2 ~ 6 parts, fresh milk essence 0.7 ~ 0.9 part, saccharin sodium 0.7 ~ 0.9 part, sodium citrate 15 ~ 25 parts.
Further, it is prepared from by the supplementary material of following weight proportion:
Fenbendazole 4 ~ 5 parts, ivermectin 0.2 ~ 0.4 part, magnesium stearate 2 ~ 2.5 parts, Icing Sugar 54.5 ~ 61, sodium lauryl sulphate 7 ~ 9 parts, xanthan gum 2 ~ 4 parts, fresh milk essence 0.8 ~ 0.9 part, saccharin sodium 0.8 ~ 0.9 part, sodium citrate 20 ~ 25 parts.
Preferably, it is prepared from by the supplementary material of following weight proportion:
Fenbendazole 4 parts, ivermectin 0.4 part, magnesium stearate 2 parts, Icing Sugar 61 parts, sodium lauryl sulphate 7 parts, xanthan gum 4 parts, fresh milk essence 0.8 part, saccharin sodium 0.8 part, sodium citrate 20 parts;
Or, fenbendazole 5 parts, ivermectin 0.2 part, magnesium stearate 2.5 parts, Icing Sugar 54.5 parts, sodium lauryl sulphate 9 parts, xanthan gum 2 parts, fresh milk essence 0.9 part, saccharin sodium 0.9 part, sodium citrate 25 parts.
Present invention also offers the preparation method of above-mentioned wettable fenbendazole ivermectin powder, it comprises following operating procedure:
(1) supplementary material is taken by weight ratio;
(2) by after various supplementary material mixing, be crushed to 200 orders, obtain wettable fenbendazole ivermectin powder.
Present invention also offers the purposes of above-mentioned wettable fenbendazole ivermectin powder in preparation anthelmintic drug for animals.
Further, described medicine is the medicine of control nematicide or arthropod parasites disease.
Preferably, described nematicide is ascarid; Described arthropod is acarid.
Wettable fenbendazole ivermectin powder of the present invention, significantly improves ivermectin and the dispersibility of fenbendazole in water, makes it be evenly distributed on for a long time in water, facilitate clinical drinking water administration; Increase luring function, for the olfactory sensation such as pig, the faunichron that has a sharp sense of taste, have luring function; Preparation technology of the present invention is simple, low production cost, is applicable to industrialized great production.
Below in conjunction with detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Detailed description of the invention
The preparation of embodiment 1 wettable fenbendazole ivermectin powder
Get fenbendazole 4g, ivermectin 0.4g, magnesium stearate 2g, Icing Sugar 61g, sodium lauryl sulphate 7g, xanthan gum 4g, fresh milk essence 0.8g, saccharin sodium 0.8g, sodium citrate 20g, after above-mentioned supplementary material mix homogeneously, be crushed to 200 object impalpable powders, packaging, obtains wettable fenbendazole ivermectin powder of the present invention.
The preparation of embodiment 2 wettable fenbendazole ivermectin powder
Get fenbendazole 5g, ivermectin 0.2g, magnesium stearate 2.5g, Icing Sugar 54.5g, sodium lauryl sulphate 9g, xanthan gum 2g, fresh milk essence 0.9g, saccharin sodium 0.9g, sodium citrate 25g, after above-mentioned supplementary material mix homogeneously, be crushed to 200 object impalpable powders, packaging, obtains wettable fenbendazole ivermectin powder of the present invention.
The supplementary material compatibility screening of embodiment 3 wettable fenbendazole ivermectin powder
(1) preparation of different formulations product
Get the supplementary material in table 1 formula, prepare wettable fenbendazole ivermectin powder according to the method for embodiment 1, and evaluate the quality of each formula.
