CN109091461A - A kind of scutelloside aluminium powder agent and preparation method thereof for treating grice diarrhoea - Google Patents
A kind of scutelloside aluminium powder agent and preparation method thereof for treating grice diarrhoea Download PDFInfo
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Abstract
The present invention discloses a kind of scutelloside aluminium powder agent and preparation method thereof for treating grice diarrhoea, and the scutelloside aluminium powder agent of the treatment grice diarrhoea is in terms of mass fraction including following components: active constituent: 510~550 parts；Filler: 440~470 parts；Corrigent: 10~20 parts；Wherein, the active constituent is scutelloside and the scutelloside aluminum complex that aluminium salt is prepared into.The present invention reacts prepared scutelloside aluminum complex using scutelloside raw material with aluminium salt as active constituent, scutelloside aluminium powder agent is prepared by mixing into filler and corrigent, improve the scutelloside purity in the pulvis, reach while improving the therapeutic effect to grice diarrhoea, has reduced the technical effect of side effect.
Description
Technical field
The present invention relates to treating epidemic disease of domestic animals Prevention Technique field, in particular to a kind of scutelloside aluminium powder agent for treating grice diarrhoea
And preparation method thereof.
Background technique
Grice diarrhoea is a kind of typical multifactor property disease under intensive pig production working condition.The disease is most tight at present
One of the piglet diseases group of weight, and cause the major reason of piglet death.According to relevant report, piglet accounts for piglet because of diarrhea death
The 39.8% of dead sum.In recent years, China's grice diarrhoea is very universal, 30kg piglet below, average of the whole year disease incidence
46.5%, the death rate 10.3%.In such as U.S. of the more developed country of pig breeding industry, the death rate about 15.5% before weaned piglet, Holland
11.5%~14.2%, grice diarrhoea ranks first in pig breeding industry harm, seriously threatens the sound development of pig breeding industry, causes to raise
Expect that rate of returns is lower, piglet survival ratio decline, slow growth, growth and development are stagnated, or even dead.
At present treatment the most common method of grice diarrhoea be using antibacterials, since the drug resistance of current bacterium is serious,
Cause therapeutic effect poor.Also the relevant technologies replace antibacterials using Chinese medicine, for example, by using scutelloside aluminium powder agent, the radix scutellariae
The agent of glycosides aluminium powder is prepared by Baical Skullcap root P.E (effective component extracted from radix scutellariae) and aluminium salt reaction, however the radix scutellariae
The complicated component of extract, purity is low, has certain side effect to piglet.
Summary of the invention
The main object of the present invention is to propose a kind of scutelloside aluminium powder agent and preparation method thereof for treating grice diarrhoea, it is intended to
There is provided that a kind of pair of grice diarrhoea therapeutic effect be good, scutelloside aluminium powder agent of Small side effects.
To achieve the above object, the present invention proposes a kind of scutelloside aluminium powder agent for treating grice diarrhoea, in terms of mass fraction
Including following components:
Active constituent: 510~550 parts；
Filler: 440~470 parts；
Corrigent: 10~20 parts；
Wherein, the active constituent is scutelloside and the scutelloside aluminum complex that aluminium salt is prepared into.
Preferably, the mass fraction of the active constituent is 520~540 parts, the mass fraction of the filler is 450~
460；The mass fraction of corrigent is 10~20 parts.
Preferably, the filler is one of corn flour, calcium monohydrogen phosphate and calcium carbonate or a variety of.
Preferably, the filler is calcium monohydrogen phosphate, and the mass fraction of the calcium monohydrogen phosphate is 460 parts.
Preferably, the corrigent is one of sorbierite, stevioside and mannitol or a variety of.
Preferably, the partial size of the active constituent is 100~200 mesh；And/or
The partial size of the filler and the corrigent is 100~200 mesh.
To achieve the above object, it is also proposed that a kind of preparation side of the scutelloside aluminium powder agent for the treatment of grice diarrhoea as described above
Method, comprising the following steps:
By scutelloside aluminum complex grinding and sieving, active constituent is obtained；
Filler and corrigent are distinguished into grinding and sieving, to deserved filler powder and corrigent powder；
The active constituent, the filler powder and the corrigent powder are mixed evenly, scutelloside aluminium powder is obtained
Agent.
