CN108785325A - A kind of scutelloside zinc dry suspensoid agent and preparation method thereof for treating grice diarrhoea - Google Patents
A kind of scutelloside zinc dry suspensoid agent and preparation method thereof for treating grice diarrhoea Download PDFInfo
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Abstract
The present invention discloses a kind of scutelloside zinc dry suspensoid agent and preparation method thereof for treating grice diarrhoea, and the scutelloside zinc dry suspensoid agent for treating grice diarrhoea is in terms of mass fraction including following components：Active constituent：510~550 parts；Filler：435~485 parts；Suspending agent：5~15 parts；Wherein, the active constituent is the scutelloside Zn complex that scutelloside and zinc salt are prepared into.The present invention reacts prepared scutelloside Zn complex using scutelloside raw material with zinc salt as active constituent, it is prepared by mixing into scutelloside zinc dry suspensoid agent with filler and suspending agent, improve the purity of scutelloside Zn complex in the dry suspensoid agent, dosage of scutelloside zinc dry suspensoid agent when for treating grice diarrhoea is reduced, and improves therapeutic effect, reduce side effect.
Description
Technical field
The present invention relates to treating epidemic disease of domestic animals Prevention Technique field, more particularly to a kind of scutelloside zinc for treating grice diarrhoea is dry-mixed
Suspension and preparation method thereof.
Background technology
Grice diarrhoea is a kind of typical multifactor property disease under intensive pig production working condition.The disease is most tight at present
One of the piglet diseases group of weight, and cause the major reason of piglet death.According to relevant report, piglet accounts for piglet because of diarrhea death
The 39.8% of dead sum.In recent years, China's grice diarrhoea is very universal, 30kg piglets below, average of the whole year incidence
46.5%, the death rate 10.3%.In such as U.S. of the more flourishing country of pig breeding industry, the death rate about 15.5% before weaned piglet, Holland
11.5%~14.2%, grice diarrhoea ranks first in pig breeding industry harm, seriously threatens the sound development of pig breeding industry, causes to raise
Expect that rate of returns is relatively low, piglet survival ratio declines, is slow-growing, growth and development is stagnated, or even dead.
The treatment most common method of grice diarrhoea is to use antibacterials at present, since the drug resistance of current bacterium is serious,
Cause therapeutic effect poor.Also the relevant technologies replace antibacterials using Chinese medicine, it, should for example, by using scutelloside zinc dry suspensoid agent
Scutelloside zinc dry suspensoid agent is prepared by Baical Skullcap root P.E (active ingredient extracted in radix scutellariae) and zinc salt reaction, however,
Active ingredient in the Baical Skullcap root P.E is complicated, and purity is low, has certain side effect to piglet.
Invention content
The main object of the present invention is to propose a kind of scutelloside zinc dry suspensoid agent and preparation method thereof for treating grice diarrhoea,
It is intended to provide a kind of scutelloside zinc dry suspensoid agent good to grice diarrhoea therapeutic effect, Small side effects.
To achieve the above object, the present invention proposes a kind of scutelloside zinc dry suspensoid agent for treating grice diarrhoea, with mass parts
Number meter includes following components：
Active constituent：510~550 parts；
Filler：435~485 parts；
Suspending agent：5~15 parts；
Wherein, the active constituent is the scutelloside Zn complex that scutelloside and zinc salt are prepared into.
Preferably, the mass fraction of the active constituent is 520~540 parts, the mass fraction of the filler is 450~
470 parts, the suspending agent is 10~15 parts.
Preferably, the filler is one or more in mannitol, microcrystalline cellulose and lactose.
Preferably, the suspending agent is one or more in xanthans, sodium alginate and sodium carboxymethylcellulose.
Preferably, the suspending agent is xanthans, and the mass fraction of the xanthans is 10 parts.
Preferably, the grain size of the active constituent is 100~200 mesh；And/or
The grain size of the filler and the suspending agent is 100~200 mesh.
Preferably, the grain size of the active constituent is 200 mesh；And/or
The grain size of the filler and the suspending agent is 100 mesh.
