CN103536624B - A kind of wettable three-ingredient white composition powder and preparation method thereof - Google Patents
A kind of wettable three-ingredient white composition powder and preparation method thereof Download PDFInfo
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- CN103536624B CN103536624B CN201310532790.3A CN201310532790A CN103536624B CN 103536624 B CN103536624 B CN 103536624B CN 201310532790 A CN201310532790 A CN 201310532790A CN 103536624 B CN103536624 B CN 103536624B
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- wettable
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- 238000002360 preparation method Methods 0.000 title claims abstract description 39
- 239000000454 talc Chemical group 0.000 claims abstract description 40
- 229910052623 talc Chemical group 0.000 claims abstract description 40
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- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical group [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims abstract 3
- 239000012467 final product Substances 0.000 claims description 21
- 239000001508 potassium citrate Substances 0.000 claims description 15
- 229960002635 potassium citrate Drugs 0.000 claims description 15
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention belongs to technical field of medicine, disclose a kind of wettable three-ingredient white composition powder and preparation method thereof.The wettable three-ingredient white composition powder that the present invention provides is dissipated in vain by the three of 72.2～99.6 weight portions, the suspending agent of 0.1～10 weight portions and the deflocculant of 0.1～16 weight portions are made, wherein, three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form.This wettable three-ingredient white composition powder significantly improves three dispersibility being dispersed in water in vain, drinking water administration can be passed through, be administered uniformly, significantly reduce administration working strength, and improve three palatabilities dissipated in vain, it is more beneficial for three promotion and application being dispersed in animal husbandry in vain.The preparation technology of this wettable three-ingredient white composition powder is simple, with low cost, is suitable for industrialized great production.
Description
Technical field
The invention belongs to technical field of medicine, particularly to a kind of wettable three-ingredient white composition powder
And preparation method thereof.
Background technology
Three white dissipating are made up of Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum three taste Chinese medicine, under wherein Matrii Sulfas Exsiccatus bitter cold is rushed down, lead
Rush down Gastrointestinal excess heat, for monarch drug；Gypsum Fibrosum pungent sweet Great Cold, part of the body cavity above the diaphragm housing the heart and lungs lung-heat can be rushed down clearly, middle burnt stomach of having loose bowels again
Fire, principal drug assistance rushes down Gastrointestinal excess heat, for ministerial drug；Talcum is sweet light cold, and clearing away heat and promoting diuresis is treating stranguria, and heat conduction is descending,
For adjuvant drug.Three medicines share, and logical two just rush down part of the body cavity above the diaphragm housing the heart and lungs excess-heat, play the merit of clearing stomach, pathogenic fire purging, relieving constipation altogether.Profound bright
Powder is dried through air slaking after being typically processed as Natrii Sulfas by Mirabilitum again and prepares, and modern pharmacology research finds,
Heavy dose of Natrii Sulfas and Mirabilitum xylol induced mice auricle edema all have certain inhibitory action；Natrii Sulfas and
Mirabilitum, Matrii Sulfas Exsiccatus all have obvious facilitation, the most again with the effect of Matrii Sulfas Exsiccatus to mouse small intestine motion
The strongest.Gypsum Fibrosum typically by natural dihydrate gypsum, i.e. Gypsum Fibrosum, through calcining, levigate prepare, stone
Cream has the diuresis of mitigation, refrigeration function；Gypsum Fibrosum decocting liquid is to caused by TAB/VAC
Fever in rabbit has significant refrigeration function.Talcum is a kind of common silicate mineral, and Talcum decoct is to wound
Cold bacillus, Salmonella paratyphi, gold-coloured staphylococci and meningococcus have inhibitory action.
