CN108938570A - A kind of scutelloside aluminium pre-mixing agent and preparation method thereof for treating grice diarrhoea - Google Patents
A kind of scutelloside aluminium pre-mixing agent and preparation method thereof for treating grice diarrhoea Download PDFInfo
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Abstract
The present invention discloses a kind of scutelloside aluminium pre-mixing agent and preparation method thereof for treating grice diarrhoea, and the scutelloside aluminium pre-mixing agent of the treatment grice diarrhoea is in terms of mass fraction including following components: active constituent: 510~550 parts；Filler: 450~490 parts；Wherein, the active constituent is scutelloside and the scutelloside aluminum complex that aluminium salt is prepared into.The present invention reacts prepared scutelloside aluminum complex using scutelloside raw material with aluminium salt as active constituent, scutelloside aluminium pre-mixing agent is prepared by mixing into filler, improve the purity of scutelloside aluminum complex in the pre-mixing agent, dosage of scutelloside aluminium pre-mixing agent when for treating grice diarrhoea is reduced, and improves therapeutic effect, reduce side effect.
Description
Technical field
The present invention relates to treating epidemic disease of domestic animals Prevention Technique field, in particular to a kind of scutelloside aluminium premix for treating grice diarrhoea
Agent and preparation method thereof.
Background technique
Grice diarrhoea is a kind of typical multifactor property disease under intensive pig production working condition.The disease is most tight at present
One of the piglet diseases group of weight, and cause the major reason of piglet death.According to relevant report, piglet accounts for piglet because of diarrhea death
The 39.8% of dead sum.In recent years, China's grice diarrhoea is very universal, 30kg piglet below, average of the whole year disease incidence
46.5%, the death rate 10.3%.In such as U.S. of the more developed country of pig breeding industry, the death rate about 15.5% before weaned piglet, Holland
11.5%~14.2%, grice diarrhoea ranks first in pig breeding industry harm, seriously threatens the sound development of pig breeding industry, causes to raise
Expect that rate of returns is lower, piglet survival ratio decline, slow growth, growth and development are stagnated, or even dead.
At present treatment the most common method of grice diarrhoea be using antibacterials, since the drug resistance of current bacterium is serious,
Cause therapeutic effect poor.Also the relevant technologies replace antibacterials using Chinese medicine, for example, by using scutelloside aluminium pre-mixing agent, the Huang
A kind of reed mentioned in ancient books glycosides aluminium pre-mixing agent is prepared by Baical Skullcap root P.E (effective component extracted in radix scutellariae) and aluminium salt reaction, however the radix scutellariae
The complicated component of extract, purity is low, has certain side effect to piglet.
Summary of the invention
The main object of the present invention is to propose a kind of scutelloside aluminium pre-mixing agent and preparation method thereof for treating grice diarrhoea, purport
A kind of pair of grice diarrhoea therapeutic effect be good, scutelloside aluminium pre-mixing agents of Small side effects providing.
To achieve the above object, the present invention proposes a kind of scutelloside aluminium pre-mixing agent for treating grice diarrhoea, with mass fraction
Meter includes following components:
Active constituent: 510~550 parts；
Filler: 450~490 parts；
Wherein, the active constituent is scutelloside and the scutelloside aluminum complex that aluminium salt is prepared into.
Preferably, the mass fraction of the active constituent is 520~540 parts, the mass fraction of the filler is 460~
480 parts.
Preferably, the filler is one of corn flour, calcium monohydrogen phosphate and calcium carbonate or a variety of.
Preferably, the filler is calcium monohydrogen phosphate, and the mass fraction of the calcium monohydrogen phosphate is 460 parts.
Preferably, the partial size of the active constituent is 50~65 mesh；And/or
The partial size of the filler is 50~65 mesh.
To realize that upper above-mentioned purpose, the present invention also propose a kind of scutelloside aluminium premix for the treatment of grice diarrhoea as described above
The preparation method of agent, comprising the following steps:
By scutelloside aluminum complex grinding and sieving, active constituent is obtained；
By filler grinding and sieving, filler powder is obtained；
The active constituent and the filler powder are mixed evenly, scutelloside aluminium pre-mixing agent is obtained.