To achieve the above object, the present invention also proposes a kind of preparation method of scutelloside zinc dry suspensoid agent as described above,
Include the following steps：
By scutelloside Zn complex grinding and sieving, active constituent is obtained；
Filler and suspending agent are distinguished into grinding and sieving, to deserved filler powder and suspending agent powder；
The active constituent and the filler powder and the suspending agent powder are mixed evenly, it is dry to obtain scutelloside zinc
Suspension.
Preferably, the active constituent and the filler powder and the suspending agent powder are mixed evenly, obtain Huang
The step of a kind of reed mentioned in ancient books glycosides zinc dry suspensoid agent, specially：
The active constituent is uniformly mixed with the filler powder and the suspending agent powder according to equal increments method,
Obtain scutelloside zinc dry suspensoid agent.
In technical solution provided by the invention, prepared scutelloside zinc cooperation is reacted with zinc salt using scutelloside raw material
Object is prepared by mixing into scutelloside zinc dry suspensoid agent as active constituent, with filler and suspending agent, improves the dry suspensoid agent
The purity of middle scutelloside Zn complex reduces the scutelloside zinc dry suspensoid agent and uses agent when for treating grice diarrhoea
Amount, and improve therapeutic effect, reduce side effect.
Specific implementation mode
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
The present invention proposes a kind of scutelloside zinc dry suspensoid agent for treating grice diarrhoea, including with the following group in terms of mass fraction
Point：Active constituent：510~550 parts；Filler：435~485 parts；Suspending agent：5~15 parts；Wherein, the active constituent is Huang
The scutelloside Zn complex that a kind of reed mentioned in ancient books glycosides and zinc salt are prepared into.
Radix scutellariae is a kind of traditional Chinese medicine, is used as medicine with root, bitter, cold in nature, there is heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, tocolysis
And other effects, cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, movement of the foetus not
The diseases such as peace, hypertension, carbuncle swells furuncle sore.The clinical antibiotic property of radix scutellariae is better than the coptis, and does not develop immunity to drugs.
Scutelloside is that a kind of flavone compound separated is extracted from the dry root of radix scutellariae, is faint yellow under room temperature
Powder, bitter, have significant bioactivity, have antibacterial, diuresis, anti-inflammatory, norcholesterol, antithrombus formation, alleviate asthma,
Purging intense heat and detonicating, hemostasis, tocolysis, antiallergic action and spasmolysis.Studies have shown that scutelloside antibacterial range is wider, especially to gold
Staphylococcus aureus, Pseudomonas aeruginosa effect are stronger, or even also have bacteriostasis to drug-resistant S. aureus.
Existing scutelloside zinc dry suspensoid agent is anti-by Baical Skullcap root P.E (active ingredient extracted in radix scutellariae) and zinc salt
It should be prepared, however, the extract component in the Baical Skullcap root P.E is complicated, scutelloside purity is low, as treatment grice diarrhoea
Drug when, have certain side effect to piglet.
Directly reacted using scutelloside raw material with zinc salt in the present invention prepared scutelloside Zn complex as it is active at
Point, it is prepared by mixing into scutelloside zinc dry suspensoid agent with filler and suspending agent, scutelloside zinc in the dry suspensoid agent is improved and matches
The purity for closing object, reduces dosage of scutelloside zinc dry suspensoid agent when for treating grice diarrhoea, can be used for
Treatment is mainly due to grice diarrhoea caused by bacterium infection, and wean, turns group and stress wait grice diarrhoea caused by reasons, to son
The therapeutic effect of diarrhea of pigs significantly, few side effects.It should be noted that preparing scutelloside metal with scutelloside and reacting metal salt
Complex belongs to the prior art, and the invention reside in choose using the scutelloside raw material of high-purity to react preparation with zinc salt as reactant
Active constituent of the scutelloside zinc as the dry suspensoid agent therefore scutelloside is reacted with zinc salt and prepares the cooperation of scutelloside zinc
The preparation method and process of object do not repeat.
As a kind of preferred embodiment provided by the invention, the mass fraction of the active constituent is 520~540 parts,
The mass fraction of the filler is 450~470 parts, and the suspending agent is 10~15 parts.