Preferably, the active constituent, the filler powder and the corrigent powder are mixed evenly, obtain radix scutellariae
The step of glycosides aluminium powder agent, specifically:
The active constituent, the filler powder and the corrigent powder are uniformly mixed according to equal increments method,
Obtain scutelloside aluminium powder agent.
In technical solution provided by the invention, prepared scutelloside aluminum complex is reacted with aluminium salt using scutelloside raw material
As active constituent, it is prepared by mixing into scutelloside aluminium powder agent with filler and corrigent, improves the scutelloside in the pulvis
Purity has reached while improving the therapeutic effect to grice diarrhoea, has reduced the technical effect of side effect.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
The present invention proposes a kind of scutelloside aluminium powder agent for treating grice diarrhoea, including following components in terms of mass fraction: living
Property ingredient: 510~550 parts；Filler: 450~490 parts；Corrigent: 10~20 parts；Wherein, the active constituent is scutelloside
The scutelloside aluminum complex being prepared into aluminium salt.
Scutelloside is that a kind of flavone compound separated is extracted from the dry root of radix scutellariae, is faint yellow under room temperature
Powder, bitter, have significant bioactivity, have antibacterial, diuresis, anti-inflammatory, norcholesterol, antithrombus formation, alleviate asthma,
Purging fire for removing toxin, hemostasis, miscarriage prevention, antiallergic action and spasmolysis.Studies have shown that scutelloside antibacterial range is wider, especially to gold
Staphylococcus aureus, Pseudomonas aeruginosa effect are stronger, or even also have bacteriostasis to drug-resistant S. aureus.
When the active constituent of the existing drug using Baicalin metal complex as treatment grice diarrhoea, the scutelloside metal
Complex is prepared with Baical Skullcap root P.E and reacting metal salt, however, the complicated component of Baical Skullcap root P.E, scutelloside purity
It is low, when being used as the drug for the treatment of grice diarrhoea, there is certain side effect to piglet.
Directly reacted using scutelloside raw material with aluminium salt in the present invention prepared scutelloside aluminum complex as it is active at
Point, it is prepared by mixing into scutelloside aluminium powder agent with filler and corrigent, the scutelloside purity in the pulvis is improved, reduces
Dosage when for treating grice diarrhoea can be used for treating mainly due to grice diarrhoea caused by bacterium infection, and disconnected
Milk turns group and stress wait grice diarrhoea caused by reasons, while improving the therapeutic effect to grice diarrhoea, reduces to piglet
Side effect.It should be noted that the prior art is belonged to scutelloside and reacting metal salt preparation Baicalin metal complex, this
It invents and is to choose the scutelloside aluminium for reacting preparation with aluminium salt using the scutelloside raw material of high-purity as reactant as the powder
The active constituent of agent, therefore, react with aluminium salt the preparation method for preparing scutelloside aluminum complex to scutelloside and process do not do it is superfluous
It states.
As a kind of preferred embodiment provided by the invention, the mass fraction of the active constituent is 520~540 parts,
The mass fraction of the filler is 450~460；The mass fraction of corrigent is 10~20 parts.
Pulvis is medically also referred to as powder, refers to drug or the drying with suitable auxiliary material through crushing, being uniformly mixed
Powder preparation, in addition to can be directly as dosage form and other dosage forms such as granule, capsule, tablet, pulvis, aerosol, powder
The intermediate of the preparations such as mist agent and spray.Pulvis includes oral powder and externally-applied powder, refers to oral type pulvis in the present invention,
When making Piglet by Oral, it can be scattered in water, dilution or other liquid and gavage, can also directly be delivered with water, or
It can also be administered by the way of being added in feed.Pulvis is the maximum preparation of degree of scatter in solid dosage forms, drug grain
Diameter is small, large specific surface area, has the advantages that be easily dispersed, absorbs fast, rapid-action, and is easy to carry about with one, is convenient to take, particularly with
For the big drug of dosage, pulvis is easier to be easily accepted by the patient.