Dissipate in vain because of three and there is the functions such as clearing stomach, pathogenic fire purging and relieving constipation, therefore veterinary clinic is mainly used to prevent and treat:
Poultry are because of " take advantage of hungry paddy material of feeding too much, subimbition, usage immediately after feeding " or " heat is put
Herding usage improper, pathogenic heat enter stomach, and consumption injures one's stomach Tianjin " caused by gastric heat lack of appetite；Because " raising inappropriate, for a long time
Feed thick and stiff stodgy feedstuff, drink water and deficiency of moving " or " pathogenic heat is hindered in internal organs, consumption of body fluid by heat,
Intestinal juice is short " caused by constipation；Because of " summer-heat sky, heat of overworking, subimbition, heat note bladder
Or the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels " or " search for food mould lose, poisonous feedstuff, feedstuff is cohesion, pass note bladder " and send out
Oliguria with reddish urine (pyretic stranguria).
As a kind of determined curative effect, few side effects and low-cost Chinese patent medicine, three dissipate in vain with traditional
Powder form is applied in livestock-raising production.Three dissipate powder in vain can solve the problem that certain in livestock-raising produces
The problem of a little aspects, but, because powder in use can only be by the way of " fill and feed " or " spice "
Dispensing so that this better quality products at good values, for scale, intensive modern cultivation, is deposited
Limit its application being administered uneven, the problem such as workload is bigger.
Summary of the invention
In view of this, it is an object of the invention to provide a kind of wettable three-ingredient white composition powder and system thereof
Preparation Method, this wettable three-ingredient white composition powder significantly improves three dispersibility being dispersed in water in vain, can
With by drinking water administration, it is administered uniformly, reduces administration working strength, be more beneficial for three and be dispersed in herding in vain
Promotion and application in industry.
In order to realize the goal of the invention of the present invention, the present invention adopts the following technical scheme that:
The invention provides a kind of wettable three-ingredient white composition powder, be made up of following weight portion supplementary material:
Three dissipate 72.2～99.6 parts in vain
Suspending agent 0.1～10 parts
Deflocculant 0.1～16 parts；
Wherein, three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form.
Preferably, the wettable three-ingredient white composition powder that the present invention provides is by following weight portion supplementary material system
Become:
Three dissipate 88.6～92.8 parts in vain
Suspending agent 4～6 parts
Deflocculant 2～4 parts；
Wherein, three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form.
In some embodiments of the invention, the wettable three-ingredient white composition powder that the present invention provides is by such as
Lower weight portion supplementary material is made:
Three dissipate 88.6 parts in vain
Suspending agent 6 parts
Deflocculant 4 parts；
Wherein, three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form.
In the other embodiment of the present invention, the wettable three-ingredient white composition powder that the present invention provides
It is made up of following weight portion supplementary material:
Three dissipate 92.8 parts in vain
Suspending agent 4 parts
Deflocculant 2 parts；
Wherein, three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form.
In the other embodiment of the present invention, the wettable three-ingredient white composition powder that the present invention provides
In supplementary material also include the one in pharmaceutically acceptable spice or pharmaceutically acceptable sweeting agent or
Both mixture.
Three dissipate in vain because Matrii Sulfas Exsiccatus flavour of a drug are pungent salty in former medicine, so existing three the most scattered powders have certain
Zest flavour of a drug, palatability is poor, and when the faunichron having a sharp sense of taste for pig etc., easily producing reloads answers
Swash reaction, not only affect the feed intake of disease pig but also affect drug effect.And the three white powder compositions that the present invention provides can
The supplementary material of WP also includes in pharmaceutically acceptable spice or pharmaceutically acceptable sweeting agent
A kind of or both mixture, mask the three zest flavour of a drug dissipating former medicines in vain, improve three and dissipate in vain
Palatability, creates certain luring function.The three white powder compositions that the results show present invention provides
Wettable powder does not has generation to reload stress during drinking water administration, does not affect the feed intake of disease pig.
In the other embodiment of the present invention, the wettable three-ingredient white composition powder that the present invention provides
It is made up of following weight portion supplementary material:
Wherein, three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form.
In the other embodiment of the present invention, the wettable three-ingredient white composition powder that the present invention provides
It is made up of following weight portion supplementary material:
Wherein, three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form.
In the other embodiment of the present invention, the wettable three-ingredient white composition powder that the present invention provides
It is made up of following weight portion supplementary material:
Wherein, three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form.