Dry suspensoid agent refers to insoluble drug and powder or shot-like particle is made in proper auxiliary materials, faces the used time and water is added to shake
Suspension is dispersed into for oral liquid preparation, the characteristics of the existing solid pharmaceutical preparation of dry suspensoid agent (particle), is such as convenient for carrying, transports
It is convenient, stability is good etc., and has the advantage of liquid preparation, conveniently take, be suitable for swallowing the patient having any problem, such as children, always
People etc..Ideal dry suspensoid agent gently shakes energy in addition to should have validity and chemical stability after should also settling slow, sedimentation
Redisperse, thus in preparation process in addition to filler is added as carrier, it is also necessary to suspending agent is added.
In the present embodiment, the filler is one or more in mannitol, microcrystalline cellulose and lactose, both can be with
It is any one in above-mentioned three kinds of substances, can also be arbitrary two kinds or three kinds of mixture in above-mentioned three kinds of substances,
It can be as the filler in the embodiment of the present invention.
The suspending agent is one or more in xanthans, sodium alginate and sodium carboxymethylcellulose, either on
Any one in three kinds of substances is stated, can also be arbitrary two kinds or three kinds of mixture in above-mentioned three kinds of substances,
Phase is disclosure satisfy that using the sedimentation volume ratio as the suspending agent in the embodiment of the present invention, the prepared dry suspensoid agent
The requirement of pass standard.
It is highly preferred that the suspending agent is xanthans, and the mass fraction of the xanthans is 10 parts.Xanthans is selected to make
For the suspending agent, not only sedimentation volume ratio disclosure satisfy that the requirement of relevant criterion to the prepared dry suspensoid agent, but also have
There is good redispersibility energy.
Since the scutelloside zinc dry suspensoid agent is during the use for treating grice diarrhoea, need to make Piglet by Oral
Enter in vivo, in order to avoid the phenomenon that dysphagia occurs in piglet, the grain size of the scutelloside zinc dry suspensoid agent should not be too large, at this
The grain size in inventive embodiments being preferably the active constituent is 100~200 mesh；And/or the filler and the suspending agent
Grain size be 100~200 mesh, can smoothly be gulped down in this way, not only contributing to piglet when taking the scutelloside zinc dry suspensoid agent
Pharynx, can also make the efficient mixing of scutelloside zinc dry suspensoid agent supplementary material in preparation process.
It is highly preferred that the grain size of the active constituent is 200 mesh；And/or the grain size of the filler and the suspending agent
For 100 mesh, the grain size of the active constituent is less than the grain size of the filler and the suspending agent so that the active constituent energy
It enough spreads more evenly across in the filler and the suspending agent.
The present invention also proposes a kind of preparation method of the scutelloside zinc dry suspensoid agent for the treatment of grice diarrhoea as described above, packet
Include following steps：
Step S10, by scutelloside Zn complex grinding and sieving, active constituent is obtained；
Step S20, filler and suspending agent are distinguished into grinding and sieving, to deserved filler powder and suspending agent powder；
Step S30, the active constituent and the filler powder and the suspending agent powder are mixed evenly, obtain Huang
A kind of reed mentioned in ancient books glycosides zinc dry suspensoid agent.
Wherein, step S10 and step S20 can be step S10 preceding, and step S20 is rear；Can also be that step S20 exists
Before, step S10 is rear；It can also be while separately carrying out, be not particularly limited herein.
Step S10 and step S20 in the specific implementation, may be used high speed disintegrator or mortar, mill etc. and routinely set
It is standby to carry out, it below will be by using being illustrated for Universalpulverizer, the specific implementation method of step S10 and step S20 are as follows：
Scutelloside Zn complex is smashed it through into 100~200 mesh sieve, obtains active constituent；Filler and suspending agent are smashed it through respectively
100~200 mesh sieve, to deserved filler powder and suspending agent powder.
In step slo, scutelloside Zn complex is more preferably smashed it through into 200 mesh sieve, obtains active constituent；In step
In S20, more preferably filler and suspending agent smash it through 100 mesh sieve respectively, to deserved filler powder and suspending agent powder,
In this way, the grain size of the active constituent is less than the grain size of the filler and the suspending agent so that the active constituent can
It spreads more evenly across in the filler and the suspending agent.