Used auxiliary material is generally comprised as the filler of carrier and to improve the pulvis during the preparation process
The smell of pulvis and the corrigent of taste are stated, in the present embodiment, the filler is preferably corn flour, calcium monohydrogen phosphate and carbonic acid
One of calcium is a variety of, either any one in above-mentioned three kinds of substances, is also possible to appointing in above-mentioned three kinds of substances
The mixture of two kinds or three kinds of meaning, can be used as the filler in the embodiment of the present invention.
It is highly preferred that the filler is calcium monohydrogen phosphate, and the mass fraction of the calcium monohydrogen phosphate is 460 parts.Compared to
For using corn flour and calcium carbonate as the pulvis prepared by the filler, using calcium monohydrogen phosphate as the filler institute
The hydroscopicity of the pulvis of preparation is lower, and mobility is more preferable.
The corrigent is one of sorbierite, stevioside and mannitol or a variety of, either above-mentioned three kinds of substances
In any one, any two kinds or three kinds of mixture being also possible in above-mentioned three kinds of substances can be used as this hair
The corrigent in bright embodiment, to improve the smell and taste of the pulvis, so that the pulvis has sweet taste and is easier to
In taking in piglet.
For pulvis, the requirement to its granularity is more stringent, in four general rules 0115 of " Chinese Pharmacopoeia " version in 2015
Describe the granularity Detection of powder (namely described pulvis in the present invention): unless otherwise specified, chemical drugs topical powder and
For burning or the Chinese medicine topical powder and paediatrics powder of severe trauma, according to granularity and determination of particle size distribution (general rule
0982 single sieve method) measurement.The powder weight and traditional Chinese powder medicine that chemical powdered medicine sieves (120 mesh, 125 μm) by No. seven pass through
The powder weight of No. six sieves (100 mesh, 150 μm) must not be less than 95%.It is in embodiments of the present invention preferably the active constituent
Partial size be 100~200 mesh；And/or the partial size of the filler and the corrigent is 100~200 mesh, in this way, prepared
Pulvis can satisfy the granularity requirements in relevant criterion, degree of scatter is big, and also more abundant in the mixing of preparation process
Uniformly.
The present invention also proposes a kind of as described above preparation method of the scutelloside aluminium powder agent for the treatment of grice diarrhoea, including with
Lower step:
Step S10, by scutelloside aluminum complex grinding and sieving, active constituent is obtained；
Step S20, filler and corrigent are distinguished into grinding and sieving, to deserved filler powder and corrigent powder；
Step S30, the active constituent, the filler powder and the corrigent powder are mixed evenly, obtain Huang
A kind of reed mentioned in ancient books glycosides aluminium powder agent.
Wherein, step S10 and step S20 can be step S10 preceding, and step S20 is rear；It is also possible to step S20 to exist
Before, step S10 is rear；It is also possible to separately carry out simultaneously, is not particularly limited herein.
Step S10 and step S20 in the specific implementation, can routinely be set using high speed disintegrator or mortar, mill etc.
It is standby to carry out, it will be illustrated for using Universalpulverizer below, the specific implementation method of step S10 and step S20 are as follows:
Scutelloside aluminum complex is smashed it through into 100~200 meshes, obtains active constituent；Filler is smashed it through 100~200 respectively
Mesh obtains filler powder.
Step S30 in the specific implementation, specifically: by the active constituent and the filler powder according to equal increments
Method is uniformly mixed, and obtains scutelloside aluminium powder agent.In the present embodiment, i.e., are as follows: first take the corrigent and with the corrigent etc.
The active constituent and the filler of quality, are placed in be uniformly mixed in high-speed mixer and form mixture, then thereto
The active constituent and the filler with quality such as the mixtures is added, is uniformly mixed again, in this way, until described
All addition finishes and after mixing for active constituent and the filler, obtains the scutelloside aluminium powder agent.
Technical solution of the present invention is described in further detail below in conjunction with specific embodiment, it should be understood that following real
It applies example to be only used to explain the present invention, be not intended to limit the present invention.
One, the preparation of scutelloside aluminium powder agent
Embodiment 1
(1) raw material weighs: scutelloside aluminum complex 520g, corn flour 460g, stevioside 20g；
(2) preparation of scutelloside aluminium powder agent: scutelloside aluminum complex is smashed it through into 100 meshes with Universalpulverizer, is obtained
Active constituent；Corn flour, stevioside are smashed it through into 100 meshes with Universalpulverizer, obtain corn flour and stevioside powder；It will live
Property ingredient with corn flour and stevioside powder mix mixing according to equal increments method, the agent of scutelloside aluminium powder is made.