In the other embodiment of the present invention, the wettable three-ingredient white composition powder that the present invention provides
It is made up of following weight portion supplementary material:
Wherein, three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form.
Preferably, in the wettable three-ingredient white composition powder that the present invention provides, suspending agent is carboxymethyl cellulose
Element sodium, carboxymethyl starch sodium, gelatin, sodium alginate, tragakanta, arabic gum, xanthan gum, card
A kind of or both mixture above in ripple nurse or glucosan.
In some embodiments of the invention, the wettable three-ingredient white composition powder that the present invention provides helps
Suspension is sodium carboxymethyl cellulose or carboxymethyl starch sodium.
Preferably, in the wettable three-ingredient white composition powder that the present invention provides, deflocculant is potassium citrate
And/or sodium citrate.
In some embodiments of the invention, in the wettable three-ingredient white composition powder that the present invention provides instead
Flocculant is potassium citrate.
Preferably, acceptable spice on the wettable three-ingredient white composition powder Chinese materia medica that the present invention provides
For the one in meat flavor essence, grass taste essence, fresh milk essence, Fructus Citri Limoniae essence or fish raw meat essence or both
Above mixture.
In some embodiments of the invention, the wettable three-ingredient white composition powder Chinese medicine that the present invention provides
On, acceptable spice is fresh milk essence, Fructus Citri Limoniae essence or fish raw meat essence.
Preferably, acceptable sweet taste on the wettable three-ingredient white composition powder Chinese materia medica that the present invention provides
Agent be the one in aspartame, acesulfame potassium, saccharin, saccharin sodium, sucralose or neotame or both
Above mixture.
In some embodiments of the invention, the wettable three-ingredient white composition powder Chinese medicine that the present invention provides
Acceptable sweeting agent saccharin sodium, sucralose or neotame on.
Present invention also offers the preparation method of a kind of wettable three-ingredient white composition powder, including following step
Rapid:
Take Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum, be 4:3:3 mixing according to mass ratio, obtain three and dissipate in vain；
Take 72.2～99.6 weight portions three in vain dissipate, 0.1～10 weight portion suspending agent and 0.1～16 weight portions anti-
Flocculant mixes, and 625 mesh～4000 mesh are pulverized, and to obtain final product.
Preferably, the preparation method that the present invention provides comprises the following steps:
Take Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum, be 4:3:3 mixing according to mass ratio, obtain three and dissipate in vain；
Take 88.6～92.8 weight portions three in vain dissipate, 4～6 weight portion suspending agent and 2～4 weight portions deflocculated
Agent mixes, and 625 mesh～4000 mesh are pulverized, and to obtain final product.
In some embodiments of the invention, the preparation method that the present invention provides comprises the following steps:
Take Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum, be 4:3:3 mixing according to mass ratio, obtain three and dissipate in vain；
Take 88.6 weight portions three scattered, 6 weight portion suspending agents and 4 weight portion deflocculants in vain to mix, 625
Mesh～4000 mesh are pulverized, and to obtain final product.
In the other embodiment of the present invention, the preparation method that the present invention provides comprises the following steps:
Take Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum, be 4:3:3 mixing according to mass ratio, obtain three and dissipate in vain；
Take 92.8 weight portions three scattered, 4 weight portion suspending agents and 2 weight portion deflocculants in vain to mix, 625
Mesh～4000 mesh are pulverized, and to obtain final product.
In the other embodiment of the present invention, the preparation method that the present invention provides comprises the following steps:
Take Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum, be 4:3:3 mixing according to mass ratio, obtain three and dissipate in vain；
Take 72.2～99.6 weight portions three dissipate in vain, 0.1～10 weight portion suspending agents, 0.1～16 weight portion anti-
Flocculant, 0～0.9 pharmaceutically can the connecing of the pharmaceutically acceptable spice of weight portion and 0.1～0.9 weight portion
The sweeting agent being subject to mixes, and 625 mesh～4000 mesh are pulverized, and to obtain final product.