Preferably, the active constituent and the filler powder are mixed evenly, obtain the step of scutelloside aluminium pre-mixing agent
Suddenly, specifically:
The active constituent and the filler powder are uniformly mixed according to equal increments method, obtain scutelloside aluminium premix
Agent.
In technical solution provided by the invention, prepared scutelloside aluminum complex is reacted with aluminium salt using scutelloside raw material
As active constituent, it is prepared by mixing into scutelloside aluminium pre-mixing agent with filler, scutelloside aluminium in the pre-mixing agent is improved and cooperates
The purity of object reduces dosage of scutelloside aluminium pre-mixing agent when for treating grice diarrhoea, and improves and control
Therapeutic effect reduces side effect.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
The present invention proposes a kind of scutelloside aluminium pre-mixing agent for treating grice diarrhoea, including following components in terms of mass fraction:
Active constituent: 510~550 parts；Filler: 450~490 parts；Wherein, the active constituent is that scutelloside and aluminium salt are prepared into
Scutelloside aluminum complex.
Scutelloside is that a kind of flavone compound separated is extracted from the dry root of radix scutellariae, is faint yellow under room temperature
Powder, bitter, have significant bioactivity, have antibacterial, diuresis, anti-inflammatory, norcholesterol, antithrombus formation, alleviate asthma,
Purging fire for removing toxin, hemostasis, miscarriage prevention, antiallergic action and spasmolysis.Studies have shown that scutelloside antibacterial range is wider, especially to gold
Staphylococcus aureus, Pseudomonas aeruginosa effect are stronger, or even also have bacteriostasis to drug-resistant S. aureus.
When the active constituent of the existing drug using Baicalin metal complex as treatment grice diarrhoea, the scutelloside metal
Complex is that Baical Skullcap root P.E and reacting metal salt are prepared, however the complicated component of the Baical Skullcap root P.E, scutelloside are pure
Spend it is low, be used as treatment grice diarrhoea drug when, have certain side effect to piglet.
Directly reacted using scutelloside raw material with aluminium salt in the present invention prepared scutelloside aluminum complex as it is active at
Point, it is prepared by mixing into scutelloside aluminium pre-mixing agent with filler, improves the purity of scutelloside aluminum complex in the pre-mixing agent, is dropped
Low dosage of scutelloside aluminium pre-mixing agent when for treating grice diarrhoea can be used for treating mainly due to bacterium
Grice diarrhoea caused by infecting, and wean, turn group and stress wait grice diarrhoea caused by reasons, to the therapeutic effect of grice diarrhoea
Significantly, few side effects.It should be noted that belonging to existing skill with scutelloside and reacting metal salt preparation Baicalin metal complex
Art, the invention reside in choose to react with aluminium salt the scutelloside aluminium for preparing using the scutelloside raw material of high-purity as reactant as institute
The active constituent of pre-mixing agent is stated, therefore, the preparation method and process for preparing scutelloside aluminum complex are reacted scutelloside with aluminium salt
It does not repeat them here.
As a kind of preferred embodiment provided by the invention, the mass fraction of the active constituent is 520~540 parts,
The mass fraction of the filler is 460~480 parts.
Pre-mixing agent refers to drug and the powdered or granular formulations that suitable matrix is uniformly mixed, and generally passes through feeding
Material is administered with certain drug concentration.Matrix in the pre-mixing agent includes filler etc., should usually have stable, mobility
It is good, the characteristics of easily mixing with drug and feed.In the present embodiment, the filler is preferably corn flour, calcium monohydrogen phosphate and carbon
One of sour calcium is a variety of, either any one in above-mentioned three kinds of substances, is also possible in above-mentioned three kinds of substances
Any two kinds or three kinds of mixture, can be used as the filler in the embodiment of the present invention.
It is highly preferred that the filler is calcium monohydrogen phosphate, and the mass fraction of the calcium monohydrogen phosphate is 460 parts.Compared to
For using corn flour and calcium carbonate as the pre-mixing agent prepared by the filler, using calcium monohydrogen phosphate as the filler
The hydroscopicity of the prepared pre-mixing agent is lower, and mobility is more preferable.