Embodiment 2
(1) raw material weighs: scutelloside aluminum complex 520g, calcium carbonate 460g, stevioside 20g；
(2) preparation of scutelloside aluminium powder agent: scutelloside aluminum complex is smashed it through into 100 meshes with Universalpulverizer, is obtained
Active constituent；Calcium carbonate, stevioside are smashed it through into 100 meshes with Universalpulverizer, obtain calcium carbonate and stevioside powder；It will live
Property ingredient with calcium carbonate and stevioside powder mix mixing according to equal increments method, the agent of scutelloside aluminium powder is made.
Embodiment 3
(1) raw material weighs: scutelloside aluminum complex 520g, calcium monohydrogen phosphate 460g, stevioside 20g；
(2) preparation of scutelloside aluminium powder agent: scutelloside aluminum complex is smashed it through into 100 meshes with Universalpulverizer, is obtained
Active constituent；Calcium monohydrogen phosphate, stevioside are smashed it through into 100 meshes with Universalpulverizer, obtain calcium monohydrogen phosphate and stevioside powder；
Active constituent is mixed into mixing according to equal increments method with calcium monohydrogen phosphate and stevioside powder, the agent of scutelloside aluminium powder is made.
The hydroscopicity and mobility of scutelloside aluminium powder agent prepared by embodiment 1 to embodiment 3 are (with angle of repose average value table
Show) it is as shown in table 1 below.
The hydroscopicity and mobility of the scutelloside aluminium powder agent of the different filler preparations of table 1
| Filler | Average hydroscopicity (%) | Angle of repose average value (°) | |
| Embodiment 1 | Corn flour | 15.67 | -- |
| Embodiment 2 | Calcium carbonate | 1.80 | 58.78 |
| Embodiment 3 | Calcium monohydrogen phosphate | 1.13 | 38.39 |
As shown in Table 1, the hydroscopicity of the scutelloside aluminium powder agent prepared using corn flour as filler is excessively high, therefore
Filler described in the embodiment of the present invention is more preferably calcium carbonate or calcium monohydrogen phosphate；Meanwhile as can be seen from Table 1, compared to
The scutelloside aluminium powder agent prepared using calcium carbonate as the filler, using calcium monohydrogen phosphate as radix scutellariae prepared by the filler
The mobility of glycosides aluminium powder agent more preferably, therefore is carried out so that the filler is calcium monohydrogen phosphate as an example in subsequent embodiment of the invention
Explanation.
Embodiment 4
(1) raw material weighs: scutelloside aluminum complex 525g, calcium monohydrogen phosphate 455g, stevioside 20g；
(2) preparation of scutelloside aluminium powder agent: scutelloside aluminum complex is smashed it through into 60 meshes with Universalpulverizer, obtains work
Property ingredient；Calcium monohydrogen phosphate, stevioside are smashed it through into 100 meshes with Universalpulverizer, obtain calcium monohydrogen phosphate and stevioside powder；It will
Active constituent mixes mixing according to equal increments method with calcium monohydrogen phosphate and stevioside powder, and the agent of scutelloside aluminium powder is made.
Embodiment 5
(1) raw material weighs: scutelloside aluminum complex 530g, calcium monohydrogen phosphate 455g, stevioside 15g；
(2) preparation of scutelloside aluminium powder agent: scutelloside aluminum complex is smashed it through into 65 meshes with Universalpulverizer, obtains work
Property ingredient；Calcium monohydrogen phosphate, stevioside are smashed it through into 100 meshes with Universalpulverizer, obtain calcium monohydrogen phosphate and stevioside powder；It will
Active constituent mixes mixing according to equal increments method with calcium monohydrogen phosphate and stevioside powder, and the agent of scutelloside aluminium powder is made.