Step S30 in the specific implementation, specially：By the active constituent and the filler powder and the suspending agent
Powder is uniformly mixed according to equal increments method, obtains scutelloside zinc dry suspensoid agent.Equal increments method is in order to avoid in production medicine
During product or food, due in formula each component ratio differ greatly and the problem of be not easy mixing, concrete operation method
It is：The component for taking the amount of a small amount of components and equivalent big, while being placed in mixing machinery and being uniformly mixed, add same mixture etc.
The component that the amount of amount is big is uniformly mixed, and so a times amount is increased up until adding the big component of whole amount.In the present embodiment, i.e.,
For：First take the suspending agent and with the active constituent of the quality such as the suspending agent and the filler, it is mixed to be placed in high speed
It is uniformly mixed in conjunction machine and forms mixture, then be added thereto and the active constituent of the quality such as the mixture and described
Filler is uniformly mixed again, in this way, until the active constituent and the filler all add and finish and be uniformly mixed
Afterwards, the scutelloside zinc dry suspensoid agent is obtained.
Technical scheme of the present invention is described in further detail below in conjunction with specific embodiment, it should be understood that following real
It applies example to be only used to explain the present invention, be not intended to limit the present invention.
One, the preparation of scutelloside zinc dry suspensoid agent
Embodiment 1
(1) raw material weighs：Scutelloside Zn complex 530g, xanthans 15g, lactose 455g；
(2) preparation of scutelloside zinc dry suspensoid agent：Scutelloside Zn complex is smashed it through into 200 mesh with Universalpulverizer
Sieve, obtains active constituent；Xanthans and lactose are smashed it through into 100 mesh sieve with Universalpulverizer respectively, obtain xanthans powder and breast
Icing Sugar material；Active constituent is uniformly mixed with xanthans powder and lactose powder according to equal increments method, it is dry that scutelloside zinc is made
Suspension.
Embodiment 2
(1) raw material weighs：Scutelloside Zn complex 520g, xanthans 13g, lactose 467g；
(2) preparation of scutelloside zinc dry suspensoid agent：Scutelloside Zn complex is smashed it through into 150 mesh with Universalpulverizer
Sieve, obtains active constituent；Xanthans and lactose are smashed it through into 100 mesh sieve with Universalpulverizer respectively, obtain xanthans powder and breast
Icing Sugar material；Active constituent is uniformly mixed with xanthans powder and lactose powder according to equal increments method, it is dry that scutelloside zinc is made
Suspension.
Embodiment 3
(1) raw material weighs：Scutelloside Zn complex 540g, xanthans 10g, lactose 450g；
(2) preparation of scutelloside zinc dry suspensoid agent：Scutelloside Zn complex is smashed it through into 100 mesh with Universalpulverizer
Sieve, obtains active constituent；Xanthans and lactose are smashed it through into 100 mesh sieve with Universalpulverizer respectively, obtain xanthans powder and breast
Icing Sugar material；Active constituent is uniformly mixed with xanthans powder and lactose powder according to equal increments method, it is dry that scutelloside zinc is made
Suspension.
Embodiment 4
(1) raw material weighs：Scutelloside Zn complex 525g, xanthans 12g, lactose 463g；
(2) preparation of scutelloside zinc dry suspensoid agent：Scutelloside Zn complex is smashed it through into 200 mesh with Universalpulverizer
Sieve, obtains active constituent；Xanthans and lactose are smashed it through into 150 mesh sieve with Universalpulverizer respectively, obtain xanthans powder and breast
Icing Sugar material；Active constituent is uniformly mixed with xanthans powder and lactose powder according to equal increments method, it is dry that scutelloside zinc is made
Suspension.
Embodiment 5
(1) raw material weighs：Scutelloside Zn complex 535g, xanthans 12g, lactose 453g；
(2) preparation of scutelloside zinc dry suspensoid agent：Scutelloside Zn complex is smashed it through into 200 mesh with Universalpulverizer
Sieve, obtains active constituent；Xanthans and lactose are smashed it through into 200 mesh sieve with Universalpulverizer respectively, obtain xanthans powder and breast
Icing Sugar material；Active constituent is uniformly mixed with xanthans powder and lactose powder according to equal increments method, it is dry that scutelloside zinc is made
Suspension.