Since the pre-mixing agent is in the use process for treating grice diarrhoea, need to mix the pre-mixing agent with feed
Close uniformly after make piglet intake in vivo, in order to make the pre-mixing agent when being mixed with feed be easier be uniformly mixed, and be easy to by
Piglet is taken in vivo together with feed in edible feed, and the partial size of the preferably described active constituent is in embodiments of the present invention
50~65 mesh；And/or the partial size of the filler is 50~65 mesh, in this way, the pre-mixing agent is easier to mix with feed
It is even, feed is selectively only taken in avoid there is piglet in edible feed, the phenomenon that without taking in the pre-mixing agent.
The present invention also proposes a kind of preparation method of the scutelloside aluminium pre-mixing agent for the treatment of grice diarrhoea as described above, including
Following steps:
Step S10, by scutelloside aluminum complex grinding and sieving, active constituent is obtained；
Step S20, by filler grinding and sieving, filler powder is obtained；
Step S30, the active constituent and the filler powder are mixed evenly, obtain scutelloside aluminium pre-mixing agent.
Wherein, step S10 and step S20 can be step S10 preceding, and step S20 is rear；It is also possible to step S20 to exist
Before, step S10 is rear；It is also possible to separately carry out simultaneously, is not particularly limited herein.
Step S10 and step S20 in the specific implementation, can routinely be set using high speed disintegrator or mortar, mill etc.
It is standby to carry out, it will be illustrated for using Universalpulverizer below, the specific implementation method of step S10 and step S20 are as follows:
Scutelloside aluminum complex is smashed it through into 50~65 meshes, obtains active constituent；Filler is smashed it through to 50~65 meshes respectively,
Obtain filler powder.
Step S30 in the specific implementation, specifically: by the active constituent and the filler powder according to equal increments
Method is uniformly mixed, and obtains scutelloside aluminium pre-mixing agent.
Technical solution of the present invention is described in further detail below in conjunction with specific embodiment, it should be understood that following real
It applies example to be only used to explain the present invention, be not intended to limit the present invention.
One, the preparation of scutelloside aluminium pre-mixing agent
Embodiment 1
(1) raw material weighs: scutelloside aluminum complex 540g, corn flour 460g；
(2) preparation of scutelloside aluminium pre-mixing agent: scutelloside aluminum complex is smashed it through into 50 meshes with Universalpulverizer, is obtained
Active constituent；Corn flour is smashed it through into 50 meshes with Universalpulverizer, obtains corn flour powder；By active constituent and corn flour powder
Material is mixed according to equal increments method and is mixed, and scutelloside aluminium pre-mixing agent is made.
Embodiment 2
(1) raw material weighs: scutelloside aluminum complex 540g, calcium carbonate 460g；
(2) preparation of scutelloside aluminium pre-mixing agent: scutelloside aluminum complex is smashed it through into 50 meshes with Universalpulverizer, is obtained
Active constituent；Calcium carbonate is smashed it through into 50 meshes with Universalpulverizer, obtains calcium carbonate powder；By active constituent and Paris white
Agent is mixed according to equal increments method and is mixed, and scutelloside aluminium pre-mixing agent is made.
Embodiment 3
(1) raw material weighs: scutelloside aluminum complex 520g, calcium monohydrogen phosphate 480g；
(2) preparation of scutelloside aluminium pre-mixing agent: scutelloside aluminum complex is smashed it through into 50 meshes with Universalpulverizer, is obtained
Active constituent；Calcium monohydrogen phosphate is smashed it through into 50 meshes with Universalpulverizer, obtains calcium monohydrogen phosphate powder；By active constituent and phosphoric acid
Hydrogen calcium powder material is mixed according to equal increments method and is mixed, and scutelloside aluminium pre-mixing agent is made.
The hydroscopicity and mobility of scutelloside aluminium pre-mixing agent prepared by embodiment 1 to embodiment 3 are (with angle of repose average value table
Show) it is as shown in table 1 below.