In the other embodiment of the present invention, the preparation method that the present invention provides, comprise the following steps:
Take Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum, be 4:3:3 mixing according to mass ratio, obtain three and dissipate in vain；
Take 88.6～92.8 weight portions three dissipate in vain, 4～6 weight portion suspending agents, 2～4 weight portion deflocculants,
0.6～the 0.7 pharmaceutically acceptable spice of weight portion and 0.6～0.7 weight portion pharmaceutically acceptable sweet
Taste agent mixes, and 625 mesh～4000 mesh are pulverized, and to obtain final product.
In the other embodiment of the present invention, the preparation method that the present invention provides, comprise the following steps:
Take Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum, be 4:3:3 mixing according to mass ratio, obtain three and dissipate in vain；
Take 88.6 weight portions three scattered, 6 weight portion suspending agents, 4 weight portion deflocculants, 0.7 weight portion in vain
Pharmaceutically acceptable spice and 0.7 weight portion pharmaceutically acceptable sweeting agent mixing, 625 mesh～
4000 mesh are pulverized, and to obtain final product.
In the other embodiment of the present invention, the preparation method that the present invention provides, comprise the following steps:
Take Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum, be 4:3:3 mixing according to mass ratio, obtain three and dissipate in vain；
Take 92.8 weight portions three scattered, 4 weight portion suspending agents, 2 weight portion deflocculants, 0.6 weight portion in vain
Pharmaceutically acceptable spice and 0.6 weight portion pharmaceutically acceptable sweeting agent mixing, 625 mesh～
4000 mesh are pulverized, and to obtain final product.
Present invention also offers a kind of wettable three-ingredient white composition powder, its preparation method includes following step
Rapid:
Take Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum, be 4:3:3 mixing according to mass ratio, obtain three and dissipate in vain；
Take 72.2～99.6 weight portions three in vain dissipate, 0.1～10 weight portion suspending agent and 0.1～16 weight portions anti-
Flocculant mixes, and 625 mesh～4000 mesh are pulverized, and to obtain final product.
Present invention also offers wettable three-ingredient white composition powder in preventing and treating domestic animal constipation, pyretic stranguria or gastric heat
Application in lack of appetite.
In some embodiments of the invention, the application that the present invention provides is preventing and treating pig constipation.
The invention provides a kind of wettable three-ingredient white composition powder and preparation method thereof.This three the most scattered group
Compound wettable powder is dissipated in vain by the three of 72.2～99.6 weight portions, the suspending agent of 0.1～10 weight portions and
The deflocculant of 0.1～16 weight portions is made, wherein, three dissipate in vain by the Matrii Sulfas Exsiccatus that mass ratio is 4:3:3,
Gypsum Fibrosum and Talcum composition.The three white powder compositions that the present invention provides in some embodiments of the invention are wettable
The supplementary material of property powder also includes in pharmaceutically acceptable spice or pharmaceutically acceptable sweeting agent
Kind or both mixture.Test result indicate that, the wettable three-ingredient white composition powder that the present invention provides,
Significantly improve three dispersibility being dispersed in water in vain, drinking water administration can be passed through, be administered uniformly, significantly
Reduce administration working strength, and improve three palatabilities dissipated in vain, be more beneficial for three and be dispersed in animal husbandry in vain
In promotion and application.Meanwhile, the preparation technology of the wettable three-ingredient white composition powder that the present invention provides
Simply, with low cost, it is suitable for industrialized great production.
Detailed description of the invention
The invention discloses a kind of wettable three-ingredient white composition powder and preparation method thereof.Art technology
Personnel are referred to present disclosure, it is thus achieved that this wettable three-ingredient white composition powder, it is achieved its application, special
Not it is pointed out that all similar replacements and change are apparent for a person skilled in the art
, they are considered as being included in the present invention.The preparation method and application of the present invention has been passed through preferably
Embodiment be described, related personnel substantially can be without departing from present invention, spirit and scope
This paper preparation method and application it is modified or suitably changes and combine, realize and apply skill of the present invention
Art.
Examination used in a kind of wettable three-ingredient white composition powder that the present invention provides and preparation method thereof
Agent and raw material all can be buied by market.