Embodiment 6
(1) raw material weighs：Scutelloside Zn complex 510g, xanthans 5g, mannitol 485g；
(2) the preparation method is the same as that of Example 1 for scutelloside zinc dry suspensoid agent.
Embodiment 7
(1) raw material weighs：Scutelloside Zn complex 550g, xanthans 10g, microcrystalline cellulose 440g；
(2) the preparation method is the same as that of Example 1 for scutelloside zinc dry suspensoid agent.
Embodiment 8
(1) raw material weighs：Scutelloside Zn complex 510g, sodium alginate 5g, lactose 485g；
(2) the preparation method is the same as that of Example 1 for scutelloside zinc dry suspensoid agent.
Embodiment 9
(1) raw material weighs：Scutelloside Zn complex 525g, sodium alginate 15g, lactose 460g；
(2) the preparation method is the same as that of Example 1 for scutelloside zinc dry suspensoid agent.
Embodiment 10
(1) raw material weighs：Scutelloside Zn complex 510g, sodium alginate 10g, lactose 480g；
(2) the preparation method is the same as that of Example 1 for scutelloside zinc dry suspensoid agent.
Embodiment 11
(1) raw material weighs：Scutelloside Zn complex 550g, sodium carboxymethylcellulose 5g, lactose 445g；
(2) the preparation method is the same as that of Example 1 for scutelloside zinc dry suspensoid agent.
Embodiment 12
(1) raw material weighs：Scutelloside Zn complex 540g, sodium carboxymethylcellulose 10g, lactose 450g；
(2) the preparation method is the same as that of Example 1 for scutelloside zinc dry suspensoid agent.
Embodiment 13
(1) raw material weighs：Scutelloside Zn complex 525g, sodium carboxymethylcellulose 15g, lactose 460g；
(2) the preparation method is the same as that of Example 1 for scutelloside zinc dry suspensoid agent.
Comparative example 1
(1) raw material weighs：Scutelloside Zn complex 450g, xanthans 3g, lactose 547g；
(2) the preparation method is the same as that of Example 1 for scutelloside zinc dry suspensoid agent.
Comparative example 2
(1) raw material weighs：Scutelloside Zn complex 490g, xanthans 4g, lactose 500g, wherein the Huang in this comparative example
A kind of reed mentioned in ancient books glycosides Zn complex is to react the product prepared with zinc salt with Baical Skullcap root P.E；
(2) the preparation method is the same as that of Example 1 for scutelloside zinc dry suspensoid agent.
According to《Republic of China Veterinary Pharmacopoeia》The regulation of (version one in 2015) in relation to dry suspensoid agent sedimentation volume ratio
It is tested, measures the sedimentation volume ratio of scutelloside zinc dry suspensoid agent prepared by embodiment 1 to embodiment 12, as a result see the table below 1.
According to《Chinese veterinary pharmacopoeia》The quality evaluating method of (version in 2015) about dry suspensoid agent measures Huang prepared by embodiment 1 to 12
The suspension performance of a kind of reed mentioned in ancient books glycosides zinc dry suspensoid agent, the results are shown in Table 1.
The suspension performance of scutelloside zinc dry suspensoid agent prepared by 1 embodiment and comparative example of table
According to《Republic of China Veterinary Pharmacopoeia》About the related rule under suspension item in (version one in 2015) annex
It is fixed, weight differential < 10%, loss on drying < 2%, judgement dry suspensoid agent whether qualified leading indicator for sedimentation volume ratio not
Less than 0.90.By the data in table 1 it is found that the settling volume of scutelloside zinc dry suspensoid agent prepared by the embodiment of the present invention 1 to 12
Than being all higher than 0.90, meet regulation；Moreover, when select active constituent cross 200 mesh sieve, using 10 parts of xanthans as suspending agent,
And suspending agent and filler, when sieving with 100 mesh sieve, the redispersibility of prepared scutelloside zinc dry suspensoid agent is substantially better than other realities
Apply example.And it is more less than 250 parts of comparative example 1 and scutelloside Zn complex additive amount for scutelloside Zn complex additive amount
For 400 parts of comparative example 2, sedimentation volume ratio does not meet fixation less than 0.90, and redispersibility is also poor.