The hydroscopicity and mobility of the scutelloside aluminium pre-mixing agent of the different filler preparations of table 1
| Filler | Average hydroscopicity (%) | Angle of repose average value (°) | |
| Embodiment 1 | Corn flour | 15.38 | -- |
| Embodiment 2 | Calcium carbonate | 1.76 | 58.69 |
| Embodiment 3 | Calcium monohydrogen phosphate | 1.2 | 38.46 |
As shown in Table 1, the hydroscopicity of the scutelloside aluminium pre-mixing agent prepared using corn flour as filler is excessively high, therefore
The filler is more preferably calcium carbonate or calcium monohydrogen phosphate in embodiments of the present invention；Meanwhile as can be seen from Table 1, it compares
In the scutelloside aluminium pre-mixing agent prepared using calcium carbonate as the filler, using calcium monohydrogen phosphate as prepared by the filler
The mobility of scutelloside aluminium pre-mixing agent more preferably, therefore is using the filler as calcium monohydrogen phosphate in subsequent embodiment of the invention
Example is illustrated.
Embodiment 4
(1) raw material weighs: scutelloside aluminum complex 525g, calcium monohydrogen phosphate 475g；
(2) preparation of scutelloside aluminium pre-mixing agent: scutelloside aluminum complex is smashed it through into 60 meshes with Universalpulverizer, is obtained
Active constituent；Calcium monohydrogen phosphate is smashed it through into 50 meshes with Universalpulverizer, obtains calcium monohydrogen phosphate powder；By active constituent and phosphoric acid
Hydrogen calcium is mixed according to equal increments method and is mixed, and scutelloside aluminium pre-mixing agent is made.
Embodiment 5
(1) raw material weighs: scutelloside aluminum complex 530g, calcium monohydrogen phosphate 470g；
(2) preparation of scutelloside aluminium pre-mixing agent: scutelloside aluminum complex is smashed it through into 65 meshes with Universalpulverizer, is obtained
Active constituent；Calcium monohydrogen phosphate is smashed it through into 50 meshes with Universalpulverizer, obtains calcium monohydrogen phosphate powder；By active constituent and phosphoric acid
Hydrogen calcium is mixed according to equal increments method and is mixed, and scutelloside aluminium pre-mixing agent is made.
Embodiment 6
(1) raw material weighs: scutelloside aluminum complex 535g, calcium monohydrogen phosphate 465g；
(2) preparation of scutelloside aluminium pre-mixing agent: scutelloside aluminum complex is smashed it through into 50 meshes with Universalpulverizer, is obtained
Active constituent；Calcium monohydrogen phosphate is smashed it through into 60 meshes with Universalpulverizer, obtains calcium monohydrogen phosphate powder；By active constituent and phosphoric acid
Hydrogen calcium is mixed according to equal increments method and is mixed, and scutelloside aluminium pre-mixing agent is made.
Embodiment 7
(1) raw material weighs: scutelloside aluminum complex 540g, calcium monohydrogen phosphate 460g；
(2) preparation of scutelloside aluminium pre-mixing agent: scutelloside aluminum complex is smashed it through into 50 meshes with Universalpulverizer, is obtained
Active constituent；Calcium monohydrogen phosphate is smashed it through into 65 meshes with Universalpulverizer, obtains calcium monohydrogen phosphate powder；By active constituent and phosphoric acid
Hydrogen calcium is mixed according to equal increments method and is mixed, and scutelloside aluminium pre-mixing agent is made.
Embodiment 8
(1) raw material weighs: scutelloside aluminum complex 510g, calcium monohydrogen phosphate 490g；
(2) preparation method of scutelloside aluminium pre-mixing agent is the same as embodiment 3.
Embodiment 9
(1) raw material weighs: scutelloside aluminum complex 550g, calcium monohydrogen phosphate 450g；
(2) preparation method of scutelloside aluminium pre-mixing agent is the same as embodiment 3.
Embodiment 10
(1) raw material weighs: scutelloside aluminum complex 515g, calcium monohydrogen phosphate 485g；
(2) preparation method of scutelloside aluminium pre-mixing agent is the same as embodiment 3.