Embodiment 6
(1) raw material weighs: scutelloside aluminum complex 535g, calcium monohydrogen phosphate 450g, stevioside 15g；
(2) preparation of scutelloside aluminium powder agent: scutelloside aluminum complex is smashed it through into 100 meshes with Universalpulverizer, is obtained
Active constituent；Calcium monohydrogen phosphate, stevioside are smashed it through into 60 meshes with Universalpulverizer, obtain calcium monohydrogen phosphate and stevioside powder；
Active constituent is mixed into mixing according to equal increments method with calcium monohydrogen phosphate and stevioside powder, the agent of scutelloside aluminium powder is made.
Embodiment 7
(1) raw material weighs: scutelloside aluminum complex 540g, calcium monohydrogen phosphate 450g, stevioside 10g；
(2) preparation of scutelloside aluminium powder agent: scutelloside aluminum complex is smashed it through into 100 meshes with Universalpulverizer, is obtained
Active constituent；Calcium monohydrogen phosphate, stevioside are smashed it through into 65 meshes with Universalpulverizer, obtain calcium monohydrogen phosphate and stevioside powder；
Active constituent is mixed into mixing according to equal increments method with calcium monohydrogen phosphate and stevioside powder, the agent of scutelloside aluminium powder is made.
Embodiment 8
(1) raw material weighs: scutelloside aluminum complex 510g, calcium monohydrogen phosphate 470g, stevioside 20g；
(2) preparation method of scutelloside aluminium powder agent is the same as embodiment 3.
Embodiment 9
(1) raw material weighs: scutelloside aluminum complex 550g, calcium monohydrogen phosphate 440g, stevioside 10g；
(2) preparation method of scutelloside aluminium powder agent is the same as embodiment 3.
Embodiment 10
(1) raw material weighs: scutelloside aluminum complex 530g, calcium monohydrogen phosphate 455g, sorbierite 15g is spare；
(2) preparation method of scutelloside aluminium powder agent is the same as embodiment 3.
Embodiment 11
(1) raw material weighs: scutelloside aluminum complex 530g, calcium monohydrogen phosphate 455g, mannitol 15g is spare；
(2) preparation method of scutelloside aluminium powder agent is the same as embodiment 3.
Comparative example 1
(1) raw material weighs: scutelloside aluminum complex 450g, calcium monohydrogen phosphate 530g, stevioside 20g；
(2) preparation method of scutelloside aluminium powder agent is the same as embodiment 3.
Comparative example 2
(1) raw material weighs: scutelloside aluminum complex 490g, calcium monohydrogen phosphate 500g, stevioside 10g, wherein in this comparative example
Scutelloside aluminum complex be Baical Skullcap root P.E reacted with aluminium salt prepare product；
(2) preparation method of scutelloside aluminium powder agent is the same as embodiment 3.
Two, the agent of scutelloside aluminium powder is used to treat the clinical trial of grice diarrhoea
1, case diagnosis: with natural cases according to epidemiology, clinical symptoms, pathological change, Laboratory Diagnosed.Comprehensive point
Analysis, is made a definite diagnosis.
2, result judgement:
Cure: affected animal illness completely disappears after medication 3-4 times, and spirit, body temperature, appetite restore normal, and urine excrement is normal.
Effective: affected animal illness disappears substantially after medication 3-4 times, and spirit, body temperature, appetite make moderate progress, and urine excrement is normal.
Invalid: affected animal illness does not disappear after medication 4 times, and sb.'s illness took a turn for the worse or dead, and urine stool colour, character are abnormal.
Scutelloside aluminium powder agent prepared by embodiment 1 to embodiment 13 and comparative example 1, comparative example 2 is separately verified to 5 days
Age, 10 ages in days, 15 ages in days and wean one week grice diarrhoea clinical trial, including count the agent of scutelloside aluminium powder have to piglet
Efficiency, cure rate and side effect.
15 age in days diarrhea piglet of Application Example
5 age in days diarrhea piglets 150 are chosen, 10 are one group, are divided into 13 groups of (test group 1 to test group 13 and comparisons
Group 1 and contrast groups 2), administration mode are as follows: the scutelloside aluminium powder agent that Example 1 to embodiment 11 and comparative example 1 are prepared
(embodiment 1 to the pulvis that embodiment 11 is prepared respectively corresponds the powder that medicine-feeding test group 1 is prepared to test group 11, comparative example 1
Contrast groups 1 are administered in agent), every 20g mono- is wrapped, daily feeding 1 time, and the dosage for feeding the agent of scutelloside aluminium powder every time is 1g/ head；Take comparative example
The 2 scutelloside aluminium powder delivery contrast groups 2 being prepared, every 15g mono- are wrapped, daily feeding 1 time, feed the agent of scutelloside aluminium powder every time
Dosage is 1.5g/ head.After administration 1 day, treatment results are observed.As a result as shown in table 2 below.