Two, scutelloside zinc dry suspensoid agent is tested for the effect for the treatment of grice diarrhoea
1, case diagnosis：With natural cases according to epidemiology, clinical symptoms, pathological change, Laboratory Diagnosed.Comprehensive point
Analysis, is made a definite diagnosis.
2, result judgement：
It cures：3-4 rear affected animal illness of medication completely disappears, and spirit, body temperature, appetite restore normal, and urine excrement is normal.
Effectively：3-4 rear affected animal illness of medication disappears substantially, and spirit, body temperature, appetite make moderate progress, and urine excrement is normal.
In vain：Affected animal illness does not disappear after medication 4 times, and sb.'s illness took a turn for the worse or dead, and urine stool colour, character are abnormal.
Separately verify the scutelloside zinc dry suspensoid agent pair that embodiment 1 is prepared to embodiment 13 and comparative example 1, comparative example 2
The effect of one week 5 ages in days, 10 ages in days, 15 ages in days and wean grice diarrhoea, tests, including statistics scutelloside zinc dry suspensoid agent pair
The effective percentage of piglet, cure rate and there is non-evident effect.
15 age in days diarrhea piglet of Application Example
5 age in days diarrhea piglets 300 are chosen, 20 are one group, are divided into 15 groups of (test group 1 to test group 13 and comparisons
Group 1 and contrast groups 2), administering mode is：The scutelloside zinc that Example 1 is prepared to embodiment 13 and comparative example 1 is dry-mixed
(dry suspensoid agent that embodiment 1 to embodiment 13 is prepared corresponds to medicine-feeding test group 1 to test group 13, comparative example 1 to suspension respectively
Contrast groups 1 are administered in the dry suspensoid agent of preparation), it is wrapped per 20g mono-, when use adds water to be mixed, and is made into the suspension (suspension of 100mL
A concentration of 0.2g/mL of middle scutelloside zinc dry suspensoid agent), it feeds daily 1 time, it is 5mL/ each (to be equivalent to and feed radix scutellariae every time
The dosage of glycosides zinc dry suspensoid agent is 1g/)；The scutelloside zinc dry suspensoid agent administration contrast groups 2 that comparative example 2 is prepared are taken, often
15g mono- is wrapped, and when use adds water mixing, is made into suspension (a concentration of 0.3g/ of scutelloside zinc suspension in suspension of 50mL
ML), feed daily 1 time, it is 5mL/ each (it is 1.5g/ to be equivalent to and feed the dosage of scutelloside zinc dry suspensoid agent every time).It gives
After medicine 1 day, treatment results are observed.As a result as shown in table 2 below.
Curative effect Comparative result in 2 Application Example 1 of table
2 10 age in days severe diarrhea piglet of Application Example
Choose 10 age in days severe diarrhea piglets 300,20 are one group, be divided into 15 groups (test group 1 to test group 13, with
And contrast groups 1 and contrast groups 2), administering mode is：The scutelloside that Example 1 is prepared to embodiment 13 and comparative example 1
Zinc dry suspensoid agent (dry suspensoid agent that embodiment 1 to embodiment 13 is prepared corresponds to medicine-feeding test group 1 to test group 13 respectively,
Contrast groups 1 are administered in dry suspensoid agent prepared by comparative example 1), it is wrapped per 20g mono-, when use adds water to be mixed, and is made into the suspension of 100mL
(a concentration of 0.2g/mL of scutelloside zinc dry suspensoid agent in suspension), feeds 2 times daily, 5mL/ each (to be equivalent to each filling
The dosage for feeding scutelloside zinc dry suspensoid agent is 1g/)；Take the scutelloside zinc dry suspensoid agent administration comparison that comparative example 2 is prepared
Group 2 is wrapped per 15g mono-, and when use adds water mixing, and being made into the suspension of 50mL, (scutelloside zinc suspension is a concentration of in suspension
0.3g/mL), it feeds daily 2 times, 5mL/ each (it is 1.5g/ to be equivalent to and feed the dosage of scutelloside zinc dry suspensoid agent every time
Head).After administration 2 days, treatment results are observed.Treatment results are as shown in table 3 below.