Embodiment 11
(1) raw material weighs: scutelloside aluminum complex 545g, calcium monohydrogen phosphate 455g；
(2) preparation method of scutelloside aluminium pre-mixing agent is the same as embodiment 3.
Comparative example 1
(1) raw material weighs: scutelloside aluminum complex 450g, calcium monohydrogen phosphate 550g；
(2) preparation method of scutelloside aluminium pre-mixing agent is the same as embodiment 3.
Comparative example 2
(1) raw material weighs: scutelloside aluminum complex 490g, calcium monohydrogen phosphate 510g, wherein the scutelloside aluminium in this comparative example
Complex is that the medical fluid after carrying out soak extraction by raw material of radix scutellariae reacts the product prepared with aluminium salt；
(2) scutelloside aluminium intervenes the preparation method of mixture with embodiment 3.
Two, scutelloside aluminium pre-mixing agent is used to treat the clinical trial of grice diarrhoea
1, case diagnosis: with natural cases according to epidemiology, clinical symptoms, pathological change, Laboratory Diagnosed.Comprehensive point
Analysis, is made a definite diagnosis.
2, result judgement:
Cure: affected animal illness completely disappears after medication 3-4 times, and spirit, body temperature, appetite restore normal, and urine excrement is normal.
Effective: affected animal illness disappears substantially after medication 3-4 times, and spirit, body temperature, appetite make moderate progress, and urine excrement is normal.
Invalid: affected animal illness does not disappear after medication 4 times, and sb.'s illness took a turn for the worse or dead, and urine stool colour, character are abnormal.
Scutelloside aluminium pre-mixing agent prepared by embodiment 1 to embodiment 11 and comparative example 1, comparative example 2 is separately verified to 5
Age in days, 10 ages in days, 15 ages in days and wean one week grice diarrhoea clinical trial, including count scutelloside aluminium pre-mixing agent to piglet
Effective percentage, cure rate and side effect.
15 age in days diarrhea piglet of Application Example
5 age in days diarrhea piglets 260 are chosen, 20 are one group, are divided into 13 groups of (test group 1 to test group 11 and comparisons
Group 1 and contrast groups 2), administration mode are as follows: the scutelloside aluminium premix that Example 1 to embodiment 11 and comparative example 1 are prepared
(embodiment 1 to the pre-mixing agent that embodiment 11 is prepared respectively corresponds medicine-feeding test group 1 to test group 11, prepared by comparative example 1 for agent
The corresponding administration contrast groups 1 of pre-mixing agent), every 20g mono- is wrapped, and when use is mixed with feed, is made into the dosage of scutelloside aluminium pre-mixing agent
For the mixture of 1g/Kg, feeding piglet 1 time, 1Kg/ each (to be equivalent to piglet and take in scutelloside aluminium pre-mixing agent every time daily
Dosage is 1g/)；The scutelloside aluminium pre-mixing agent administration contrast groups 2 for taking comparative example 2 to be prepared, every 15g mono- are wrapped, when use with
Feed mixes, and the dosage for being made into scutelloside aluminium pre-mixing agent is the mixture of 1.5g/Kg, feeding piglet 1 time daily, each 1Kg/ head
(being equivalent to piglet and taking in the dosage of scutelloside aluminium pre-mixing agent every time is 1.5g/).After administration 1 day, treatment results are observed.As a result
As shown in table 2 below.
Efficacy result comparison in 2 Application Example 1 of table
2 10 age in days severe diarrhea piglet of Application Example
Choose 10 age in days severe diarrhea piglets 260,20 are one group, be divided into 13 groups (test group 1 to test group 11, with
And contrast groups 1 and contrast groups 2), administration mode are as follows: the scutelloside that Example 1 to embodiment 11 and comparative example 1 are prepared
(embodiment 1 to the pre-mixing agent that embodiment 11 is prepared respectively corresponds medicine-feeding test group 1 to test group 11, comparison to aluminium pre-mixing agent
The corresponding administration contrast groups 1 of pre-mixing agent prepared by example 1), every 20g mono- is wrapped, and when use is mixed with feed, is made into scutelloside aluminium pre-mixing agent
Dosage be 1g/Kg mixture, feeding piglet 2 times daily, 1Kg/ each (being equivalent to piglet, to take in scutelloside aluminium every time pre-
The dosage of mixture is 1g/)；The scutelloside aluminium pre-mixing agent administration contrast groups 2 for taking comparative example 2 to be prepared, every 15g mono- are wrapped, are made
Used time and feed mix, and the dosage for being made into scutelloside aluminium pre-mixing agent is the mixture of 1.5g/Kg, feeding piglet 2 times daily, every time
1Kg/ (being equivalent to piglet and taking in the dosage of scutelloside aluminium pre-mixing agent every time is 1.5g/).After administration 2 days, observation treatment knot
Fruit.Treatment results are as shown in table 3 below.