In order to make those skilled in the art better understood when technical scheme, below
In conjunction with the embodiments, the present invention is expanded on further:
The recipe determination of embodiment 1 wettable three-ingredient white composition powder
Supplementary product kind, consumption and auxiliary material combination etc., be the key factor of preparation, and they are directly connected to energy
No acquisition pharmaceutical preparation and the quality of the obtained quality of the pharmaceutical preparations.For the present invention " wettable powder ",
Main inspection target is dispersion and sedimentation velocity.In order to prepare be uniformly dispersed, sedimentation velocity slow
Wettable powder, pharmaceutical formulation is screened by the present invention.
Formula:
The wettable three-ingredient white composition powder formula that experimental design 7 is different, each formula composition is shown in Table
1。
The formula of table 1 wettable three-ingredient white composition powder of the present invention
Note: three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form
Preparation method:
According to the formula of table 1, take three dissipate in vain, sodium carboxymethyl cellulose, fresh milk essence, saccharin sodium and lemon
Lemon acid potassium, after mix homogeneously, 625 mesh are pulverized, and to obtain final product.
The quality evaluation of the wettable three-ingredient white composition powder of different formulations:
Dispersion and sedimentation volume ratio is used to evaluate the wettable three-ingredient white composition powder that the present invention prepares
Quality, concrete grammar is as follows:
Dispersion is evaluated: take the wettable three-ingredient white composition powder prepared by table 1 formula 1～formula 7
Each 1g, puts in 1000mL drinking water, observes or stir and observe its deployment conditions.Dispersion relatively slow and
Uneven it is chosen as " poor "；Dispersion is relatively slow, has caking or granule in dispersive process, and agitation as appropriate i.e. dispersibles
Uniformly, " qualified " it is chosen as；Dispersion is fast, and gentle agitation can be uniformly dispersed, and is chosen as " good "；Dispersion is fast,
Need not stir and can be uniformly dispersed, be chosen as " excellent ".The results are shown in Table 3.
Sedimentation volume ratio is evaluated: by " interior in " People's Republic of China's veterinary drug allusion quotation (version in 2010) " annex
Take solution, suspensoid for oral administration, Emulsion for oral administration " sedimentation volume ratio inspection technique requirement, join according to table 1
The wettable three-ingredient white composition powder of side 1～formula 7 preparation carries out sedimentation volume ratio mensuration.Take sample
0.25g puts in 50mL tool plug graduated cylinder, adds water to 50mL, fills in close, firmly shakes 1min, write down suspendible
Thing starts height H0, stands 3h and writes down suspended matter final height H, is calculated as follows: sedimentation volume ratio
=H/H0, sedimentation volume ratio should be not less than 0.90.The results are shown in Table 3.
Palatability quality evaluation: the three white powder composition wettabilitys will prepared by formula 1 in table 1～formula 7
Powder converts drinking water by the concentration of 0.625% (in terms of 6.25mg/mL) respectively, drinks for healthy swinery,
Observing and record swinery and drink situation, choose palatability grade, evaluation criterion is shown in 2.The results are shown in Table 3.
Table 2 palatability criteria of quality evaluation
| Opinion rating | Evaluation criterion |
| Excellent | When providing the drinking-water of dosing, swinery is induced by abnormal smells from the patient, actively fights for drinking. |
| Good | When providing the drinking-water of dosing, swinery is drunk by daily drinking habit. |
| Difference | When providing the drinking-water of dosing, swinery refusal is drunk or the amount of drinking declines the most usually. |
The quality evaluation result of table 3 wettable three-ingredient white composition powder of the present invention
Can be obtained by table 3, formula 1～formula 6 wettable three-ingredient white composition powder prepared is the most qualified,
The most again with formula 3, formula 4 for optimum.
The preparation of embodiment 2 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 32kg, Gypsum Fibrosum 24kg, Talcum 24kg, sodium carboxymethyl cellulose 3kg, fresh milk essence
0.5kg, saccharin sodium 0.9kg, potassium citrate 15.6kg, after mix homogeneously, 625 mesh are pulverized, packaging, i.e.
?.