Curative effect Comparative result in 3 Application Example 2 of table
3 15 age in days diarrhea piglet of Application Example
Choose 15 age in days diarrhea piglets 300,20 are one group, are divided into 15 groups of (test groups 1 to test group 13 and right
Than group 1 and contrast groups 2), administering mode is：The scutelloside zinc that Example 1 to embodiment 13 and comparative example 1 is prepared is dry
(dry suspensoid agent that embodiment 1 to embodiment 13 is prepared corresponds to medicine-feeding test group 1 to test group 13, comparison to suspension respectively
Contrast groups 1 are administered in dry suspensoid agent prepared by example 1), it is wrapped per 20g mono-, when use adds water to be mixed, and the suspension for being made into 100mL (is suspended
A concentration of 0.2g/mL of scutelloside zinc dry suspensoid agent in liquid), it feeds daily 1 time, it is 5mL/ each (to be equivalent to and feed Huang every time
The dosage of a kind of reed mentioned in ancient books glycosides zinc dry suspensoid agent is 1g/)；The scutelloside zinc dry suspensoid agent administration contrast groups 2 that comparative example 2 is prepared are taken,
It is wrapped per 15g mono-, when use adds water mixing, is made into suspension (a concentration of 0.3g/ of scutelloside zinc suspension in suspension of 50mL
ML), feed daily 1 time, it is 5mL/ each (it is 1.5g/ to be equivalent to and feed the dosage of scutelloside zinc dry suspensoid agent every time).It gives
After medicine 1 day, treatment results are observed.As a result as shown in table 4 below.
The effect of 4 Application Example 3 of table Comparative result
The diarrhea piglet of the wean of Application Example 4 after a week
Choose wean diarrhea piglet 300 after a week, 20 are one group, be divided into 15 groups (test group 1 to test group 13,
And contrast groups 1 and contrast groups 2), administering mode is：The radix scutellariae that Example 1 is prepared to embodiment 13 and comparative example 1
(dry suspensoid agent that embodiment 1 to embodiment 13 is prepared corresponds to medicine-feeding test group 1 to test group to glycosides zinc dry suspensoid agent respectively
13, contrast groups 1 are administered in dry suspensoid agent prepared by comparative example 1), it is wrapped per 20g mono-, when use adds water to be mixed, and is made into the suspension of 100mL
Liquid (a concentration of 0.2g/mL of scutelloside zinc dry suspensoid agent in suspension), feeds 2 times (once in the morning and once at night), each 5mL/ daily
Head (it is 1g/ to be equivalent to and feed the dosage of scutelloside zinc dry suspensoid agent every time)；Take the scutelloside zinc that comparative example 2 is prepared dry
Suspensions administration contrast groups 2 are wrapped per 15g mono-, and when use adds water mixing, are made into suspension (the scutelloside zinc in suspension of 50mL
A concentration of 0.3g/mL of suspension), it feeds daily 2 times (once in the morning and once at night), it is 5mL/ each (to be equivalent to and feed radix scutellariae every time
The dosage of glycosides zinc dry suspensoid agent is 1.5g/).After successive administration 3 days, treatment results are observed.As a result as shown in table 5 below.
The effect of 5 Application Example 4 of table Comparative result
Curative effect result in from table 2 to table 5 can be seen that is less than 510 parts compared to scutelloside Zn complex additive amount
For comparative example 1, the average cure rate and average effectiveness level of test group 1-13 are apparently higher than contrast groups 1, illustrate implementation of the present invention
The scutelloside zinc dry suspensoid agent that example 1 to 13 provides is more notable to the therapeutic effect of grice diarrhoea；Compared to Baical Skullcap root P.E
The scutelloside Zn complex prepared in being reacted with zinc salt is test group 1-13 and contrast groups 2 for the comparative example 2 of active constituent
Average effectiveness level is not much different, but being averaged for test group 1-13 has cure rate higher, moreover, the dry suspensoid agent in contrast groups 2
Used dosage is 1.5g/ heads during treating grice diarrhoea, hence it is evident that is higher than the 1g/ heads of test group 1-13, and tests
Piglet in group 1-13 does not occur apparent side effect over the course for the treatment of, this may be since embodiment 1 to 13 provides
Scutelloside zinc dry suspensoid agent in scutelloside Zn complex purity higher, and make dry suspensoid agent dosage smaller, say
For the scutelloside zinc dry suspensoid agent that the bright embodiment of the present invention 1 to 13 provides when for treating grice diarrhoea, not only dosage is small,
And therapeutic effect is more notable, few side effects.