Efficacy result comparison in 2 Application Example 1 of table
2 10 age in days diarrhea piglet of Application Example
Choose 10 age in days diarrhea piglets 150,10 are one group, are divided into 13 groups of (test groups 1 to test group 13 and right
Than group 1 and contrast groups 2), administration mode are as follows: the scutelloside aluminium powder that Example 1 to embodiment 11 and comparative example 1 are prepared
(embodiment 1 to the pulvis that embodiment 11 is prepared respectively corresponds what medicine-feeding test group 1 was prepared to test group 11, comparative example 1 for agent
Powder delivery contrast groups 1), every 20g mono- is wrapped, and is fed 1 time daily, and the dosage for feeding the agent of scutelloside aluminium powder is 1g/ head；Comparative example 2 is taken to make
Standby obtained scutelloside aluminium powder delivery contrast groups 2, every 15g mono- are wrapped, and are fed 1 time daily, feed the dosage of scutelloside aluminium powder agent every time
For 1.5g/ head.After administration 2 days, treatment results are observed.Treatment results are as shown in table 3 below.
Efficacy result comparison in 3 Application Example 2 of table
3 15 age in days diarrhea piglet of Application Example
Choose 15 age in days diarrhea piglets 150,10 are one group, are divided into 13 groups of (test groups 1 to test group 13 and right
Than group 1 and contrast groups 2), administration mode are as follows: the scutelloside aluminium powder that Example 1 to embodiment 11 and comparative example 1 are prepared
(embodiment 1 to the pulvis that embodiment 11 is prepared respectively corresponds what medicine-feeding test group 1 was prepared to test group 11, comparative example 1 for agent
Powder delivery contrast groups 1), every 20g mono- is wrapped, and is fed 1 time daily, and the dosage for feeding the agent of scutelloside aluminium powder every time is 1g/ head；Take comparative example
The 2 scutelloside aluminium powder delivery contrast groups 2 being prepared, every 15g mono- are wrapped, and are fed 1 time daily, feed the agent of scutelloside aluminium powder agent every time
Amount is 1.5g/ head.After administration 1 day, treatment results are observed.As a result as shown in table 4 below.
The efficacy result of 4 Application Example 3 of table compares
The diarrhea piglet of the wean of Application Example 4 after a week
Choose wean after a week diarrhea piglet 150,10 are one group, be divided into 13 groups (test group 1 to test group 13,
And contrast groups 1 and contrast groups 2), administration mode are as follows: the radix scutellariae that Example 1 to embodiment 11 and comparative example 1 are prepared
(embodiment 1 to the pulvis that embodiment 11 is prepared respectively corresponds medicine-feeding test group 1 to test group 11, comparative example 1 to the agent of glycosides aluminium powder
The powder delivery contrast groups 1 of preparation), every 20g mono- is wrapped, and is fed 1 time daily, and the dosage for feeding the agent of scutelloside aluminium powder every time is 1g/ head；It takes
The scutelloside aluminium powder delivery contrast groups 2 that comparative example 2 is prepared, every 15g mono- are wrapped, and are fed 1 time daily, feed scutelloside aluminium powder every time
The dosage of agent is 1.5g/ head.After successive administration 3 days, treatment results are observed.As a result as shown in table 5 below.