The preparation of embodiment 3 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 32kg, Gypsum Fibrosum 24kg, Talcum 24kg, carboxymethyl starch sodium 4kg, Fructus Citri Limoniae essence
0.9kg, sucralose 0.6kg, potassium citrate 14.5kg, after mix homogeneously, 700 mesh are pulverized, packaging,
Obtain.
The preparation of embodiment 4 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 32kg, Gypsum Fibrosum 24kg, Talcum 24kg, sodium carboxymethyl cellulose 6kg, fish raw meat essence
0.9kg, neotame 0.1kg, potassium citrate 13kg, after mix homogeneously, 725 mesh are pulverized, and packaging to obtain final product.
The preparation of embodiment 5 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 28.88kg, Gypsum Fibrosum 21.66kg, Talcum 21.66kg, sodium carboxymethyl cellulose 5kg,
Arabic gum 5kg, fish raw meat essence 0.5kg, acesulfame potassium 0.5kg, potassium citrate 8kg, sodium citrate 8kg,
After mix homogeneously, 750 mesh are pulverized, and packaging to obtain final product.
The preparation of embodiment 6 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 35.44kg, Gypsum Fibrosum 26.58kg, Talcum 26.58kg, sodium carboxymethyl cellulose 6kg,
Fish raw meat essence 0.5kg, Fructus Citri Limoniae essence 0.2kg, aspartame 0.7kg, sodium citrate 4kg, mix homogeneously
After, 800 mesh are pulverized, packaging, to obtain final product.
The preparation of embodiment 7 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 39.84kg, Gypsum Fibrosum 29.88kg, Talcum 29.88kg, sodium carboxymethyl cellulose 0.1kg,
Saccharin sodium 0.4kg, potassium citrate 0.1kg, after mix homogeneously, 900 mesh are pulverized, and packaging to obtain final product.
The preparation of embodiment 8 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 37.12kg, Gypsum Fibrosum 27.84kg, Talcum 27.84kg, carboxymethyl starch sodium 4kg, fish
Raw meat essence 0.6kg, neotame 0.3kg, aspartame 0.3kg, potassium citrate 2kg, after mix homogeneously, 1250
Mesh is pulverized, packaging, to obtain final product.
The preparation of embodiment 9 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 30.88kg, Gypsum Fibrosum 23.16kg, Talcum 23.16kg, sodium carboxymethyl cellulose 0.1kg,
Potassium citrate 16kg, after mix homogeneously, 1600 mesh are pulverized, and packaging to obtain final product.
The preparation of embodiment 10 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 39.84kg, Gypsum Fibrosum 29.88kg, Talcum 29.88kg, sodium carboxymethyl cellulose 5kg,
Arabic gum 5kg, potassium citrate 0.1kg, after mix homogeneously, 4000 mesh are pulverized, and packaging to obtain final product.
The preparation of embodiment 11 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 35.44kg, Gypsum Fibrosum 26.58kg, Talcum 26.58kg, sodium carboxymethyl cellulose 6kg,
Potassium citrate 2kg, sodium citrate 2kg, after mix homogeneously, 2400 mesh are pulverized, and packaging to obtain final product.
The preparation of embodiment 12 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 37.12kg, Gypsum Fibrosum 27.84kg, Talcum 27.84kg, xanthan gum 2kg, carbomer 2kg,
Potassium citrate 1kg, sodium citrate 1kg, after mix homogeneously, 2600 mesh are pulverized, and packaging to obtain final product.
The preparation of embodiment 13 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 36g, Gypsum Fibrosum 27kg, Talcum 27kg, glucosan 2kg, tragakanta 3kg, lemon
Lemon acid potassium 2kg, sodium citrate 1kg, after mix homogeneously, 3250 mesh are pulverized, and packaging to obtain final product.
The preparation of embodiment 14 wettable three-ingredient white composition powder
Take Matrii Sulfas Exsiccatus 32g, Gypsum Fibrosum 24kg, Talcum 24kg, sodium carboxymethyl cellulose 5kg, fresh milk essence
0.45kg, Fructus Citri Limoniae essence 0.45kg, potassium citrate 8kg, after mix homogeneously, 2000 mesh are pulverized, packaging,
Obtain.