The preferred version of table 1 wettable fenbendazole ivermectin powder formula
(2) quality evaluation of wettable fenbendazole ivermectin powder
Dispersion is evaluated: get each 1g of wettable fenbendazole ivermectin powder by the preparation of table 1 formula 1 ~ formula 6, drops in 1000ml drinking water, observes or stir and observe its deployment conditions.Disperse slower and to be unevenly chosen as " poor "; Dispersion is comparatively slow, and have caking or granule in dispersive process, agitation as appropriate can be uniformly dispersed, and is chosen as " qualified "; Dispersion is fast, and gentle agitation can be uniformly dispersed, and is chosen as " good "; Dispersion is fast, need not stir and can be uniformly dispersed, be chosen as " excellent ".The results are shown in Table 2.
Sedimentation volume ratio is evaluated: by " solution for oral administration, suspensoid for oral administration, Emulsion for oral administration " sedimentation volume ratio inspection technique requirement in " People's Republic of China's veterinary drug allusion quotation (version in 2010) " annex, sedimentation volume ratio mensuration is carried out to the wettable fenbendazole ivermectin powder prepared by formula 1 ~ formula 6, sample thief 0.25g puts in 50ml tool plug graduated cylinder, add water to 50ml, fill in close, firmly jolting 1min, writes down suspended matter and starts height H
0, leave standstill and within 3 hours, write down the final height H of suspended matter, be calculated as follows: sedimentation volume ratio=H/H
0, sedimentation volume ratio should be not less than 0.90.The results are shown in Table 2.
Table 2 wettable fenbendazole ivermectin powder quality evaluation result
Listed 4 indexs of his-and-hers watches 1 are carried out comprehensive analysis and can be obtained: formula 2 ~ formula 6 is all qualified, be wherein optimum with formula 4, formula 5 again.
Beneficial effect of the present invention is illustrated below by way of test example.
Test example 1 wettable fenbendazole ivermectin powder therapeutic effect that is sick to ascaris suum and acariasis is investigated
Material: fenbendazole powder (5%, market products); Ivermectin powder (0.2%, market products); Fenbendazole ivermectin powder (5%+0.2%, prepared by embodiment 2).
Case: (sick pig continues to become thin ascaris suum case 48 example of Chengdu suburbs and counties under the jurisdiction of a large city first pig farm natural occurrence, is off one's feed, and spirit is depressed, get disease swine excrement, carry out worm's ovum inspection, detect oval in yellowish-brown, chorion is thicker, and adventitia is rough wavy ascaris suum germ cell); (sick pig becomes thin pig acarid case 56 example of Person B pig farm, suburb, Chengdu natural occurrence, down in spirits, likes in wall friction, the vesicle, incrustation, depilation etc. that occur after visible galling skin; Collect the scurf of disease pig injury moistening, be directly coated on microscope slide, can be observed the demodicid mite that lives).
Method: select the clinical onset growing and fattening pigs that body weight is substantially suitable, be divided into matched group, test group and negative control group at random under identical rearing conditions in same pig house; Matched group by fenbendazole powder+ivermectin powder (1:1 mixing) by 0.2% concentration spice, feeding for sick pig, be used in conjunction 3 days; Test group wettable fenbendazole ivermectin powder converts drinking water by 0.05% concentration, drinks for sick pig, is used in conjunction 3 days; Negative control group is raised by daily feeding manner, not administration.
Efficacy determination method: medication is after 5 days, and spiritual appetite recovers normal, and microscopy, without the parasite lived or worm's ovum, is judged to recovery from illness; Medication is after 5 days, and spiritual appetite takes a turn for the better, the parasite that microscopy is lived as seen on a small quantity, is judged to effectively; Medication is after 5 days, and symptom is not improved, and it is invalid to be judged to.
Experimental result: in table 3, table 4.