The efficacy result of 5 Application Example 4 of table compares
It can be seen that from efficacy result of the table 2 into table 5 and be less than 510 parts compared to scutelloside aluminum complex additive amount
For comparative example 1, scutelloside aluminium powder agent provided in an embodiment of the present invention is to treat average cure rate peace when grice diarrhoea
Equal effective percentage is apparently higher than comparative example 1, illustrates that the treatment of grice diarrhoea is imitated in scutelloside aluminium powder agent provided in an embodiment of the present invention
Fruit is more significant；The scutelloside aluminum complex prepared in reacting compared to Baical Skullcap root P.E with aluminium salt is the comparative example of active constituent
For 2, although the average cure rate and average effectiveness level to grice diarrhoea are not much different, the pulvis in comparative example 2 is being controlled
Used dosage is apparently higher than embodiment 1 to 11 during treating grice diarrhoea, and the piglet in Application Example 1 to 11 is being controlled
Apparent side effect is not occurred during treating, and illustrates that scutelloside aluminium powder agent provided in an embodiment of the present invention is being improved to piglet
While the therapeutic effect of diarrhea, also have the advantages that dosage is small, few side effects.
Make in conclusion directly reacting prepared scutelloside aluminium with aluminium salt using scutelloside raw material in the embodiment of the present invention
For active constituent, it is prepared by mixing into scutelloside aluminium powder agent with filler and corrigent, the oral medication as treatment grice diarrhoea,
The scutelloside purity in the pulvis is improved, significant to the therapeutic effect of grice diarrhoea, Small side effects can be used as antibiotic
Alternative medicine, and during treating grice diarrhoea, the dosage that piglet is taken in every time is only 1g/ head, and dosage is less.
The above is only a preferred embodiment of the present invention, is not intended to limit the scope of the invention, for this field
For technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any
Modification, equivalent replacement, improvement etc. should all be included within the scope of the present invention.
Claims (8)
1. a kind of scutelloside aluminium powder agent for treating grice diarrhoea, which is characterized in that including following components in terms of mass fraction:
Active constituent: 510~550 parts；
Filler: 440~470 parts；
Corrigent: 10~20 parts；
Wherein, the active constituent is scutelloside and the scutelloside aluminum complex that aluminium salt is prepared into.
2. the scutelloside aluminium powder agent for the treatment of grice diarrhoea as described in claim 1, which is characterized in that the matter of the active constituent
Measuring number is 520~540 parts, and the mass fraction of the filler is 450~460；The mass fraction of corrigent is 10~20 parts.
3. the scutelloside aluminium powder agent for the treatment of grice diarrhoea as claimed in claim 2, which is characterized in that the filler is corn
One of powder, calcium monohydrogen phosphate and calcium carbonate are a variety of.
4. the scutelloside aluminium powder agent for the treatment of grice diarrhoea as claimed in claim 3, which is characterized in that the filler is phosphoric acid
Hydrogen calcium, the mass fraction of the calcium monohydrogen phosphate are 460 parts.
5. the scutelloside aluminium powder agent for the treatment of grice diarrhoea as claimed in claim 2, which is characterized in that the corrigent is sorb
One of alcohol, stevioside and mannitol are a variety of.
6. the scutelloside aluminium powder agent for the treatment of grice diarrhoea as claimed in claim 2, which is characterized in that the grain of the active constituent
Diameter is 100~200 mesh；And/or
The partial size of the filler and the corrigent is 100~200 mesh.
7. a kind of preparation method of the scutelloside aluminium powder agent of the treatment grice diarrhoea as described in claim 1 to 6 any one,
It is characterized in that, comprising the following steps:
By scutelloside aluminum complex grinding and sieving, active constituent is obtained；
Filler and corrigent are distinguished into grinding and sieving, to deserved filler powder and corrigent powder；
The active constituent, the filler powder and the corrigent powder are mixed evenly, scutelloside aluminium powder agent is obtained.
8. the preparation method of the scutelloside aluminium powder agent for the treatment of grice diarrhoea as claimed in claim 7, which is characterized in that will be described
The step of active constituent, the filler powder and the corrigent powder are mixed evenly, obtain scutelloside aluminium powder agent, specifically
Are as follows:
The active constituent, the filler powder and the corrigent powder are uniformly mixed according to equal increments method, obtained
Scutelloside aluminium powder agent.
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| CN106176935A (en) * | 2016-07-16 | 2016-12-07 | 南京正宽医药科技有限公司 | A kind of baicalin aluminium glue capsule and preparation method thereof |
| CN106667915A (en) * | 2016-10-24 | 2017-05-17 | 武汉轻工大学 | Baicalin-aluminum dry suspension for treating pigling diarrhoea |
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Application publication date: 20181228 |