Embodiment 15 wettable three-ingredient white composition powder clinical tests to pig constipation
The wettable three-ingredient white composition powder that Example 2 prepares, investigates it and imitates the treatment of pig constipation
Really, three commercially available the most scattered conduct comparisons.Commercially available three dissipate in vain that to derive from Chengdu Qian Shengchang biotechnology limited
Company, every 1000g 400g Han Matrii Sulfas Exsiccatus, Gypsum Fibrosum 300g and Talcum 300g.
Case: pig constipation case 43 example of Pixian County, Chengdu natural occurrence, disease condition is similar.Symptom is:
Sick temperature of pig body is normal, and loss of appetite, abdominal part expand, often performance defecation shape, but discharge feces stagnant slow, row is a small amount of
Argol or do not discharge feces, amount of drinking water increases, slightly uneasy, sends rumble cry, has pain with hands pressing abdominal part
Sense reaction, minimizing of urinating, yellow skin retrogradation.
Method: at random disease pig is divided into matched group 15, experimental group 15 and negative control group 13.
Matched group provides commercially available three to dissipate in vain, and spice is administered, by percentage to the quality, and three concentration dissipated in vain in feedstuff
It is 1%, throws something and feeds feedstuff by daily method for breeding, be used in conjunction 5 days；Experimental group provides embodiment 2 to prepare
Wettable three-ingredient white composition powder, drinking water administration, by percentage to the quality, three concentration dissipated in vain in water
It is 0.625%, supplies water by daily method for breeding, be used in conjunction 5 days；Negative control group is raised by daily feeding manner
Support, be not administered.Daily check disease pig clinical manifestation, recording exceptional response situation.
Efficacy determination method: after medication 5 days, appetite recovers normal, clinical symptom disappearance, is judged to recovery from illness；
After medication 5 days, appetite takes a turn for the better, clinical symptom relief, is judged to effectively；After medication 5 days, symptom is without bright
Aobvious improvement, it is invalid to be judged to.
After being administered 5, statistical experiment group, matched group and the disease condition of negative control group pig, different
The clinical tests of group disease pig the results are shown in Table 3.
The clinical tests result of the different group disease pig of table 3
Can be obtained by table 3, the wettable three-ingredient white composition powder that embodiment 2 the provides treatment to pig constipation
Effect is better than commercially available three and dissipates in vain；Meanwhile, experiment also finds, the feed intake of experimental group disease pig is not subject to
To impact, the stress that reloads does not occurs；And matched group the feed intake of ill pig all decrease,
Reduce 5%～32% respectively, occur in that the stress that reloads.So, the three of embodiment 2 offer dissipate in vain
Composite wettable powder can be administered to use drinking water administration mode, easy to use, greatly reduces administration
Working strength, and improve three palatabilities dissipated in vain, it is more beneficial for three popularization dissipated in vain and uses.
Use identical experimental technique, investigate the three the most scattered groups that the embodiment of the present invention 3 to embodiment 14 prepares
Compound wettable powder curative effect in treatment pig constipation, it is thus achieved that similar experimental result, the i.e. present invention
The wettable three-ingredient white composition powder that embodiment 3 to embodiment 14 prepares all can use drinking water administration to control
Treat pig constipation, easy to use, greatly reduce administration working strength, and improve three palatabilities dissipated in vain,
It is more beneficial for three popularization dissipated in vain and uses.
Below it is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred implementation is not
Should be regarded as limitation of the present invention, protection scope of the present invention should be with claim limited range
Accurate.For those skilled in the art, without departing from the spirit and scope of the present invention,
Can also make some improvements and modifications, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (7)
1. a wettable three-ingredient white composition powder, it is characterised in that by the supplementary material of following weight portion
Composition:
Three dissipate 88.6～92.8 parts in vain
Suspending agent 4～6 parts
Deflocculant 2～4 parts；
Wherein, described three white dissipating by mass ratio are that the Matrii Sulfas Exsiccatus of 4:3:3, Gypsum Fibrosum and Talcum form；
Described suspending agent is sodium carboxymethyl cellulose；
Described deflocculant is potassium citrate；
The grinding particle size of described supplementary material is 625 mesh～4000 mesh.