Efficacy result comparison in 3 Application Example 2 of table
3 15 age in days diarrhea piglet of Application Example
Choose 15 age in days diarrhea piglets 260,20 are one group, are divided into 13 groups of (test groups 1 to test group 11 and right
Than group 1 and contrast groups 2), administration mode are as follows: the scutelloside aluminium that Example 1 to embodiment 11 and comparative example 1 are prepared is pre-
(embodiment 1 to the pre-mixing agent that embodiment 11 is prepared respectively corresponds medicine-feeding test group 1 to test group 11 to mixture, and comparative example 1 is made
The corresponding administration contrast groups 1 of standby pre-mixing agent), every 20g mono- is wrapped, and when use is mixed with feed, is made into the agent of scutelloside aluminium pre-mixing agent
Amount is the mixture of 1g/Kg, and feeding piglet 1 time, 1Kg/ each (to be equivalent to piglet and take in scutelloside aluminium pre-mixing agent every time daily
Dosage be 1g/)；The scutelloside aluminium pre-mixing agent administration contrast groups 2 for taking comparative example 2 to be prepared, every 15g mono- are wrapped, when use
It is mixed with feed, the dosage for being made into scutelloside aluminium pre-mixing agent is the mixture of 1.5g/Kg, feeding piglet 1 time daily, each 1Kg/
Head (being equivalent to piglet and taking in the dosage of scutelloside aluminium pre-mixing agent every time is 1.5g/).After administration 1 day, treatment results are observed.Knot
Fruit is as shown in table 4 below.
The efficacy result of 4 Application Example 3 of table compares
The diarrhea piglet of the wean of Application Example 4 after a week
Choose wean after a week diarrhea piglet 260,20 are one group, be divided into 13 groups (test group 1 to test group 11,
And contrast groups 1 and contrast groups 2), administration mode are as follows: the radix scutellariae that Example 1 to embodiment 11 and comparative example 1 are prepared
(embodiment 1 to the pre-mixing agent that embodiment 11 is prepared respectively corresponds medicine-feeding test group 1 to test group 11 to glycosides aluminium pre-mixing agent, right
The corresponding administration contrast groups 1 of pre-mixing agent prepared by ratio 1), every 20g mono- is wrapped, and when use is mixed with feed, is made into scutelloside aluminium and is premixed
The dosage of agent is the mixture of 1g/Kg, feeds piglet 2 times (once in the morning and once at night) daily, each 1Kg/ (it is each to be equivalent to piglet
The dosage for taking in scutelloside aluminium pre-mixing agent is 1g/)；The scutelloside aluminium pre-mixing agent administration contrast groups for taking comparative example 2 to be prepared
2, every 15g mono- are wrapped, and when use mixes with feed, and the dosage for being made into scutelloside aluminium pre-mixing agent is the mixture of 1.5g/Kg, is raised daily
It feeds piglet 2 times (once in the morning and once at night), it is 1Kg/ each (to be equivalent to piglet and take in the dosage of scutelloside aluminium pre-mixing agent every time and be
1.5g/).After successive administration 3 days, treatment results are observed.As a result as shown in table 5 below.