Table 3 wettable fenbendazole ivermectin powder is to the clinical tests result of ascaris suum disease
Table 4 wettable fenbendazole ivermectin powder is to the clinical tests result of acariasis
As can be seen from experimental result, wettable fenbendazole ivermectin powder therapeutic effect that is sick to ascaris suum and pig acariasis is all better than commercially available fenbendazole ivermectin powder; The convenience that wettable fenbendazole ivermectin powder uses is better than commercially available fenbendazole ivermectin powder, greatly reduces the working strength of administration.Also find in test, owing to taking the mode administration added of drinking water, wettable fenbendazole ivermectin powder does not affect the feed intake of disease pig.
Claims (5)
1. a wettable fenbendazole ivermectin powder, is characterized in that:
It is prepared from by the supplementary material of following weight proportion:
Fenbendazole 4 parts, ivermectin 0.4 part, magnesium stearate 2 parts, Icing Sugar 61 parts, sodium lauryl sulphate 7 parts, xanthan gum 4 parts, fresh milk essence 0.8 part, saccharin sodium 0.8 part, sodium citrate 20 parts;
Or, fenbendazole 5 parts, ivermectin 0.2 part, magnesium stearate 2.5 parts, Icing Sugar 54.5 parts, sodium lauryl sulphate 9 parts, xanthan gum 2 parts, fresh milk essence 0.9 part, saccharin sodium 0.9 part, sodium citrate 25 parts.
2. the preparation method of wettable fenbendazole ivermectin powder described in claim 1, is characterized in that: it comprises following operating procedure:
(1) supplementary material is taken by weight ratio;
(2) by after various supplementary material mixing, be crushed to 200 orders, obtain wettable fenbendazole ivermectin powder.
3. the purposes of wettable fenbendazole ivermectin powder described in claim 1 in preparation anthelmintic drug for animals.
4. purposes according to claim 3, is characterized in that: described medicine is the medicine of control nematicide or arthropod parasites disease.
5. purposes according to claim 4, is characterized in that: described nematicide is ascarid; Described arthropod is acarid.
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| CN103340884B true CN103340884B (en) | 2015-07-22 |
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Citations (4)
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|---|---|---|---|---|
| CN101011408A (en) * | 2007-01-29 | 2007-08-08 | 江西省百思特动物药业有限公司 | Animal-used compound preparation for treating parasitic disease in or out of livestock and fowl body and preparation method thereof |
| CN101268810A (en) * | 2008-05-16 | 2008-09-24 | 赵光政 | Composite prebiotics feed additive |
| CN101375856A (en) * | 2007-08-28 | 2009-03-04 | 天津生机集团有限公司 | Compound ivermectin injection and preparation method |
| CN103083348A (en) * | 2012-05-10 | 2013-05-08 | 重庆金邦动物药业有限公司 | Albendazole/ivermectin powder for livestock |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011408A (en) * | 2007-01-29 | 2007-08-08 | 江西省百思特动物药业有限公司 | Animal-used compound preparation for treating parasitic disease in or out of livestock and fowl body and preparation method thereof |
| CN101375856A (en) * | 2007-08-28 | 2009-03-04 | 天津生机集团有限公司 | Compound ivermectin injection and preparation method |
| CN101268810A (en) * | 2008-05-16 | 2008-09-24 | 赵光政 | Composite prebiotics feed additive |
| CN103083348A (en) * | 2012-05-10 | 2013-05-08 | 重庆金邦动物药业有限公司 | Albendazole/ivermectin powder for livestock |
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Address after: 611130 Wenjiang, Chengdu, Chengdu cross strait science and Technology Industrial Development Zone, Jin Fu Road, Sichuan Patentee after: Chengdu Qiankun animal pharmaceutical Limited by Share Ltd Patentee after: Shanghai Simenon Biotech Co., Ltd. Address before: 611130 Wenjiang, Chengdu, Chengdu cross strait science and Technology Industrial Development Zone, Jin Fu Road, Sichuan Patentee before: Chengdu Qiankun Animal Pharmaceutical Co.,Ltd. Patentee before: Shanghai Simenon Biotech Co., Ltd. |
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Granted publication date: 20150722 Termination date: 20200718 |