Wettable three-ingredient white composition powder the most according to claim 1, it is characterised in that by such as
The supplementary material composition of lower weight portion:
Three dissipate 88.6 parts in vain
Suspending agent 6 parts
Deflocculant 4 parts.
3. a wettable three-ingredient white composition powder, it is characterised in that by described in claim 1
A kind of in supplementary material, pharmaceutically acceptable spice or pharmaceutically acceptable sweeting agent or both is mixed
Compound forms.
Wettable three-ingredient white composition powder the most according to claim 3, it is characterised in that described
Pharmaceutically acceptable spice is that meat flavor essence, grass taste essence, fresh milk essence, Fructus Citri Limoniae essence or fish raw meat are fragrant
A kind of or both mixture above in essence.
Wettable three-ingredient white composition powder the most according to claim 3, it is characterised in that described
Pharmaceutically acceptable sweeting agent is aspartame, acesulfame potassium, saccharin, saccharin sodium, sucralose or knob
A kind of or both mixture above in sweet.
6. the preparation method of a wettable three-ingredient white composition powder, it is characterised in that by following steps system
For obtaining:
Take Matrii Sulfas Exsiccatus, Gypsum Fibrosum and Talcum, be 4:3:3 mixing according to mass ratio, obtain three and dissipate in vain；
Take described in 88.6～92.8 weight portions three dissipate in vain, 4～6 weight portion sodium carboxymethyl cellulose and 2～4 weights
Amount part potassium citrate mixing, 625 mesh～4000 mesh are pulverized, and to obtain final product.
7. the wettable three-ingredient white composition powder that a preparation method as claimed in claim 6 prepares.
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| CN1939339A (en) * | 2006-09-28 | 2007-04-04 | 天津生机集团有限公司 | Chinese-medicinal composition for treating fowl and animal thermal stress |
| CN103054808A (en) * | 2012-12-27 | 2013-04-24 | 成都乾坤动物药业有限公司 | Tilmicosin dry suspension, method for preparing dry suspension and uses thereof |
| CN103083348A (en) * | 2012-05-10 | 2013-05-08 | 重庆金邦动物药业有限公司 | Albendazole/ivermectin powder for livestock |
| CN103340885A (en) * | 2013-07-18 | 2013-10-09 | 成都乾坤动物药业有限公司 | Wettable albendazole ivermectin powder |
| CN103340884A (en) * | 2013-07-18 | 2013-10-09 | 成都乾坤动物药业有限公司 | Wettable fenbendazole ivermectin powder |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU204697B (en) * | 1988-12-22 | 1992-02-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing veterinary composition comprising n-(5-nitrofufurilidene)-3-amino-2-oxazolidone |
| AU722767B2 (en) * | 1995-11-02 | 2000-08-10 | Eli Lilly & Co (Nz) Limited | Wettable powder compositions of ionophore antibiotics |
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2013
- 2013-10-31 CN CN201310532790.3A patent/CN103536624B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939339A (en) * | 2006-09-28 | 2007-04-04 | 天津生机集团有限公司 | Chinese-medicinal composition for treating fowl and animal thermal stress |
| CN103083348A (en) * | 2012-05-10 | 2013-05-08 | 重庆金邦动物药业有限公司 | Albendazole/ivermectin powder for livestock |
| CN103054808A (en) * | 2012-12-27 | 2013-04-24 | 成都乾坤动物药业有限公司 | Tilmicosin dry suspension, method for preparing dry suspension and uses thereof |
| CN103340885A (en) * | 2013-07-18 | 2013-10-09 | 成都乾坤动物药业有限公司 | Wettable albendazole ivermectin powder |
| CN103340884A (en) * | 2013-07-18 | 2013-10-09 | 成都乾坤动物药业有限公司 | Wettable fenbendazole ivermectin powder |
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