The efficacy result of 5 Application Example 4 of table compares
It can be seen that from efficacy result of the table 2 into table 5 and be less than 510 parts compared to scutelloside aluminum complex additive amount
For comparative example 1, the average cure rate and average effectiveness level of test group 1-11 is apparently higher than contrast groups 1, illustrates implementation of the present invention
The scutelloside aluminium pre-mixing agent that example 1 to 11 provides is more significant to the therapeutic effect of grice diarrhoea；Compared to Baical Skullcap root P.E and aluminium
For the scutelloside aluminum complex prepared in reactant salt is the comparative example 2 of active constituent, test group 1-11 is averaged with contrast groups 2
Effective percentage is not much different, but the average cure rate of test group 1-11 is higher, moreover, the pre-mixing agent in contrast groups 2 is young in treatment
Dosage used in during diarrhea of pigs is 1.5g/ head, hence it is evident that higher than the 1g/ head in test group 1-11, and in test group 1-11
Piglet do not occur apparent side effect over the course for the treatment of, illustrate the embodiment of the present invention 1 to 11 provide scutelloside aluminium
For pre-mixing agent when being used to treat grice diarrhoea, not only dosage is small, but also therapeutic effect is more significant, few side effects.
The above is only a preferred embodiment of the present invention, is not intended to limit the scope of the invention, for this field
For technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any
Modification, equivalent replacement, improvement etc. should all be included within the scope of the present invention.
Claims (7)
1. a kind of scutelloside aluminium pre-mixing agent for treating grice diarrhoea, which is characterized in that including following components in terms of mass fraction:
Active constituent: 510~550 parts；
Filler: 450~490 parts；
Wherein, the active constituent is scutelloside and the scutelloside aluminum complex that aluminium salt is prepared into.
2. the scutelloside aluminium pre-mixing agent for the treatment of grice diarrhoea as described in claim 1, which is characterized in that the active constituent
Mass fraction is 520~540 parts, and the mass fraction of the filler is 460~480 parts.
3. the scutelloside aluminium pre-mixing agent for the treatment of grice diarrhoea as described in claim 1, which is characterized in that the filler is jade
One of rice flour, calcium monohydrogen phosphate and calcium carbonate are a variety of.
4. the scutelloside aluminium pre-mixing agent for the treatment of grice diarrhoea as claimed in claim 3, which is characterized in that the filler is phosphorus
Sour hydrogen calcium, the mass fraction of the calcium monohydrogen phosphate are 460 parts.
5. the scutelloside aluminium pre-mixing agent for the treatment of grice diarrhoea as described in claim 1, which is characterized in that the active constituent
Partial size is 50~65 mesh；And/or
The partial size of the filler is 50~65 mesh.
6. a kind of preparation method of the scutelloside aluminium pre-mixing agent of the treatment grice diarrhoea as described in claim 1 to 5 any one,
Characterized by comprising the following steps:
By scutelloside aluminum complex grinding and sieving, active constituent is obtained；
By filler grinding and sieving, filler powder is obtained；
The active constituent and the filler powder are mixed evenly, scutelloside aluminium pre-mixing agent is obtained.
7. the preparation method of the scutelloside aluminium pre-mixing agent for the treatment of grice diarrhoea as claimed in claim 6, which is characterized in that by institute
State active constituent and the step of the filler powder is mixed evenly, obtains scutelloside aluminium pre-mixing agent, specifically:
The active constituent and the filler powder are uniformly mixed according to equal increments method, obtain scutelloside aluminium pre-mixing agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811078610.8A CN108938570A (en) | 2018-09-14 | 2018-09-14 | A kind of scutelloside aluminium pre-mixing agent and preparation method thereof for treating grice diarrhoea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811078610.8A CN108938570A (en) | 2018-09-14 | 2018-09-14 | A kind of scutelloside aluminium pre-mixing agent and preparation method thereof for treating grice diarrhoea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108938570A true CN108938570A (en) | 2018-12-07 |
Family
ID=64476795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811078610.8A Withdrawn CN108938570A (en) | 2018-09-14 | 2018-09-14 | A kind of scutelloside aluminium pre-mixing agent and preparation method thereof for treating grice diarrhoea |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108938570A (en) |
-
2018
- 2018-09-14 CN CN201811078610.8A patent/CN108938570A/en not_active Withdrawn
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Application publication date: 20181207 |