It these are only the preferred embodiment of the present invention, be not intended to limit the scope of the invention, for this field
For technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, any made by
Modification, equivalent replacement, improvement etc. should all be included within the scope of the present invention.
Claims (9)
1. a kind of scutelloside zinc dry suspensoid agent for treating grice diarrhoea, which is characterized in that including following components in terms of mass fraction：
Active constituent：510~550 parts；
Filler：435~485 parts；
Suspending agent：5~15 parts；
Wherein, the active constituent is the scutelloside Zn complex that scutelloside and zinc salt are prepared into.
2. the scutelloside zinc dry suspensoid agent for the treatment of grice diarrhoea as described in claim 1, which is characterized in that the active constituent
Mass fraction be 520~540 parts, the mass fraction of the filler is 450~470 parts, and the suspending agent is 10~15 parts.
3. the scutelloside zinc dry suspensoid agent for the treatment of grice diarrhoea as described in claim 1, which is characterized in that the filler is
It is one or more in mannitol, microcrystalline cellulose and lactose.
4. the scutelloside zinc dry suspensoid agent for the treatment of grice diarrhoea as described in claim 1, which is characterized in that the suspending agent is
It is one or more in xanthans, sodium alginate and sodium carboxymethylcellulose.
5. the scutelloside zinc dry suspensoid agent for the treatment of grice diarrhoea as claimed in claim 4, which is characterized in that the suspending agent is
The mass fraction of xanthans, the xanthans is 10 parts.
6. the scutelloside zinc dry suspensoid agent for the treatment of grice diarrhoea as described in claim 1, which is characterized in that the active constituent
Grain size be 100~200 mesh；And/or
The grain size of the filler and the suspending agent is 100~200 mesh.
7. the scutelloside zinc dry suspensoid agent for the treatment of grice diarrhoea as claimed in claim 6, which is characterized in that the active constituent
Grain size be 200 mesh；And/or
The grain size of the filler and the suspending agent is 100 mesh.
8. a kind of preparation side of the scutelloside zinc dry suspensoid agent for the treatment of grice diarrhoea as described in claim 1 to 7 any one
Method, which is characterized in that include the following steps：
By scutelloside Zn complex grinding and sieving, active constituent is obtained；
Filler and suspending agent are distinguished into grinding and sieving, to deserved filler powder and suspending agent powder；
The active constituent and the filler powder and the suspending agent powder are mixed evenly, it is dry-mixed outstanding to obtain scutelloside zinc
Agent.
9. the preparation method of the scutelloside zinc dry suspensoid agent for the treatment of grice diarrhoea as claimed in claim 8, which is characterized in that will
The active constituent is mixed evenly with the filler powder and the suspending agent powder, obtains the step of scutelloside zinc dry suspensoid agent
Suddenly, specially：
The active constituent is uniformly mixed with the filler powder and the suspending agent powder according to equal increments method, is obtained
Scutelloside zinc dry suspensoid agent.
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| CN201811078827.9A CN108785325A (en) | 2018-09-14 | 2018-09-14 | A kind of scutelloside zinc dry suspensoid agent and preparation method thereof for treating grice diarrhoea |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106667915A (en) * | 2016-10-24 | 2017-05-17 | 武汉轻工大学 | Baicalin-aluminum dry suspension for treating pigling diarrhoea |
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2018
- 2018-09-14 CN CN201811078827.9A patent/CN108785325A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106667915A (en) * | 2016-10-24 | 2017-05-17 | 武汉轻工大学 | Baicalin-aluminum dry suspension for treating pigling diarrhoea |
Non-Patent Citations (1)
| Title |
|---|
| 冯蕾: "《黄芩苷锌质量控制与稳定性实验研究》", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
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